Journal of Obstetrics and Gynaecology of Eastern and Central Africa最新文献

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Phyllodes breast tumor in a patient on hormonal replacement therapy for primary ovarian failure with chronic kidney disease, hypertension with dilated cardiomyopathy and diabetes mellitus: A case report 一名因原发性卵巢功能衰竭、慢性肾病、高血压伴扩张型心肌病和糖尿病而接受激素替代治疗的患者患上了植物乳腺肿瘤:病例报告
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2024-02-14 DOI: 10.59692/jogeca.v36i1.270
Lauryn Mengesa, Daki Dido, D. Muchiri, Philomena Owende
{"title":"Phyllodes breast tumor in a patient on hormonal replacement therapy for primary ovarian failure with chronic kidney disease, hypertension with dilated cardiomyopathy and diabetes mellitus: A case report","authors":"Lauryn Mengesa, Daki Dido, D. Muchiri, Philomena Owende","doi":"10.59692/jogeca.v36i1.270","DOIUrl":"https://doi.org/10.59692/jogeca.v36i1.270","url":null,"abstract":"Background: Phyllodes tumors account for <1% of all breast neoplasms with a median age ofpresentation of the fourth decade. It is a fibroepithelial neoplasm that presents as a morphologiccontinuum from benign to malignant. The use of hormone replacement therapy has been linked to thedevelopment of breast cancer. The risk is increased with longer periods of use and with hormonalreplacement therapy. Phyllodes tumor is associated with Li-Fraumeni syndrome, a rare autosomaldominant condition characterized by the development of multiple tumors. Surgery is the preferred modeof treatment and involves wide local excision.Case presentation: A 37-year-old nulliparous presented with a left breast lump on self-examination. Shewas on follow-up for ovarian dysgerminoma when she first presented to a peripheral facility at the age of12 years with abdominal swelling. Hysterectomy and right oophorectomy were performed, followed by 10courses of chemotherapy with vincristine, actinomycin, and cyclophosphamide. She has also been onhormonal replacement therapy with on-and-off cyclical spotting and postcoital bleeding. She also hashypertension, diabetes, and dilated cardiomyopathy since 2016, and in 2018, she was diagnosed withchronic obstructive hydronephrosis. She then presented with a left breast lump in September 2023, andan ultrasound-guided core biopsy revealed a spindle cell neoplasm of malignant phyllodes tumor.Mastectomy was performed in December 2023, followed by radiotherapy, and hormonal replacementtherapy was stopped.Conclusion: Malignant phyllodes tumors differ from the more common type of breast cancer becausethey are less likely to respond to hormonal therapy and chemotherapy. Therefore, there is need for closefollow-up and monitoring.","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":"75 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point-of-care ultrasound, today, tomorrow, and the future – the place for task sharing 护理点超声波,今天、明天和未来--任务共享的场所
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2024-02-14 DOI: 10.59692/jogeca.v36i1.183
Gichangi Peter, Mercylyn Mokeira, Eric Wefukho, Patricia Owira, Edward Serem
{"title":"Point-of-care ultrasound, today, tomorrow, and the future – the place for task sharing","authors":"Gichangi Peter, Mercylyn Mokeira, Eric Wefukho, Patricia Owira, Edward Serem","doi":"10.59692/jogeca.v36i1.183","DOIUrl":"https://doi.org/10.59692/jogeca.v36i1.183","url":null,"abstract":"Background: Maternal and neonatal morbidity and mortality remain public health concerns. A study onmortality in Kenyan hospitals found that neonates comprise two-thirds of deaths in the pediatric agegroup (0–13 years). These deaths are caused by preventable conditions or those, which can bemanaged better if diagnosed early, such as placenta insufficiency, placenta previa, severe fetal growthrestriction, congenital abnormalities, multiple pregnancies, and breech presentation; these can all beidentified using point-of-care ultrasound (POCUS). Obstetrical ultrasound availability is limited to level 4and higher facilities, yet most women access lower levels of health care. Implementation of POCUS iscurrently limited because of a lack of appropriate training, limited scope of practice for frontline workers,and legal framework.Objective: The POCUS project is being undertaken to develop national guidelines to facilitate the roll outand scale-up of obstetrical POCUS.Methods: A collaborative participatory approach is planned for the development of the national POCUSguidelines. The key in this process is the identification of suitable frontline workers who, with adjustmentto their scope of practice, appropriate training, implementation of a supervision/referral system, canundertake obstetrical POCUS and gain buy-in from regulatory bodies, the inclusion of voices of relevantstakeholders, and leadership from government. A landscape and stakeholders analysis will also beundertaken as part of the process of the guideline development.Results: Narrative literature review shows that the WHO recommends effective and reliable antenatalultrasound services to be available to all pregnant women to optimize maternal and newborn healthoutcomes and at least one ultrasound scan up to 24 weeks of pregnancy. That there are deliberateefforts in Kenya to introduce POCUS with pilot training and implementation. Where obstetrical POCUS isimplemented, it is useful in diagnosing fetal malpresentation, placenta previa, congenital malformations,or multiple pregnancies. Appropriate interventions, such as reduction of cesarean delivery, induction oflabor, reduction of small for gestational age, low birthweight, preterm birth, and stillbirths, can improve thehealth outcome of the mother and neonate. There is a need to develop national POCUS guidelines.Conclusions: Implementation of POCUS may be riddled with difficulties, particularly where frontlineworkers’ current scope of practice may not allow them to perform such procedures, regulatoryframework, lack of knowledge, awareness, negative attitude, or behavior. The proposed guidelines willaddress these barriers.","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal lower urinary tract obstruction caused by sacrococcygeal teratoma: A case report 骶尾部畸胎瘤导致的胎儿下尿路梗阻:病例报告
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2024-02-14 DOI: 10.59692/jogeca.v36i1.190
Maryanne Mwangi, S. Wanyonyi
{"title":"Fetal lower urinary tract obstruction caused by sacrococcygeal teratoma: A case report","authors":"Maryanne Mwangi, S. Wanyonyi","doi":"10.59692/jogeca.v36i1.190","DOIUrl":"https://doi.org/10.59692/jogeca.v36i1.190","url":null,"abstract":"Background: Fetal lower urinary tract obstruction (LUTO) is a rare occurrence that is usually associatedwith major morbidity and mortality after birth. It has an incidence of 2.2 in 10000 pregnancies. In males,the most common cause is persistent posterior urethral valves (50-60%). Other causes include urethralatresia with a poor prognosis. Most fetuses that survive to term with LUTO need dialysis or renaltransplant.Case presentation: A 35-year-old gravida 3 presented for routine antenatal follow-up. Her antenatalfollow-up remained normal until she underwent a growth scan at 33 weeks. Ultrasound revealed a fetuswithin normal growth centiles, but the renal system had features of obstruction. Renal calyces weredilated with hyperechoic renal parenchyma. The bladder was also markedly distended and had athickened wall, and a keyhole sign was present. There was a multicystic lesion in the sacral regionwithout blood flow on Doppler imaging. There was oligohydramnios. She had fetal vesicocentesis, whichrevealed normal kidney function. She had serial fetal vesicocentesis, and renal ultrasound showedimprovement in the corticomedullary differentiation of the kidney. At 38 weeks, the patient underwent acesarean delivery. Imaging studies showed a sacrococcygeal teratoma that was causing pressure on therenal system. This was excised, and the patient was allowed to return home on physiotherapy. Renalfunction test after delivery remained normal.Conclusion: Fetal lower urinary tract obstruction in males is mostly managed using the placement ofvesicoamniotic shunts or stents. In male fetuses with posterior urethral valves, ablation is performed inutero using cystoscopy. In this case report, LUTO was managed by serial vesicocentesis, whichpreserved renal function. In low-resource settings where surgery is not available, serial vesicocentesiscan be performed to relieve obstruction.","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":"435 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RISK FACTORS FOR INVASIVE CERVICAL CANCER AMONG WOMEN LIVING WITH HIV/AIDS AT JARAMOGI OGINGA ODINGA TEACHING & REFERRAL HOSPITAL IN KISUMU COUNTY: A 5-YEAR HOSPITAL BASED CASE-CONTROL STUDY. 基苏木县 JARAMOGI OINGGA ODINGA 教学和转诊医院中感染 HIV/AIDS 的妇女患浸润性宫颈癌的风险因素:一项为期 5 年的医院病例对照研究。
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.197
R. Achapa, R. Kosgei, A. Osoti, F. Odawa, A. Pulei, M. Masinde, M. Kilonzo, A. Kihara, O. Ogutu, P. M. Ndavi
{"title":"RISK FACTORS FOR INVASIVE CERVICAL CANCER AMONG WOMEN LIVING WITH HIV/AIDS AT JARAMOGI OGINGA ODINGA TEACHING & REFERRAL HOSPITAL IN KISUMU COUNTY: A 5-YEAR HOSPITAL BASED CASE-CONTROL STUDY.","authors":"R. Achapa, R. Kosgei, A. Osoti, F. Odawa, A. Pulei, M. Masinde, M. Kilonzo, A. Kihara, O. Ogutu, P. M. Ndavi","doi":"10.59692/jogeca.v32i1.197","DOIUrl":"https://doi.org/10.59692/jogeca.v32i1.197","url":null,"abstract":"Background: Cervical cancer is the leading cause of mortality among reproductive women in resource constrained countries especially among the HIV infected group. HIV infection accelerates the transition of  cervical dysplasia to invasive cervical cancer. An overview of the risk factors among the HIV infected women  in this county is significant despite the paucity of data in this setting. \u0000Objective: To determine the risk factors of invasive cervical cancer in HIV-infected women in Kisumu County. Methodology \u0000Study design: An unmatched 5 year case control study from 2012-2016. \u0000Study setting: Jaramogi Oginga Odinga Teaching and Referral Hospital, largest hospital in Western Kenya. Study population: A total of 200 patient records, 100 cases and controls each. \u0000Data collection and analysis : A structured questionnaire was used as a standard tool for extraction of data  from both cases and controls. The determinants of invasive cervical cancer were analyzed using univariate  and multivariate analysis. Relevant tests to determine statistical significance were also carried out, p-value of  <0.05 was considered statistically significant. \u0000Results: HIV-infected women with invasive cervical cancer had poor socio-economic status, lower education  level (p=0.028), a higher parity (p=0.001), they also lived far away from the hospital facility (p=<0.0001,OR  4.6,C.I 1.62-12.9) and had a lower CD4 count (OR 18.6,C.I4.0-86.6) than those without invasive cervical  cancer.  \u0000Conclusion: Majority of the HIV-infected women with invasive cervical cancer had poor socio-economic  status, lived far away from the hospital facility, had done more prior pap smears and had a lower CD4 count  than those without. \u0000 ","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VAGINAL METASTASIS OF CHORIOCARCINOMA IN A 3O YEAR OLD FEMALE INITIALLY DIAGNOSED AS UTERINE PROLAPSE. 一名 3 岁女性的绒毛膜癌阴道转移,最初被诊断为子宫脱垂。
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.203
G.N Wanjiku
{"title":"VAGINAL METASTASIS OF CHORIOCARCINOMA IN A 3O YEAR OLD FEMALE INITIALLY DIAGNOSED AS UTERINE PROLAPSE.","authors":"G.N Wanjiku","doi":"10.59692/jogeca.v32i1.203","DOIUrl":"https://doi.org/10.59692/jogeca.v32i1.203","url":null,"abstract":"Introduction: Vaginal metastasis in choriocarcinoma complicates about 30% of patients with  choriocarcinoma. The commonest site of metastatic is the lungs and is seen in a majority of patients with  choriocarcinoma.   \u0000Vaginal metastasis of choriocarcinoma can be misleading at the time of presentation resulting in  misdiagnosis and delay in initiation of life saving treatment.   \u0000The case is presented of a 30-year-old, para1+1 with history of a slow growing, painful and easily bleeding  vaginal mass that was initially thought to be uterine prolapse or a prolapsed leiomyoma. ","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":" 63","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Perinatal Mortality and characteristic of mothers delivered at Juba Teaching Hospital, South Sudan: A Cross Sectional Study 南苏丹朱巴教学医院产妇的早期围产期死亡率和特征:横断面研究
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.199
W.P Flora, R.K Kamau, M.M James, O. Ogutu, J. Karanja, A. Osoti, O. Kireki, A. Kihara, R. Kosgei, M. Obimbo, A. Bosire, P.K Koigi, P. M. Ndavi
{"title":"Early Perinatal Mortality and characteristic of mothers delivered at Juba Teaching Hospital, South Sudan: A Cross Sectional Study","authors":"W.P Flora, R.K Kamau, M.M James, O. Ogutu, J. Karanja, A. Osoti, O. Kireki, A. Kihara, R. Kosgei, M. Obimbo, A. Bosire, P.K Koigi, P. M. Ndavi","doi":"10.59692/jogeca.v32i1.199","DOIUrl":"https://doi.org/10.59692/jogeca.v32i1.199","url":null,"abstract":"Background/Objectives: Perinatal mortality rates are highest in Africa where it is more than five times  higher than in developed regions. South Sudan has some of the worst health outcome indicators globally, in  spite of modest improvements over the last five years. The aim of this study is to determine the magnitude  and characteristic of women with early perinatal mortality at Juba Teaching Hospital, South Sudan. \u0000Methodology \u0000Study design: A cross-sectional study.  \u0000Study site/setting: Juba Teaching Hospital maternal word. \u0000Study population: Comprised of mothers and their newborn babies delivered at JTH during the study  period. \u0000Sampling: Consecutive sampling techniques was most appropriate for the selection of mothers who  delivered their babies during the study period. \u0000Data collection & management: Data was analyzed using SPSS, version 23. Descriptive analysis was  conducted to summarize characteristics of participants. Multivariable analysis conducted using binary  logistic regression analysis to identify the predictors of EPNM. Statistical significance based on a p value of  0.05. \u0000Result: Early perinatal mortality rate was 122.3 per 1000 total birth with stillbirth rate of 82.7 per 1000  total births with majority attributable to fresh still births 14(41%). Factors associated with early perinatal  mortality: Non-formal education ( OR=5; 95% CI 2.1-10.1 P val. <0.000) , pervious history of stillbirth,  (OR = 2.6; 95% CI 1.1-6.3; p val. 0.04), ANC < 4 visit (OR=3.2, 95% CI 1.5-7.0; p val, 0.0005) and  gestation age ≤ 36 weeks (OR= 5.1; 95% CI 2.4-11; p val. 0.0001), were associated with increased risk  of EPNM. While parity of ≥ 4 (OR= 0.4; 95% CI 0.2-0.09; p val. 0.04), appeared to significantly, reduce  EPNM among women delivered at JTH during the study period. \u0000Conclusions: The lack of formal education, younger maternal age, previous history of stillbirth, low  antenatal clinic attendance and pre-term gestation increased the risk of early perinatal mortality among  mothers delivered in JTH. \u0000 ","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PREVALENCE BY CRITERION BASIS FOR POLYCYSTIC OVARY SYNDROME AMONG WOMEN PRESENTING WITH AMENORRHEA AND OLIGOMENORRHEA AT THE KENYATTA NATIONAL HOSPITAL IN 2018 2018年在肯雅塔国立医院就诊的闭经和少经妇女中多囊卵巢综合征的流行率标准依据
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.202
F. Odera, J. Karanja, J. Kinuthia, O. Kireki, M. Kilonzo, A. Pulei, A. Kihara, M. Masinde, F. Odawa, R. Kosgei, O. Ogutu
{"title":"PREVALENCE BY CRITERION BASIS FOR POLYCYSTIC OVARY SYNDROME AMONG WOMEN PRESENTING WITH AMENORRHEA AND OLIGOMENORRHEA AT THE KENYATTA NATIONAL HOSPITAL IN 2018","authors":"F. Odera, J. Karanja, J. Kinuthia, O. Kireki, M. Kilonzo, A. Pulei, A. Kihara, M. Masinde, F. Odawa, R. Kosgei, O. Ogutu","doi":"10.59692/jogeca.v32i1.202","DOIUrl":"https://doi.org/10.59692/jogeca.v32i1.202","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is the commonest endocrinological condition associated  with anovulatory infertility in women. Worldwide, the prevalence is highly variable, ranging from 2.2% to  as high as 26%. Similarly, the prevalence of PCOS is variable in Africa, occurring in about 1 in 6 infertile  Nigerian women and 32% of infertile women in Tanzania. The variable prevalence could be attributable  to multiplicity of diagnostic criteria, and similarity in presentation with other syndromes that present with  amenorrhea and the population studied.  \u0000Objectives: To determine the prevalence by criterion basis of PCOS among women with amenorrhea and  oligomenorrhea attending the Kenyatta National Hospital in 2018.  \u0000Methodology: This was a descriptive cross sectional study. The study population comprised of 131 women  recruited at Kenyatta National Hospital gynecology department. Those enrolled, gave an informed consent,  filled a questionnaire, had their anthropometric measurements taken, then underwent a pelvic ultrasound scan  and a blood sample for serum free testosterone levels was taken. PCOS was determined using the Rotterdam  2003, the NIH 1990 and the AE-PCOS 2006 criteria.  \u0000Results: PCOS was diagnosed in 49(37%) using the Rotterdam criteria, 26(20%) using the NIH 1990 criteria  and 15(12%) using the AE-PCOS 2006 criteria.   \u0000Conclusion: When the Rotterdam criteria is used, the prevalence is highest, followed by the NIH 1990 and  lastly the AE-PCOS 2006.  \u0000Recommendation: The Rotterdam criteria for diagnosis of PCOS should be used as it more representative. ","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":" 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASSOCIATION BETWEEN SERUM FOLATE LEVELS AND EARLY PREGNANCY LOSS AT KNH. A CASE CONTROL STUDY 孕妇血清叶酸水平与早孕损失之间的关系。病例对照研究
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.201
M.A Okango, O.W Gachuno, H. Tamooh, P.K Koigi, A. Bosire, A. Osoti, M. Obimbo, C.B Wekesa, R. Kosgei, A. Kihara, O. Ogutu
{"title":"ASSOCIATION BETWEEN SERUM FOLATE LEVELS AND EARLY PREGNANCY LOSS AT KNH. A CASE CONTROL STUDY","authors":"M.A Okango, O.W Gachuno, H. Tamooh, P.K Koigi, A. Bosire, A. Osoti, M. Obimbo, C.B Wekesa, R. Kosgei, A. Kihara, O. Ogutu","doi":"10.59692/jogeca.v32i1.201","DOIUrl":"https://doi.org/10.59692/jogeca.v32i1.201","url":null,"abstract":"Background: The World Health Organization (WHO) defines Early Pregnancy Loss (EPL) as termination  of pregnancy before 20 weeks gestation or with a fetal weight of below 500grams. EPL occurs in 10% of  all clinically recognized pregnancies, 80% of which occurs in the first trimester. About 50% of EPLs are  due to chromosomal abnormalities. Other factors implicated include: immunologic; anatomic; endocrine;  hematologic and micronutrient factors, including folic acid deficiency. This study aimed at assessing the  association between serum folic acid levels and EPL among patients attending Ante natal services at the  Kenyatta National Hospital (KNH).   \u0000Methodology: This was a case control study where cases were women aged 18 to 40 years presenting with  EPL (below 16 weeks of gestation) while the controls were women with viable pregnancy matched for  gestation age. Consecutive sampling was used to identify 82 women with EPL and 95 women with normal  pregnancy.2mls of blood was collected from the ante cubital fossa for assessment of folic acid levels.   \u0000Results: There was a statistically significant difference in the median folic acid level between the EPL group  and the normal pregnancy group (17.3ng/ml and 19.7ng/ml respectively) (p, 0.022). Using the KNH normal  reference range for serum folic acid levels in pregnancy of 12.9 – 20ng/ml, there was no significant association  between folate levels and EPL. Two-thirds in the EPL group (69.5%) and majority (89.5%) of the pregnant  group were married. Pregnancy loss was significantly associated with marital status (p, 0.001), education level  (p, 0.042), number of previous miscarriages (p, 0.003) and antenatal clinic attendance (p,0.016).  \u0000Conclusion and recommendations: From our study we concluded that normal serum folate levels do not  seem to confer protection against EPL in this population. Supplementation is essential to high risk population  i.e. those with low education level, single status and those not attending antenatal clinics.It is recommended  that WHO levels for normal serum folic acid be used as the normal and then conduct further studies using  this standard.","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":" 91","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Perinatal mortality in the region, are we prepared for this persistent matter in our midst? 社论:本地区的围产期死亡率,我们准备好应对这一长期存在的问题了吗?
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.198
Ogutu Omondi
{"title":"Editorial: Perinatal mortality in the region, are we prepared for this persistent matter in our midst?","authors":"Ogutu Omondi","doi":"10.59692/jogeca.v32i1.198","DOIUrl":"https://doi.org/10.59692/jogeca.v32i1.198","url":null,"abstract":"","PeriodicalId":517202,"journal":{"name":"Journal of Obstetrics and Gynaecology of Eastern and Central Africa","volume":" 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FACTORS ASSOCIATED WITH TIMING OF ANTENATAL CLINIC ATTENDANCE AT MEDINA HOSPITAL, SOMALIA 与索马里麦地那医院产前检查就诊时间有关的因素
Journal of Obstetrics and Gynaecology of Eastern and Central Africa Pub Date : 2020-03-31 DOI: 10.59692/jogeca.v32i1.200
A.H Nima, R. Kosgei, A. Osoti, P.K Koigi, M. Obimbo, O. Ogutu, J. Karanja, A. Bosire, A. Kihara
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