Immunology and Allergology: Science and Practice最新文献

{"title":"МЕЛАТОНІН ТА МОЖЛИВОСТІ ЗАСТОСУВАННЯ У ПАЦІЄНТІВ КОМОРБІДНОГО ПРОФІЛЮ","authors":"N. Kozak, Bohdan Kozak","doi":"10.37321/immunology.2023.4-06","DOIUrl":"https://doi.org/10.37321/immunology.2023.4-06","url":null,"abstract":"У статті наведено огляд новітніх результатів клінічних досліджень по застосуванню плейотропного гормону мелатоніну у пацієнтів різного терапевтичного профілю та з коморбідністю. Приведені дані про застосування мелатоніну для нормалізації сну, покращення емоційної сфери, а також як препарату, що чинить протизапальний, імуномодулюючий та антиоксидантний ефекти.","PeriodicalId":516971,"journal":{"name":"Immunology and Allergology: Science and Practice","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"РЕТРОСПЕКТИВНИЙ АНАЛІЗ ТЕРАПІЇ ПСОРІАЗУ ЕКСИМЕРНИМ ЛАЗЕРОМ 308 НМ","authors":"A. Kurchenko, Olha Mankivska, Halyna Fedoruk, Kostiantyn Kurchenko","doi":"10.37321/immunology.2023.4-03","DOIUrl":"https://doi.org/10.37321/immunology.2023.4-03","url":null,"abstract":"У цьому дослідницькому огляді ми визначили, що при терапії псоріазу ексимерним лазером було визначено три основні протоколи: протокол MED, протокол індурації і протокол MBD. Показано, що це ефективний варіант лікування в комбінованій терапії з місцевими засобами, а також варіант лі- кування псоріазу, стійкого до системного лікування. Ексимер-лазер залишається чудовим варіантом лікування псоріазу, і його слід розглядати як додатковий варіант лікування місцевих або системних засобів.","PeriodicalId":516971,"journal":{"name":"Immunology and Allergology: Science and Practice","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMMUNOLOGICAL FEATURES OF COVID-19 IN PATIENTS WITH NEUROPSYCHIATRIC SYMPTOMS AND HHV-6-INFECTION","authors":"Олена Миколаївна Надіжко, Svitlana Zubchenko","doi":"10.37321/immunology.2023.4-02","DOIUrl":"https://doi.org/10.37321/immunology.2023.4-02","url":null,"abstract":"SARS-CoV-2 infection in most cases is characterised by mild symptoms of fever, tiredness and dry cough. Coronaviruses can also induce cognitive, emotional, neurovegetative and behavioral dysregulation due to direct neurological injury through hypoxic damage and neuroinvasion. Most SARS-CoV-2 infections resolve within two weeks. However, the infection, which is characterized by neurological and neuropsychiatric symptoms, may last longer than 12 weeks. This phenomenon has been termed as Long COVID (LC) – a multisystemic condition, associated with acute phase disease severities. Several hypotheses for its pathogenesis have been suggested, including immune dysregulation with or without reactivation of herpesviruses. The inflammation is central to pathogenesis of psychiatric symptoms in COVID-19 patients, which is often associated with presence of neural autoantibodies. \u0000The following changes are established of innate immunity in patients with SARS-CoV-2 infection and long COVID: 1) cytokine storm, which manifests itself in high concentration of proinflammatory cytokines and chemokines (IFN-β, IFN-λ1, IFN-γ, CXCL9, CXCL10, IL-8, IL-1α/β, IP-10, MCP-1); 2) elevated level C-reactive protein; 3) decreased number of NK, NKT cells and its exhaustion; 4) lower expression of NKG2C, upregulation of checkpoint receptors (LAG3, TIGIT and TIM3) on NK cells; 5) poor interacting between monocytes, infectious agents and Tolllike receptor (TLR) ligands; 6) reinforced products of thromboxane-A2, resulting in increased platelet aggregation, which mediate thrombus formation. It was also found in such patients the changes of adaptive immunity: 1) T cell alterations, including exhausted T cells; 2) reduced CD4+ and CD8+ effector memory cell numbers, which mainly express PD-1, CTLA-4, TIGIT and Tim-3; 3) a lack of naive T and B cells; 4) increases in the numbers of IL-4- and IL-6-secreting CD4+ T cells; 5) higher expression of cytotoxic granules (GrA, GrB, perforin) on CD8+ T cells. \u0000The exact mechanisms underlying the immune response after SARS-CoV-2 infection remain unclear. The count of helper T cells, regulatory T cells and memory T cells are all diminished in severe COVID- 19 cases, though Th1 and Th2 cytokine levels remain high. T cell activation (indicated by CD38 and HLA-DR) occur during severe COVID-19. Besides, T cells are overactivated in COVID-19 patients, leading to cytokine storm, and decreased Treg cells are a reason for severe disease. A subset of T cell expressed at the same time both: T cell immunoglobulin and mucin domain-3 (Tim-3) and programmed death-1 (PD-1). \u0000The overproduction of several inflammatory cytokines, overactivated and exhausted T cells, overstimulation of immune system and loss of self-tolerance alone can cause the production of autoantibodies. In addition, are activated the extrafollicular B cells in conjunction with autoantibody-secreting B cells. As seen in COVID-19 patients with autoantibodies and autoreactive CD4+ and CD8+ cells, pr","PeriodicalId":516971,"journal":{"name":"Immunology and Allergology: Science and Practice","volume":"220 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139894197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}