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Use of Cystoinflation to Prevent Urinary Tract Injuries in Patients with Placenta Previa 使用膀胱充气术预防前置胎盘患者的尿路损伤

BioSight Pub Date : 2024-01-15 DOI: 10.46568/bios.v5i1.183

Uzma Hussain, Faryal Kanwal, Muhammad Essa, Uswah Shoiab, Maria Imran, Snovia Ishaq, Huma Khan, Muhammad Irshad, Zain Ul Abideen

{"title":"Use of Cystoinflation to Prevent Urinary Tract Injuries in Patients with Placenta Previa","authors":"Uzma Hussain, Faryal Kanwal, Muhammad Essa, Uswah Shoiab, Maria Imran, Snovia Ishaq, Huma Khan, Muhammad Irshad, Zain Ul Abideen","doi":"10.46568/bios.v5i1.183","DOIUrl":"https://doi.org/10.46568/bios.v5i1.183","url":null,"abstract":"Introduction: There is insufficient evidence to support the use of cystoinflation to prevent bladder injury in women with placenta previa. The purpose of this study is to find the effectiveness and safety of cystoinflation to prevent bladder injury in women with placenta previa. Methods: The study was conducted at Gynecology & Obstetrics Department, lady Willing-don hospital, Lahore for six months duration . The research was conducted by forming two groups. Women in Group-A (inflated urinary bladder) had significantly lower bladder injury as compared to women in Group-B (deflated urinary bladder). i.e. 1.9% vs. 11.32%, p-value=0.050. Results: Homeostatic sutures requirement was significantly higher in Group-B as that of Group-A. i.e. 15.1% vs. 18.9%, p-value=0.604 Duration of hospital stay showed no significant difference between groups. i.e. 96.2% patients in Group-A and 88.7% patients in Group-B discharged from hospital within 3-4 days. Conclusion: Based on the results of this study, women presenting with placenta previa had significantly lower incidences of bladder injury as a result of cystoinflation during cesarean section.","PeriodicalId":516564,"journal":{"name":"BioSight","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Mucosal- Associated Invariant T Cell Levels And Their Correlation With Tumor Immune Status In Patients With Brain Tumors 脑肿瘤患者粘膜相关不变 T 细胞水平及其与肿瘤免疫状态的相关性分析

BioSight Pub Date : 2024-01-15 DOI: 10.46568/bios.v5i1.185

Barha Latif, Hafiz Muhammad, Haseeb Khaliq, Asad Ullah, Khawar Anwar, Adnan Arshad, Kausar Abdullah, Malik

{"title":"Analysis of Mucosal- Associated Invariant T Cell Levels And Their Correlation With Tumor Immune Status In Patients With Brain Tumors","authors":"Barha Latif, Hafiz Muhammad, Haseeb Khaliq, Asad Ullah, Khawar Anwar, Adnan Arshad, Kausar Abdullah, Malik","doi":"10.46568/bios.v5i1.185","DOIUrl":"https://doi.org/10.46568/bios.v5i1.185","url":null,"abstract":"Introduction: Primary brain tumors refer to a heterogeneous group of tumors arising from cells within the CNS, and can be benign or malignant. In recent years, experimental evidence suggests that, despite the presence of blood-brain barrier (BBB) and lack of discrete lymphoid tissue, there are immunocompetent cells (TILs-Tumor infiltrating lymphocytes) within the brain parenchyma. Many of these cells are T-Lymphocytes known as CD8+ Mucosal-associated invariant T (MAIT) cells, which proliferate with stimulation, and are cytotoxic to tumor cells in vitro. To evaluate the frequency of unconventional MAIT cells in the setting of brain tumors by expression analysis of their three defining markers CD3D, KLRB1 (CD161) and a TCR a-chain variant Va7.2 (TRAV1-2 gene). Methodology: The study involved collecting EDTA blood samples and fresh brain tissue biopsies from selected population followed by RNA extraction and cDNA synthesis for measurement of relative expression analysis in blood and tissues samples. Expression data was generated by semi-quantitative real time PCR. Results: The outcome of this study demonstrated higher expression level of CD3D, KLRB1 (CD161) and a TCR a-chain variant Va7.2 (TRAV1-2 gene) in the blood of patients compared to the tissue samples showed little to no transmigration of these MAIT cells in the diseased tissues. Also, the expression of genes under-investigation was observed decreasing in both blood and tissue samples with the progression of tumor. Conclusion: MAIT cells might undergo depletion in the tumor micro-environment due to chronic activation induced exhaustion of these cells.","PeriodicalId":516564,"journal":{"name":"BioSight","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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