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Clinical Advances in Hematology & Oncology最新文献

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Diagnosis and treatment of secondary hemophagocytic lymphohistiocytosis in adults. 成人继发性噬血细胞淋巴组织细胞病的诊断与治疗。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
Bita Shakoory, Joseph M Rocco
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引用次数: 0
Is there a universal standard of care for frontline therapy in multiple myeloma? 对于多发性骨髓瘤的一线治疗是否有一个通用的护理标准？
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
Sagar Lonial
{"title":"Is there a universal standard of care for frontline therapy in multiple myeloma?","authors":"Sagar Lonial","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 6","pages":"379-381"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midyear highlights in gastrointestinal cancers: expert perspectives. 胃肠癌的年中亮点：专家观点。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
Tanios S Bekaii-Saab, David H Ilson
{"title":"Midyear highlights in gastrointestinal cancers: expert perspectives.","authors":"Tanios S Bekaii-Saab, David H Ilson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 Suppl 9 6","pages":"4-15"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging role of antibody-drug conjugates in metastatic colorectal cancer. 抗体-药物结合物在转移性结直肠癌中的新作用。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
John H Strickler
{"title":"The emerging role of antibody-drug conjugates in metastatic colorectal cancer.","authors":"John H Strickler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 6","pages":"385-387"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of immunotherapy into the frontline treatment of acute lymphoblastic leukemia. 将免疫疗法纳入急性淋巴细胞白血病的一线治疗。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
Ajoy Dias, Mark R Litzow
{"title":"Integration of immunotherapy into the frontline treatment of acute lymphoblastic leukemia.","authors":"Ajoy Dias, Mark R Litzow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunotherapy has transformed the treatment of acute lymphoblastic leukemia (ALL) over the past 2 decades, leading to excellent outcomes in adults and children. This is especially true in the setting of relapsed and refractory (R/R) disease, in which treatment outcomes formerly were dismal. Several immune therapies have shown efficacy and safety in the R/R setting, including monoclonal antibodies, bispecific antibodies, antibody-drug conjugates (ADCs), and chimeric antigen receptor (CAR) T-cell therapy. These new immunotherapy approaches have brought about a major paradigm shift in the treatment of R/R ALL, with very few long-term side effects in comparison with standard chemotherapy. These agents are now being used in patients with newly diagnosed ALL, with good response rates. This review discusses novel immunotherapeutic options, including bispecific antibodies, ADCs, and CAR T-cell-based therapies, in the upfront setting. It also discusses the incorporation of novel agents either as monotherapy or in combination with cytotoxic chemotherapy and describes our views on how best to use these agents in patients with newly diagnosed disease.</p>","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 6","pages":"350-360"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midyear highlights in gastrointestinal cancers. 年中以胃肠道癌为主。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
{"title":"Midyear highlights in gastrointestinal cancers.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 Suppl 9 6","pages":"1-18"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDA regulatory pathways for expedited drug development and approval. FDA加快药物开发和批准的监管途径。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-09-01
Aaron S Kesselheim
{"title":"FDA regulatory pathways for expedited drug development and approval.","authors":"Aaron S Kesselheim","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 6","pages":"382-384"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The addition of darolutamide to androgen deprivation therapy in metastatic hormone-sensitive prostate cancer. 在转移性激素敏感前列腺癌的雄激素剥夺治疗中加入达洛鲁胺。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-07-01
Fred Saad
{"title":"The addition of darolutamide to androgen deprivation therapy in metastatic hormone-sensitive prostate cancer.","authors":"Fred Saad","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 5","pages":"307-309"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights in upper gastrointestinal cancer from the 2025 American Society of Clinical Oncology Annual Meeting. 2025年美国临床肿瘤学会年会上上消化道肿瘤的亮点。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-07-01
{"title":"Highlights in upper gastrointestinal cancer from the 2025 American Society of Clinical Oncology Annual Meeting.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 5","pages":"317-319"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing breast cancer treatment: the promise of antibody-drug conjugates. 革命性的乳腺癌治疗：抗体-药物结合物的前景。
IF 1.1
Clinical Advances in Hematology & Oncology Pub Date : 2025-07-01
Samer Alkassis, John A Glaspy, Aditya Bardia
{"title":"Revolutionizing breast cancer treatment: the promise of antibody-drug conjugates.","authors":"Samer Alkassis, John A Glaspy, Aditya Bardia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antibody-drug conjugates (ADCs) have significantly advanced the treatment of breast cancer by integrating the specificity of monoclonal antibodies with the cytotoxic efficacy of chemotherapy, thereby enabling a targeted therapeutic approach that reduces off-target toxicity to normal tissues. Currently, 4 ADCs-sacituzumab govitecan, trastuzumab deruxtecan, trastuzumab emtansine, and the more-recent datopotamab deruxtecan-are approved for clinical application, with several others in advanced stages of development. Although these agents have demonstrated promising clinical efficacy, challenges such as ADC resistance and associated toxicities have emerged, underscoring the need for continued research. Multiple strategies are under investigation to enhance therapeutic benefit through combination regimens with other classes of medications, as are approaches to mitigate resistance mechanisms. Progress in next-generation ADCs, incorporating novel linkers and more potent cytotoxic payloads, holds promise for further improvement in clinical outcomes. Additionally, biomarker-driven strategies to identify those patients most likely to benefit from ADC therapy will support more personalized approaches to treatment. This review explores the structural and mechanistic features of ADCs in breast cancer, highlighting their therapeutic potential, and discusses ongoing clinical trials exploring new-generation ADCs and combination therapies.</p>","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"23 5","pages":"290-299"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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