Clinical Advances in Hematology & Oncology最新文献

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Updates in the management of small cell lung cancer. 小细胞肺癌治疗的最新进展。
IF 1.1
Jyoti Malhotra
{"title":"Updates in the management of small cell lung cancer.","authors":"Jyoti Malhotra","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3","pages":"177-179"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to implement DPYD genotyping into practice. 如何在实践中实施DPYD基因分型。
IF 1.1
Alan P Venook
{"title":"How to implement DPYD genotyping into practice.","authors":"Alan P Venook","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3","pages":"170-172"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemophagocytic lymphohistiocytosis: new grading classification and targeted therapies. 噬血细胞淋巴组织细胞病:新的分级、分类和靶向治疗。
IF 1.1
Edo Schaefer, Tishi Shah, Alissa Zhu, Mitchell S Cairo
{"title":"Hemophagocytic lymphohistiocytosis: new grading classification and targeted therapies.","authors":"Edo Schaefer, Tishi Shah, Alissa Zhu, Mitchell S Cairo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hemophagocytic lymphohistiocytosis (HLH), both primary/familial HLH and secondary HLH, is associated with multiorgan dysfunction caused by excessive immune activation and cytokine release. The high morbidity and mortality rates are in part due to diagnostic challenges leading to a delay in treatment initiation. The diagnosis, which uses the Histiocyte Society clinical criteria from 2004 and the HScore, remains challenging, with limited improvement in outcomes. No grading system is available for HLH. Although etoposide with dexamethasone remains the most frequently used first-line regimen, various new therapies are now being employed in the management of HLH. The interferon gamma inhibitor emapalumab, the Janus kinase signal transducer and activator of transcription pathway inhibitor ruxolitinib, and the interleukin 6 (IL-6) inhibitor tocilizumab have been trialed in HLH management, with additional treatment options being inhibition of IL-18 and tumor necrosis factor alpha. Here, we summarize current management options for HLH; we also propose a new grading system for HLH based on Common Terminology Criteria for Adverse Events version 5.0 as well as on known prognostic factors (eg, abnormal bilirubin and transaminase levels, elevated creatinine level, respiratory failure, neutropenia, hypertriglyceridemia, hypoalbuminemia, and coagulopathy), which could standardize the diagnosis and guide prompt and appropriate management.</p>","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3","pages":"134-144"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periprocedural management of patients on antithrombotic therapy. 抗栓治疗患者的围手术期管理。
IF 1.1
Robert D McBane
{"title":"Periprocedural management of patients on antithrombotic therapy.","authors":"Robert D McBane","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3","pages":"173-176"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cabozantinib plus nivolumab as first-line therapy for advanced renal cell carcinoma with bone metastases: a clinical case report. 卡博赞替尼联合纳武单抗作为晚期肾细胞癌骨转移的一线治疗:临床病例报告
IF 1.1
Daniel J George
{"title":"Cabozantinib plus nivolumab as first-line therapy for advanced renal cell carcinoma with bone metastases: a clinical case report.","authors":"Daniel J George","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3 Suppl 3","pages":"1-12"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on immune checkpoint inhibition for cervical cancer. 子宫颈癌免疫检查点抑制的最新进展。
IF 1.1
Linda R Duska
{"title":"Update on immune checkpoint inhibition for cervical cancer.","authors":"Linda R Duska","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3","pages":"167-169"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The addition of PARP inhibition to androgen receptor pathway inhibition in metastatic hormone-sensitive prostate cancer. 转移性激素敏感前列腺癌中雄激素受体途径抑制中加入PARP抑制。
IF 1.1
Gerhardt Attard
{"title":"The addition of PARP inhibition to androgen receptor pathway inhibition in metastatic hormone-sensitive prostate cancer.","authors":"Gerhardt Attard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 3","pages":"157-159"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights in multiple myeloma from the 2025 American Society of Hematology Annual Meeting. 来自2025年美国血液学会年会的多发性骨髓瘤的亮点。
IF 1.1
{"title":"Highlights in multiple myeloma from the 2025 American Society of Hematology Annual Meeting.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 2","pages":"112-114"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is there an optimal sequential order to androgen receptor axis therapeutics? 雄激素受体轴治疗是否有一个最佳的顺序?
IF 1.1
Jacob Alex, Julie N Graff
{"title":"Is there an optimal sequential order to androgen receptor axis therapeutics?","authors":"Jacob Alex, Julie N Graff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hormonal therapeutic landscape in prostate cancer has expanded greatly over the last few decades with the advent of abiraterone acetate and second-generation antiandrogens such as enzalutamide, darolutamide, and apalutamide. These agents are superior to first-generation antiandrogens because they are more effective at blocking the androgen receptor signaling pathway and can overcome many of the resistance mechanisms that limited first-generation antiandrogens. With the growing number of available treatments, questions have arisen regarding patient-specific factors influencing medication selection, stage-specific use, and strategies for combination therapy and sequencing. This manuscript is intended to provide a comprehensive review of the landmark clinical trials that led to the US Food and Drug Administration approval of abiraterone and second-generation antiandrogens in various settings of prostate cancer, along with real-world off-label prescribing practices. Additionally, the article offers insight into the optimal sequencing of antiandrogens based on current data.</p>","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 2","pages":"78-88"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The sequencing of covalent and noncovalent BTK inhibitors in CLL. CLL中共价和非共价BTK抑制剂的测序。
IF 1.1
Jennifer A Woyach
{"title":"The sequencing of covalent and noncovalent BTK inhibitors in CLL.","authors":"Jennifer A Woyach","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51585,"journal":{"name":"Clinical Advances in Hematology & Oncology","volume":"24 2","pages":"99-101"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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