The Open Biomarkers Journal最新文献

Red Blood Cell Distribution Width as a Diagnostic Marker of Hepatocellular Carcinoma in Cirrhotic Patients 作为肝硬化患者肝细胞癌诊断指标的红细胞分布宽度

The Open Biomarkers Journal Pub Date : 2024-01-19 DOI: 10.2174/0118753183275959231129064650

N. Hawash, Reham M. Gameaa, Doaa Elwy, S. Mansour

{"title":"Red Blood Cell Distribution Width as a Diagnostic Marker of Hepatocellular Carcinoma in Cirrhotic Patients","authors":"N. Hawash, Reham M. Gameaa, Doaa Elwy, S. Mansour","doi":"10.2174/0118753183275959231129064650","DOIUrl":"https://doi.org/10.2174/0118753183275959231129064650","url":null,"abstract":"\u0000 \u0000 Although α-fetoprotein (AFP) is the main marker used for the diagnosis of hepatocellular carcinoma(HCC), its sensitivity and specificity as a screening tool have been questionable. Red blood cell distribution width (RDW) has been involved as a prognostic tool for many diseases and cancers including liver diseases. Still, its role in the diagnosis of HCC needs to be identified. This study aimed to evaluate the clinical importance of RDW as a novel marker in the diagnosis of HCC in Egyptian cirrhotic patients.\u0000 \u0000 \u0000 \u0000 This cross-sectional study was carried out on 162 cirrhotic patients who attended Tropical medicine department clinics and inpatient wards at the Faculty of Medicine, Tanta University. Then they were divided into 2 groups of 81 patients each depending on their diagnosis with or without HCC (group I and group II respectively). Complete blood picture (CBC) that included red cell distribution width- coefficient of variation (RDW-CV) and AFP were obtained from all patients.\u0000 \u0000 \u0000 \u0000 There was a statistically significant elevation in RDW-CV in the HCC group as its mean± SD was 15.2.± 1.86 in HCC group versus 13.8 ± 1.99 in non HCC group (P<0.001). In addition, AFP was significantly elevated in group I than in group II (P<0.001). RDW-CV at a cut–off >14% had a 66.76%sensitivity and 61.73%specificity while AFP at a cut-off value>20 ng/ml had a 60.49%sensitivity and 79.01%specificity in the diagnosis of HCC. The combination of RDW-CV and AFP increased the sensitivity and specificity for the diagnosis of HCC(72.84% and 87.65% respectively) than each marker alone.\u0000 \u0000 \u0000 \u0000 RDW may be considered a novel and cheap biomarker for the diagnosis of HCC either alone or in combination with AFP as it is readily available in CBC and does not need sophisticated techniques.\u0000","PeriodicalId":515774,"journal":{"name":"The Open Biomarkers Journal","volume":"75 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure. 尿酸水平与急性心力衰竭诊断和预后的关系。

The Open Biomarkers Journal Pub Date : 2012-07-13 DOI: 10.2174/1875318301205010009

Queen Henry-Okafor, Sean P Collins, Cathy A Jenkins, Karen F Miller, David J Maron, Allen J Naftilan, Neal Weintraub, Gregory J Fermann, John McPherson, Santosh Menon, Douglas B Sawyer, Alan B Storrow

引用次数: 8

Soluble ST2 as a Diagnostic and Prognostic Marker for Acute Heart Failure Syndromes. 可溶性ST2作为急性心力衰竭综合征的诊断和预后指标

The Open Biomarkers Journal Pub Date : 2012-04-20 DOI: 10.2174/1875318301205010001

Queen Henry-Okafor, Sean P Collins, Cathy A Jenkins, Karen F Miller, David J Maron, Allen J Naftilan, Neal Weintraub, Gregory J Fermann, John McPherson, Santosh Menon, Douglas B Sawyer, Alan B Storrow

{"title":"Soluble ST2 as a Diagnostic and Prognostic Marker for Acute Heart Failure Syndromes.","authors":"Queen Henry-Okafor, Sean P Collins, Cathy A Jenkins, Karen F Miller, David J Maron, Allen J Naftilan, Neal Weintraub, Gregory J Fermann, John McPherson, Santosh Menon, Douglas B Sawyer, Alan B Storrow","doi":"10.2174/1875318301205010001","DOIUrl":"https://doi.org/10.2174/1875318301205010001","url":null,"abstract":"OBJECTIVES: We investigated the association of sST2 with diagnostic and prognostic outcomes and assessed whether it aids B-natriuretic peptide (BNP) in diagnosing and predicting outcomes in emergency department (ED) patients with suspected AHFS. METHODS: We recruited patients who presented to the ED of 3 tertiary hospitals with signs or symptoms of AHFS and met modified Framingham criteria for AHFS. Outcome measures were a final diagnosis of AHFS and 5-and 30-day adverse events. RESULTS: In the 295 subjects with sST2 available, the median sST2 was 0.20 ng/ml (IQR=0.10, 0.34). Although unadjusted analyses indicated sST2 was significantly associated with the diagnosis of AHFS (p=0.02), this was not so in the adjusted analysis (p=0.33). Moderately low diagnostic utility was noted with an AUC of 0.62 (95% CI=0.56, 0.69). Similar sST2 test characteristics were seen when BNP was restricted between 100 and 500 pg/ml. While sST2 was associated with AHFS readmission at 30-days (p=0.04), in the adjusted analyses it was not associated with adverse events. CONCLUSION: In patients with signs or symptoms of AHFS, unadjusted analyses indicated that sST2 was significantly associated with the diagnosis of AHFS and with 30-day AHFS recidivism. However, the associations did not carry over to adjusted analyses, and sST2 did not add significant information with regard to explaining the diagnostic and prognostic variability of BNP.","PeriodicalId":515774,"journal":{"name":"The Open Biomarkers Journal","volume":"2012 5","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2012-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578210/pdf/nihms440184.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31264107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Riboflavin as an oral tracer for monitoring compliance in clinical research. 核黄素作为口服示踪剂在临床研究中监测依从性。

The Open Biomarkers Journal Pub Date : 2011-01-01 DOI: 10.2174/1875318301104010001

V M Sadagopa Ramanujam, Karl E Anderson, James J Grady, Fatima Nayeem, Lee-Jane W Lu

{"title":"Riboflavin as an oral tracer for monitoring compliance in clinical research.","authors":"V M Sadagopa Ramanujam, Karl E Anderson, James J Grady, Fatima Nayeem, Lee-Jane W Lu","doi":"10.2174/1875318301104010001","DOIUrl":"10.2174/1875318301104010001","url":null,"abstract":"We studied urinary riboflavin as an objective biomarker of compliance in clinical research using a simplified method amenable to high throughput analysis. Six healthy women not taking vitamin supplements ingested a study pill containing riboflavin (32 mg) as an inactive tracer and the soy isoflavones daidzin (0.243 mmole) and genistin (0.222 mmole) as active ingredients once daily for four days. Riboflavin and metabolites of the isoflavones were measured in urine samples obtained before and after each pill. Urinary excretion of riboflavin and metabolites of both isoflavones peaked within 8 hrs and remained higher than baseline for 24 hrs. Urinary excretion of riboflavin was also measured in 152 additional women with unrestricted dietary supplement intakes. Mean and median urinary riboflavin concentrations in these women were 0.42 and 0.31 μg/mL, respectively, compared to 0.2 μg/mL during a riboflavin-restricted diet. Receiver operating characteristics (ROC) curves indicated that urinary riboflavin within 24 hrs after a 32 mg dose would perform well as a measure of compliance (all areas under the ROC curves ≥0.84. Samples collected during the initial 8 hrs after pill ingestion performed better as a compliance measure than later collections. In summary, compliance in a clinical study can be monitored in real time by incorporating 32 mg of riboflavin into study pills, with compliance indicated by urinary riboflavin levels increasing over individual baselines or to ≥1.0 μg/mL, with a false positive rate of being classified as compliant at <5%.","PeriodicalId":515774,"journal":{"name":"The Open Biomarkers Journal","volume":"2011 4","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176727/pdf/nihms322332.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30023245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness. 血清神经调节蛋白-1 β作为心血管健康的生物标志物。

The Open Biomarkers Journal Pub Date : 2009-01-01 DOI: 10.2174/1875318300902010001

Vaibhav Moondra, Satyam Sarma, Tracy Buxton, Radwan Safa, Gregory Cote, Thomas Storer, Nathan K Lebrasseur, Douglas B Sawyer

{"title":"Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness.","authors":"Vaibhav Moondra, Satyam Sarma, Tracy Buxton, Radwan Safa, Gregory Cote, Thomas Storer, Nathan K Lebrasseur, Douglas B Sawyer","doi":"10.2174/1875318300902010001","DOIUrl":"10.2174/1875318300902010001","url":null,"abstract":"PURPOSE: Neuregulins (NRG) are growth factors that bind to receptors of the erbB family, and are known to mediate a number of processes involved in diverse tissues. Neuregulin-1beta is expressed in skeletal muscle and is activated by exercise. We hypothesized that NRG-1beta might circulate in the bloodstream and increase as a consequence of physical activity. A study was conducted in healthy subjects to determine if NRG-1beta is immunodetectable in human serum, and if so whether levels relate acutely or chronically to exercise. METHODS: Nine healthy men underwent three bouts of exercise of varying degrees of intensity on a bicycle ergometer over a period of three weeks. Cardio-respiratory fitness was determined by measurement of maximal oxygen uptake (VO(2)max). Serum was sampled prior to and immediately after each session (up to 30 minutes post) and serum NRG-1beta was quantified utilizing an indirect sandwich ELISA assay developed in our lab. RESULTS: Across subjects, mean serum NRG-1beta levels ranged from 32 ng/mL to 473 ng/mL. Individual subjects showed relatively stable levels during the study period that did not change acutely after exercise. Serum NRG-1beta demonstrated a positive correlation with VO(2)max (r2=0.49, p =.044). CONCLUSIONS: These preliminary observations suggest that at least in healthy men, serum NRG-1beta is an indicator of cardio-respiratory fitness and does not change acutely with exercise.","PeriodicalId":515774,"journal":{"name":"The Open Biomarkers Journal","volume":"2 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903891/pdf/nihms97296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29127021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of Psychological Stress in Health Disparities Research. 健康差异研究中心理应激的生物标志物

The Open Biomarkers Journal Pub Date : 2008-01-01 DOI: 10.2174/1875318300801010007

Zora Djuric, Chloe E Bird, Alice Furumoto-Dawson, Garth H Rauscher, Mack T Ruffin, Raymond P Stowe, Katherine L Tucker, Christopher M Masi

{"title":"Biomarkers of Psychological Stress in Health Disparities Research.","authors":"Zora Djuric, Chloe E Bird, Alice Furumoto-Dawson, Garth H Rauscher, Mack T Ruffin, Raymond P Stowe, Katherine L Tucker, Christopher M Masi","doi":"10.2174/1875318300801010007","DOIUrl":"10.2174/1875318300801010007","url":null,"abstract":"Psychological stress can contribute to health disparities in populations that are confronted with the recurring stress of everyday life. A number of biomarkers have been shown to be affected by psychological stress. These biomarkers include allostatic load, which is a summary measure of the cumulative biological burden of the repeated attempts to adapt to daily stress. Allostatic load includes effects on the hypothalamic-pituitary axis, the sympathetic nervous system and the cardiovascular system. These in turn affect the immune system via bidirectional signaling pathways. Evidence is also building that psychological stress, perhaps via heightened inflammatory states, can increase oxidative stress levels and DNA damage. The inter-relationships of ethnicity, genotype, gene expression and ability to adequately mitigate stress response are just starting to be appreciated. The need to conduct these studies in disadvantaged populations is clear and requires methods to address potential logistical barriers. Biomarkers can help characterize and quantify the biological impact of psychological stress on the etiology of health disparities.","PeriodicalId":515774,"journal":{"name":"The Open Biomarkers Journal","volume":"1 ","pages":"7-19"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841407/pdf/nihms89659.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28848515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of Blood Cell Omega-3 Fatty Acid Content. 血细胞Omega-3脂肪酸含量的决定因素。

The Open Biomarkers Journal Pub Date : 2008-01-01 DOI: 10.2174/1875318300801010001

Robert C Block, William S Harris, James V Pottala

引用次数: 0