Queen Henry-Okafor, Sean P Collins, Cathy A Jenkins, Karen F Miller, David J Maron, Allen J Naftilan, Neal Weintraub, Gregory J Fermann, John McPherson, Santosh Menon, Douglas B Sawyer, Alan B Storrow
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Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure.
Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).
Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.
Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.
Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.
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