Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure.

Queen Henry-Okafor, Sean P Collins, Cathy A Jenkins, Karen F Miller, David J Maron, Allen J Naftilan, Neal Weintraub, Gregory J Fermann, John McPherson, Santosh Menon, Douglas B Sawyer, Alan B Storrow
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引用次数: 8

Abstract

Objectives: We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).

Methods: We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.

Results: Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.

Conclusion: Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.

Abstract Image

尿酸水平与急性心力衰竭诊断和预后的关系。
目的:我们评估血浆尿酸单独和联合b型利钠肽(BNP)在急诊科(ED)诊断和急性心力衰竭(AHF)患者30天预后中的相关性。方法:我们前瞻性地招募了322例疑似AHF的成人ED患者。采用Wilcoxon秩和检验、多变量logistic回归和似然比检验进行统计分析。结果:尿酸的诊断效用较差,未能显示出与30天临床结果的显著关联。尿酸也没有显著增加BNP结果。结论:在疑似AHF的ED患者中,尿酸的诊断和预后价值较差。
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