Chinese Journal of Traumatology最新文献

{"title":"Platelet-rich plasma in anterior cruciate ligament reconstruction: An updated systematic review and quantitative meta-analysis of randomized controlled trials.","authors":"Ibrahim Serag, Mohamed Abouzid, Heba Hikal, Ahmed Abdelhadi, Mohammed Nabil Abdelaal, Ahmed Gamal Mohamed, Mostafa Hossam El Din Moawad","doi":"10.1016/j.cjtee.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.008","url":null,"abstract":"<p><strong>Purpose: </strong>Anterior cruciate ligament (ACL) injuries significantly impact athletes' careers and quality of life, necessitating ACL reconstruction to restore knee functionality. Platelet-rich plasma (PRP) has been investigated as an adjunct therapy for enhancing recovery post-ACL reconstruction due to its potential pro-regenerative properties. However, the empirical evidence on PRP's efficacy in ACL reconstruction outcomes remains mixed. This study aims to evaluate the effectiveness and safety of PRP vs. control treatments in patients undergoing ACL reconstruction, focusing on pain management and knee function recovery.</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic review and meta-analysis of randomized controlled trials comparing PRP with control interventions post-ACL reconstruction. Comprehensive searches were performed across PubMed, Scopus, Web of Science, and Cochrane Library databases up to July 2024. We used \"platelet-rich plasma\", \"controls\", and \"anterior cruciate ligament reconstruction surgery\" as keywords. Statistical analysis was conducted using RevMan 5.3, employing the inverse variance method under a random effects model. We reported outcomes as mean difference (MD) or standardized with confidence intervals (CI). A p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The analysis incorporated data from 18 studies involving 1082 patients. KT-1000 measurements indicated improved knee stability (MD: -0.57 mm, 95% CI: -0.94 to -0.20, p = 0.002). However, no significant improvements were observed in the Lysholm score (MD: 0.68, 95% CI: =1.24 to 2.26, p = 0.484), visual analog scale pain score (MD: -0.34, 95% CI: -0.68 to -0.01, p = 0.057), International Knee Documentation Committee score (MD: 1.08, 95% CI: -1.05 to 3.42, p = 0.298), Tegner score (MD: 0.13, 95% CI: -0.32 to 0.57, p = 0.575), and femoral and tibial tunnel diameters (femoral MD: -0.07 mm, 95% CI: -0.46 to 0.32, p = 0.726; tibial MD: 0.08 mm, 95% CI: -0.60 to 0.75, p = 0.818).</p><p><strong>Conclusion: </strong>Our findings provide moderate evidence that PRP can significantly enhance knee stability post-ACL reconstruction. However, further high-quality randomized controlled trials are needed to clarify PRP's overall effectiveness and optimal use in ACL reconstruction rehabilitation protocols.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal intracranial bleedings in a viper bite.","authors":"Santosh Govind Rathod, Vinayagapandian Sakthivel, Ajay Vane, Saima Kabir, Vishvdeep Kishen Khushoo","doi":"10.1016/j.cjtee.2025.02.007","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.007","url":null,"abstract":"","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for traumatic fracture related infection in surgically treated ankle fracture: A multicenter retrospective study.","authors":"Yong Yang, Tian You, Yanling Wei, Jingting Yan, Sumeng Chen, Yuxin Yan, Xintao Zhang, Ying Shan, Lu Bai","doi":"10.1016/j.cjtee.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.006","url":null,"abstract":"<p><strong>Purpose: </strong>Infection after ankle fracture fixation is a serious complication, leading to a prolonged healing period and dysfunction in a long-term follow-up. Identifying risk factors for ankle fracture-related infection (FRI) is beneficial in preventing complications and reducing the risk of treatment. The study aims to retrospectively analyze clinical risk factors for ankle FRI.</p><p><strong>Methods: </strong>A cross-sectional retrospective study of operatively treated ankle fractures was conducted at 2 medical centers from March 2020 to March 2023. Patients with open or pathological conditions were excluded, and 298 patients who underwent surgical treatment for ankle fractures were included. Risk factors of the patients who were diagnosed of FRI were analyzed using univariate analysis and binary logistic regression. Regression coefficients were used to calculate statistical probabilities of FRI.</p><p><strong>Result: </strong>Of the 298 patients, 21 (7.1%) were diagnosed infection. On univariate analysis, soft tissue bloody blisters (p=0.002) and ankle dislocation (p=0.001) were associated with a significantly higher incidence of infection. On binary logistic multifactorial regression analysis, the risk factors for FRI were ankle dislocation (p<0.001, odd ratio (OR)=11.799, 95% confidence interval (CI): 3.307-42.135), soft tissue bloody blisters (p=0.045, OR=8.004, 95%CI: 1.045-61.340), Langer-Hans typing pronation-abduction (p=0.033, OR=1.746, 95%CI: 1.183-27.766), and smoking (p=0.037, OR=4.94, 95%CI: 1.105-22.162).</p><p><strong>Conclusion: </strong>The risk factors of FRI were soft tissue conditions including bloody blisters and ankle dislocation, when dealing with ankle fractures. The results of this study will help surgeons to inform patients of the risk of FRI and prevent it accordingly before ankle fracture surgery.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical performance of proximal tibia fracture plates: A review.","authors":"Radovan Zdero, Pawel Brzozowski, Emil H Schemitsch","doi":"10.1016/j.cjtee.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.005","url":null,"abstract":"<p><strong>Purpose: </strong>Proximal fractures of the tibia (i.e., shin bone) are often treated using proximal tibia fracture plates (PTFPs) that are not always biomechanically optimal. This is a review of biomechanical papers that studied the effect of modifying PTFP plate and screw variables.</p><p><strong>Methods: </strong>PubMed, Scopus, and Web of Science databases were searched for English-language papers published before February 2024 using the terms \"biomechanics\" plus \"proximal or plateau\" plus \"tibia\" plus \"fracture or \"plate.\" Eligibility criteria were applied: (1) biomechanical studies only; (2) optimization studies that systematically permutated plate or screw variables; (3) plate-and-screw fixation only; (4) intra-articular or extra-articular fractures. The papers were examined for implant variables such as plate geometry, plate material, screw number, etc., while papers were also examined for outcome metrics like interfragmentary motion, plate stress, overall stiffness, etc. RESULTS: The 52 eligible PTFP papers considered the biomechanical effect of plate geometry, material, hole type, number, and position, while screw variables included geometry, number, and angle. Outcome metrics were interfragmentary motion (0-22.53 mm or 0-60.1°), bone stress (1-1170 MPa), plate stress (3-586 MPa), and screw stress (3-1613 MPa), bone stress under the plate (2-11 MPa), number of loading cycles to failure (11,500-1,000,000), overall stiffness (22-24,869 N/mm or 0.4-63.8 Nm/degree), and failure strength (259-14,387 N). Reviewed papers showed that a PTFP's biomechanical stability could be maximized by using 1 or 2 plates that were contoured, larger, locking, metal, and/or placed on the largest surface of the bone fragment(s), while head, kickstand, and/or shaft screws should be longer, thicker, solid, metal, and/or angled. But more future work could be done on the biomechanical effect of plate design (e.g., alternative materials), bone quality (e.g., normal vs. osteoporotic), loading mode (i.e., axial, bending, torsion), etc. CONCLUSIONS: PTFPs should have their plate and screw variables optimized to provide the best biomechanical performance and clinical outcomes, but more work is required to determine the optimal conditions. Engineers and surgeons may find this review beneficial for designing, analyzing, or utilizing PTFPs.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of scaphoid nonunion with dual screw fixation in preventing postoperative humpback deformity.","authors":"Jingtong Lyu, Xiao Liu, Yuanqiang Li, Zhenyu Wang, Yunjiao Wang, Wei Wang, Lin Guo","doi":"10.1016/j.cjtee.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.cjtee.2024.10.010","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the treatment of scaphoid nonunion with dual screw fixation in preventing postoperative humpback deformity.</p><p><strong>Methods: </strong>This retrospective study is from December 2010 to December 2021, 18 patients with scaphoid nonunion were treated with dual screw fixation through the dorsal approach. This study included patients aged 16-60 years with scaphoid nonunion (>6 months) classified as Mack-Lichtman types I-III (mild arthritis), while excluding those with immature osteogenesis (<16 years), osteoporosis (>60 years), prior wrist surgery or fractures, avascular necrosis, advanced degenerative changes (types IV-V), small fragment fixation difficulty, or loss to follow-up. Scaphoid length and angles were assessed on X-rays. Wrist function was assessed based on the Mayo wrist score.</p><p><strong>Results: </strong>The average age of the participants was 27 (range 17-49) years. The mean time from injury to surgery was 13 (range 6-48) months. There were types I (n=5), II (n=11), and III (n=2) nonunions based on the Mack-Lichtman classification. Nonunion sites included proximal 1/3 (n=4), waist (n=8), and distal 1/3 (n=6). All nonunions healed at a mean of 15 (range 10-28) weeks. The preoperative scaphoid length was 20 (range 17-23) mm, and the data at bone union was 23 (range 21-26) mm. The preoperative scapholunate angle was 46° (range 18°-72°), and the data at bone union was 39° (range 30°-48°). The preoperative radiolunate angle was 24° (range 5°-51°), and the data at bone union was 18° (range 8°-29°). Follow-up lasted for a mean of 52 (range 24-119) months. Mayo wrist score improved from 47 (range 13-64) to 95 (range 78-100). There were 15 excellent, 2 good, and 1 satisfactory results.</p><p><strong>Conclusion: </strong>In the treatment of scaphoid nonunion, dual screw fixation through the dorsal approach can successfully prevent postoperative humpback deformity. Reduction is maintained to bone union without complications. The technique can be an alternative for the treatment of scaphoid nonunion.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors, pathogenic bacteria characteristics, and drug resistance of postoperative surgical site infection in adults with limb fractures","authors":"Yan-Jun Wang ,&nbsp;Zi-Hou Zhao ,&nbsp;Shuai-Kun Lu ,&nbsp;Guo-Liang Wang ,&nbsp;Shan-Jin Ma ,&nbsp;Lin-Hu Wang ,&nbsp;Hao Gao ,&nbsp;Jun Ren ,&nbsp;Zhong-Wei An ,&nbsp;Cong-Xiao Fu ,&nbsp;Yong Zhang ,&nbsp;Wen Luo ,&nbsp;Yun-Fei Zhang","doi":"10.1016/j.cjtee.2024.04.007","DOIUrl":"10.1016/j.cjtee.2024.04.007","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;We carried out the study aiming to explore and analyze the risk factors, the distribution of pathogenic bacteria, and their antibiotic-resistance characteristics influencing the occurrence of surgical site infection (SSI), to provide valuable assistance for reducing the incidence of SSI after traumatic fracture surgery.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective case-control study enrolling 3978 participants from January 2015 to December 2019 receiving surgical treatment for traumatic fractures was conducted at Tangdu Hospital of Air Force Medical University. Baseline data, demographic characteristics, lifestyles, variables related to surgical treatment, and pathogen culture were harvested and analyzed. Univariate analyses and multivariate logistic regression analyses were used to reveal the independent risk factors of SSI. A bacterial distribution histogram and drug-sensitive heat map were drawn to describe the pathogenic characteristics.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Included 3978 patients 138 of them developed SSI with an incidence rate of 3.47% postoperatively. By logistic regression analysis, we found that variables such as gender (males) (odds ratio (&lt;em&gt;OR&lt;/em&gt;) = 2.012, 95% confidence interval (&lt;em&gt;CI&lt;/em&gt;&lt;em&gt;)&lt;/em&gt;: 1.235 − 3.278, &lt;em&gt;p&lt;/em&gt; = 0.005), diabetes mellitus (&lt;em&gt;OR&lt;/em&gt; = 5.848, 95% &lt;em&gt;CI&lt;/em&gt;: 3.513 − 9.736, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), hypoproteinemia (&lt;em&gt;OR&lt;/em&gt; = 3.400, 95% &lt;em&gt;CI&lt;/em&gt;: 1.280 − 9.031, &lt;em&gt;p&lt;/em&gt; = 0.014), underlying disease (&lt;em&gt;OR&lt;/em&gt; = 5.398, 95% &lt;em&gt;CI&lt;/em&gt;: 2.343 − 12.438, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), hormonotherapy (&lt;em&gt;OR&lt;/em&gt; = 11.718, 95% &lt;em&gt;CI&lt;/em&gt;: 6.269 − 21.903, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), open fracture (&lt;em&gt;OR&lt;/em&gt; = 29.377, 95% &lt;em&gt;CI&lt;/em&gt;: 9.944 − 86.784, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), and intraoperative transfusion (&lt;em&gt;OR&lt;/em&gt; = 2.664, 95% &lt;em&gt;CI&lt;/em&gt;: 1.572 − 4.515, &lt;em&gt;p&lt;/em&gt; &lt; 0.001) were independent risk factors for SSI, while, aged over 59 years (&lt;em&gt;OR&lt;/em&gt; = 0.132, 95% &lt;em&gt;CI&lt;/em&gt;: 0.059 − 0.296, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), prophylactic antibiotics use (&lt;em&gt;OR&lt;/em&gt; = 0.082, 95% &lt;em&gt;CI&lt;/em&gt;: 0.042 − 0.164, &lt;em&gt;p&lt;/em&gt; &lt; 0.001) and vacuum sealing drainage use (&lt;em&gt;OR&lt;/em&gt; = 0.036, 95% &lt;em&gt;CI&lt;/em&gt;: 0.010 − 0.129, &lt;em&gt;p&lt;/em&gt; &lt; 0.001) were protective factors. Pathogens results showed that 301 strains of 38 species of bacteria were harvested, among which 178 (59.1%) strains were Gram-positive bacteria, and 123 (40.9%) strains were Gram-negative bacteria. &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (108, 60.7%) and &lt;em&gt;Enterobacter cloacae&lt;/em&gt; (38, 30.9%) accounted for the largest proportion. The susceptibility of Gram-positive bacteria to Vancomycin and Linezolid was almost 100%. The susceptibility of Gram-negative bacteria to Imipenem, Amikacin, and Meropenem exceeded 73%.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Orthopedic surgeons need to develop appropriate surgical plans based on the risk factors and protective factors associated with postoperative SSI to reduce its","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages 241-251"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Author","authors":"","doi":"10.1016/S1008-1275(25)00072-0","DOIUrl":"10.1016/S1008-1275(25)00072-0","url":null,"abstract":"","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages I-V"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The construction and application of a trauma limb salvage map in Shaanxi province","authors":"Meng Wang ,&nbsp;Jian-Min Liu ,&nbsp;Xing-Bo Dang ,&nbsp;Long-Yang Ma ,&nbsp;Gong-Liang Du ,&nbsp;Wei Hu","doi":"10.1016/j.cjtee.2024.08.004","DOIUrl":"10.1016/j.cjtee.2024.08.004","url":null,"abstract":"<div><div>Trauma is an important cause of death in young- and middle-aged people. Trauma is comprehensive and includes many surgical specialties, and the surgical techniques of these specialties have long been mature. To reduce the mortality and disability rate of trauma patients, it is necessary to improve trauma management. Trauma has attracted attention in China and trauma treatment and care developed rapidly in recent years. To decrease traumatic mortality and disability rates, our team is committed to building an efficient trauma system in Shaanxi province and has successfully developed a trauma limb salvage map to address the high rates of amputation and disability in patients with limb injuries. This article elaborates on the construction experience of a trauma limb salvage map and its application details in Shaanxi province of China.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages 235-240"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric and anatomic characteristics of pronator quadratus muscle","authors":"Nurşen Zeybek ,&nbsp;Özcan Gayretli ,&nbsp;Yüsra Nur Şanlıtürk ,&nbsp;Ayşin Kale","doi":"10.1016/j.cjtee.2024.09.004","DOIUrl":"10.1016/j.cjtee.2024.09.004","url":null,"abstract":"<div><h3>Purpose</h3><div>In surgical procedures commonly employed for the management of scaphoid and distal radial fractures, the incision and dissection of the pronator quadratus muscle play a pivotal role. Nevertheless, comprehensive investigations into the anatomical intricacies of the pronator quadratus muscle have been relatively scarce within the clinical community. In light of this, our study endeavors to make a substantive contribution to the medical literature by conducting a meticulous examination of the morphology and morphometry of this muscle.</div></div><div><h3>Methods</h3><div>This study is a cross-sectional observational study conducted on 22 cadaveric upper extremities (44 sides) preserved between January 2005 and December 2018 at Istanbul University. The study included specimens with intact dissection areas and no prior surgical intervention. Observations focused on the morphometry of the pronator quadratus muscle and related anatomical structures. Statistical analysis was performed using SPSS v23.0, employing Student's <em>t</em>-test and paired <em>t</em>-test, with significance set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Significant differences were found in the morphometric measurements of the pronator quadratus muscle between the right and left upper extremities, particularly in the vertical distance between the proximal and distal attachment points of the pronator quadratus to the radius (<em>p</em> = 0.008). Additionally, significant differences were observed between male and female samples for radius length (<em>p &lt;</em> 0.001), ulna length (<em>p &lt;</em> 0.001), pronator quadratus width (<em>p &lt;</em> 0.001), and the vertical distance between pronator quadratus attachment points on both the radius (<em>p</em> = 0.001) and ulna (<em>p</em> = 0.001). Furthermore, significant correlations were identified between radius length and parameters such as the vertical distance between pronator quadratus attachment points on both the radius (<em>p</em> = 0.002) and pronator quadratus width (<em>p</em> = 0.030), and between ulna length and parameters including the vertical distances on the radius (<em>p</em> = 0.001) and ulna (<em>p</em> = 0.024).</div></div><div><h3>Conclusion</h3><div>In light of our comprehensive analysis, which encompasses not only the anatomical features of the pronator quadratus muscle but also its vascular supply and the organization of its neurovascular structures, we posit that our study holds significant implications for the field of orthopedic surgery. We anticipate that this research will furnish valuable insights that can inform and enhance orthopedic procedures.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages 252-256"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanism underlying the protective effects of ischemic preconditioning in total knee arthroplasty","authors":"Yongli Wang ,&nbsp;Bencai Du ,&nbsp;Xueliang Han ,&nbsp;Lianjun Qu","doi":"10.1016/j.cjtee.2024.02.007","DOIUrl":"10.1016/j.cjtee.2024.02.007","url":null,"abstract":"<div><h3>Propose</h3><div>To investigate the molecular mechanisms underlying the protective effects of ischemic preconditioning (IPC) in patients undergoing total knee arthroplasty.</div></div><div><h3>Methods</h3><div>GSE21164 was extracted from an online database, followed by an investigation of differentially expressed genes (DEGs) between IPC treatment samples at 2 time points (T0T and T1T). Function and pathway enrichment analyses were performed on the DEGs. A protein-protein interaction network was constructed to identify hub genes according to 5 different algorithms, followed by enrichment analysis. In addition, long noncoding RNAs (lncRNAs) were identified between the T0T and T1T samples. Furthermore, a competing endogenous RNA network was predicted based on the identified lncRNA-messenger RNA (mRNA), lncRNA-microRNA (miRNA), and mRNA-miRNA relationships revealed in this study. Finally, a drug-gene network was investigated. Statistical analyses were performed using GraphPad Prism 8.0. Differences between groups were determined using an unpaired <em>t</em>-test. <em>p</em> &lt; 0.05 was considered significant.</div></div><div><h3>Results</h3><div>A total of 343 DEGs at T0 and 10 DEGs at T1 were identified and compared with their respective control groups, followed by 100 DEGs between T0T and T1T. Based on these 100 DEGs, protein-protein interaction network analysis revealed 9 hub genes, mainly with mitochondria-related functions and the carbon metabolism pathway. Six differentially expressed lncRNAs were investigated between T0T and T1T. A competing endogenous RNA network was constructed using 259 lncRNA–miRNA–mRNA interactions, including alpha-2-macroglobulin antisense RNA 1-miR-7161-5p-iron-sulfur cluster scaffold. Finally, 13 chemical drugs associated with the hub genes were explored.</div></div><div><h3>Conclusion</h3><div>Iron-sulfur cluster scaffold may promote IPC-induced ischemic tolerance mediated by alpha-2-macroglobulin antisense RNA 1-miR-7161-5p axis. Moreover, IPC may induce a protective response after total knee arthroplasty via mitochondria-related functions and the carbon metabolism pathway, which should be further validated in the near future.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages 257-268"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}