The Open Biochemistry Journal最新文献

Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases 牛磺酸与线粒体：在人类疾病药物治疗中的应用

The Open Biochemistry Journal Pub Date : 2024-06-13 DOI: 10.2174/011874091x326224240610075455

Heather Tarbet

引用次数: 0

Amlodipine Protects against Methotrexate-Induced Acute Kidney Injury in Rats 氨氯地平可预防甲氨蝶呤诱发的大鼠急性肾损伤

The Open Biochemistry Journal Pub Date : 2024-05-20 DOI: 10.2174/011874091x312641240424110832

Dina Kutbi

{"title":"Amlodipine Protects against Methotrexate-Induced Acute Kidney Injury in Rats","authors":"Dina Kutbi","doi":"10.2174/011874091x312641240424110832","DOIUrl":"https://doi.org/10.2174/011874091x312641240424110832","url":null,"abstract":"\u0000 \u0000 Methotrexate (MTX) is a commonly used chemotherapy drug with known nephrotoxic effects, including the potential for acute kidney injury. However, the precise mechanism through which MTX induces nephrotoxicity remains unclear, though oxidative stress and direct toxic effects on renal tubules are believed to play key roles. Recent studies suggest that calcium channel blockers may offer promise in slowing down the progression of chronic kidney diseases.\u0000 \u0000 \u0000 \u0000 The purpose of this study was to explore the potential of Amlodipine, a calcium channel blocker, to alleviate acute kidney injury caused by the administration of MTX in rats.\u0000 \u0000 \u0000 \u0000 Three groups of twenty-four male Wistar rats were randomly assigned: Group 1—the control group was given normal saline orally. Group II, underwent five days of continuous administration of a single intraperitoneal (IP) dosage of 20 mg/kg MTX. The same dosage of MTX was given to Group III followed by an oral dose of Amlodipine at 5 mg/kg over the same period. Upon completion of the experiment, serum biochemical parameters, renal damage markers, oxidative stress, inflammatory markers, and kidney tissue histology were assessed.\u0000 \u0000 \u0000 \u0000 The results indicate that MTX administration significantly increased the levels of serum biochemical parameters, renal damage markers, inflammatory markers, oxidative stress markers, and induced alterations in kidney histology. However, the administration of Amlodipine following MTX treatment protected against these changes.\u0000 \u0000 \u0000 \u0000 Amlodipine exhibits therapeutic potential in mitigating MTX-induced kidney injury in rats and its associated side effects.\u0000","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"47 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141118530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells. GPCR拮抗药物CM-20刺激人RPE细胞线粒体活性。

The Open Biochemistry Journal Pub Date : 2022-01-01 Epub Date: 2022-08-22 DOI: 10.2174/1874091X-v16-e2206270

Qing Chang, Siquan Chen, Tahua Yang

{"title":"The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells.","authors":"Qing Chang, Siquan Chen, Tahua Yang","doi":"10.2174/1874091X-v16-e2206270","DOIUrl":"https://doi.org/10.2174/1874091X-v16-e2206270","url":null,"abstract":"Background: Mitochondrial dysfunction in retinal pigment epithelium (RPE) is a pathogenic factor in age-related macular degeneration (AMD). Improvement of mitochondrial function may ameliorate RPE bioenergetics status, which may in turn nourish the retinal photoreceptors against degenerative loss.Objective: The purpose of this study is to examine the G-protein coupled receptor (GPCR) antagonistic drug CM-20 in modulating mitochondrial function in RPE cells.Methods: Human-derived ARPE-19 cell line was differentiated to improve RPE morphology. Dose response of CM-20 was performed to examine mitochondrial membrane potential (MMP). Secondary validation with multiplexed live-cell mitochondrial imaging was performed. Protection of CM-20 to mitochondria against oxidative stress was detected under co-treatment with hydrogen peroxide.Results: Treatment with CM-20 elicited a dose-dependent increase of MMP. Multiplexed live-cell mitochondrial imaging showed consistent increase of MMP at an optimal concentration of CM-20 (12.5 μM). MMP was significantly reduced under hydrogen peroxide-induced oxidative stress and treatment with CM-20 showed rescue effects to MMP.Conclusion: CM-20 increases mitochondrial function and protects mitochondria under oxidative stress. As both GPCRs and mitochondria are potential drug targets, retinal neuroprotective testing of CM-20 is warranted in animal models of retinal degeneration.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"16 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9460984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33459804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Co-Administration of Fish Oil With Signal Transduction Inhibitors Has Anti-Migration Effects in Breast Cancer Cell Lines, in vitro. 鱼油与信号转导抑制剂联合使用对乳腺癌细胞系的体外抗迁移作用

The Open Biochemistry Journal Pub Date : 2018-08-31 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010130

Zoë Davison, Robert I Nicholson, Stephen Hiscox, Charles M Heard

{"title":"Co-Administration of Fish Oil With Signal Transduction Inhibitors Has Anti-Migration Effects in Breast Cancer Cell Lines, in vitro.","authors":"Zoë Davison, Robert I Nicholson, Stephen Hiscox, Charles M Heard","doi":"10.2174/1874091X01812010130","DOIUrl":"https://doi.org/10.2174/1874091X01812010130","url":null,"abstract":"Background: There is an urgent need for new therapies to treat cancer metastasis. Fish oil, with high omega 3 fatty acid content, has shown anticancer activity and signal transduction inhibitors have shown anti-metastatic properties.Objective: To provide preliminary in vitro data on the anti-migration potential of signal transduction inhibitors and co-administered fish oil.Methods: MCF-7, TamR and FasR breast cancer cell lines were used to determine the effects of combinations of PD98059, LY294002 and fish oil in growth assays. Modulations of p-Src and COX-2, both mediators of motility and invasion, were then determined by Western blotting and IHC to ascertain effects on migration potential.Results: Migration rates for the three cell lines examined were ranked: FasR>TamR>MCF-7 (p <0.05). Addition of fish oil reduced the number of TamR cells migrating after 48h (p <0.05), while the addition of PD98059 and LY294002 also decreased migratory potential of TamR cells (p <0.05). Addition of PD98059 and LY294002 to TamR cells did not result in a significant decrease in p-Src levels; as was the case when PD98059, LY294002 and 4-hydroxytamoxifen were added to MCF-7 cells. However, the co-administration of fish oil markedly reduced p-Src and COX-2 expression in both cell lines.Conclusion: Co-administration of a commercial fish oil with signal transduction inhibitors results in decreased cell migration via an unknown co-operative mechanism and could constitute a novel approach for the treatment of breast cancer metastasis.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"130-148"},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36546988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

RpbL12 Assists Catalysis by Correctly Positioning the Incoming Aminoacyl-tRNA in the A-Site of E. coli 70S Ribosomes. RpbL12通过在大肠杆菌70S核糖体的a位点正确定位进入的氨基酰基trna来辅助催化。

The Open Biochemistry Journal Pub Date : 2018-07-31 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010113

Jean-Bernard Créchet, Fulbert K Agbo'Saga, Soria Baouz, Codjo Hountondj

{"title":"RpbL12 Assists Catalysis by Correctly Positioning the Incoming Aminoacyl-tRNA in the A-Site of E. coli 70S Ribosomes.","authors":"Jean-Bernard Créchet, Fulbert K Agbo'Saga, Soria Baouz, Codjo Hountondj","doi":"10.2174/1874091X01812010113","DOIUrl":"https://doi.org/10.2174/1874091X01812010113","url":null,"abstract":"Introduction: We have recently demonstrated that Lys-65 of the 62GANK65 motif of E. coli RpbL12 was affinity labeled with a tRNA analogue, resulting in the loss of activity.Materials and methods: In this report, we show that mutations operated at the position of Lys-65 led to an impairment in the activity of the mutant ribosomes, except the K65R or K65H bL12 mutants, suggesting that the only requirement of the reaction catalyzed or facilitated by RpbL12is the positive charge of the side chain of Lys-65. We also demonstrate that Lys-65 did not play any role in the peptidyl transferase reaction with respect to puromycin, but rather assisted the binding of the incoming aminoacyl-tRNA to the ribosomal A-site.Results & discussions: The protonated, positively charged εNH3+ form of Lys-65 is likely to participate to the binding of aa-tRNA through ionic bonds with phosphate groups, in order to insure the accurate positioning required for the nucleophilic attack of its α-amino group on the carbonyl carbone of peptidyl-tRNA.Conclusion: This α-NH2 group is likely to be generated by the unprotonated εNH2 form of Lys-65 which is capable of withdrawing a proton from the α-NH3+ group of aa-tRNA.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"113-129"},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36475787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Testosterone Retention Mechanism in Sertoli Cells: A Biochemical Perspective. 睾酮保留机制在支持细胞:生化角度。

The Open Biochemistry Journal Pub Date : 2018-06-29 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010103

Manjeet Kaur Gill-Sharma

{"title":"Testosterone Retention Mechanism in Sertoli Cells: A Biochemical Perspective.","authors":"Manjeet Kaur Gill-Sharma","doi":"10.2174/1874091X01812010103","DOIUrl":"https://doi.org/10.2174/1874091X01812010103","url":null,"abstract":"Mechanism(s) involved in regulating Intratesticular Testosterone levels (iT) have assumed importance in recent years, from the point of view of hormonal contraception. Contraceptives using Testosterone (T) in combination with Progestins (P), for more effective suppression of pituitary gonadotropins thereby iT, are not 100% effective in suppressing spermatogenesis in human males, likely due to pesrsistence of Intratesticular Dihydrotestosterone (iD) in poor-responders. Several lacunae pertaining to the mechanism of action of principal male hormone T during spermatogenesis remain to be resolved. Notably, the mechanism through which T brings about the stage-specific differentiation of germ cells lacking Androgen Receptors (AR). Testosterone is a highly anabolic steroid with a rapid tissue clearance rate. T is intratesticular substrate for synthesis of Dihydrotestosterone (DHT) and Estradiol (E2) involved in spermtaogenesis. Therefore, it is important to delineate the mechanism(s) for retention of iT, in order to understand regulation of its bioavailability in testis. In depth studies, pertaining to the role of androgen-binding protein(s) in sequestration, retention and bioavailability of T/DHT are required to understand male fertility regulation. The appropriate approach to overcome this lacuna would be development of mice lacking functional testicular Androgen-Binding Protein (ABPKO), but not deficient T/DHT, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), in order to understand its physiological functions. Insights gained about androgen retention mechanism(s) from the ABPKO murine model will be of immense help in improving the efficacy of male hormonal contraceptives and infertility management.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"103-112"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36362190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Clock Genes Are Involved in The Deterioration of Atopic Dermatitis after Day-and-Night Reversed Physical Stress in NC/Nga Mice. 时钟基因参与NC/Nga小鼠昼夜应激逆转后特应性皮炎的恶化。

The Open Biochemistry Journal Pub Date : 2018-06-29 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010087

Keiichi Hiramoto, Kumi Orita, Yurika Yamate, Emiko Kasahara, Satoshi Yokoyama, Eisuke F Sato

{"title":"The Clock Genes Are Involved in The Deterioration of Atopic Dermatitis after Day-and-Night Reversed Physical Stress in NC/Nga Mice.","authors":"Keiichi Hiramoto, Kumi Orita, Yurika Yamate, Emiko Kasahara, Satoshi Yokoyama, Eisuke F Sato","doi":"10.2174/1874091X01812010087","DOIUrl":"https://doi.org/10.2174/1874091X01812010087","url":null,"abstract":"Background: In modern society, irregular lifestyles are a problem. It is well known that Atopic Dermatitis (AD) occurs during physical stress in people with an irregular lifestyle. We evaluated the influence that day-and-night reversal physical stress has on AD.Methods: Six-week-old specific-pathogen-free and conventional NC/Nga male mice were used. For the day-and-night reversal procedure, the mice ran on a treadmill at a slow speed of 10 m/min for 12 h (between 8:00 and 20:00). Then, between 20:00 and 8:00, we put the mice in a dark place. This treatment was repeated every day for two weeks. The behavioral circadian rhythm of the mice was evaluated with the open field test. Then, the mice were sacrificed and histological examinations of the tissues, the expression of peptide hormones, corticosterone, Immunoglobulin E, histamine, and cytokines was performed using an enzyme-linked immunosorbent assay.Results: In the treadmill-treated conventional NC/Nga mice, AD symptoms were deteriorated compared with the non-treated conventional NC/Nga mice. The levels of Period (Per) 2, Clock, and brain and muscle arnt-like protein 1 (Bmal1) in the skin were increased constantly in the treadmill-treated conventional mice. Furthermore, the expression of Retinoic Acid-related Orphan Receptor (ROR)α, which activates Bmal1, was increased in the treadmill-treated conventional mice compared with the non-treated conventional mice. In addition, when non-treated conventional mice were administrated by the agonist of RORα, AD symptoms were deteriorated similar to treadmill-treated conventional mice.Conclusion: In the day-and-night reversal mice, the clock genes were increased constantly, indicating that this is a factor that deteriorated AD.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"87-102"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36362189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Micro-RNAs -106a and -362-3p in Peripheral Blood of Inflammatory Bowel Disease Patients. 炎症性肠病患者外周血微rna -106a和-362-3p

The Open Biochemistry Journal Pub Date : 2018-06-29 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010078

Ameneh Omidbakhsh, Mohsen Saeedi, Masoud Khoshnia, Abdoljalal Marjani, Safoura Hakimi

{"title":"Micro-RNAs -106a and -362-3p in Peripheral Blood of Inflammatory Bowel Disease Patients.","authors":"Ameneh Omidbakhsh, Mohsen Saeedi, Masoud Khoshnia, Abdoljalal Marjani, Safoura Hakimi","doi":"10.2174/1874091X01812010078","DOIUrl":"https://doi.org/10.2174/1874091X01812010078","url":null,"abstract":"Objective: MicroRNAs (miRNAs) can regulate various genes after binding to target mRNAs. Studies on Inflammatory Bowel Disease (IBD) in relation with miRNA are much less shown. The aim of the present study was to assess the expression patterns of microRNA 106a and microRNA 362-3p in peripheral blood samples of Inflammatory Bowel Disease (IBD) patients including Crohn's Disease(CD) and Ulcerative Colitis (UC).Methods: This study consisted of 32 CD, 32 UC patients and 32 controls. The expression level of the micro-RNAs -106a and -362-3p was determined using reverse transcription and real-time RT-PCR.Results: Our findings showed that MiR-106a and miR-362-3p are expressed at significantly higher levels in the peripheral blood from patients with CD and UC compared to controls. MiR-106a and miR-362-3p expression are also different in the peripheral blood of patients regarding the activity score of the disease. There were significant differences of miR362-3p in active UC relative to inactive UC.Conclusion: Altogether our findings suggest that miR-106a and miR-363-3p can play an important role in the pathogenesis of IBD. The differences in expression of miR106a and miR362-3p in peripheral blood of the UC and CD patients in an active phase in comparison to inactive disease suggest that these miRNAs may be useful as potential biomarkers for diagnosis and monitoring the disease activity.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36362188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Short Exposures to an Extremely Low-Frequency Magnetic Field (ELF MF) Enhance Protein but not mRNA Alkaline Phosphatase Expression in Human Osteosarcoma Cells. 短时间暴露于极低频磁场(ELF MF)可增强人骨肉瘤细胞中蛋白质而非mRNA碱性磷酸酶的表达。

The Open Biochemistry Journal Pub Date : 2018-04-17 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010065

Tania Rescigno, Anna Capasso, Bruno Bisceglia, Mario Felice Tecce

{"title":"Short Exposures to an Extremely Low-Frequency Magnetic Field (ELF MF) Enhance Protein but not mRNA Alkaline Phosphatase Expression in Human Osteosarcoma Cells.","authors":"Tania Rescigno, Anna Capasso, Bruno Bisceglia, Mario Felice Tecce","doi":"10.2174/1874091X01812010065","DOIUrl":"https://doi.org/10.2174/1874091X01812010065","url":null,"abstract":"Background: Among electromagnetic fields treatments used in orthopedics, extremely low-frequency magnetic fields (ELF MF) need more detailed information about the molecular mechanisms of their effects and exposure conditions.Objective: Evaluation of the effects of an ELF MF exposure system, recently introduced among current clinical treatments for fracture healing and other bone diseases, on Alkaline Phosphatase (ALP) activity and expression in a human osteosarcoma cell line (SaOS-2), as marker typically associated to osteogenesis and bone tissue regeneration.Method: Cells were exposed to the ELF MF physical stimulus (75 Hz, 1.5 mT) for 1h. Cell viability, enzymatic activity, protein and mRNA expression of alkaline phosphatase were then measured at different times after exposure (0, 4 and 24 h).Results: Data demonstrate that this signal is active on an osteogenic process already one hour after exposure. Treatment was, in fact, capable, even after an exposure shorter than those commonly used in clinical applications, to significantly up-regulate alkaline phosphatase enzymatic activity. This regulation is produced essentially through an increase of ALP protein level, without changes of its mRNA concentration, while assessed magnetic field did not affect cell growth and viability and did not produce temperature variations.Conclusion: Tested low-frequency magnetic field affects cellular ALP expression with a posttranslational mechanism, without the involvement of regulations at gene transcription and mRNA level. This molecular effect is likely produced even within treated tissues during therapies with this signal and may be implicated in the induction of observed effects in treated patients.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"65-77"},"PeriodicalIF":0.0,"publicationDate":"2018-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874091X01812010065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36099298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Protective and Restorative Effects of Nutrients and Phytochemicals. 营养物质和植物化学物质的保护和恢复作用。

The Open Biochemistry Journal Pub Date : 2018-04-17 eCollection Date: 2018-01-01 DOI: 10.2174/1874091X01812010046

Tania Rescigno, Mario F Tecce, Anna Capasso

{"title":"Protective and Restorative Effects of Nutrients and Phytochemicals.","authors":"Tania Rescigno, Mario F Tecce, Anna Capasso","doi":"10.2174/1874091X01812010046","DOIUrl":"https://doi.org/10.2174/1874091X01812010046","url":null,"abstract":"Intoroduction: Dietary intake fundamentally provides reintegration of energy and essential nutrients to human organisms. However, its qualitative and quantitative composition strongly affects individual's health, possibly being either a preventive or a risk factor. It was shown that nutritional status resulting from long-term exposition to specific diet formulations can outstandingly reduce incidences of most common and most important diseases of the developed world, such as cardiovascular and neoplastic diseases. Diet formulations result from different food combinations which bring specific nutrient molecules. Numerous molecules, mostly but not exclusively from vegetal foods, have been characterized among nutritional components as being particularly responsible for diet capabilities to exert risk reduction. These \"bioactive nutrients\" are able to produce effects which go beyond basic reintegration tasks, i.e. energetic and/or structural, but are specifically pharmacologically active within pathophysiological pathways related to many diseases, being able to selectively affect processes such as cell proliferation, apoptosis, inflammation, differentiation, angiogenesis, DNA repair and carcinogens activation.Conclusion: The present review was aimed to know the molecular mechanisms and pathways of activity of bioactive molecules; which will firstly allow search for optimal food composition and intake, and then use them as possible therapeutical targets and/or diagnostics. Also, the present review discussed the therapeutic effect of both nutrients and phytochemicals.","PeriodicalId":515405,"journal":{"name":"The Open Biochemistry Journal","volume":"12 ","pages":"46-64"},"PeriodicalIF":0.0,"publicationDate":"2018-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36099299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15