Laura Bishop, Cory D Lamar, Robin A Hurley, Katherine H Taber
{"title":"Neuroimaging and neuropsychological consequences of cardiac arrest.","authors":"Laura Bishop, Cory D Lamar, Robin A Hurley, Katherine H Taber","doi":"10.1176/appi.neuropsych.270202","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.270202","url":null,"abstract":"FIGURE 1. MRI has shown promise for differentiating survivors of cardiac arrest (CA) with a poor prognosis from those individuals who are more likely to recover. Diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) sequences are both of value during the acute stage, although DWI may provide visualization of some areas of injury earlier than FLAIR. Poor outcome (death, vegetative state, or severe disability) is associated with more widespread and severe areas of abnormality. Left: A DWI scan result of a middle-aged patient obtained approximately 36 hours after CA is essentially normal, showing no evidence of acute hypoxic-ischemic brain injury. An EEG obtained in the first 24 hours shows diffuse background slowing. Right: A DWI scan of a young adult patient obtained approximately 48 hours after CA demonstrates widespread diffuse acute hypoxic-ischemic brain injury. An EEG obtained in the first 24 hours after CA shows a burst suppression pattern.","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"75-9"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.270202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33261869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Urbano, Leonore Okwara, Paul Manser, Kathrin Hartmann, Stephen I Deutsch
{"title":"A trial of d-cycloserine to treat the social deficit in older adolescents and young adults with autism spectrum disorders.","authors":"Maria Urbano, Leonore Okwara, Paul Manser, Kathrin Hartmann, Stephen I Deutsch","doi":"10.1176/appi.neuropsych.13070155","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13070155","url":null,"abstract":"<p><p>Autism spectrum disorders are difficult for older adolescents and young adults as impaired social communication affects the transition to adult life. d-Cycloserine, a partial glycine agonist at the N-methyl-d-aspartic acid receptor, was tested in a double-blind randomized trial in 20 older adolescents and young adults with autism spectrum disorders using two dosing strategies (50 mg daily versus 50 mg weekly) for 8 weeks with a 2-week follow-up after discontinuation. d-Cycloserine caused statistically and clinically significant improvement with no differentiation between dosing strategies on the Social Responsiveness Scale and the Aberrant Behavior Checklist before and after d-cycloserine administration. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"133-8"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13070155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33261874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systematic review of an emerging trend in china: resting-state functional connectivity in major depressive disorder.","authors":"Donald F Smith","doi":"10.1176/appi.neuropsych.13110343","DOIUrl":"10.1176/appi.neuropsych.13110343","url":null,"abstract":"<p><p>Major depressive disorder continues to challenge medical and psychological resources worldwide. A marked surge has occurred recently in China in neuroimaging studies of major depressive disorder. Those studies represent an emerging trend in neuropsychiatry in that such research has previously been extremely rare in China. The present article provides a systematic review of reports published in English by research institutes in China on resting-state functional connectivity studied by MRI in depressed subjects and healthy control subjects. Particular attention is given to whether the information may advance effective diagnosis and treatment options for patients with major depressive disorder. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"104-11"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32695071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system.","authors":"Ana Hategan, James A Bourgeois","doi":"10.1176/appi.neuropsych.14010011","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14010011","url":null,"abstract":"","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e140-1"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14010011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33135187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Experience in delirium: is it distressing?","authors":"Sandeep Grover, Abhishek Ghosh, Deepak Ghormode","doi":"10.1176/appi.neuropsych.13110329","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13110329","url":null,"abstract":"<p><p>A total of 203 consecutive patients were assessed on a delirium experience questionnaire 24 hours after recovery from delirium. One third (35%) of the patients could recollect their experiences during the delirium, and the majority (86%) of them were distressed by these experiences. The level of distress was moderate in most of the subjects (52.5%). Fear and visual hallucination were the most common distressing themes recollected. When the patients who could recall their experience of delirium were compared with those who could not recall, the authors noted that recall of delirium experience was associated with a higher prevalence of perceptual disturbances and language disturbances and a higher severity of delirium. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"139-46"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13110329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32618218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janardhanan C Narayanaswamy, Sunil V Kalmady, Ganesan Venkatasubramanian, Bangalore N Gangadhar
{"title":"Clinical correlates of superior temporal gyrus volume abnormalities in antipsychotic-naïve schizophrenia.","authors":"Janardhanan C Narayanaswamy, Sunil V Kalmady, Ganesan Venkatasubramanian, Bangalore N Gangadhar","doi":"10.1176/appi.neuropsych.14030049","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14030049","url":null,"abstract":"In this study, the authors report superior temporal gyrus (STG) and Heschl's gyrus (HG) volume deficits in a large sample of medication-naïve patients with schizophrenia (N=55) in comparison with healthy control subjects (N=45) with structural MRI using voxel-based morphometry. Patients had significantly smaller volumes of left HG [X=-41, Y=-22, Z=11; Brodmann's area (BA)-41), right HG (X=47, Y=-18, Z=11; BA-41), and left STG (X=-50, Y=-34, Z=11; BA-42] compared with healthy control subjects. In addition, Positive and Negative Syndrome Scale positive score had a significant negative correlation with left HG. Findings observed in a large sample of antipsychotic-naive patients with schizophrenia emphasize the role of HG and STG in the pathophysiology of schizophrenia.","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e128-33"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14030049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33135185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sameer Belvi Mangalwedhe, Aditya A Pandurangi, Anand K Pandurangi, Rajendra I Dugani
{"title":"Anti-N-Methyl-D-Aspartate Receptor Encephalitis Presenting With Psychiatric Symptoms.","authors":"Sameer Belvi Mangalwedhe, Aditya A Pandurangi, Anand K Pandurangi, Rajendra I Dugani","doi":"10.1176/appi.neuropsych.14030066","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14030066","url":null,"abstract":"","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e152-3"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14030066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33135193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey E Max, Keren Friedman, Elisabeth A Wilde, Erin D Bigler, Gerri Hanten, Russell J Schachar, Ann E Saunders, Maureen Dennis, Linda Ewing-Cobbs, Sandra B Chapman, Tony T Yang, Harvey S Levin
{"title":"Psychiatric disorders in children and adolescents 24 months after mild traumatic brain injury.","authors":"Jeffrey E Max, Keren Friedman, Elisabeth A Wilde, Erin D Bigler, Gerri Hanten, Russell J Schachar, Ann E Saunders, Maureen Dennis, Linda Ewing-Cobbs, Sandra B Chapman, Tony T Yang, Harvey S Levin","doi":"10.1176/appi.neuropsych.13080190","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13080190","url":null,"abstract":"<p><p>This study aimed to better understand the occurrence of novel psychiatric disorders (NPDs) in children with mild traumatic brain injury (mTBI) in relation to preinjury variables, injury-related variables, and concurrent neurocognitive outcome. Eighty-seven children aged 5-14 years who had experienced mTBI were studied from consecutive hospital admissions with semistructured psychiatric interviews soon after injury (baseline). Fifty-four children were reassessed 24 months postinjury. Standardized instruments were used to evaluate injury severity, lesion characteristics, preinjury variables (lifetime psychiatric disorder, family psychiatric history, family function, socioeconomic status, psychosocial adversity, adaptive function, and academic function), and finally, postinjury neurocognitive and adaptive function. At 24 months postinjury, NPDs had occurred in 17 of 54 (31%) participants. NPD at 24 months was related to frontal white matter lesions and was associated with estimated preinjury reading, preinjury adaptive function, and concurrent deficits in reading, processing speed, and adaptive function. These findings extend earlier reports that the psychiatric morbidity after mTBI in children is more common than previously thought, and moreover, it is linked to preinjury individual variables and injury characteristics and is associated with postinjury adaptive and neurocognitive functioning. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"112-20"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13080190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33261872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergio Starkstein, Milan Dragovic, Simone Brockman, Mark Wilson, Veronica Bruno, Marcelo Merello
{"title":"The impact of emotional distress on motor blocks and festination in Parkinson's disease.","authors":"Sergio Starkstein, Milan Dragovic, Simone Brockman, Mark Wilson, Veronica Bruno, Marcelo Merello","doi":"10.1176/appi.neuropsych.13030053","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13030053","url":null,"abstract":"<p><p>Recent studies suggest that depression and anxiety in patients with Parkinson's disease may predispose them to freezing. Although festination is also frequent, the association with emotional disorders has not been examined. The aim of the authors was to clarify the association between freezing and festination with anxiety, depressive disorders, and emotional distress. The authors examined a consecutive series of 95 patients with Parkinson's disease using comprehensive psychiatric assessments and a new instrument specifically designed to assess the severity of freezing, festination, and emotional distress (Motor Blocks and Festination Scale). All patients were assessed with the Motor Blocks and Festination Scale, the Mini International Neuropsychiatric Interview, and scales to measure the severity of mood and anxiety disorders. A linear regression analysis showed that both motor blocks and festination were significantly associated with emotional distress and deficits on activities of daily living. Conversely, there was no significant association between motor blocks or festination and generalized anxiety disorder, panic disorder, agoraphobia, social phobia, or depression. Motor blocks and festination are significantly associated with emotional distress, but no significant associations were found with anxiety or affective disorders. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"121-6"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13030053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33261873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janardhanan C Narayanaswamy, Dania Jose, Sunil V Kalmady, Ganesan Venkatasubramanian, Y C Janardhan Reddy
{"title":"Pituitary volume in medication-naïve adults with obsessive compulsive disorder.","authors":"Janardhanan C Narayanaswamy, Dania Jose, Sunil V Kalmady, Ganesan Venkatasubramanian, Y C Janardhan Reddy","doi":"10.1176/appi.neuropsych.13080188","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13080188","url":null,"abstract":"<p><p>Pituitary volume is considered to reflect hypothalamic-pituitary-adrenal axis dysregulation, and this has been studied in various psychiatric disorders. This study demonstrates that pituitary volume as assessed through the region of interest manual tracing method in 50 medication-naïve adult patients with obsessive-compulsive disorder was not significantly different compared with 40 healthy control subjects (687.80 ± 126.60 versus 694.73 ± 131.59, F=0.55, p=0.46). The authors also compared the patients with obsessive-compulsive disorder without any comorbid axis I conditions (N=35) with healthy control subjects and found no difference in the pituitary volumes (681.62 ± 130.85 versus 694.72 ± 131.59, F=0.90, p=0.35). This emphasizes the need to examine hypothalamo-pituitary axis structures after taking into consideration various potential confounders such as medications and depression.</p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e97-9"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13080188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32935221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}