Epidemiologia e Servicos de Saude最新文献

{"title":"Vaccination coverage in children up to 2 years old born in 2017 and 2018 in the municipalities of São Paulo and Campinas, Brazil: comparison of the results of a national survey and the National Immunization Program Information System.","authors":"Manoela Alves Algodres, Ana Paula França, José Cássio de Moraes, Adriana Ilha da Silva, Alberto Novaes Ramos, Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Gloria Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo","doi":"10.1590/S2237-96222024v33e2023539.especial2.en","DOIUrl":"10.1590/S2237-96222024v33e2023539.especial2.en","url":null,"abstract":"<p><strong>Objective: </strong>To estimate and compare vaccination coverage among children born in 2017-2018 in São Paulo and Campinas, according to the Vaccination Coverage Survey (ICV 2020) and the National Immunization Program Information System (SI-PNI).</p><p><strong>Methods: </strong>ICV 2020 analyzed vaccination card records. Coverage was calculated and compared to doses recorded on the SI-PNI, divided by the target population.</p><p><strong>Results: </strong>In São Paulo, according to ICV, in 2017 only BCG (91.7%; 95%CI 87.0;94.7) and rotavirus first dose (90.6%; 95%CI 86.5;93.5) achieved the goals; in 2018, BCG (93.4%; 95%CI 89.5;95.8), rotavirus first dose (90.5%; 95%CI 85.3;94.0), pneumococcal first dose (95.3%; 95%CI 91.7;97.4), meningococcal C first dose (95.1%; 95%CI 91.5;97.2) and pneumococcal second dose (95.0%; 95%CI 91.4;95.0). In Campinas, only BCG achieved the target in 2017 (93.0%; 95%CI 88.8;95.7) and none in 2018. According to the SI-PNI, no vaccine achieved the target in either city.</p><p><strong>Conclusion: </strong>Vaccination coverage was lower than expected and more precise estimates are necessary for adequate monitoring of childhood vaccination status.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe2","pages":"e2023539"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of polio vaccination status in a cohort of live births in 2017 and 2018 in Brazilian cities: a national vaccination coverage survey.","authors":"Alessandra Lucchesi de Menezes Xavier Franco, Ana Paula França, José Cássio de Moraes, Manoel Carlos Sampaio de Almeida Ribeiro, Adriana Ilha da Silva, Alberto Novaes Ramos, Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Gloria Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo","doi":"10.1590/S2237-96222024v33e20231303.en","DOIUrl":"10.1590/S2237-96222024v33e20231303.en","url":null,"abstract":"<p><strong>Objective: </strong>To describe the polio vaccination status in 26 state capitals, the Federal District, and 12 municipalities in Brazil, among children born between 2017 and 2018.</p><p><strong>Methods: </strong>This was a population-based household survey conducted from 2020 to 2022, which assessed polio vaccination coverage in children, considering valid, administered, and timely doses by municipality.</p><p><strong>Results: </strong>Data were collected from 37,801 children. Vaccination coverage for the complete valid dose schedule was 87.5% (95%CI 86.2;88.7), dropping to 79.6% (95%CI 78.1;81.0), when the booster dose was considered. The dropout rate was 4.5% for the complete schedule, and 11.7% for the first booster. There was no correlation between campaign implementation and high coverage.</p><p><strong>Conclusion: </strong>Vaccination coverage for the complete valid dose schedule and the first booster did not meet the 95.0% target. Regional disparities and the association between vaccination coverage and social indicators should be taken into consideration in strategies to increase coverage.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe2","pages":"e20231303"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination coverage, vaccine hesitancy and factors associated with incomplete vaccination: a household survey conducted with children born between 2017 and 2018 in the inland municipalities of Northeastern Brazil.","authors":"Anderson Fuentes Ferreira, Alberto Novaes Ramos, Adjoane Mauricio Silva Maciel, Jaqueline Caracas Barbosa, Ramon da Costa Saavedra, Maria Bernadete de Cerqueira Antunes, Luisa Helena de Oliveira Lima, Rejane Christine de Sousa Queiroz, Taynara Lais Silva, Martha Suely Itaparica de Carvalho Santiago, Ana Paula França, Carla Magda Allan Santos Domingues, José Cássio de Moraes, Maria da Gloria Teixeira, Adriana Ilha da Silva, Alberto Novaes Ramos, Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Gloria Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo","doi":"10.1590/S2237-96222024v33e20231224.especial2.en","DOIUrl":"10.1590/S2237-96222024v33e20231224.especial2.en","url":null,"abstract":"<p><strong>Objective: </strong>To analyze vaccination coverage and factors associated with incomplete vaccination in inland municipalities of Northeastern Brazil.</p><p><strong>Methods: </strong>This was a household survey using cluster sampling conducted in Vitória da Conquista, Bahia state, Caruaru, Pernambuco state, Sobral, Ceará state and Imperatriz, Maranhão state between 2020 and 2022. Vaccination coverage by valid doses and vaccine hesitancy were analyzed, with the odds ratio (OR) estimated and adjusted using logistic regression.</p><p><strong>Results: </strong>Among 1,847 children, complete vaccination coverage was 49.2% (95%CI 43.9;54.5). Factors associated with incomplete vaccination included: higher income (OR 1.53; 95%CI 1.02;2.31), residence in Sobral (OR 4.35; 95%CI 3.04; 6.21) and >1 child (OR 1.20; 95%CI 1.11;1.32). Parental decision not to vaccinate and difficulties in traveling to vaccination centers contributed to vaccine hesitancy.</p><p><strong>Conclusion: </strong>Low vaccination coverage and incomplete vaccination were associated with social issues in the socioeconomic strata analyzed.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe2","pages":"e20231224"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life of trans people using a specialized health service in Manaus, Amazonas state, Brazil, 2023: a cross-sectional study.","authors":"Erivan Clementino Gualberto Júnior, Açucena Amâncio Dall'Alba, André Luiz Machado das Neves, David Câmara Gurgel do Amaral, Aline Barreto Soares, Fernando José Herkrath, Ana Paula Corrêa de Queiroz Herkrath","doi":"10.1590/S2237-96222024v33e2024361.especial.en","DOIUrl":"10.1590/S2237-96222024v33e2024361.especial.en","url":null,"abstract":"<p><strong>Objective: </strong>To assess health-related quality of life and associated factors among trans people.</p><p><strong>Methods: </strong>This was a cross-sectional study conducted in 2023. The 12-Item Short- Form Health Survey was used with trans women, trans men, travestis, and non-binary people who were users of a health service in Manaus, capital city of Amazonas state.</p><p><strong>Results: </strong>A total of 71 participants were included: 36 trans women; 29 trans men; 2 travestis; and 4 non-binary people, with a mean age 30.1 years. The physical component scored 44.6±7.8, and the mental component scored 38.4±11.1. The emotional aspect with a score of 16.0±1.1, was the most affected domain. Paid employment was associated with better mental quality of life, while having lived in street situations was associated with worse physical quality of life, with mean differences of 4.4 (95%CI 2.3;6.9) and -3.3 (95%CI -7.7;2.3) respectively.</p><p><strong>Conclusion: </strong>Among trans people, the mental component was more affected than the physical, with the greatest impairment observed in the emotional aspect. Socioeconomic characteristics were associated with quality of life.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe1","pages":"e2024361"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination coverage, delay and loss to follow-up of the triple viral vaccine, in live births between 2017 and 2018 in Brazilian cities.","authors":"Tatiana Lang D'Agostini, Fernanda Florencia Fregnan Zambom, José Cássio de Moraes, Ana Paula França, Jéssica Pires de Camargo, Manoel Carlos Sampaio de Almeida Ribeiro, Rita Barradas Barata, Adriana Ilha da Silva, Alberto Novaes Ramos, Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Gloria Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo","doi":"10.1590/S2237-96222024v33e20231218.especial2.en","DOIUrl":"10.1590/S2237-96222024v33e20231218.especial2.en","url":null,"abstract":"<p><strong>Objective: </strong>To estimate measles-mumps-rubella vaccination coverage, delay and loss to follow-up in children up to 24 months old living in Brazilian cities.</p><p><strong>Methods: </strong>Surveys and questionnaires with a retrospective cohort of live births in 2017-2018, analyzing vaccination coverage and sociodemographic data of children and families, based on vaccination card records and interviews.</p><p><strong>Results: </strong>Valid coverage of first dose was 90.0% (95%CI 88.9;91.0) and 81.1% for the second dose (95%CI 79.8;82.4). Delay for both doses was 23.2% (95%CI 21.9;24.5) and loss to follow-up was 10.8% (95%CI 9.9;11.8). Socioeconomic stratum A had the lowest vaccination coverage and the higher the child's birth order, the lower the vaccination coverage for the second dose. Children whose mothers had 13 to 15 years of education had higher vaccination coverage.</p><p><strong>Conclusion: </strong>Coverage did not meet the recommended target. Differentiated strategies to resolve difficulties in access, misinformation, and vaccination hesitancy will help improve vaccination coverage.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe2","pages":"e20231218"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination opportunity in children up to 6 months old born in 2017 and 2018 in the city of Londrina-PR, Brazil: a population-based survey.","authors":"Heloísa Dias Brites, Ana Paula França, José Cássio de Moraes, Adriana Ilha da Silva, Alberto Novaes Ramos, Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Gloria Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo","doi":"10.1590/S2237-96222024v33e2024432.especial2.en","DOIUrl":"10.1590/S2237-96222024v33e2024432.especial2.en","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate opportunity for vaccination in children born alive in Londrina, up to 6 months old and the relationship between socioeconomic stratum and vaccination regularity.</p><p><strong>Method: </strong>Population survey study based on a retrospective cohort of children born in 2017 and 2018 that identified vaccines not administered in a given session. Vaccination regularity was compared between socioeconomic strata using Pearson's chi-square test.</p><p><strong>Results: </strong>Out of 456 vaccination cards, the proportion of vaccination opportunities not recovered for doses to be administered at birth and at two, four and six months was 5.0% (95%CI 3.1;7.5), 4. 5% (95%CI 2.8;6.9), 7.2% (95%CI 5.0;10.2) and 2.1% (95%CI 1.0;4.0), respectively. There was no statistical difference in vaccination regularity between the strata.</p><p><strong>Conclusion: </strong>Missed opportunities for vaccination were found at all ages. Socioeconomic stratum did not influence vaccination regularity.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe2","pages":"e2024432"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine hesitancy and consequences for vaccination coverage in children at 24 months of age, born in 2017-2018, living in the state capitals, Federal District and 12 inner region cities of Brazil.","authors":"Rita Barradas Barata, Ana Paula França, Ione Aquemi Guibu, Gabriel Munhoz, Carla Magda Allan Santos Domingues, Maria da Gloria Teixeira, José Cássio de Moraes, Adriana Ilha da Silva, Alberto Novaes Ramos, Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Gloria Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo","doi":"10.1590/S2237-96222024v33e20231097.especial2.en","DOIUrl":"10.1590/S2237-96222024v33e20231097.especial2.en","url":null,"abstract":"<p><strong>Objective: </strong>To analyze vaccine hesitancy associated factors and repercussions on vaccination coverage.</p><p><strong>Methods: </strong>Cohort of children born in 2017-2018, living in Brazilian state capitals, Federal District (FD), and 12 inner region cities, stratified by socioeconomic level. National Vaccination Coverage Survey (2020) data on hesitancy, access and programmatic difficulties were obtained by interview and coverage was calculated from vaccination card dose and date records.</p><p><strong>Results: </strong>37801 children were studied, 31001 in the capitals/FD, 6800 in the inner cities. Hesitation between 38.8(95%CI 33.6;44.4) and 57.9(95%CI 54.1;61.6) in high versus low stratum; 64.1(95%CI 58.9;68.9) to 41.7(95%CI 38.4;45.8) among mothers with <8 years of schooling versus 16 years or more; 42.1(95%CI 38.2;46.2) to 55.0(95%CI 52.0;54.7) among private service users versus public service only users. Coverage: full=7.2(95%CI 1.0;38.3); 25.3(95%CI 18.7;33.3) for hesitant people; and 44.7(95%CI 43.0;46.4) for the remainder.</p><p><strong>Conclusion: </strong>High vaccine hesitancy in several groups affecting vaccination coverage and hindering vaccination target achievement. Access problems and programmatic difficulties contribute to low coverage.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 spe2","pages":"e20231097"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewed article: Carvalho EA, Hopker RH, Pedroso GH, Almeida LS, Pacher JAT, Antônio ALM, Souza J, Zeny MS, Santos MLSF, Valle DAV, Andrade FA. Characterization of patients treated at a rare disease referral service: a descriptive study, 2016-2021. Epidemiol Serv Saúde. 2024;33:e20240204. 10.1590/S2237-96222024v33e20240204.en.","authors":"Cassio Hartmann","doi":"10.1590/S2237-96222024v33e20240204.a","DOIUrl":"https://doi.org/10.1590/S2237-96222024v33e20240204.a","url":null,"abstract":"","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 ","pages":"e20240204.a"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of patients treated at a rare disease referral service: a descriptive study, 2016-2021.","authors":"Everson Andrade de Carvalho, Roberto Del Claro Hopker, Gustavo Henrique Pedroso, Leonardo Silva de Almeida, José Alfredo Trevisan Pacher, André Lucas Miranda Antônio, Josiane de Souza, Michelle Silva Zeny, Mara Lúcia Schmitz Ferreira Santos, Daniel Almeida do Valle, Fabiana Antunes Andrade","doi":"10.1590/S2237-96222024v33e20240204.en","DOIUrl":"https://doi.org/10.1590/S2237-96222024v33e20240204.en","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the first referral service for rare diseases accredited by the Brazilian Ministry of Health, focusing on referral from the primary healthcare network through to diagnosis.</p><p><strong>Methods: </strong>This is a descriptive study with patients treated between 2016 and 2021 at a referral hospital service located in Curitiba, Paraná, Brazil. Clinical and epidemiological data were obtained from medical records, as were the results of genetic tests at the hospital's clinical analysis laboratory. Qualitative data were expressed as absolute and relative frequencies, while quantitative data were expressed as medians and interquartile ranges and compared using the Kruskal-Wallis test.</p><p><strong>Results: </strong>The study included 1,751 cases, 34.1% were diagnosed with rare diseases, with average time until diagnosis being 3.0 years, whereby mucopolysaccharidosis type II (4.0%) and tuberous sclerosis (3.9%) were the most common. Greater length of time for obtaining diagnosis (p-value 0.004) and receiving specialized care (p-value<0.001) was found in patients from the interior region of Paraná state, compared to those residing in Curitiba city and its metropolitan region.</p><p><strong>Conclusion: </strong>Diagnosis of rare diseases occurred in approximately one third of cases. The average time until diagnosis suggests a possible positive impact of implementing the referral service. The longer time until diagnosis and specialized care found among patients from the interior region of Paraná represent challenges regarding adequate referral to specialized services.</p>","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 ","pages":"e20240204"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewed article: Carvalho EA, Hopker RH, Pedroso GH, Almeida LS, Pacher JAT, Antônio ALM, Souza J, Zeny MS, Santos MLSF, Valle DAV, Andrade FA. Characterization of patients treated at a rare disease referral service: a descriptive study, 2016-2021. Epidemiol Serv Saúde. 2024;33:e20240204. 10.1590/S2237-96222024v33e20240204.en.","authors":"Cassandra de Sousa Costa","doi":"10.1590/S2237-96222024v33e20240204.b","DOIUrl":"https://doi.org/10.1590/S2237-96222024v33e20240204.b","url":null,"abstract":"","PeriodicalId":51473,"journal":{"name":"Epidemiologia e Servicos de Saude","volume":"33 ","pages":"e20240204.b"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}