The Open Neurology Journal最新文献_第2页

Dystonia in Patients with Spinocerebellar Ataxia 3 - Machado-Joseph disease: An Underestimated Diagnosis? 脊髓小脑共济失调3 - Machado-Joseph病患者的肌张力障碍:被低估的诊断?

The Open Neurology Journal Pub Date : 2018-05-31 eCollection Date: 2018-01-01 DOI: 10.2174/1874205X01812010041

Ligia Maria Perrucci Catai, Carlos Henrique Ferreira Camargo, Adriana Moro, Gustavo Ribas, Salmo Raskin, Hélio Afonso Ghizoni Teive

{"title":"Dystonia in Patients with Spinocerebellar Ataxia 3 - Machado-Joseph disease: An Underestimated Diagnosis?","authors":"Ligia Maria Perrucci Catai, Carlos Henrique Ferreira Camargo, Adriana Moro, Gustavo Ribas, Salmo Raskin, Hélio Afonso Ghizoni Teive","doi":"10.2174/1874205X01812010041","DOIUrl":"https://doi.org/10.2174/1874205X01812010041","url":null,"abstract":"Background: Spinocerebellar Ataxia type 3 (SCA3) or Machado-Joseph Disease (MJD) is characterized by cerebellar, central and peripheral symptoms, including movement disorders. Dystonia can be classified as hereditary and neurodegenerative when present in SCA3.Objective: The objective of this study was to evaluate the dystonia characteristics in patients with MJD.Method: We identified all SCA3 patients with dystonia from the SCA3 HC-UFPR database, between December 2015 and December 2016.Their medical records were reviewed to verify the diagnosis of dystonia and obtain demographic and clinical data. Standardized evaluation was carried out through the classification of Movement Disorders Society of 2013 and Burke Fahn-Marsden scale (BFM).Results: Amongst the presenting some common characteristics, 381 patients with SCA3, 14 (3.7%) subjects presented dystonia: 5 blepharospasm, 1 cervical dystonia, 3 oromandibular, 3 multifocal and 2 generalized dystonia. Regarding dystonia's subtypes, 71.4% had SCA3 subtype I and 28.6% SCA3 subtype II. The average age of the disease onset was 40±10.7 years; the SCA3 disease duration was 11.86± 6.13 years; the CAG repeat lengths ranged from 75 to 78, and the BFM scores ranged from 1.0 to 40. There was no correlation between the dystonia severity and CAG repeat lengths or the SCA3 clinical evolution.Conclusion: Dystonia in SCA3 is frequent and displays highly variable clinical profiles and severity grades. Dystonia is therefore a present symptom in SCA3, which may precede the SCA3 classic symptoms. Dystonia diagnosis is yet to be properly recognized within SCA3 patient.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"12 ","pages":"41-49"},"PeriodicalIF":0.0,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874205X01812010041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36311516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cognitive and Language Deficits in Multiple Sclerosis: Comparison of Relapsing Remitting and Secondary Progressive Subtypes. 多发性硬化症的认知和语言缺陷:复发缓解型和继发进展型的比较

The Open Neurology Journal Pub Date : 2018-03-12 eCollection Date: 2018-01-01 DOI: 10.2174/1874205X01812010019

Katerina Ntoskou, Lambros Messinis, Grigorios Nasios, Maria Martzoukou, Giorgos Makris, Elias Panagiotopoulos, Panagiotis Papathanasopoulos

{"title":"Cognitive and Language Deficits in Multiple Sclerosis: Comparison of Relapsing Remitting and Secondary Progressive Subtypes.","authors":"Katerina Ntoskou, Lambros Messinis, Grigorios Nasios, Maria Martzoukou, Giorgos Makris, Elias Panagiotopoulos, Panagiotis Papathanasopoulos","doi":"10.2174/1874205X01812010019","DOIUrl":"https://doi.org/10.2174/1874205X01812010019","url":null,"abstract":"Objective: The objective of this study was to investigate the pattern and severity of cognitive and language impairment in Greek patients with Relapsing-remitting (RRMS) and Secondary Progressive Multiple Sclerosis (SPMS), relative to control participants.Method: A prospective study was conducted in 27 patients with multiple sclerosis (PwMS), (N= 15) with RRMS, (N= 12) with SPMS, and (N= 12) healthy controls. All participants were assessed with a flexible comprehensive neuropsychological - language battery of tests that have been standardized in Greece and validated in Greek MS patients. They were also assessed on measures of disability (Expanded Disability Status Scale; EDSS), fatigue (Fatigue Severity Scale; FSS) and depression (Beck Depression Inventory - fast screen; BDI-FS).Results: Our results revealed that groups were well matched on baseline demographic and clinical characteristics. The two clinical groups (RRMS; SPMS) did not differ on overall global cognitive impairment but differed in the initial encoding of verbal material, mental processing speed, response inhibition and set-shifting. RRMS patients differed from controls in the initial encoding of verbal material, learning curve, delayed recall of verbal information, processing speed, and response inhibition. SPMS patients differed in all utilized measures compared to controls. Moreover, we noted increased impairment frequency on individualized measures in the progressive SPMS group.Conclusion: We conclude that MS patients, irrespective of clinical subtype, have cognitive deficits compared to healthy participants, which become increasingly worse when they convert from RRMS to SPMS.On the contrary,the pattern of impairment remains relatively stable.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"12 ","pages":"19-30"},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874205X01812010019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35946050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

A High-fat and High-Cholesterol Diet Potentiates Oxidative Damage in Hippocampus of Mice Lacking Apolipoprotein E. 高脂高胆固醇饮食可增强载脂蛋白E缺乏小鼠海马的氧化损伤。

The Open Neurology Journal Pub Date : 2018-02-21 eCollection Date: 2018-01-01 DOI: 10.2174/1874205X01812010012

Mary Guaraldi, Thomas B Shea

{"title":"A High-fat and High-Cholesterol Diet Potentiates Oxidative Damage in Hippocampus of Mice Lacking Apolipoprotein E.","authors":"Mary Guaraldi, Thomas B Shea","doi":"10.2174/1874205X01812010012","DOIUrl":"https://doi.org/10.2174/1874205X01812010012","url":null,"abstract":"Objective: We examined genetic and dietary challenge on hippocampal oxidative damage. Mice expressing (ApoE+/+) or lacking apolipoprotein E (ApoE-/-) were maintained on a standard diet or a high fat /high cholesterol (challenge) diet for 11-31 weeks. Similar levels of oxidative species were observed for ApoE+/+ and -/- mice maintained on the basal diet.Method: However, treatment of ApoE-/- homogenates with hydrogen peroxide and iron increased oxidative species by >100%, indicating an equivalent amount of potential oxidative species in latent form. We observed a time- and region-specific induction of oxidative damage in the hippocampi of ApoE-/- but not +/+ mice while maintained on the challenge diet. Notably, however, additional significant latent oxidative products were detected during this time. After 31 weeks of dietary challenge, by which time hippocampal oxidative species had doubled, there was an additional 50% in the latent form.Conclusion: This highlights the degree to which ApoE deficiency places hippocampal tissue at risk for oxidative damage. Even a modest dietary deficiency may be sufficient to provoke oxidative damage to hippocampal tissue. These results highlight the combinatorial impact of genetic and dietary deficiencies on oxidative damage to hippocampal tissue.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"12 ","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2018-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35914515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hospital Mortality Among Elderly Patients Admitted With Neurological Disorders Was Not Predicted by any Particular Diagnosis in a Tertiary Medical Center. 老年神经系统疾病住院患者的死亡率在三级医疗中心没有任何特定的诊断预测。

The Open Neurology Journal Pub Date : 2018-01-22 eCollection Date: 2018-01-01 DOI: 10.2174/1874205X01812010001

Aroldo Bacellar, Telma Assis, Bruno B Pedreira, Gersonita Costa, Osvaldo J M Nascimento

{"title":"Hospital Mortality Among Elderly Patients Admitted With Neurological Disorders Was Not Predicted by any Particular Diagnosis in a Tertiary Medical Center.","authors":"Aroldo Bacellar, Telma Assis, Bruno B Pedreira, Gersonita Costa, Osvaldo J M Nascimento","doi":"10.2174/1874205X01812010001","DOIUrl":"https://doi.org/10.2174/1874205X01812010001","url":null,"abstract":"Background: Neurological disorders (NDs) are associated with high hospital mortality. We aimed to identify predictors of hospital mortality among elderly inpatients with NDs. Methods: Patients aged ≥60 years admitted to the hospital between January 1, 2009 and December 31, 2010 with acute NDs, chronic NDs as underpinnings of acute clinical disorders, and neurological complications of other diseases were studied. We analyzed demographic data, NDs, and comorbidities as independent predictors of hospital mortality. Logistic regression was performed for multivariable analysis. Results: Overall, 1540 NDs and 2679 comorbidities were identified among 798 inpatients aged ≥ 60 years (mean 75.8±9.1). Of these, 54.5% were female. Diagnostic frequency of NDs ranged between 0.3% and 50.8%. Diagnostic frequency of comorbidities ranged from 5.6% to 84.5%. Comorbidities varied from 0 to 9 per patient (90% of patients had ≥2 comorbidities), mean 3.2±1.47(CI, 3.1-3.3). Patients with multimorbidities presented with a mean of 4.7±1.7 morbidities per patient. Each ND and comorbidity were associated with high hospital mortality, producing narrow ranges between the lowest and highest incidences of death (hospital mortality = 18%) (95% CI, 15%-21%). After multivariable analysis, advanced age (P<0.001) and low socioeconomic status (P=0.003) were recognized as predictors of mortality, totaling 9% of the variables associated with hospital mortality. Conclusion: Neither a particular ND nor an individual comorbidity predicted hospital mortality. Age and low socioeconomic class accounted for 9% of predictors. We suggest evaluating whether functional, cognitive, or comorbidity scores will improve the risk model of hospital mortality in elderly patients admitted with ND.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"12 ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874205X01812010001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35842618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Clinical Outcomes of Repeated Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Chronic Haemorrhagic Stroke. A One-Year Follow Up. 自体骨髓间充质干细胞反复脑室内移植治疗慢性出血性中风的临床疗效。一年的随访。

The Open Neurology Journal Pub Date : 2017-12-19 eCollection Date: 2017-01-01 DOI: 10.2174/1874205X01711010074

Asra Al Fauzi, Purwati Sumorejo, Nur Setiawan Suroto, Muhammad Arifin Parenrengi, Joni Wahyuhadi, Agus Turchan, Ferdiansyah Mahyudin, Heri Suroto, Fedik Abdul Rantam, Mochammad Hasan Machfoed, Abdul Hafid Bajamal, Christianto Benjamin Lumenta

{"title":"Clinical Outcomes of Repeated Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Chronic Haemorrhagic Stroke. A One-Year Follow Up.","authors":"Asra Al Fauzi, Purwati Sumorejo, Nur Setiawan Suroto, Muhammad Arifin Parenrengi, Joni Wahyuhadi, Agus Turchan, Ferdiansyah Mahyudin, Heri Suroto, Fedik Abdul Rantam, Mochammad Hasan Machfoed, Abdul Hafid Bajamal, Christianto Benjamin Lumenta","doi":"10.2174/1874205X01711010074","DOIUrl":"https://doi.org/10.2174/1874205X01711010074","url":null,"abstract":"Object: Stroke, one of the most devastating diseases, is a leading cause of death and disability throughout the world and is also associated with emotional and economic problems. The main goal of this study was to investigate the clinical outcome of the intraventricular transplantation of bone marrow mesenchymal stem cells (BM-MSCs) in post-haemorrhagic stroke patients.Method: This study was done consisting of eight patients with supratentorial haemorrhagic stroke, who had undergone 24 weeks of standard treatment of stroke with stable neurological deficits. All of the patients received stem cell transplantation intraventricularly using autologous BM-MSCs. Six months and Twelve months after stem cells treatment, the clinical outcomes were measured using the National Institute of Health Stroke Scale (NIHSS) and adverse effect also observed.Result: The results of this study showed improvement of NIHSS score values before and after the treatment in five patients. No adverse effects or complications were detected during the 1-year observation.Conclusion: Intraventricular transplantation of BM-MSCs has shown benefits in improving the functional status of post-haemorrhagic stroke patients with no adverse effect.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"11 ","pages":"74-83"},"PeriodicalIF":0.0,"publicationDate":"2017-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874205X01711010074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35699987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Do Cannabinoids Confer Neuroprotection Against Epilepsy? An Overview. 大麻素对癫痫有神经保护作用吗?概述。

The Open Neurology Journal Pub Date : 2017-12-18 eCollection Date: 2017-01-01 DOI: 10.2174/1874205X01711010061

Anna Capasso

引用次数: 7

Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer's Disease. 阿尔茨海默病患者大脑中Bax磷酸化的增强及其在线粒体中的易位

The Open Neurology Journal Pub Date : 2017-11-16 eCollection Date: 2017-01-01 DOI: 10.2174/1874205X01711010048

L E Henderson, M A Abdelmegeed, S H Yoo, S G Rhee, X Zhu, M A Smith, R Q Nguyen, G Perry, B J Song

{"title":"Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer's Disease.","authors":"L E Henderson, M A Abdelmegeed, S H Yoo, S G Rhee, X Zhu, M A Smith, R Q Nguyen, G Perry, B J Song","doi":"10.2174/1874205X01711010048","DOIUrl":"https://doi.org/10.2174/1874205X01711010048","url":null,"abstract":"Background: Despite increased neuronal death, senile plaques, and neurofibrillary tangles observed in patients suffering from Alzheimer's disease (AD), the detailed mechanism of cell death in AD is still poorly understood.Method: We hypothesized that p38 kinase activates and then phosphorylates Bax, leading to its translocation to mitochondria in AD brains compared to controls. The aim of this study was to investigate the role of p38 kinase in phosphorylation and sub-cellular localization of pro-apoptotic Bax in the frontal cortex of the brains from AD and control subjects. Increased oxidative stress in AD individuals compared to control was evaluated by measuring the levels of carbonylated proteins and oxidized peroxiredoxin, an antioxidant enzyme. The relative amounts of p38 kinase and phospho-Bax in mitochondria in AD brains and controls were determined by immunoblot analysis using the respective antibody against each protein following immunoprecipitation.Results: Our results showed that the levels of oxidized peroxiredoxin-SO3 and carbonylated proteins are significantly elevated in AD brains compared to controls, demonstrating the increased oxidative stress.Conclusion: The amount of phospho-p38 kinase is increased in AD brains and the activated p38 kinase appears to phosphorylate Thr residue(s) of Bax, which leads to its mitochondrial translocation, contributing to apoptosis and ultimately, neurodegeneration.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"11 ","pages":"48-58"},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35698935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Robot-Embodied Neuronal Networks as an Interactive Model of Learning. 机器人嵌入神经元网络作为一种交互学习模型。

The Open Neurology Journal Pub Date : 2017-09-30 eCollection Date: 2017-01-01 DOI: 10.2174/1874205X01711010039

Abraham M Shultz, Sangmook Lee, Mary Guaraldi, Thomas B Shea, Holly C Yanco

{"title":"Robot-Embodied Neuronal Networks as an Interactive Model of Learning.","authors":"Abraham M Shultz, Sangmook Lee, Mary Guaraldi, Thomas B Shea, Holly C Yanco","doi":"10.2174/1874205X01711010039","DOIUrl":"https://doi.org/10.2174/1874205X01711010039","url":null,"abstract":"Background and objective: The reductionist approach of neuronal cell culture has been useful for analyses of synaptic signaling. Murine cortical neurons in culture spontaneously form an ex vivo network capable of transmitting complex signals, and have been useful for analyses of several fundamental aspects of neuronal development hitherto difficult to clarify in situ. However, these networks lack the ability to receive and respond to sensory input from the environment as do neurons in vivo. Establishment of these networks in culture chambers containing multi-electrode arrays allows recording of synaptic activity as well as stimulation.Method: This article describes the embodiment of ex vivo neuronal networks neurons in a closed-loop cybernetic system, consisting of digitized video signals as sensory input and a robot arm as motor output.Results: In this system, the neuronal network essentially functions as a simple central nervous system. This embodied network displays the ability to track a target in a naturalistic environment. These findings underscore that ex vivo neuronal networks can respond to sensory input and direct motor output.Conclusion: These analyses may contribute to optimization of neuronal-computer interfaces for perceptive and locomotive prosthetic applications. Ex vivo networks display critical alterations in signal patterns following treatment with subcytotoxic concentrations of amyloid-beta. Future studies including comparison of tracking accuracy of embodied networks prepared from mice harboring key mutations with those from normal mice, accompanied with exposure to Abeta and/or other neurotoxins, may provide a useful model system for monitoring subtle impairment of neuronal function as well as normal and abnormal development.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"11 ","pages":"39-47"},"PeriodicalIF":0.0,"publicationDate":"2017-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35622173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Lumbar Spinal Angiolipoma with Expanding Left Neural Foramen Mimicking Lumbar Schwannoma; Case Report and Review of The Literature. 腰椎神经血管脂肪瘤伴左侧神经孔扩张模拟腰椎神经鞘瘤病例报告及文献回顾。

The Open Neurology Journal Pub Date : 2017-09-26 eCollection Date: 2017-01-01 DOI: 10.2174/1874205X01711010020

Yener Akyuva, Aylin Gonultas, Numan Karaaslan, Zehra Gulciftci Dagci, Semih Saglik, Mehmet Isyar, Mahir Mahirogullari

{"title":"Lumbar Spinal Angiolipoma with Expanding Left Neural Foramen Mimicking Lumbar Schwannoma; Case Report and Review of The Literature.","authors":"Yener Akyuva, Aylin Gonultas, Numan Karaaslan, Zehra Gulciftci Dagci, Semih Saglik, Mehmet Isyar, Mahir Mahirogullari","doi":"10.2174/1874205X01711010020","DOIUrl":"https://doi.org/10.2174/1874205X01711010020","url":null,"abstract":"Aim: To describe a patient with lumbar angiolipoma mimicking schwannoma in the posterolateral side of the spinal canal with expansion of the left lumbar foramen and to discuss the clinical, radiologic, and surgical features of these lesions with literature.Methods: Without language restriction in this paper, the electronic databases; The Cochrane Collaboration the Cochrane, The Cochrane Library (Issue 2 of 12, Feb. 2011), ProQuest, US National Library of Medicine, National Institutes of Health (NLM) and PubMed dating from 1966 September to January Week 2 2017, were searched for comparative experimental studies using the terms: \"OR\", \"AND\". On-line literature searches were conducted using the key words \"lumbar angiolipoma\", \"schwannoma \", \"spinal angiolipoma\", \"spinal cord\", and \"spinal canal\". We compared this research with our patient.Results: Bilateral L2 total laminectomy, excision of the tumors and bilateral L2-L3 transpedicular stabilization were performed, and complaints improved prominently. Pathological examination was reported as angiolipoma.Conclusion: The research shows that a probable diagnosis in such tumor cases could be made by sufficient pre-op scanning before surgical operations and although angiolipoma has been rarely seen in lumbar posterolateral space, it can be seen in lumbar region and mimic schwannoma as producing symptoms and signs of spinal cord and nerve root compression.","PeriodicalId":513493,"journal":{"name":"The Open Neurology Journal","volume":"11 ","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2017-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35622171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Specific Effects of Anti-Hypertensive Treatment in an Older Patient with Dementia. 老年痴呆患者抗高血压治疗的特异性效果。

The Open Neurology Journal Pub Date : 2017-04-17 eCollection Date: 2017-01-01 DOI: 10.2174/1874205X01711010015

Jadwiga Attier Zmudka, Jean Marie Sérot, Salif Dao, Claire Sorel, Anne-Sophie Macaret, Olivier Balédent

引用次数: 2