Journal of Translational Internal Medicine最新文献

{"title":"Effective albumin - A novel paradigm in the management of decompensated liver cirrhosis.","authors":"Mauro Bernardi","doi":"10.2478/jtim-2022-0070","DOIUrl":"https://doi.org/10.2478/jtim-2022-0070","url":null,"abstract":"Synthesis Human albumin, a 66.5-kDa globular protein synthesized by hepatocytes, is the most abundant serum protein whose concentration ranges from 3.5 to 5 g/dL. Under normal conditions, albumin production is stable (10–15 g daily), but can increase up to 3–4 fold. Hormonal factors, such as insulin, cortisol, and growth hormone, stimulate, while mediators of inflammation, such as proinflammatory cytokines, inhibit albumin synthesis.[1–3]","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"11-14"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/76/jtim-11-1-jtim-2022-0070.PMC10202013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells and connective tissue diseases: From bench to bedside.","authors":"Yue Shi,&nbsp;Nan Jiang,&nbsp;Mengtao Li,&nbsp;Xiaofeng Zeng,&nbsp;Xinping Tian","doi":"10.2478/jtim-2022-0028","DOIUrl":"https://doi.org/10.2478/jtim-2022-0028","url":null,"abstract":"<p><p>The pathogenesis of connective tissue diseases (CTDs), represented by systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS), and idiopathic inflammatory myopathies (IIM), includes various immune cells involved in both innate and adaptive immunity. The mesenchymal stem cells (MSCs) are unique due to their regulatory effect on immunity. This makes them a promising therapeutic approach for patients with immune-mediated disorders such as CTD. The safety and clinical efficacy of MSC treatment in CTD have been tested in a growing number of preclinical and clinical studies. Administration of MSCs has consistently shown benefits with both symptomatic and histologic improvement in CTD animal models. MSC therapies in severe and drug-resistant CTD patients have shown promise in a number of the pilot studies, cohort studies, and randomized controlled trials in SLE, RA, and SSc, but some problems still need to be resolved in the transition from the bench to the bedside. The relevant studies in pSS and IIM are still in their infancy, but have displayed encouraging outcomes. Considerable efficacy variations have been observed in terms of the route of delivery, time of MSC injection, origin of the MSCs and dosage. Furthermore, the optimization of conventional drugs combined with MSC therapies and the applications of novel cell engineering approaches requires additional research. In this review, we summarize the current evidence about the immunoregulatory mechanism of MSCs, as well as the preclinical and clinical studies of MSC-based therapy for the treatment of CTDs.</p>","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"30-45"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/15/jtim-11-1-jtim-2022-0028.PMC10393058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of avatrombopag in aplastic anemia patients with liver disease.","authors":"Huaquan Wang,&nbsp;Guangsheng He,&nbsp;Jinsong Jia,&nbsp;Mengyuan Liu,&nbsp;Hui Liu,&nbsp;Ting Wang,&nbsp;Chunyan Liu,&nbsp;Rong Fu","doi":"10.2478/jtim-2023-0006","DOIUrl":"https://doi.org/10.2478/jtim-2023-0006","url":null,"abstract":"Huaquan Wang1, Guangsheng He2, Jinsong Jia3, Mengyuan Liu1, Hui Liu1, Ting Wang1, Chunyan Liu1, Rong Fu1 1Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China; 2Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, Jiangsu Province, China; 3Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"90-93"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/90/jtim-11-1-jtim-2023-0006.PMC10393059.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9932999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas chromatography-mass spectrometry pilot study to identify volatile organic compound biomarkers of childhood obesity with dyslipidemia in exhaled breath.","authors":"Tan Xu,&nbsp;Jiaxing Wang,&nbsp;Jiang Tan,&nbsp;Tao Huang,&nbsp;Guojun Han,&nbsp;Yizhou Li,&nbsp;Haiyi Yu,&nbsp;Jiang Zhou,&nbsp;Ming Xu","doi":"10.2478/jtim-2022-0035","DOIUrl":"https://doi.org/10.2478/jtim-2022-0035","url":null,"abstract":"<p><strong>Objectives: </strong>Childhood obesity affects multiple organs in the body and is associated with both significant morbidity and ultimately premature mortality. Childhood obesity, especially dyslipidemia, can lead to early atherosclerosis and premature cardiovascular disease (CVD) in adulthood. The detection of exhaled volatile organic compounds (VOCs) in the breath offers the opportunity for the discovery of novel disease-specific biomarkers. This study aimed to identify VOCs that correlate with childhood obesity accompanied by dyslipidemia.</p><p><strong>Methods: </strong>A total of 82 overweight or obese children between the ages of 8 and 12 years were recruited from the exercise on obesity adolescents in Peking (EXCITING) study (NCT04984005). The breath VOCs of the participants were measured by gas chromatography-mass spectrometry (GC-MS). The classification was performed using principal component analysis (PCA) of the relative abundance of VOCs. The difference between the obese and overweight groups with or without dyslipidemia was analyzed.</p><p><strong>Results: </strong>Among the 82 children, 25 were overweight, of whom 10 had dyslipidemia. The other 57 children were obese, and 17 of them had dyslipidemia. Obese children with dyslipidemia had higher triglycerides and elevated non-high-density lipoprotein-cholesterol compared to overweight children without dyslipidemia. We confirmed 13 compounds based on database well matches (average score > 80) for mass spectra and refractive index. These 13 VOCs were grouped into three chemical functional groups: saturated hydrocarbons, aromatic hydrocarbons and unsaturated aldehydes. For obese children with dyslipidemia, the PCA scatter plot of the three chemical groups was obviously separated from the other groups. Some of the candidates, including heptadecane, naphthalene, and <i>cis</i>-6-nonnenol, were significantly higher in obese children with dyslipidemia than in overweight groups with or without dyslipidemia.</p><p><strong>Conclusion: </strong>A suite of VOCs from three chemical function groups, saturated hydrocarbons, aromatic hydrocarbons, and unsaturated aldehydes, were separated in the obese children with dyslipidemia. Heptadecane, naphthalene, and <i>cis</i>-6-nonenol were significantly elevated in obese children with dyslipidemia. Our findings underscore the potential value of the candidate VOCs for future risk categorization.</p>","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"81-89"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/70/jtim-11-1-jtim-2022-0035.PMC10202018.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9871527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox: A real new warning or just a sign of times?","authors":"Sara P Georgiadou,&nbsp;Evangelos J Giamarellos-Bourboulis,&nbsp;George N Dalekos","doi":"10.2478/jtim-2023-0005","DOIUrl":"https://doi.org/10.2478/jtim-2023-0005","url":null,"abstract":"Sara P. Georgiadou1, Evangelos J. Giamarellos-Bourboulis2,3 George N. Dalekos1 1Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, European Reference Network on Hepatological Diseases (ERN-Rare Liver), General University Hospital of Larissa, Larissa 41110, Greece; 24th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens 11527, Greece; 3Hellenic Institute for the Study of Sepsis, Athens 11528, Greece","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"15-18"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/9f/jtim-11-1-jtim-2023-0005.PMC10393060.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe acute hepatitis of unknown origin in children: Clinical issues of concern.","authors":"Hai-Jing Fu,&nbsp;Min Zhou,&nbsp;Zhi-Hui Huang,&nbsp;Yong-Xu Chen,&nbsp;Xiao-Xin Wu","doi":"10.2478/jtim-2023-0010","DOIUrl":"https://doi.org/10.2478/jtim-2023-0010","url":null,"abstract":"19 Address for Correspondence: Dr. Xiao-Xin Wu, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing Chun Road, Hangzhou 310003, Zhejiang Province, China. E-mail: xiaoxinwu@zju.edu.cn","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"19-23"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/49/jtim-11-1-jtim-2023-0010.PMC10393056.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized inhalation capability assessment: A key to optimal inhaler selection for inhalation therapy.","authors":"Yixing Wu,&nbsp;Jing Zhang","doi":"10.2478/jtim-2022-0073","DOIUrl":"https://doi.org/10.2478/jtim-2022-0073","url":null,"abstract":"Inhalation therapy has become one of the fundamental treatments for chronic obstructive pulmonary disease (COPD) and bronchial asthma (asthma). [1,2] Meanwhile, with the development of inhaled formulations and devices, inhalation therapy has shown a wide prospect of expanding indications, including respiratory diseases such as lower respiratory tract infections,[3] interstitial lung diseases, lung cancer,[4] as well as other diseases such as diabetes and depression.[5] Compared to oral and intravenous administration, the aerosolized drug is inhaled and acts directly on the airways and lungs, which has the advantages of rapid onset, sustained efficacy, and low systemic adverse effects.[6] Compared to the nebulizer, the hand-held inhaler is a better option for out-of-hospital drug delivery because the latter is easier to operate, requires shorter inhalation time, and has less environment extravasation.[6]","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"26-29"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/6f/jtim-11-1-jtim-2022-0073.PMC10202017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9517196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction note: Hydrogel: A promising new technique for treating Alzheimer's disease (in Volume 10 Issue 3).","authors":"","doi":"10.2478/jtim-2022-0090","DOIUrl":"https://doi.org/10.2478/jtim-2022-0090","url":null,"abstract":"","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"94"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/b0/jtim-11-1-jtim-2022-0090.PMC10393053.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9981770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of progression in idiopathic inflammatory myopathies with interstitial lung disease.","authors":"Heng Cao,&nbsp;Jiao Huang,&nbsp;Jie Chang,&nbsp;Yaqin Zhu,&nbsp;Junyu Liang,&nbsp;Chuanyin Sun,&nbsp;Jin Lin","doi":"10.2478/jtim-2022-0029","DOIUrl":"https://doi.org/10.2478/jtim-2022-0029","url":null,"abstract":"<p><p>The idiopathic inflammatory myopathies (IIMs) are a group of connective tissue diseases that afect multiple organ systems, including the lungs. Interstitial lung disease (ILD) is the most common and heterogeneous complication of IIMs, with its degree ranging from mild to fatal. Thus, it is critical to identify clinical features and validated biomarkers for predicting disease progression and prognosis, which could be beneficial for therapy adjustment. In this review, we discuss predictors for rapid progression of IIM-ILD and propose guidance for disease monitoring and implications of therapy. Systematic screening of myositis-specific antibodies, measuring serum biomarker levels, pulmonary function tests, and chest high-resolution computer tomography will be beneficial for the evaluation of disease progression and prognosis.</p>","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"46-56"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/a6/jtim-11-1-jtim-2022-0029.PMC10393057.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal models: An essential tool to dissect the heterogeneity of chronic obstructive pulmonary disease.","authors":"Jingxian Jiang,&nbsp;Shuanglan Xu,&nbsp;Zi Chen,&nbsp;Weihua Liu,&nbsp;Liuchao Zhang,&nbsp;Jianmin Li,&nbsp;Zhou Zhu,&nbsp;Linfu Zhou","doi":"10.2478/jtim-2023-0007","DOIUrl":"https://doi.org/10.2478/jtim-2023-0007","url":null,"abstract":"Jingxian Jiang1#, Shuanglan Xu1#, Zi Chen1#, Weihua Liu1, Liuchao Zhang1, Jianmin Li2, Zhou Zhu3, Linfu Zhou1,2,4 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China; 2Animal Core Facility, Key Laboratory of Model Animal, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China; 3Department of Pediatrics and Department of Molecular Microbiology and Immunology, Brown University Warren Alpert Medical School, Providence, RI 02912, USA; 4Institute of Integrative Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"11 1","pages":"4-10"},"PeriodicalIF":4.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/d1/jtim-11-1-jtim-2023-0007.PMC10393054.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10307927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}