Journal of Geriatric Cardiology最新文献

{"title":"Routine invasive strategy and frailty burden in non-ST-segment elevation acute myocardial infarction.","authors":"Albert Ariza-Solé, Juan Andrés Bermeo, Francesc Formiga, Héctor Bueno, Gemma Miñana, Oriol Alegre, David Martí, Manuel Martínez-Sellés, Laura Domínguez-Pérez, Pablo Díez-Villanueva, José A Barrabés, Francisco Marín, Adolfo Villa, Marcelo Sanmartín, Cinta Llibre, Alessandro Sionís, Antoni Carol, Sergio García-Blas, María José Morales Gallardo, Jaime Elízaga, Iván Gómez-Blázquez, Fernando Alfonso, Bruno García Del Blanco, Julio Núñez, Juan Sanchis","doi":"10.26599/1671-5411.2024.10.005","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.005","url":null,"abstract":"<p><strong>Objective: </strong>To assess the prognostic impact of a routine invasive strategy according to the frailty burden in patients with non-ST-segment elevation myocardial infarction (NSTEMI) from the MOSCA-FRAIL clinical trial.</p><p><strong>Methods: </strong>The MOSCA-FRAIL trial randomized 167 frail patients, defined by a Clinical Frailty Scale (CFS) ≥ 4, with NSTEMI to an invasive or conservative strategy. The primary endpoint was the number of days alive and out of hospital (DAOH) one year after discharge. For this subanalysis, we compared the impact of an invasive strategy on the outcomes between vulnerable (CFS = 4, <i>n</i> = 43) and frail (CFS > 4, <i>n</i> = 124) patients.</p><p><strong>Results: </strong>Compared to vulnerable patients, frail patients presented lower values of DAOH (289.8 <i>vs.</i> 320.6, <i>P</i> = 0.146), more readmissions (1.03 <i>vs.</i> 0.58, <i>P</i> = 0.046) and higher number of days spent at the hospital during the first year (10.8 <i>vs.</i> 3.8, <i>P</i> = 0.014). The causes of readmission were mostly non-cardiac (56%). Among vulnerable patients, DAOH were similar regardless of strategy (invasive <i>vs.</i> conservative: 325.7 <i>vs.</i> 314.7, <i>P</i> = 0.684). Among frailest patients, the invasive group tended to have less DAOH (267.7 <i>vs.</i> 311.1, <i>P</i> = 0.117). Indeed, patients with CFS > 4, invasively managed lived 29 days less than their conservative counterparts. In contrast, there were no differences in the subgroup with CFS = 4.</p><p><strong>Conclusions: </strong>Adult patients with frailty and NSTEMI showed different prognosis according to the degree of frailty. A routine invasive strategy does not improve outcomes and might be harmful to the frailest patients.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"954-961"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of peripheral blood mononuclear cell <i>'</i> s mitochondrial respiratory dysfunction in heart failure severity prediction in patients with cardioverter-defibrillator implantation indications.","authors":"Tariel A Atabekov, Sergey N Krivolapov, Mikhail S Khlynin, Viacheslav A Korepanov, Tatiana Yu Rebrova, Elvira F Muslimova, Sergey A Afanasiev, Roman E Batalov, Sergey V Popov","doi":"10.26599/1671-5411.2024.10.006","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.006","url":null,"abstract":"<p><strong>Background: </strong>It has been reported that the mitochondrial respiratory dysfunction (MRD) is important mechanisms affecting the heart failure (HF) pathogenesis. We sought to evaluate the potential role of MRD of peripheral blood mononuclear cells (PBMC) in HF severity prediction in patients with cardioverter-defibrillator implantation indications.</p><p><strong>Methods: </strong>In this single-center study patients with HF of New York Heart Association (NYHA) I-III functional class (FC) and cardioverter-defibrillator implantation indications underwent transthoracic echocardiography (TTE) and MRD assessment using PBMC. Mitochondrial respiration rate (MRR) indicators (pyruvate + malate + adenosine diphosphate; succinate + adenosine diphosphate; pyruvate + malate - adenosine diphosphate [V_4.1]; succinate - adenosine diphosphate) were calculated. Correlations between HF NYHA FC, TTE and MRR indicators were evaluated. Based on our data, we developed a risk model regarding HF severity.</p><p><strong>Results: </strong>Of 53 (100.0%) HF patients, 33 (62.3%) had mild exercise intolerance (1^st group) and 20 (37.7%) had moderate-to-severe exercise intolerance (2^nd group). Patients with mild exercise intolerance were likely to have a higher V_4.1 (<i>P</i> < 0.001) values. V_4.1 was independently associated with moderate-to-severe exercise intolerance in univariate and multivariate logistic regression (OR = 0.932, 95% CI: 0.891-0.975, <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>The severity of HF is associated with PBMC mitochondrial respiratory dysfunction in patients with cardioverter-defibrillator implantation indications. Our HF severity risk model including V_4.1 parameters is able to distinguish patients with mild and moderate-to-severe exercise intolerance. Further investigations of their predictive significance are warranted.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"981-991"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic and panvascular multimorbidity associated with motoric cognitive risk syndrome in older adults.","authors":"Rui She, Zhong-Rui Yan, Peng Wang, Ya-Jun Liang, Cheng-Xuan Qiu","doi":"10.26599/1671-5411.2024.10.001","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.001","url":null,"abstract":"<p><strong>Background: </strong>Motoric cognitive risk (MCR) syndrome as a pre-dementia syndrome often co-occurring with chronic health conditions. This study aims to investigate the prevalence of MCR and its association with cardiometabolic and panvascular multimorbidity among older people living in rural China.</p><p><strong>Methods: </strong>This population-based study included 1450 participants who were aged ≥ 60 years (66.2% women) and who undertook the second wave examination of the Confucius Hometown Aging Project in Shandong, China when information to define MCR was collected. Data were collected through in-person interviews, clinical examinations, and laboratory tests. Cardiometabolic and panvascular multimorbidity were defined following the international criteria. MCR was defined as subjective cognitive complaints and slow gait speed in individuals free of dementia and functional disability. Multivariable logistic regression models were used to examine the associations of MCR with multimorbidity.</p><p><strong>Results: </strong>MCR was present in 6.3% of all participants, and the prevalence increased with advancing age. Cerebrovascular disease, ischemic heart disease, heart failure, and increased serum cystatin C were associated with increased likelihoods of MCR (multivariable-adjusted odds ratio range: 1.90-3.02, <i>P</i> < 0.05 for all). Furthermore, there was a dose-response relationship between the number of cardiometabolic diseases and panvascular diseases and the likelihood of MCR. The multivariable-adjusted odds ratio (95% CI) of MCR associated with cardiometabolic and panvascular multimorbidity were 2.47 (1.43-4.26) and 3.85 (2.29-6.47), respectively.</p><p><strong>Conclusions: </strong>Older adults with cardiometabolic and panvascular multimorbidity are at a higher likelihood of MCR. These findings may have implications for identifying older adults at pre-dementia state as targets for early preventive interventions to delay dementia onset.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"944-953"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cerebral small vessel disease burden on prognosis in patients with acute coronary syndrome.","authors":"Xiao-Jun Ding, Yu Zhao, Ze-Ya Li, Yong-Bo Zhang, An-Qi Yang, Yi He, Rong-Chong Huang","doi":"10.26599/1671-5411.2024.10.003","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.003","url":null,"abstract":"<p><strong>Background: </strong>Acute coronary syndrome (ACS) presents with a variable prognosis, posing significant public health challenges. This study investigated the potential link between cerebral small vessel disease (CSVD) burden and outcomes in patients with ACS.</p><p><strong>Methods: </strong>In this retrospective cohort study, ACS patients admitted to Beijing Friendship Hospital, Capital Medical University, Beijing, China from January 2020 to October 2021, were analyzed. CSVD burden was assessed using magnetic resonance imaging markers, including white matter lesions, lacunar infarcts, cerebral microbleeds, and enlarged perivascular spaces. The correlation between CSVD burden and clinical outcomes, including major adverse cardiovascular and cerebrovascular events, myocardial infarction (MI), target vessel revascularization, stroke, and mortality was examined over a one-year follow-up.</p><p><strong>Results: </strong>Out of 248 patients, 216 patients were categorized into the low score group (LSG-CSVD) and 32 patients were categorized into the high score group (HSG-CSVD). Patients in the HSG-CSVD group exhibited significantly worse prognosis, with an elevated risk of major adverse cardiovascular and cerebrovascular events, MI, and target vessel revascularization. After adjusting for age, sex, hypertension, troponin T, and estimated glomerular filtration rate, a significantly higher risk of MI was observed in the HSG-CSVD group (HR = 4.51, 95% CI: 1.53-13.26, <i>P</i> = 0.006). Subgroup analysis by age and sex consistently demonstrated increased adverse outcomes in the HSG-CSVD.</p><p><strong>Conclusions: </strong>The study highlights a direct association between increased CSVD burden and poorer ACS outcomes, particularly in MI risk. These findings underscore the importance of considering CSVD burden as a crucial prognostic factor in ACS management, facilitating risk stratification and guiding personalized treatment strategies.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"972-980"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic disease and peripheral artery disease.","authors":"Sheng-Shou Hu","doi":"10.26599/1671-5411.2024.10.008","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.008","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of car-diovascular health in China. In connection with the previous section, this 10&lt;sup&gt;th&lt;/sup&gt; section of the report offers a comprehensive analysis of aortic disease and peripheral artery disease. Aortic dissection is a critical disease, with a higher incidence in men than in women. The main risk factors include hypertension, gene mutations, and so on. Recent studies suggest that young patients with aortic dissection have a higher body mass index, and there is a significant correlation between low ambient temperature and sudden temperature drop and the onset of dissection. The main hazards are aortic rupture or poor branch perfusion, which is life threatening. According to the lesion location, it is divided into Stanford A type (involving the ascending aorta) and Stanford B type (not involving the ascending aorta). The treatment of type A dissection is mainly open surgery, while the treatment of type B dissection is preferably endovascular treatment. In recent years, with the continuous development of endovascular technique, the treatment of aortic arch lesions has transformed gradually from open to hybrid, and then to total endovascular treatment. The prevalence of abdominal aortic aneurysm is relatively low (&lt; 1%), and its risk factors mainly include smoking, hypertension, dyslipidemia, etc. The main hazard is the rupture of the aneurysm leading to death. Currently, treatment methods include endovascular repair and open surgery. According to data from Hospital Quality Monitoring System (HQMS), in the past five years, the number of open and endovascular operations for aortic disease in China has shown an upward trend, which may be due to the popularization of diagnostic and therapeutic techniques and increased attention to aortic disease. The in-hospital mortality rates of thoracic endovascular aortic repair, endovascular aortic repair, and Bentall operations are relatively low (all &lt; 2%). Due to the complexity and difficulty of the operation, the in-hospital mortality of total arch replacement is 5.9%-7.4%. Overall, the in-hospital mortality decreased while the number of surgeries increased. This section also elaborates on the five peripheral artery diseases (PADs): lower extremity artery disease (LEAD), carotid atherosclerotic disease, subclavian artery stenosis, mesenteric artery disease and renal artery stenosis, from the perspectives of epidemiology, risk factors, evaluation methods, diagnosis, and treatment. PAD is common among middle-aged and elderly people, and is significantly related to the risk factors of cardiovascular disease. Diagnosis and treatment methods are constantly being improved and updated. Besides traditional evaluation methods, artificial intelligence, molecular biology and other methods have been continuously developed, improving diagnostic sensitivity and specificity. Treatment methods include risk factor control, medication,","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"931-943"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular lithotripsy successfully open recurrent in-stent chronic occlusion lesion combined with circular calcification.","authors":"Yu Zhao, Xue-Qing Dong, Jun-Jie Li, Ji Qiu, Jia-Hui Liu, Hui-Juan Li, Ying Liu, Meng-Ying Wang, Hai-Yan Wang, Wen-Hui Fan, Yuan-Yang Jia, Jing Bai","doi":"10.26599/1671-5411.2024.10.004","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.004","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"997-1002"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory index as a predictive marker for the severity of coronary artery disease in individuals with chronic kidney disease.","authors":"Meng-Qi Zhao, Yang Zhang, Xin Huang, Jian-Jun Peng","doi":"10.26599/1671-5411.2024.10.002","DOIUrl":"https://doi.org/10.26599/1671-5411.2024.10.002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the correlation between the inflammatory intensity, as indicated by the systemic inflammatory index (SII), and the severity of coronary artery disease (CAD) in patients with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>A total of 280 CKD patients who underwent coronary angiography were enrolled. CAD was evaluated using the Gensini score (GS). Patients were divided into the low, medium and high SII groups according to the tertiles of the SII values. Logistic regression analysis was conducted to analyze the relationship between SII and GS. The cutoff points for the sensitivity and specificity of SII in predicting GS were estimated by performing the receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>Patients in the higher SII group had a higher prevalence of CAD (<i>P</i> = 0.013). In addition, the high SII group had more patients with complex CAD (triple-vessel disease and/or left main coronary artery stenosis) and chronic total occlusion lesions, and more patients required revascularization (<i>P</i> < 0.05). Correlation analysis suggested a positive relationship between SII and GS, and in comparison to neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, SII displayed a stronger correlation with GS (<i>r</i> = 0.332, <i>P</i> < 0.001). Multifactorial logistic regression analysis revealed that SII is independently associated with the severity of CAD (adjusted OR = 1.14, 95% CI: 1.08-1.21, <i>P</i> < 0.01), particularly among elderly patients (age ≥ 65 years). Receiver operating characteristic curve analysis indicated that the optimal cutoff value for SII in predicting severe coronary artery stenosis (GS > 60) was 6.01 (sensitivity: 76.30%, specificity: 53.50%), with an area under the curve (AUC) of 0.705 (95% CI: 0.642-0.768, <i>P</i> < 0.001), which was statistically significantly better than platelet-to-lymphocyte ratio (AUC = 0.646, 95% CI: 0.579-0.713, <i>P</i> < 0.001) and neutrophil-to-lymphocyte ratio (AUC = 0.643, 95% CI: 0.574-0.712, <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>In patients with CKD, SII is independently associated with the severity of CAD, especially in individuals aged 65 years or older. Furthermore, SII functions as a predictive marker for the severity of coronary lesions.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 10","pages":"962-971"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of multimodality imaging in calcified valves with infective endocarditis.","authors":"Aker Amir, Alexander Fuks, Salim Adawi, Yuval Avidan, Vsevolod Tabachnikov, Amnon Eitan, Avinoam Shiran","doi":"10.26599/1671-5411.2024.09.006","DOIUrl":"10.26599/1671-5411.2024.09.006","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"927-930"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effect of psoriasis on aortic valve stenosis: a two-sample Mendelian randomization study.","authors":"Ke-Xin Jiang, Yan Wang, Yu-Tong Liu, Yanjiani Xu, Fang-Yang Huang, Mao Chen","doi":"10.26599/1671-5411.2024.09.002","DOIUrl":"10.26599/1671-5411.2024.09.002","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological studies have suggested a potential connection between psoriasis and an increased risk of aortic valve stenosis (AS), though the impact of psoriasis on AS progression remains uncertain. The study aims to investigate the causal relationship between psoriasis and AS using Mendelian randomization (MR) analysis, as well as to uncover potential mechanisms underlying this association.</p><p><strong>Methods: </strong>A two-sample MR analysis was conducted using publicly available summary statistics from genome-wide association studies (GWAS) of psoriasis and AS. Cis-eQTL and significant genes were identified for each causal single-nucleotide polymorphisms (SNPs), followed by pathway enrichment and protein-protein interaction (PPI) analysis for functional evaluation. Hub genes were pinpointed by Cytospace. The transcriptional profile of AS population was acquired, and interconnected genes networks were clustered using Molecular Complex Detection (MCODE).</p><p><strong>Results: </strong>Our results demonstrate a significant causal relationship between psoriasis and AS, with a genetic predisposition to psoriasis associated with a higher AS risk (odds ratio: 1.46). Pathway and PPI analyses unveiled 15 hub genes, including HLA-C, HLA-B, ISG15, IFIT3, and MX2, along with immune-related pathways linking psoriasis and AS. Moreover, the transcriptional profiling of the AS database highlighted the significant involvement of adaptive immune cells in AS development. Notably, among the 15 hub genes, ISG15, MX2, OAS3, OASL, IFI6, and EPSTI1 exhibited higher expression in the AS population.</p><p><strong>Conclusion: </strong>Our study provides compelling evidence supporting a causal relationship between psoriasis and AS. Furthermore, the identified hub genes and immune-related pathways may play an important role in the development of both diseases.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"865-873"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a 6-gene signature derived from RNA modification-associated genes for the diagnosis of Acute Stanford Type A Aortic Dissection.","authors":"Ting-Ting Zhang, Qun-Gen Li, Zi-Peng Li, Wei Chen, Chang Liu, Hai Tian, Jun-Bo Chuai","doi":"10.26599/1671-5411.2024.09.007","DOIUrl":"10.26599/1671-5411.2024.09.007","url":null,"abstract":"<p><strong>Background: </strong>Acute Stanford Type A Aortic Dissection (ATAAD) is a critical medical emergency characterized by significant morbidity and mortality. This study aims to identify specific gene expression patterns and RNA modification associated with ATAAD.</p><p><strong>Methods: </strong>The GSE153434 dataset was obtained from the Gene Expression Omnibus (GEO) database. Differential expression analysis was conducted to identify differential expression genes (DEGs) associated with ATAAD. To validate the involvement of RNA modification in ATAAD, RNA modification-related genes (M6A, M1A, M5C, APA, A-to-I) were acquired from GeneCards, following by Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis. A gene prediction signature consisting of key genes was established, and Real-time PCR was used to validate the gene expression in clinical samples. The patients were then divided into high and low-risk groups, and subsequent enrichment analysis, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), Gene Set Variation Analysis (GSVA), and assessments of immune infiltration. A co-expression network analysis (WGCNA) was performed to explore gene-phenotype relationships and identify key genes.</p><p><strong>Results: </strong>A total of 45 RNA modification genes were acquired. Six gene signatures (YTHDC1, WTAP, CFI, ADARB1, ADARB2, TET3) were developed for ATAAD diagnosis and risk stratification. Enrichment analysis suggested the potential involvement of inflammation and extracellular matrix pathways in the progression of ATAAD. The incorporation of pertinent genes from the GSE147026 dataset into the six-gene signature further validated the model's effectiveness. A significant upregulation in WTAP, ADARB2, and TET3 expression, whereas YTHDC1 exhibited a noteworthy downregulation in the ATAAD group.</p><p><strong>Conclusion: </strong>Six-gene signature could serve as an efficient model for predicting the diagnosis of ATAAD.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"21 9","pages":"884-898"},"PeriodicalIF":1.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}