Journal of Geriatric Cardiology最新文献

{"title":"Association between glycated hemoglobin and cognitive impairment in older adults with coronary heart disease: a multicenter prospective cohort Study.","authors":"Wen Zheng, Qin-Jie Xin, Xiao-Xia Wang, Sheng Li, Xiao Wang, Shao-Ping Nie","doi":"10.26599/1671-5411.2025.03.010","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.010","url":null,"abstract":"<p><strong>Background: </strong>The relationship between glycated hemoglobin (HbA1c) and cognitive impairment in older adults with coronary heart disease (CHD) remains unclear.</p><p><strong>Methods: </strong>The present study used a prospective cohort study design and included 3244 participants aged ≥ 65 years in Beijing, China. The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to assess cognitive function. Serum HbA1c was detected at admission. All patients were divided into high HbA1c group (≥ 6.5 mmol/L) and low HbA1c group (< 6.5 mmol/L) based on their HbA1c levels. Logistic regression analyses were used to evaluate the association between HbA1c and cognitive impairment.</p><p><strong>Results: </strong>In this study of 3244 participants, 1201 (37.0%) patients were in high HbA1c group and 2045 (63.0%) patients were in a state of cognitive impairment. Logistic regression analyses demonstrated that HbA1c was an independent risk factor for cognitive impairment regardless of whether the HbA1c was a continuous or categorical variable (OR = 1.27, 95% CI: 1.15-1.40, <i>P</i> < 0.001; OR = 1.79, 95% CI: 1.41-2.26, <i>P</i> ≤ 0.001, respectively). The restricted cubic spline curve exhibited that the relationship between the HbA1c and cognitive impairment was linear (p for non-linear = 0.323, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Elevated levels of HbA1c were associated with an increased risk of cognitive impairment in older patients with CHD. These insights could be used to improve the accuracy and sensitivity of cognitive screening in these patient populations.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"381-388"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve implantation used to treat active infective endocarditis with severe aortic regurgitation in an 88-year-old patient.","authors":"Sara Álvarez-Zaballos, Eduardo Zatarain-Nicolás, Francisco Fernández-Avilés, Patricia Muñoz, Manuel Martínez-Sellés","doi":"10.26599/1671-5411.2025.03.003","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.003","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"401-403"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of continued use of targeted therapy on patients with pulmonary arterial hypertension and complicated by hemoptysis.","authors":"Zhong-Chao Wang, Xiu-Min Han, Yao Zuo, Na Dong, Jian-Ming Wang, Li-Li Meng, Jia-Wang Xiao, Ming Zhao, Yuan Mi, Qi-Guang Wang","doi":"10.26599/1671-5411.2025.03.005","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.005","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"404-410"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024.","authors":"Shu-Yang Zhang","doi":"10.26599/1671-5411.2025.03.002","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.002","url":null,"abstract":"<p><p>In the past 6 years, significant breakthroughs have been achieved in the treatment of heart failure (HF), especially in drug therapy. The classification of chronic HF and the treatment methods for HF and its complications are also constantly being updated. In order to apply these results to the diagnosis and treatment of patients with HF in China and further improve the level of diagnosis and treatment of HF in China, the HF Group of Chinese Society of Cardiology, Chinese Medical Association, Chinese College of Cardiovascular Physician, Chinese HF Association of Chinese Medical Doctor Association, and Editorial Board of Chinese Journal of Cardiology have organized an expert group and update the consensus and evidence-based treatment methods in the field of HF based on the latest clinical research findings at home and abroad, combined with the national conditions and clinical practice in China, and referring to the latest foreign HF guidelines while maintaining the basic framework of the <i>2018 Chinese Guidelines for Diagnosis and Treatment of HF</i>.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"277-331"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of healthy lifestyle index and antihypertensive medication use with blood pressure control among employees with hypertension in China based on a workplace-based multicomponent intervention program.","authors":"Zhen Hu, Xin Wang, Cong-Yi Zheng, Xue Cao, Yi-Xin Tian, Run-Qing Gu, Jia-Yin Cai, Ye Tian, Zeng-Wu Wang","doi":"10.26599/1671-5411.2025.03.007","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.007","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients. However, the association of joint changes in antihypertensive medication use and healthy lifestyle index (HLI) with BP control among hypertension patients is seldom reported, which needs to provide more evidence by prospective intervention studies. We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between January 2013 and December 2014, a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China. Workplaces were randomly divided into intervention (&lt;i&gt;n&lt;/i&gt; = 40) and control (&lt;i&gt;n&lt;/i&gt; = 20) groups. Basic information on employees at each workplace was collected by trained professionals, including sociodemographic characteristics, medical history, family history, lifestyle behaviors, medication status and physical measurements. After baseline, the intervention group received a 2-year intervention to achieve BP control, which included: (1) a workplace wellness program for all employees; (2) a guidelines-oriented hypertension management protocol. HLI including nonsmoking, nondrinking, adequate physical activity, weight within reference range and balanced diet, were coded on a 5-point scale (range: 0-5, with higher score indicating a healthier lifestyle). Antihypertensive medication use was defined as taking drug within the last 2 weeks. Changes in HLI, antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Overall, 4655 employees were included (age: 46.3 ± 7.6 years, men: 3547 (82.3%)). After 24 months of the intervention, there was a significant improvement in lifestyle [smoking (OR = 0.65, 95% CI: 0.43-0.99; &lt;i&gt;P&lt;/i&gt; = 0.045), drinking (OR = 0.52, 95% CI: 0.40-0.68; &lt;i&gt;P&lt;/i&gt; &lt; 0.001), regular exercise (OR = 3.10, 95% CI: 2.53-3.78; &lt;i&gt;P&lt;/i&gt; &lt; 0.001), excessive intake of fatty food (OR = 0.17, 95% CI: 0.06-0.52; &lt;i&gt;P&lt;/i&gt; = 0.002), restrictive use of salt (OR = 0.26, 95% CI: 0.12-0.56; &lt;i&gt;P&lt;/i&gt; = 0.001)]. Compare to employees with a deteriorating lifestyle after the intervention, those with an improved lifestyle had a higher BP control. In the intervention group, compared with employees not using antihypertensive medication, those who consistent used (OR = 2.34; 95% CI: 1.16-4.72; &lt;i&gt;P&lt;/i&gt; = 0.017) or changed from not using to using antihypertensive medication (OR = 2.24; 95% CI: 1.08-4.62; &lt;i&gt;P&lt;/i&gt; = 0.030) had higher BP control. Compared with those having lower HLI, participants with a same (OR = 1.38; 95% CI: 0.99-1.93; &lt;i&gt;P&lt;/i&gt; = 0.056) or high (OR = 1.79; 95% CI: 1.27~2.53; &lt;i&gt;P&lt;/i&gt; &lt; 0.001) HLI had higher BP control. Those who used anti","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"389-400"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of ischemic heart disease attributable to metabolic risks: a systematic analysis of Global Burden of Disease 2021.","authors":"Bo-Qing Liu, Chang Yang, Heng-Yang Wei, Zai-Xin Yu","doi":"10.26599/1671-5411.2025.03.009","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.009","url":null,"abstract":"<p><strong>Background: </strong>Ischemic heart disease (IHD) represents the most significant disease burden among all cardiovascular diseases (CVDs). The increasing prevalence of metabolic risks in the 21^st century has a profound impact on the disease burden associated with IHD. We analyzed the global, regional, and national burdens of IHD attributable to metabolic risks from 1990 to 2021.</p><p><strong>Methods: </strong>The data were taken from Global Burden of Disease (GBD) study 2021. Deaths, disability-adjusted life years (DALYs), the average annual percent change (AAPC), age-standardized death rates per 100,000 persons (ASDR) and age-standardized rate per 100,000 persons (ASR) of DALYs ranging from 1990 to 2021, were extracted and stratified according to region, nationality, socio-demographic index (SDI), sex, and age. Additionally, the global future trends were predicted using Nordpred prediction model.</p><p><strong>Results: </strong>Compared to 1990, in 2021, the number of death and DALYs from metabolic risk-attributed IHD increased globally by 67.35% and 59.91%, respectively; whereas ASDR and ASR of DALYs showed a decreasing trend and the most severe impact was observed in male and elderly populations. In addition, the burden of disease showed an inverted V-shaped relationship with SDI from 1990 to 2021. AAPC showed a significant increase in developing countries and a decrease in developed countries. We also analyzed the effects of different risk factors including metabolic risk factors on IHD in different SDI regions and genders. The prediction of future disease burden showed that the number of death and DALYs will keep rising, while ASDR and ASR of DALYs will maintain a certain downward trend.</p><p><strong>Conclusions: </strong>The results of this study highlighted the need for screening and intervention for metabolic risk factors in specific regions and populations, this should call for increased collaboration between developing and developed countries to reduce the burden of disease and improve the prognosis of patients with IHD.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"361-380"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"F-18 fluorodeoxyglucose imaging to differentiate the response to cardiac conduction system pacing in patients with pacing induced cardiomyopathy.","authors":"Yu Zhang, Xiao-Hong Zhou, Yang Ye, Zhong-Ke Huang, Guo-Sheng Fu","doi":"10.26599/1671-5411.2025.03.001","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.001","url":null,"abstract":"","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"411-414"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting survival in atrial fibrillation: results from SAGE-AF.","authors":"David C Parish, Catarina I Kiefe, Jordy Mehawej, Edith Mensah Otabil, Carly N Beniek, Francis C Dane","doi":"10.26599/1671-5411.2025.03.004","DOIUrl":"https://doi.org/10.26599/1671-5411.2025.03.004","url":null,"abstract":"<p><strong>Background: </strong>Using Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF) data, determine how well the rich mix of demographic, clinical history, geriatric assessments, and clinically adjudicated events can predict two-year survival.</p><p><strong>Methods: </strong>Subjects were recruited from participating outpatient practices if they had non-valvular AF, were 65 or over with CHA₂DS₂-VASc scores of at least 2, and were candidates for anticoagulation. Demographics, clinical history, and geriatric qualities of life were assessed by interview and medical records review using standardized protocols and repeated at one and two years. Events identified were abstracted and submitted for adjudication using standard definitions of events and categories. Non-mortality event categories included hospitalizations (cardiovascular, bleeding, other), bleeding (major, clinically relevant non-major, minor), and seven major adverse cardiovascular events.</p><p><strong>Results: </strong>The 1245 subjects experienced 1960 events, primarily hospitalizations (935) and/or bleeding (817); 114 subjects (9.2%) died during two years of follow-up. Events initially abstracted to more than one category (172) were combined, resulting in 1788 unique incidents. Most subjects had zero or one event (69%) and fewer than 7% had more than 3 types. Most variables were significant in bivariate analysis. Using multiple logistic regression with two-year survival as the outcome variable, the best-fit model included event number and type, number of unique incidents, and number of bleeding events (R² = 0.511, C = 93.1) with sensitivity = 97.9% and specificity = 44.7%.</p><p><strong>Conclusions: </strong>Two-year survival was high. This model, if validated, could have major implications for treatment of patients with AF. Patients in the large group with no or one event are at very low risk of death (under 2%). The small group with high risk for further complications, including death, deserve reassessment to determine if this trajectory can be altered.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 3","pages":"344-350"},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between uric acid-albumin ratio and spontaneous reperfusion in ST-segment elevation myocardial infarction patients.","authors":"Jing Nan, Shuai Meng, Ruo-Fei Jia, Wei Chen, Xing-Sheng Yang, Hong-Yu Hu, Ze-Ning Jin","doi":"10.26599/1671-5411.2025.02.006","DOIUrl":"10.26599/1671-5411.2025.02.006","url":null,"abstract":"<p><strong>Background: </strong>The association between uric acid-albumin ratio (UAR) with different diseases has been evaluated before. However, the association between UAR with spontaneous reperfusion (SR) in patients with ST-segment elevation myocardial infarction (STEMI) has not been explored.</p><p><strong>Methods: </strong>STEMI patients admitted to our department and underwent primary coronary angiography between 1^st November 2018 and 31^st December 2020 were retrospectively enrolled. The patients were divided into the SR group and the non-SR group according to the index coronary angiography results. The association between UAR and SR was evaluated by uni-variable and multi-variable logistic analysis. Receiver operating characteristic curve analysis was used to determine the optimum cut-off level of UAR in predicting SR.</p><p><strong>Results: </strong>Three hundred and fifty-seven patients were finally enrolled in our study, 55 patients were divided into the SR group and 302 patients were divided into the non-SR group. In uni-variable analysis, patients with SR were older (<i>P</i> = 0.032), with higher red blood cell distribution width (<i>P</i> < 0.001) and red blood cell distribution width-to-platelet ratio (<i>P</i> < 0.001), higher level of C-reactive protein (<i>P</i> = 0.046), higher level of uric acid (<i>P</i> < 0.001) compared with patients without SR. Patients with SR had a lower level of platelets (<i>P</i> = 0.008), lower level of on-admission B-type natriuretic peptide (<i>P</i> < 0.001). As for the level of UAR, STEMI patients with SR had significantly higher levels of UAR compared with STEMI patients without SR [11.1 (8.9-13.4) <i>vs.</i> 8.3 (6.6-10.0), <i>P</i> < 0.001]. Further multi-variable logistic analysis reveals that UAR was the independent risk factor of SR in different models after adjusting different variables. Receiver operating characteristic analysis showed that UAR had good predictive value in SR (AUC = 0.75, 95% CI: 0.702-0.794, <i>P</i> < 0.01).</p><p><strong>Conclusions: </strong>Our study shows that UAR is an independent risk factor for predicting SR in STEMI patients.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 2","pages":"229-236"},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and anxiety in patients receiving an implantable cardioverter defibrillator with or without cardiac resynchronization therapy.","authors":"Sofia Plakoutsi, Elizabeth Florou, Dimitrios Sfairopoulos, Petros Skapinakis, Panagiotis Korantzopoulos","doi":"10.26599/1671-5411.2025.02.003","DOIUrl":"10.26599/1671-5411.2025.02.003","url":null,"abstract":"<p><p>Implantable cardioverter defibrillators (ICDs) represent an established therapeutic strategy for the prevention of sudden cardiac death and reduction of mortality in high-risk patients, while ICDs with cardiac resynchronization therapy defibrillators improve morbidity, quality of life, and mortality in eligible patients with heart failure who are on optimal medical therapy. However, these devices may adversely affect the patients' psychological status after the delivery of shock therapies or even because of the fear of impending therapy. On the other hand, the potential of effective treatment of malignant arrhythmias may provide a 'safety' sensation in most treated patients without significant impairment in the quality of life during periods of clinical stability. During the past few years, an increasing number of reports have investigated psychological distress, including depression and anxiety status in ICD/cardiac resynchronization therapy defibrillator recipients. However, heterogeneous results have been reported while data on the variation of these psychological indexes over time in implanted patients are quite limited. Several intrinsic and extrinsic factors affect the psychological status of these patients while variations of these disturbances in specific populations are evident. Factors that seem to be associated with a greater risk for depression and anxiety in this setting include female gender, younger age, and device shock therapies. Moreover, depression and anxiety may have an adverse impact on patients' clinical outcomes exacerbating heart failure and increasing the arrhythmic risk. In this brief review article, we provide a concise and critical overview of the current literature on this topic, and we also discuss unresolved and conflicting issues delineating future perspectives.</p>","PeriodicalId":51294,"journal":{"name":"Journal of Geriatric Cardiology","volume":"22 2","pages":"255-264"},"PeriodicalIF":1.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}