{"title":"Guide to Temporary Mechanical Support in Cardiogenic Shock","authors":"David Snipelisky MD, Jerry D. Estep MD","doi":"10.1016/j.hfc.2024.06.010","DOIUrl":"10.1016/j.hfc.2024.06.010","url":null,"abstract":"","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 4","pages":"Pages 445-454"},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Failure ClinicsPub Date : 2024-07-01Epub Date: 2024-10-18DOI: 10.1016/j.hfc.2024.09.003
Giorgia Panichella, Alberto Aimo, Giuseppe Vergaro, Vincenzo Castiglione, Chiara Arzilli, Alberto Giannoni, Marco Merlo, Giuseppe Limongelli, Michele Emdin
{"title":"Cardiac Amyloidosis: How Its Epidemiology is Changing.","authors":"Giorgia Panichella, Alberto Aimo, Giuseppe Vergaro, Vincenzo Castiglione, Chiara Arzilli, Alberto Giannoni, Marco Merlo, Giuseppe Limongelli, Michele Emdin","doi":"10.1016/j.hfc.2024.09.003","DOIUrl":"10.1016/j.hfc.2024.09.003","url":null,"abstract":"<p><p>Cardiac amyloidosis (CA) encompasses a group of disorders characterized by an abnormal accumulation of amyloid fibrils in the heart, leading to impaired cardiac function and ultimately heart failure. While the incidence of immunoglobulin light chains amyloidosis incidence seems stable at 8 to 15.2 cases per million persons (PMP)/year, the incidence and prevalence of wild type transthyretin-CA are steadily increasing, being currently estimated at 14 to 27 cases PMP/year and 30 to 170 cases PMP, respectively. This review explores the dynamic landscape of CA epidemiology and its implications for screening and management strategies.</p>","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 3S","pages":"e1-e10"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Failure ClinicsPub Date : 2024-07-01Epub Date: 2024-11-05DOI: 10.1016/j.hfc.2024.09.007
Veronica Musetti, Francesco Greco, Alberto Aimo, Vincenzo Castiglione, Giuseppe Vergaro, Giorgia Panichella, Giuseppe Limongelli, Marco Merlo, Michele Emdin, Angela Pucci
{"title":"Cardiac Amyloidosis: Role of the Endomyocardial Biopsy.","authors":"Veronica Musetti, Francesco Greco, Alberto Aimo, Vincenzo Castiglione, Giuseppe Vergaro, Giorgia Panichella, Giuseppe Limongelli, Marco Merlo, Michele Emdin, Angela Pucci","doi":"10.1016/j.hfc.2024.09.007","DOIUrl":"10.1016/j.hfc.2024.09.007","url":null,"abstract":"<p><p>Amyloidosis is characterized by protein misfolding and extracellular deposition of insoluble beta-sheet fibrils. It represents a heterogeneous disease with different aetiologies and clinical manifestations. Cardiac involvement (ie, cardiac amyloidosis) has an adverse prognosis, early diagnosis and amyloid typing being crucial for treatment. Recently, the non-invasive diagnosis of CA has increased using imaging techniques, particularly in TTR forms with no monoclonal protein. In the other settings and with inconclusive peripheral biopsy, the EMB allows the demonstration of amyloid by Congo red staining under polarized light, whereas amyloid typing is performed by using immunohistochemistry, immune-electron microscopy and/or proteomics.</p>","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 3S","pages":"e23-e31"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Failure ClinicsPub Date : 2024-07-01Epub Date: 2025-01-30DOI: 10.1016/j.hfc.2024.09.005
Giuseppe Palmiero, Paolo Milani, Federica Verrillo, Emanuele Monda, Marco Merlo, Michele Emdin, Giuseppe Limongelli, Giovanni Palladini
{"title":"Advances in the Therapy of Light Chain Cardiac Amyloidosis.","authors":"Giuseppe Palmiero, Paolo Milani, Federica Verrillo, Emanuele Monda, Marco Merlo, Michele Emdin, Giuseppe Limongelli, Giovanni Palladini","doi":"10.1016/j.hfc.2024.09.005","DOIUrl":"10.1016/j.hfc.2024.09.005","url":null,"abstract":"<p><p>Systemic light chain (AL) amyloidosis stems from abnormal production of amyloidogenic immunoglobulin light chains by plasma cells or B-cell disorders. It can present locally or systemically, with systemic forms posing significant mortality risks, especially if cardiac involvement is present. Delayed diagnosis due to nonspecific symptoms leads to progressive organ dysfunction. Early recognition is vital for timely treatment, aiming to suppress amyloid production and reduce organ damage, thus promoting recovery and improving survival rates. This review article provides a comprehensive overview of the recent advancements in medical therapy for patients with AL cardiac amyloidosis.</p>","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 3S","pages":"e45-e54"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Failure ClinicsPub Date : 2024-07-01Epub Date: 2024-11-20DOI: 10.1016/j.hfc.2024.09.008
Alberto M Marra, Giuseppe Palmiero, Mariangela Losi, Mario Mallardo, Alfonso Galati, Eduardo Bossone, Giovanni Esposito, Paolo Calabrò, Antonio Cittadini, Giuseppe Limongelli
{"title":"Exercise Training and Rehabilitation in Cardiac Amyloidosis (ERICA) Study: Rationale and Design.","authors":"Alberto M Marra, Giuseppe Palmiero, Mariangela Losi, Mario Mallardo, Alfonso Galati, Eduardo Bossone, Giovanni Esposito, Paolo Calabrò, Antonio Cittadini, Giuseppe Limongelli","doi":"10.1016/j.hfc.2024.09.008","DOIUrl":"10.1016/j.hfc.2024.09.008","url":null,"abstract":"<p><p>Notwithstanding the dramatic improvement associated with Tafamidis in Heart Failure due to wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), the effect of exercise training on ATTRwt-CA remains unexplored. We hereby present rationale and design of the Exercise training and Rehabilitation in Cardiac Amyloidosis study. This interventional, controlled study will randomize ATTRwt-CA patients into a control group and a training group. Primary endpoint will be the distance obtained at the 6-min walk test. Quality-of-life, peak oxygen consumption, left and right heart architecture and function, and natriuretic peptides will be secondary endpoints.</p>","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 3S","pages":"e55-e62"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Failure ClinicsPub Date : 2024-07-01Epub Date: 2024-12-30DOI: 10.1016/j.hfc.2024.09.006
Alberto Aimo, Yu Fu Ferrari Chen, Vincenzo Castiglione, Alessandro Valleggi, Dario Genovesi, Assuero Giorgetti, Michele Emdin, Giuseppe Vergaro
{"title":"PET and Cardiac Amyloidosis: Which Possible Role?","authors":"Alberto Aimo, Yu Fu Ferrari Chen, Vincenzo Castiglione, Alessandro Valleggi, Dario Genovesi, Assuero Giorgetti, Michele Emdin, Giuseppe Vergaro","doi":"10.1016/j.hfc.2024.09.006","DOIUrl":"10.1016/j.hfc.2024.09.006","url":null,"abstract":"<p><p>PET has recently demonstrated promising capabilities in the diagnosis and differentiation of various forms of CA. Tracers labeled with 18F, such as 18F-flutemetamol, 18F-florbetapir, and 18F-florbetaben, are being increasingly researched due to their extended half-life, eliminating the requirement for on-site cyclotrons. Unlike bone tracers, PET amyloid-binding tracers exhibit a higher affinity for light-chain fibrils, potentially enabling accurate differentiation between various types of CA. The methodology for measuring tracer uptake in PET imaging, whether dynamic or static, facilitates the quantification of disease severity and could act as a marker for monitoring the disease, assessing treatment response.</p>","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 3S","pages":"e11-e21"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Failure ClinicsPub Date : 2024-07-01Epub Date: 2024-10-18DOI: 10.1016/j.hfc.2024.09.004
Riccardo Scirpa, Federico Follesa, Ludovica De Fazio, Edoardo Cittadini, Pietro Francia, Giacomo Tini, Camillo Autore, Emanuele Barbato, Beatrice Musumeci
{"title":"Arrhythmic Stratification of Cardiac Amyloidosis: State of the Art.","authors":"Riccardo Scirpa, Federico Follesa, Ludovica De Fazio, Edoardo Cittadini, Pietro Francia, Giacomo Tini, Camillo Autore, Emanuele Barbato, Beatrice Musumeci","doi":"10.1016/j.hfc.2024.09.004","DOIUrl":"10.1016/j.hfc.2024.09.004","url":null,"abstract":"<p><p>Cardiac amyloidosis is an infiltrative myocardial disease whose prevalence significantly increased in recent years. Its clinical history is changing due to the advent of novel therapies, and careful risk stratification has become impelling. Arrhythmias, frequently found during the course of the disease, include conduction system disease, atrial fibrillation (AF), and ventricular arrhythmias (VAs). Arrhythmic risk stratification is a key to identify those patients at higher risk to develop advanced atrioventricular blocks, asymptomatic AFs, or major VAs. This carries significant clinical implications concerning the indication and timing of implantable cardiac devices, as well as the initiation of anticoagulation therapy.</p>","PeriodicalId":51292,"journal":{"name":"Heart Failure Clinics","volume":"20 3S","pages":"e33-e44"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}