Exercise Training and Rehabilitation in Cardiac Amyloidosis (ERICA) Study: Rationale and Design.

IF 2.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Failure Clinics Pub Date : 2024-07-01 Epub Date: 2024-11-20 DOI:10.1016/j.hfc.2024.09.008

Alberto M Marra, Giuseppe Palmiero, Mariangela Losi, Mario Mallardo, Alfonso Galati, Eduardo Bossone, Giovanni Esposito, Paolo Calabrò, Antonio Cittadini, Giuseppe Limongelli

引用次数: 0

Abstract

Notwithstanding the dramatic improvement associated with Tafamidis in Heart Failure due to wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), the effect of exercise training on ATTRwt-CA remains unexplored. We hereby present rationale and design of the Exercise training and Rehabilitation in Cardiac Amyloidosis study. This interventional, controlled study will randomize ATTRwt-CA patients into a control group and a training group. Primary endpoint will be the distance obtained at the 6-min walk test. Quality-of-life, peak oxygen consumption, left and right heart architecture and function, and natriuretic peptides will be secondary endpoints.

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心脏淀粉样变性的运动训练和康复（ERICA）研究：原理与设计。

尽管在野生型转甲状腺素型心脏淀粉样变（ATTRwt-CA）引起的心力衰竭中使用他法底斯有显著改善，但运动训练对ATTRwt-CA的影响仍未被探索。我们在此提出运动训练和心脏淀粉样变性康复研究的基本原理和设计。这项干预性对照研究将attrt - ca患者随机分为对照组和训练组。主要终点将是在6分钟步行试验中获得的距离。生活质量、峰值耗氧量、左右心脏结构和功能以及利钠肽将是次要终点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart Failure Clinics CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

5.40

自引率

2.90%

发文量

期刊介绍： Heart failure is quickly becoming the most pressing health problem in the United States. Heart Failure Clinics provides practical, concise and easy-to-read coverage that encompasses everything you need to know about the current literature. Topics include acute decompensated heart failure, arrhythmias and sudden cardiac death, ventricular dysfunction, comorbidities of heart failure, diastolic dysfunction, genetic evaluation, ischemic heart disease, pulmonary arterial hypertension, and surgery/transplantation.