Nature Clinical Practice. Cardiovascular Medicine最新文献_第2页

Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells. 心脏细胞治疗中的成像:治疗细胞生物学命运的体内追踪。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1159

Hung Q Ly, John V Frangioni, Roger J Hajjar

{"title":"Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells.","authors":"Hung Q Ly, John V Frangioni, Roger J Hajjar","doi":"10.1038/ncpcardio1159","DOIUrl":"https://doi.org/10.1038/ncpcardio1159","url":null,"abstract":"Clinical trials in cardiac cell-based therapy (CBT) have demonstrated the immense potential of stem progenitor cells (SPCs) to repair the injured myocardium. The bulk of evidence so far has shown that CBT can lead to structural and functional improvements. Unresolved issues remain, however, including gaps in the understanding of mechanisms and mixed results from CBT trials. To try to provide answers for these issues, assessment of the biological fate of SPCs once delivered to the injured heart has been called for. Advances in contrast agents and imaging modalities have made feasible the objective assessment of the in vivo molecular and cellular evolution of transplanted SPCs. In vivo imaging can target fundamental processes related to SPCs to gain information on their biological activities and outcomes within specific authentic microenvironments. Advantages and inherent drawbacks of imaging techniques, such as reporter-gene systems, optical imaging, radionuclide imaging, and MRI, are discussed in this Review. More than ever, it has become clear to scientists and clinicians that parallel developments in cell-based therapies and in vivo imaging modalities will strengthen this blossoming field.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"5 Suppl 2 ","pages":"S96-102"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio1159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27547284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Imaging of the vasa vasorum. 血管血管成像。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1157

Juan F Granada, Steven B Feinstein

{"title":"Imaging of the vasa vasorum.","authors":"Juan F Granada, Steven B Feinstein","doi":"10.1038/ncpcardio1157","DOIUrl":"https://doi.org/10.1038/ncpcardio1157","url":null,"abstract":"Neovascularization of the arterial walls by adventitial vasa vasorum appears to participate in the process of atherosclerosis progression and destabilization. Although the biological mechanisms associated with plaque instability are still unclear, the uncontrolled formation of intraplaque neovessels appears to contribute to the development of complex atheromatous lesions. Recent reports have described the use of several ultrasound-based techniques for the real-time detection of intraplaque neovascularization. Preliminary studies in animal models have shown that the detection and characterization of adventitial neovascularization are technically feasible. The further development of these imaging techniques relies on the successful implementation of contrast microspheres capable of enhancing microvascular structures. These contrast agents serve as surrogate red blood cells and perform acoustically as true intravascular tracers providing, in real-time, the amount and distribution of neovessels within atherosclerotic lesions. Several ultrasound-based techniques are under development for the detection of adventitial vasa vasorum in the carotid and coronary vascular territories. Although still in early validation phases, these techniques might permit the early diagnosis and stratification of subclinical atherosclerosis, thus permitting aggressive preventive therapy. In the near future, innovative contrast agents using specific ligands are likely to expand the diagnostic and therapeutic possibilities of these emerging imaging techniques.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"5 Suppl 2 ","pages":"S18-25"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio1157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27549041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 71

Imaging myocardial metabolism and ischemic memory. 心肌代谢和缺血记忆成像。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1186

Heinrich Taegtmeyer, Vasken Dilsizian

{"title":"Imaging myocardial metabolism and ischemic memory.","authors":"Heinrich Taegtmeyer, Vasken Dilsizian","doi":"10.1038/ncpcardio1186","DOIUrl":"https://doi.org/10.1038/ncpcardio1186","url":null,"abstract":"The advent of myocardial metabolic imaging more than 30 years ago ushered in a paradigm shift in the clinical management of patients with ischemic and nonischemic heart disease. A classic example is the so-called metabolic memory of altered glucose and fatty acid metabolism in regions of myocardial ischemia and reperfusion. At the cellular level, metabolic memory is driven by changes in the activities and expression of a host of metabolic enzymes, including reactivation of the fetal gene program. The future of metabolic imaging will require a more-refined understanding of the pathways of metabolic adaptation and maladaptation of the heart. Recent evidence suggests that metabolic signals alter metabolic fluxes and give rise to specific metabolic patterns that, in turn, lead to changes in translational and/or transcriptional activities in the cardiac myocyte. In other words, metabolism provides a link between environmental stimuli and a host of intracellular signaling pathways. This concept has not yet been fully explored in vivo, although metabolic adaptation represents the earliest response to myocardial ischemia and left ventricular remodeling.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"5 Suppl 2 ","pages":"S42-8"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio1186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27549045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 59

Noninvasive radionuclide imaging of cardiac gene therapy: progress and potential. 心脏基因治疗的无创放射性核素显像:进展和潜力。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1113

Asimina Hiona, Joseph C Wu

{"title":"Noninvasive radionuclide imaging of cardiac gene therapy: progress and potential.","authors":"Asimina Hiona, Joseph C Wu","doi":"10.1038/ncpcardio1113","DOIUrl":"https://doi.org/10.1038/ncpcardio1113","url":null,"abstract":"Over the past decade, several clinical trials have evaluated the efficacy of cardiac-specific gene therapy. Despite encouraging results in basic research and preclinical studies, most of the recent large, randomized, placebo-controlled cardiac gene therapy trials have failed to provide convincing evidence of improvements in clinical outcomes. Because many of these problems are due to the lack of appropriate monitoring techniques, there is a critical need to develop noninvasive imaging techniques that can verify vector delivery and gene expression in target and nontarget tissues. The field of molecular imaging of cardiac gene expression is rapidly advancing because it offers distinct advantages over conventional methods, including the ability to noninvasively measure the location, time course, and magnitude of gene expression. We aim to give readers a clear understanding of how molecular imaging can enable noninvasive tracking of cardiac gene transfer and expression. We discuss limitations of current methods for analyzing gene transfer and describe how reporter gene imaging works.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"5 Suppl 2 ","pages":"S87-95"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio1113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27547283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Intracellular and extracellular targets of molecular imaging in the myocardium. 心肌分子成像的细胞内和细胞外靶标。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1161

Hyung J Chun, Jagat Narula, Leonard Hofstra, Joseph C Wu

引用次数: 8

Magnetic resonance imaging of neural circuits. 神经回路的磁共振成像。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1248

Jeff Duyn, Alan P Koretsky

引用次数: 0

Targeted imaging of myocardial damage. 心肌损伤的靶向成像。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1115

David E Sosnovik, Matthias Nahrendorf, Ralph Weissleder

引用次数: 20

Imaging atherosclerotic plaque inflammation. 动脉粥样硬化斑块炎症成像。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1160

James H F Rudd, Zahi A Fayad

引用次数: 91

Epilogue: setting tiny targets for greater goals... 结语:为大目标设定小目标……

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-08-01 DOI: 10.1038/ncpcardio1238

Vasken Dilsizian, Jagat Narula

引用次数: 7

Reduction of proteinuria with angiotensin receptor blockers. 血管紧张素受体阻滞剂减少蛋白尿。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2008-07-01 DOI: 10.1038/ncpcardio0806

Jan Galle

{"title":"Reduction of proteinuria with angiotensin receptor blockers.","authors":"Jan Galle","doi":"10.1038/ncpcardio0806","DOIUrl":"https://doi.org/10.1038/ncpcardio0806","url":null,"abstract":"Renal pathophysiology is elicited by activation of angiotensin II type 1 (AT(1)) receptors at all stages of renovascular disease. Angiotensin receptor blockers (ARBs) that specifically block the AT(1) receptor offer the potential to prevent or delay progression to end-stage renal disease independently of reductions in blood pressure. Proteinuria--an early and sensitive marker for progressive renal dysfunction--is reduced by ARB use in patients with type 2 diabetic nephropathy and microalbuminuria or macroalbuminuria. Retrospective analysis of data available from early trials has confirmed this finding and has shown that albuminuria reduction is associated with lessening of cardiovascular risk. The ARB telmisartan is equivalent to enalapril in preventing glomerular filtration rate decline, and equivalent to valsartan in reducing proteinuria. Telmisartan is more effective than conventional therapy in lowering the risk of transition to overt nephropathy in hypertensive and normotensive patients. An additive effect has been seen in smaller studies when telmisartan has been added to lisinopril therapy, and high-dose telmisartan reduces albuminuria better than low-dose telmisartan. Similar data were obtained with other ARBs such as candesartan, losartan, valsartan, or irbesartan. These data support the proposition that blockade of the renin-angiotensin system beyond that required for maximum blood pressure reduction provides optimum renal protection.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"5 Suppl 1 ","pages":"S36-43"},"PeriodicalIF":0.0,"publicationDate":"2008-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio0806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40425260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42