Nature Clinical Practice. Cardiovascular Medicine最新文献_第8页

Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes. 人脂肪干细胞对内皮细胞和心肌细胞的可塑性。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2006-03-01 DOI: 10.1038/ncpcardio0444

John K Fraser, Ronda Schreiber, Brian Strem, Min Zhu, Zeni Alfonso, Isabella Wulur, Marc H Hedrick

引用次数: 172

Resident progenitors and bone marrow stem cells in myocardial renewal and repair. 常驻祖细胞和骨髓干细胞在心肌更新和修复中的作用。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2006-03-01 DOI: 10.1038/ncpcardio0415

Simón Méndez-Ferrer, Georgina M Ellison, Daniele Torella, Bernardo Nadal-Ginard

{"title":"Resident progenitors and bone marrow stem cells in myocardial renewal and repair.","authors":"Simón Méndez-Ferrer, Georgina M Ellison, Daniele Torella, Bernardo Nadal-Ginard","doi":"10.1038/ncpcardio0415","DOIUrl":"https://doi.org/10.1038/ncpcardio0415","url":null,"abstract":"Although cardiac transplantation is still the treatment of choice for end-stage heart disease, the side effects derived from the use of immunosuppressants and the limited availability of donors have prompted the search for alternative therapeutic strategies. Among other possibilities, cell transplantation approaches have recently emerged as new alternatives to stimulate myocardial regeneration. These approaches are mainly based on the increasing number of reports documenting the plasticity of stem cells of various origins, particularly the ability of several types of embryonic and adult stem cells to give rise to cardiomyocytes. Unprecedented in the field of 'translational research' and based on the urgent need for alternative therapies, the promising results obtained with animal models have been quickly transferred to the clinical arena, where numerous small pilot studies using different cell types are already ongoing and/or have reported promising results. Nevertheless, the lack of randomization, the variability and small size of the treated cohorts and the use of mixed populations of cells have often clouded the significance and prevented a mechanistic interpretation of the results. Here, we briefly review the use of bone-marrow-derived and cardiac-derived stem/progenitor cells in myocardial regeneration studies and discuss their significance for the future of the field of myocardial regeneration.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"3 Suppl 1 ","pages":"S83-9"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio0415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25875898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration. 常驻人心脏干细胞:在心脏细胞稳态中的作用和心肌再生的潜力。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2006-03-01 DOI: 10.1038/ncpcardio0409

Daniele Torella, Georgina M Ellison, Simón Méndez-Ferrer, Borja Ibanez, Bernardo Nadal-Ginard

{"title":"Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration.","authors":"Daniele Torella, Georgina M Ellison, Simón Méndez-Ferrer, Borja Ibanez, Bernardo Nadal-Ginard","doi":"10.1038/ncpcardio0409","DOIUrl":"https://doi.org/10.1038/ncpcardio0409","url":null,"abstract":"Current treatments for myocardial infarction have significantly reduced the acute mortality of ischemic cardiomyopathy. This reduction has resulted in the survival of a large cohort of patients left with a significant 'myocyte deficit'. Once this deficit leads to heart failure there is no available therapy to improve long-term cardiac function. Recent developments in stem cell biology have focused on the possibility of regenerating contractile myocardial tissue. Most of these approaches have entailed the transplantation of exogenous cardiac-regenerating cells. Recently, we and others have reported that the adult mammalian myocardium, including that in humans, contains a small pool of cardiac stem and progenitor cells (CSCs) that can replenish the cardiomyocyte population and, in some cases, the coronary microcirculation. The human CSCs (hCSCs) are involved in maintaining myocardial cell homeostasis throughout life and participate in remodeling in cardiac pathology. They can be isolated, propagated and cloned. The progeny of a single cell clone differentiates in vitro and in vivo into myocytes, smooth muscle and endothelial cells. Surprisingly, in response to different forms of stress, hCSCs acquire a senescent, dysfunctional phenotype. Strikingly, these nonfunctional CSCs constitute around 50% of the total CSC pool in older individuals-those most likely to be candidates for hCSC-based myocardial regeneration. Therefore, the challenge to develop clinically effective therapies of myocardial regeneration is twofold: to produce the activation of the hCSCs in situ in order to obviate the need for cell transplantation, and to elucidate the mechanisms responsible for hCSC senescence in order to prevent or reverse its development.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"3 Suppl 1 ","pages":"S8-13"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio0409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25875417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 170

The role of noninvasive imaging techniques in the assessment of stem cell therapy after acute myocardial infarction. 非侵入性成像技术在急性心肌梗死后干细胞治疗评估中的作用。

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2006-03-01 DOI: 10.1038/ncpcardio0448

José Alberto San Román, Francisco Fernández-Avilés

引用次数: 17

Stem cell therapy in postinfarction chronic coronary heart disease. 慢性冠心病梗死后干细胞治疗

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2006-03-01 DOI: 10.1038/ncpcardio0431

Michael Brehm, Bodo E Strauer

{"title":"Stem cell therapy in postinfarction chronic coronary heart disease.","authors":"Michael Brehm, Bodo E Strauer","doi":"10.1038/ncpcardio0431","DOIUrl":"https://doi.org/10.1038/ncpcardio0431","url":null,"abstract":"After acute myocardial infarction, bone-marrow-derived cells (BMDCs) improve cardiac function; it is conceivable, but not yet demonstrated, that BMDC therapy might also be useful in chronic infarction. We treated 18 consecutive patients who had chronic myocardial infarction (between 5 months and 8.5 years postinfarction) using intracoronary transplantation of autologous BMDCs and compared this group with a representative control group who did not receive cell therapy. After 3 months, infarct size in the transplantation group was reduced by 30% and both global left ventricular ejection fraction and infarction wall-movement velocity were increased significantly (15% and 57%, respectively), whereas in the control group no significant changes were observed. After transplantation of BMDCs, there was an 11% improvement in maximum oxygen uptake and a 15% increase in regional (18)F-fluordeoxyglucose uptake into infarcted tissue, as determined by positron emission tomography. These results show that functional and metabolic regeneration of infarcted and chronically avital tissue can be achieved in humans using transplantation of bone-marrow-derived cells.","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"3 Suppl 1 ","pages":"S101-4"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio0431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25875556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Reunión de consenso: Estrategias para un control eficaz de la hipertensión arterial en España Barcelona, España, 14 y 15 de octubre de 2005 共识会议:西班牙有效控制高血压的策略，西班牙巴塞罗那，2005年10月14日和15日

Nature Clinical Practice. Cardiovascular Medicine Pub Date : 2006-01-01 DOI: 10.1038/ncpcardio0656

Ottavio Alfieri, Michael E Cain, John Camm, UK Alain Carpentier, Masunori Matsuzaki, P. Serruys

引用次数: 1