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Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. 关节内注射自体脂肪源性间充质干细胞和再生细胞对犬肘关节慢性骨关节炎临床症状的影响。
Veterinary Therapeutics Pub Date : 2008-01-01
Linda L Black, James Gaynor, Cheryl Adams, Sarit Dhupa, Andrew E Sams, Robert Taylor, Susan Harman, Daniel A Gingerich, Robert Harman
{"title":"Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs.","authors":"Linda L Black,&nbsp;James Gaynor,&nbsp;Cheryl Adams,&nbsp;Sarit Dhupa,&nbsp;Andrew E Sams,&nbsp;Robert Taylor,&nbsp;Susan Harman,&nbsp;Daniel A Gingerich,&nbsp;Robert Harman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Autologous adipose-derived mesenchymal stem cell (AD-MSC) therapy involves harvesting fat from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous AD-MSC therapy in veterinary regenerative medicine has been commercially available since 2003. Previously reported results from a blinded, controlled trial in dogs with chronic osteoarthritis of the coxofemoral (hip) joint demonstrated efficacy of a single intraarticular injection of autologous AD-MSC therapy. The primary objective of the current study was to evaluate the effectiveness of this therapy in dogs with chronic osteoarthritis of the humeroradial (elbow) joints and to determine the duration of effect. Fourteen dogs were recruited. Veterinarians assessed each dog for lameness, pain on manipulation, range of motion, and functional disability using a numeric rating scale at baseline and specified intervals up to 180 days after treatment. Statistically significant improvement in outcome measures was demonstrated.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"9 3","pages":"192-200"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27834304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in antibiotic susceptability of Escherichia coli isolated from steers exposed to antibiotics during the early feeding period. 早期饲养期暴露于抗生素的阉牛分离的大肠杆菌对抗生素敏感性的变化。
Veterinary Therapeutics Pub Date : 2008-01-01
Paul H Coe, Daniel L Grooms, Ken Metz, Robert E Holland
{"title":"Changes in antibiotic susceptability of Escherichia coli isolated from steers exposed to antibiotics during the early feeding period.","authors":"Paul H Coe,&nbsp;Daniel L Grooms,&nbsp;Ken Metz,&nbsp;Robert E Holland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of therapeutic choices on antibiotic resistance of intestinal bacteria may have food safety consequences. Changes in antibiotic susceptibility of Escherichia coli to antibiotics currently approved for prevention and treatment of bovine respiratory disease were evaluated in 260 feedlot steers. Susceptibilities to antimicrobial compounds were compared among three treatment groups at three times between arrival at the feedlot and harvest to assess changes over the course of the feeding period. No significant change was found in the resistance of E. coli to tilmicosin, florfenicol, and enrofloxacin, which were used to prevent and treat respiratory disease in this study. Despite an absence of exposure to ampicillin and ceftiofur, a significant increase in resistance was observed for these two antimicrobial drugs that declined by the end of the feeding period. In this study, use of approved antimicrobials early in the feeding period for the prevention and treatment of bovine respiratory disease had little effect on antimicrobial resistance of E. coli isolated from cattle near the time of slaughter.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"9 3","pages":"241-7"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27834308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of tulathromycin or enrofloxacin for initial treatment of naturally occurring bovine respiratory disease in feeder calves. 图拉霉素或恩诺沙星对饲养小牛自然发生的牛呼吸道疾病的初步治疗效果。
Veterinary Therapeutics Pub Date : 2007-01-01
Edward J Robb, Cassius M Tucker, Lane Corley, W Lawrence Bryson, Karen C Rogers, Kynan Sturgess, Donald J Bade, Bruce Brodersen
{"title":"Efficacy of tulathromycin or enrofloxacin for initial treatment of naturally occurring bovine respiratory disease in feeder calves.","authors":"Edward J Robb,&nbsp;Cassius M Tucker,&nbsp;Lane Corley,&nbsp;W Lawrence Bryson,&nbsp;Karen C Rogers,&nbsp;Kynan Sturgess,&nbsp;Donald J Bade,&nbsp;Bruce Brodersen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After undergoing arrival processing at one of two commercial feedlots, feeder calves with clinical signs of bovine respiratory disease (BRD) were randomly assigned to receive either tulathromycin (2.4 mg/kg SC) or enrofloxacin (12.5 mg/kg SC). Additional therapy for calves that did not respond to initial treatment followed a prescribed course. Initial treatment with tulathromycin resulted in significantly higher (P = .009 and P = .031 at sites 1 and 2, respectively) therapeutic success (87.9% and 80%, respectively) than did initial treatment with enrofloxacin (70.2% and 62.5%, respectively). Animals treated with tulathromycin also had fewer subsequent treatments and higher weight gains compared with those treated with enrofloxacin.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 2","pages":"127-35"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26819083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of prednisolone on urinary calcium oxalate and struvite relative supersaturation in healthy young adult female domestic shorthaired cats. 强的松龙对健康成年雌性家短毛猫尿液草酸钙和鸟粪石相对过饱和度的影响。
Veterinary Therapeutics Pub Date : 2007-01-01
Nicole Geyer, Joseph W Bartges, Claudia A Kirk, Sherry Cox, Alisha Hezel, Tammy Moyers, Jimmy Hayes
{"title":"Influence of prednisolone on urinary calcium oxalate and struvite relative supersaturation in healthy young adult female domestic shorthaired cats.","authors":"Nicole Geyer,&nbsp;Joseph W Bartges,&nbsp;Claudia A Kirk,&nbsp;Sherry Cox,&nbsp;Alisha Hezel,&nbsp;Tammy Moyers,&nbsp;Jimmy Hayes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prednisolone (10 mg PO q24h) or placebo was administered to healthy cats for 2 weeks in a masked, placebo-controlled, crossover-design study, and 24-hour urine samples were collected. When cats received prednisolone, 24-hour urine pH was lower and 24-hour urine excretion of creatinine, magnesium, phosphate, and potassium was higher than when cats received placebo. No significant difference was found in urinary relative supersaturation for calcium oxalate (CaOx) or struvite between treatment groups. Prednisolone administration did not induce diuresis, nor was it associated with increased calcium excretion or urinary saturation for CaOx in these healthy cats. Results of this study, however, should not be extrapolated to cats that form CaOx uroliths associated with idiopathic hypercalcemia.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 4","pages":"239-46"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27213493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle. 两种抗菌素治疗实验感染牛博格彼得钩端螺旋体血清型硬结感染的疗效评价。
Veterinary Therapeutics Pub Date : 2007-01-01
Victor S Cortese, Stephen Behan, Jeff E Galvin, Dan R Penka, Deborah Ramsey, W Lawrence Bryson, Merlyn J Lucas
{"title":"Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle.","authors":"Victor S Cortese,&nbsp;Stephen Behan,&nbsp;Jeff E Galvin,&nbsp;Dan R Penka,&nbsp;Deborah Ramsey,&nbsp;W Lawrence Bryson,&nbsp;Merlyn J Lucas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study demonstrated the ability of the antimicrobials tulathromycin (Draxxin) and ceftiofur crystalline free acid sterile suspension (Excede) to clear the spirochete Leptospira borgpetersenii serovar hardjo type hardjo-bovis (L. hardjo-bovis) from experimentally infected cattle. Treatment with tulathromycin resulted in clearance of L. hardjo-bovis organisms from the urine and kidney tissue of all animals (9 of 9), and treatment with ceftiofur crystalline free acid resulted in clearance of the organisms from the urine of 8 of 10 heifers and the kidney tissue of all 10 animals. In contrast, 10 of 10 placebo-treated cattle had L. hardjo-bovis organisms in their urine and 8 of 10 had the organisms in kidney tissue.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 3","pages":"201-8"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27040333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-year duration of immunity in dogs vaccinated with a canarypox-vectored recombinant canine distemper virus vaccine. 接种了金丝雀痘载体重组犬瘟热病毒疫苗的狗的三年免疫期。
Veterinary Therapeutics Pub Date : 2007-01-01
L J Larson, R D Schultz
{"title":"Three-year duration of immunity in dogs vaccinated with a canarypox-vectored recombinant canine distemper virus vaccine.","authors":"L J Larson,&nbsp;R D Schultz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two studies evaluated the duration of serologic response to the recombinant, canarypox-vectored canine distemper virus vaccine (Recombitek, Merial). Serologic duration of immunity was shown to be at least 36 months. Thus, Recombitek provides protection when administered less frequently than the manufacturer's label. After the initial vaccination protocol of two or more doses administered approximately 4 weeks apart, with the last dose given at 12 to 16 weeks of age or older, and re-vaccination at 1 year of age, Recombitek can confidently be readministered every 3 years with assurance of protection in immunocompetent dogs. This allows the vaccine to be administered in accordance with the recommendations of the American Animal Hospital Association Canine Vaccine Task Force and others.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 2","pages":"101-6"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26818086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of polymerase chain reaction diagnosis of Cryptosporidium spp in dairy cattle and wildlife. 奶牛和野生动物隐孢子虫聚合酶链反应诊断的评价。
Veterinary Therapeutics Pub Date : 2007-01-01
Peter E Ziegler, Fiammetta Santucci, Gabriella Lindergard, Daryl V Nydam, Susan E Wade, Stephanie L Schaaf, Yung-Fu Chang, Hussni O Mohammed
{"title":"Evaluation of polymerase chain reaction diagnosis of Cryptosporidium spp in dairy cattle and wildlife.","authors":"Peter E Ziegler,&nbsp;Fiammetta Santucci,&nbsp;Gabriella Lindergard,&nbsp;Daryl V Nydam,&nbsp;Susan E Wade,&nbsp;Stephanie L Schaaf,&nbsp;Yung-Fu Chang,&nbsp;Hussni O Mohammed","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigated the utility of the polymerase chain reaction (PCR) protocol as a screening test for Cryptosporidium spp in 125 fecal samples from dairy cattle and wild rodents. Samples initially examined by fecal flotation and ELISA were evaluated using four PCR protocols (18S SSU rRNA, TRAP-C2, HSP70, and COWP), and the relative accuracy and agreement of PCR protocols was assessed. Although PCR can be both highly sensitive and accurate, the ability of these protocols to accurately detect DNA in samples can vary. A combination of techniques may be the best choice for to screen samples for this parasite.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 2","pages":"148-59"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26819085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproductive safety of vaccination with Vista 5 L5 SQ near breeding time as determined by the effect on conception rates. 通过对受孕率的影响来确定在繁殖期附近接种Vista 5 L5 SQ的生殖安全性。
Veterinary Therapeutics Pub Date : 2007-01-01
Michael Bolton, David Brister, Bill Burdett, Harold Newcomb, Scott Nordstrom, Bill Sanders, Tom Shelton
{"title":"Reproductive safety of vaccination with Vista 5 L5 SQ near breeding time as determined by the effect on conception rates.","authors":"Michael Bolton,&nbsp;David Brister,&nbsp;Bill Burdett,&nbsp;Harold Newcomb,&nbsp;Scott Nordstrom,&nbsp;Bill Sanders,&nbsp;Tom Shelton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Replacement heifers (N=799; 10 to 13 months of age) were vaccinated with Vista 5 L5 SQ (Intervet; a reconstituted vaccine-bacterin product containing modified-live cultures of infectious bovine rhinotracheitis [IBR] virus, bovine viral diarrhea virus [BVDV; types 1 and 2], parainfluenza-3 virus, and bovine respiratory syncytial virus and inactivated cultures of Leptospira serovars canicola, grippotyphosa, hardjo, icterohaemorrhagiae, and pomona with a proprietary adjuvant) at either 40 plus/minus 5 days (control; n=399) or 3 days (test; n=400) before peak breeding day. By 40 plus/minus 5 days before peak breeding day, heifers in both groups had greater average titers to IBR, BVDV types 1 and 2, and four of the five Leptospira antigens assessed as compared with prevaccination titers on day -90 plus/minus 25 days. Conception rates were not affected by treatment. This study suggests that conception rates will not differ between heifers vaccinated with Vista 5 L5 SQ 3 days before breeding and those vaccinated approximately 40 days before breeding.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 3","pages":"177-82"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27040331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onset of protection from experimental infection with type 2 bovine viral diarrhea virus following vaccination with a modified-live vaccine. 接种改良活疫苗后对2型牛病毒性腹泻病毒实验性感染的保护作用。
Veterinary Therapeutics Pub Date : 2007-01-01
K V Brock, P Widel, P Walz, H L Walz
{"title":"Onset of protection from experimental infection with type 2 bovine viral diarrhea virus following vaccination with a modified-live vaccine.","authors":"K V Brock,&nbsp;P Widel,&nbsp;P Walz,&nbsp;H L Walz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The onset of protection after the administration of a modified-live bovine viral diarrhea virus (BVDV) vaccine was determined. Protection was determined following experimental infection with a virulent type-2 BVDV (strain 1373) in cattle vaccinated 3, 5, or 7 days before BVDV infection. Protection, as measured by reduced virus shedding, lack of leukopenia, reduction in viremia, and reduced mortality, was present as early as 3 days after vaccination with a single dose of modified-live BVDV vaccine. Complete protection was obtained in cattle vaccinated 5 or 7 days before BVDV experimental infection.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 1","pages":"88-96"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26677229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. Firocoxib预防尿酸诱导的狗滑膜炎、疼痛和炎症的疗效。
Veterinary Therapeutics Pub Date : 2007-01-01
Marlene Drag, Bruce N Kunkle, Davida Romano, Peter D Hanson
{"title":"Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs.","authors":"Marlene Drag,&nbsp;Bruce N Kunkle,&nbsp;Davida Romano,&nbsp;Peter D Hanson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness. Lameness scoring and force plate gait analysis were used to assess efficacy. The resulting lameness scores and force plate ground reaction forces after urate crystal injection were not significantly different among the groups. Relative to each group's baseline (nonlame) score, only the firocoxib group was not significantly lame, based on lameness score, at the model's peak effect.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 1","pages":"41-50"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26677306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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