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Pharmacokinetics and in vitro effects of tegaserod, a serotonin 5-hydroxytryptamine 4 (5-HT4) receptor agonist with prokinetic activity in horses. 5-羟色胺4 (5-HT4)受体激动剂tegaserod在马体内的药代动力学及体外效应
Veterinary Therapeutics Pub Date : 2007-01-01
Michelle L Delco, Jorge E Nieto, Arthur L Craigmill, Scott D Stanley, Jack R Snyder
{"title":"Pharmacokinetics and in vitro effects of tegaserod, a serotonin 5-hydroxytryptamine 4 (5-HT4) receptor agonist with prokinetic activity in horses.","authors":"Michelle L Delco,&nbsp;Jorge E Nieto,&nbsp;Arthur L Craigmill,&nbsp;Scott D Stanley,&nbsp;Jack R Snyder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tegaserod, a serotonin agonist, has been shown to have prokinetic effects in horses, but pharmacokinetic information is not currently available. The pharmacokinetics and in vitro effects of tegaserod were evaluated. Tegaserod increased the contractile activity of smooth muscle preparations of the equine pelvic flexure. Pertinent pharmacokinetic parameters for a single IV and oral dose were determined. Therapeutic plasma concentrations of tegaserod were achieved by a single oral dose at 0.27 mg/kg. These findings indicate that further clinical studies are warranted to investigate potential benefits in cases of functional gastrointestinal motility disorders in horses.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 1","pages":"77-87"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26677228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of reconcile (fluoxetine) chewable tablets plus behavior management for canine separation anxiety. 调和(氟西汀)咀嚼片加行为管理对犬分离焦虑的影响。
Veterinary Therapeutics Pub Date : 2007-01-01
Barbara Sherman Simpson, Gary M Landsberg, Ilana R Reisner, John J Ciribassi, Debra Horwitz, Katherine A Houpt, Tracy L Kroll, Andrew Luescher, Kelly S Moffat, Genefer Douglass, Carol Robertson-Plouch, Melissa F Veenhuizen, Alan Zimmerman, Terrence P Clark
{"title":"Effects of reconcile (fluoxetine) chewable tablets plus behavior management for canine separation anxiety.","authors":"Barbara Sherman Simpson,&nbsp;Gary M Landsberg,&nbsp;Ilana R Reisner,&nbsp;John J Ciribassi,&nbsp;Debra Horwitz,&nbsp;Katherine A Houpt,&nbsp;Tracy L Kroll,&nbsp;Andrew Luescher,&nbsp;Kelly S Moffat,&nbsp;Genefer Douglass,&nbsp;Carol Robertson-Plouch,&nbsp;Melissa F Veenhuizen,&nbsp;Alan Zimmerman,&nbsp;Terrence P Clark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Canine separation anxiety is a common behavioral problem presented to veterinarians. Associated behaviors are distressing to both dog and owner, have the potential to disrupt the human-companion animal bond, and may lead to euthanasia. The results of this study demonstrate the clinical efficacy and safety of Reconcile (fluoxetine, 1 to 2 mg/kg/day [0.45 to 0.91 mg/lb/day]), in conjunction with behavior management, for the treatment of canine separation anxiety. The beef flavored chewable formulation was palatable to treated dogs and easy to administer. This study provides to veterinarians and owners valuable information about an effective separation anxiety treatment plan that combines use of Reconcile with behavior modification.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 1","pages":"18-31"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26677304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation. 美托咪定镇静犬在100%充氧和不充氧情况下的氧合。
Veterinary Therapeutics Pub Date : 2007-01-01
Jeff C H Ko, Ann B Weil, Takashi Kitao, Mark E Payton, Tomohito Inoue
{"title":"Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation.","authors":"Jeff C H Ko,&nbsp;Ann B Weil,&nbsp;Takashi Kitao,&nbsp;Mark E Payton,&nbsp;Tomohito Inoue","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oxygenation status was evaluated in medetomidine-sedated dogs breathing room air (M) or 100 percent oxygen (MO2). Medetomidine (40 microg/kg IV) administration resulted in peripheral vasoconstriction and decreased venous saturation as measured by an increased oxygen extraction ratio in peripheral tissues. Providing 100 percent oxygen insufflation via face mask reduced desaturation by increasing oxygen content but did not prevent vasoconstriction or reduce the oxygen extraction ratio in peripheral tissues. Atipamezole (200 microg/kg IV) reversed medetomidine-induced vasoconstriction and increased oxygen supply to tissues as indicated by a lower tissue oxygen extraction ratio. The authors conclude that 100 percent oxygen insufflation via face mask during medetomidine sedation (40 micrograms/kg [corrected] IV) benefits tissue oxygenation in healthy dogs.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 1","pages":"51-60"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26677307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-year serologic immunity against canine parvovirus type 2 and canine adenovirus type 2 in dogs vaccinated with a canine combination vaccine. 犬联合疫苗对犬细小病毒2型和犬腺病毒2型的三年血清学免疫。
Veterinary Therapeutics Pub Date : 2007-01-01
L J Larson, R D Schultz
{"title":"Three-year serologic immunity against canine parvovirus type 2 and canine adenovirus type 2 in dogs vaccinated with a canine combination vaccine.","authors":"L J Larson,&nbsp;R D Schultz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of client-owned dogs and a group of dogs at a commercial kennel were evaluated for duration of antibody responses against canine parvovirus type 2 (CPV-2) and canine adenovirus type 1 (CAV-1) after receiving a combination vaccine containing recombinant canarypox-vectored canine distemper virus (CDV) and modified-live CPV-2, CAV-2, and canine parainfluenza virus, with (C6) or without (C4) two serovars of Leptospira (Recombitek C4 or C6, Merial). Duration of antibody, which correlates with protective immunity, was found to be at least 36 months in both groups. Recombitek combination vaccines can confidently be given every 3 years with assurance of protection in immunocompetent dogs against CPV-2 and CAV-1 as well as CDV. This allows this combination vaccine, like other, similar modified- live virus combination products containing CDV, CAV-2, and CPV-2, to be administered in accordance with the recommendations of the American Animal Hospital Association Canine Vaccine Task Force.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 4","pages":"305-10"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27212281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of feeding fermented liquid whey plus dextrose inoculated with specific lactic acid bacteria of pig origin to weanling pigs challenged with Escherichia coli O149:K91:F4. 饲喂接种猪源特定乳酸菌的发酵液乳清加葡萄糖对感染大肠杆菌O149:K91:F4的断奶仔猪的影响。
Veterinary Therapeutics Pub Date : 2007-01-01
M D R Amezcua, R Friendship, C Dewey, S Weese, C F M de Lange
{"title":"The effect of feeding fermented liquid whey plus dextrose inoculated with specific lactic acid bacteria of pig origin to weanling pigs challenged with Escherichia coli O149:K91:F4.","authors":"M D R Amezcua,&nbsp;R Friendship,&nbsp;C Dewey,&nbsp;S Weese,&nbsp;C F M de Lange","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The objective of this study was to determine the efficacy of using fermented liquid whey inoculated with specific lactic acid bacteria of pig origin to reduce the severity and progression of postweaning enterotoxigenic Escherichia coli diarrhea in weanling pigs challenged with E. coli O149:K91:F4. Based on two trials, it was determined that feeding inoculated fermented whey in a liquid diet did not affect growth performance or the severity or duration of postweaning diarrhea compared with a conventional dry feed containing an antibiotic. Because this study is one of very few examining the use of liquid feed and co-products inoculated with probiotics to control postweaning E. coli diarrhea, more studies are needed to confirm these results.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 3","pages":"209-22"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27039181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease. 评估三种抗菌方案作为过敏反应在高风险的牛呼吸道疾病的储存小牛。
Veterinary Therapeutics Pub Date : 2007-01-01
D L Step, Terry Engelken, Cristina Romano, Ben Holland, Clint Krehbiel, John C Johnson, W Lawrence Bryson, Cassius M Tucker, Edward J Robb
{"title":"Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease.","authors":"D L Step,&nbsp;Terry Engelken,&nbsp;Cristina Romano,&nbsp;Ben Holland,&nbsp;Clint Krehbiel,&nbsp;John C Johnson,&nbsp;W Lawrence Bryson,&nbsp;Cassius M Tucker,&nbsp;Edward J Robb","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 894 calves at high risk for bovine respiratory disease were processed at two sites and randomly assigned to receive one of three antimicrobial metaphylactic regimens to determine if a two-drug regimen offered any advantage over the more conventional one-course regimens. On arrival, calves received either a two-course regimen of ceftiofur crystalline free acid (CCFA) followed by tulathromycin 8 days later (Group 1) or a one-course regiment of CCFA (Group 2) or tilmicosin (Group 3). At Site A, morbidity was significantly lower (52%) in Group 1 than in Group 2 (76.3%) and Group 3 (78.4%). At Site B, morbidity was significantly lower in Group 1 (2.6%) than in Group 2 (9.4%) and Group 3 (7.2%).</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 2","pages":"136-47"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26819084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of selamectin and fipronil-(S)-methoprene spot-on formulations applied to cats against adult cat fleas (Ctenocephalides felis), flea eggs, and adult flea emergence. 塞拉菌素和氟虫腈-(S)-甲氧丁烯喷涂剂对猫成体猫蚤(猫头蚤)、跳蚤卵和成体跳蚤出现的效果。
Veterinary Therapeutics Pub Date : 2007-01-01
Michael Dryden, Patricia Payne, Vicki Smith
{"title":"Efficacy of selamectin and fipronil-(S)-methoprene spot-on formulations applied to cats against adult cat fleas (Ctenocephalides felis), flea eggs, and adult flea emergence.","authors":"Michael Dryden,&nbsp;Patricia Payne,&nbsp;Vicki Smith","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was conducted to evaluate the efficacy of selamectin and fipronil-(S)-methoprene against adult cat fleas (Ctenocephalides felis), flea egg production, and the viability of flea eggs collected from treated cats. Cats were infested with approximately 50 adult fleas 2 days before treatment and weekly thereafter; flea eggs were collected and counted on days 0, 1, 2, and 3 and 48 and 72 hours after each weekly flea infestation. Live fleas were collected approximately 72 hours after treatment or infestation. Compared with fipronil-(S)-methoprene, selamectin provided significantly greater control of adult fleas from days 24 to 31 and significantly greater reduction in egg production from days 16 to 45. For the most part, both products significantly impacted larval and adult emergence for the entire 6-week study, with fipronil-(S)-methoprene providing significantly greater reduction in larval and adult emergence at week 6.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 4","pages":"255-62"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27212276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. 脂肪源性间充质干细胞和再生细胞对犬慢性髋股关节骨性关节炎跛行的影响:一项随机、双盲、多中心对照试验。
Veterinary Therapeutics Pub Date : 2007-01-01
Linda L Black, James Gaynor, Dean Gahring, Cheryl Adams, Dennis Aron, Susan Harman, Daniel A Gingerich, Robert Harman
{"title":"Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial.","authors":"Linda L Black,&nbsp;James Gaynor,&nbsp;Dean Gahring,&nbsp;Cheryl Adams,&nbsp;Dennis Aron,&nbsp;Susan Harman,&nbsp;Daniel A Gingerich,&nbsp;Robert Harman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Autologous stem cell therapy in the field of regenerative veterinary medicine involves harvesting tissue, such as fat, from the patient, isolating the stem and regenerative cells, and administering the cells back to the patient. Autologous adipose-derived stem cell therapy has been commercially available since 2003, and the current study evaluated such therapy in dogs with chronic osteoarthritis of the hip. Dogs treated with adipose-derived stem cell therapy had significantly improved scores for lameness and the compiled scores for lameness, pain, and range of motion compared with control dogs. This is the first randomized, blinded, placebo-controlled clinical trial reporting on the effectiveness of stem cell therapy in dogs.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 4","pages":"272-84"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27212278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of fipronil-(S)-methoprene on fleas, flea egg collection, and flea egg development following transplantation of gravid fleas onto treated cats. 氟虫腈-(S)-甲氧丁二烯对妊娠蚤移植后跳蚤、跳蚤卵收集和跳蚤卵发育的影响。
Veterinary Therapeutics Pub Date : 2007-01-01
M Franc, F Beugnet, S Vermot
{"title":"Efficacy of fipronil-(S)-methoprene on fleas, flea egg collection, and flea egg development following transplantation of gravid fleas onto treated cats.","authors":"M Franc,&nbsp;F Beugnet,&nbsp;S Vermot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The goal of this study was to assess the insect growth regulator activity of the combination product fipronil-(S)-methoprene under a severe challenge model. Gravid fleas were allowed to feed on untreated donor cats for 48 hours before being transplanted onto untreated control cats and treated cats (treated once on day 0); 24 hours later, adult fleas were collected from all cats and counted to assess the 24-hour kill efficacy against the transplanted fleas, and flea eggs were collected and incubated to assess viability. The process was repeated weekly for 11 weeks. The 24-hour efficacy against transplanted adult fleas in the treated group was about 100% for the first 3 weeks and gradually declined to 93.4% by week 6. Egg production numbers were reduced on the treated cats compared with controls, with geometric mean egg counts on treated cats reduced from 76.9% to 96.3% during the initial 6 weeks of the study. The combination product was 100% ovicidal through day 56 and was still about 98% effective against eggs at the end of the study (day 76).</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 4","pages":"285-92"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27212279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the mucosal immune response in dogs vaccinated with either an intranasal avirulent live culture or a subcutaneous antigen extract vaccine of Bordetella bronchiseptica. 鼻内无毒株活培养或皮下抗原提取疫苗接种犬粘膜免疫反应的比较
Veterinary Therapeutics Pub Date : 2007-01-01
Randy Davis, Huchappa Jayappa, Omar Y Abdelmagid, Rob Armstrong, Diane Sweeney, Craig Lehr
{"title":"Comparison of the mucosal immune response in dogs vaccinated with either an intranasal avirulent live culture or a subcutaneous antigen extract vaccine of Bordetella bronchiseptica.","authors":"Randy Davis,&nbsp;Huchappa Jayappa,&nbsp;Omar Y Abdelmagid,&nbsp;Rob Armstrong,&nbsp;Diane Sweeney,&nbsp;Craig Lehr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Healthy dogs with low antibody titer to Bordetella bronchiseptica were vaccinated intranasally with an avirulent live vaccine, subcutaneously with an antigen extract vaccine, or subcutaneously and intranasally with a placebo. Intranasally vaccinated dogs developed B. bronchiseptica-specific IgA titers in nasal secretions that remained at high levels until the end of the study; dogs vaccinated subcutaneously with the antigen extract or placebo did not develop measurable antigen-specific IgA titers in nasal secretions. Dogs were challenged with virulent live B. bronchiseptica 63 days after vaccination. Intranasally vaccinated dogs had significantly lower cough scores (P < or =.0058) and shed significantly fewer challenge organisms (P <.0001) than dogs in either of the other groups. Cough scores of subcutaneously vaccinated dogs were not significantly different from placebo-vaccinated dogs.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"8 1","pages":"32-40"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26677305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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