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Experimental reproduction of canine influenza virus H3N8 infection in young puppies. 犬流感病毒H3N8感染幼犬的实验繁殖。
Veterinary Therapeutics Pub Date : 2009-02-01
Muralidhar Deshpande, Omar Abdelmagid, Anna Tubbs, Huchappa Jayappa, Terri Wasmoen
{"title":"Experimental reproduction of canine influenza virus H3N8 infection in young puppies.","authors":"Muralidhar Deshpande,&nbsp;Omar Abdelmagid,&nbsp;Anna Tubbs,&nbsp;Huchappa Jayappa,&nbsp;Terri Wasmoen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Canine influenza virus (CIV) subtype H3N8 has emerged as a new pathogen with sustained transmission in the dog population in the United States. In this study, we report the experimental induction of respiratory disease in dogs using three CIV field isolates. Young (14 to 15 weeks of age) CIV-seronegative pups were challenged with one of three CIV isolates and monitored for clinical signs of respiratory disease, nasal virus shedding, seroconversion, lung lesions, and virus isolation from the lower respiratory tract. The challenged pups developed clinical signs and lung lesions typical of influenza virus infection, shed virus in their nasal secretions for 7 to 8 days after challenge, and exhibited serum antibodies at 7 and 14 days after challenge. Lung tissues and tracheal swabs collected at 3 and 6 days after challenge exhibited active virus replication. These results demonstrate that CIV causes respiratory disease in dogs.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves. 氟苯尼考-氟尼新-大聚胺与图拉霉素治疗坠落饲养小牛未分化性发热的比较。
Veterinary Therapeutics Pub Date : 2009-02-01
Joyce Van Donkersgoed, Janice Berg, Steven Hendrick
{"title":"A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves.","authors":"Joyce Van Donkersgoed,&nbsp;Janice Berg,&nbsp;Steven Hendrick","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to compare the efficacy of a new combination drug, florfenicol-flunixin meglumine, with tulathromycin for initial treatment of undifferentiated fever (UF) in fall-placed calves that received metaphylactic tilmicosin on arrival at the feedlot. No significant differences were observed in UF relapses between the two drugs. Calves treated with florfenicol-flunixin had a lower crude case fatality rate (P = .0447) than calves treated with tulathromycin but did not have a significantly lower respiratory disease and histophilosis case fatality rate (P = .12). Whether the new florfenicol-flunixin product is more cost-effective than tulathromycin for the treatment of UF in fall-placed feedlot calves will depend on how the new product is priced in the marketplace relative to tulathromycin.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"78-85"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary study of protamine zinc recombinant insulin for the treatment of diabetes mellitus in cats. 鱼精蛋白锌重组胰岛素治疗猫糖尿病的初步研究。
Veterinary Therapeutics Pub Date : 2009-02-01
Gary Norsworthy, Randy Lynn, Cynthia Cole
{"title":"Preliminary study of protamine zinc recombinant insulin for the treatment of diabetes mellitus in cats.","authors":"Gary Norsworthy,&nbsp;Randy Lynn,&nbsp;Cynthia Cole","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The efficacy of a new protamine zinc formulation based on recombinant insulin (PZIR) was compared with a veterinary-approved beef/pork-source insulin (PZI VET, Idexx Pharmaceuticals) that has been shown to significantly decrease blood glucose in cats with diabetes mellitus (DM). After being examined and weighed and having blood collected for determination of serum fructosamine concentrations, 50 cats with DM and stable glycemic control on PZI VET were switched to PZIR for 30 days at the same dose rate and interval. There was only one reported episode of hypoglycemia, and the cat was withdrawn from the study. In the 47 cats completing the study, there were no significant differences in body weight or serum fructosamine concentrations at days 15 or 30 compared with day 0. The results of this study indicate that PZIR provides glycemic control that is comparable to that of PZI VET when used at the same dose and dosing interval.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"24-8"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a combination of a fipronil-(S)-methoprene spot-on formulation and a deltamethrin-impregnated collar in controlling fleas and sandflies on dogs. 氟虫腈-(S)-甲基戊二烯喷剂与溴氰菊酯浸渍项圈组合防治狗身上跳蚤和白蛉的效果。
Veterinary Therapeutics Pub Date : 2009-02-01
M Franc, E Bouhsira
{"title":"Efficacy of a combination of a fipronil-(S)-methoprene spot-on formulation and a deltamethrin-impregnated collar in controlling fleas and sandflies on dogs.","authors":"M Franc,&nbsp;E Bouhsira","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigated the use of two commercial products, a deltamethrin-impregnated collar and a fipronil-(S)-methoprene spot-on formulation, in combination to protect dogs against sandflies and fleas when they live in or travel to leishmaniasis-enzootic areas. Interactions, tolerance, and efficacy were evaluated. The combination was well tolerated by the six treated dogs. The antifeeding effect on Phlebotomus perniciosus ranged from 89.6% (day 1) to 99.51% (day 21) and exceeded 95% from day 7 through the end of the study; the mortality effect against P. perniciosus ranged from 87.52% (day 22) to 96.82% (day 15). The combination was 100% effective in controlling Ctenocephalides felis felis infestations for 36 days after treatment. These results suggest that it is feasible and advantageous to combine these two commercial products to protect dogs against sandflies and fleas in leishmaniasis-enzootic areas.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"71-7"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a 1-hour IV infusion of doxorubicin on the development of cardiotoxicity in dogs as evaluated by electrocardiography and echocardiography. 通过心电图和超声心动图评估1小时静脉输注阿霉素对犬心脏毒性发展的影响。
Veterinary Therapeutics Pub Date : 2009-02-01
Sarah Gillings, Jeffrey Johnson, Amanda Fulmer, Marlene Hauck
{"title":"Effect of a 1-hour IV infusion of doxorubicin on the development of cardiotoxicity in dogs as evaluated by electrocardiography and echocardiography.","authors":"Sarah Gillings,&nbsp;Jeffrey Johnson,&nbsp;Amanda Fulmer,&nbsp;Marlene Hauck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiotoxicity is a potentially life-threatening consequence of treatment with doxorubicin. Without reliable predictive or monitoring tests for early intervention, preventive methods are warranted. This study tested the hypothesis that a 1-hour infusion of doxorubicin would reduce the incidence of cardiotoxicity compared with historical incidences. Inclusion criteria for this retrospective trial were a minimum of three doses of doxorubicin administered as a 1-hour infusion in patients with at least two echocardiographic or electrocardiographic examinations during the course of treatment (median cumulative dose, 120 mg/m2). Of 133 dogs, 16 (12%) developed electrocardiographic abnormalities during or after treatment, which was statistically lower than the historical incidence of 17.7% (31 of 175 dogs). Only seven dogs (5.3%) developed abnormalities during the course of therapy. Three (2%) developed congestive heart failure.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"46-58"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a bioelectric impedance device in obese and lean healthy dogs to estimate body fat percentage. 在肥胖和瘦弱的健康狗身上使用生物电阻抗装置来估计体脂百分比。
Veterinary Therapeutics Pub Date : 2009-02-01
Richard Stone, Nora Berghoff, Jorg Steiner, Deb Zoran
{"title":"Use of a bioelectric impedance device in obese and lean healthy dogs to estimate body fat percentage.","authors":"Richard Stone,&nbsp;Nora Berghoff,&nbsp;Jorg Steiner,&nbsp;Deb Zoran","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A hand-held bioelectric impedance device was used to obtain body fat percentages from obese and lean healthy client-owned dogs. Bioelectric impedance values were compared with body condition scores assigned on a 9-point scale during physical examination to evaluate the correlation of these two methods for assessing body composition. A good correlation was revealed between body fat percentage as measured by the bioelectric impedance device and body condition score. The results of this study suggest that bioelectric impedance measurements of body fat percentage could be used by veterinary practitioners as an objective measure of adiposity when diagnosing and managing obese dogs.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"59-70"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28393272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Prevalence of intestinal parasites in companion animals in Ontario and Quebec, Canada, during the winter months. 关于加拿大安大略省和魁北克省冬季伴侣动物肠道寄生虫的流行情况。
Veterinary Therapeutics Pub Date : 2009-02-01
Andrew S Peregrine, Jan M Sargeant
{"title":"Re: Prevalence of intestinal parasites in companion animals in Ontario and Quebec, Canada, during the winter months.","authors":"Andrew S Peregrine,&nbsp;Jan M Sargeant","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 1-2","pages":"5-6; author reply 6-7"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28396002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of calcium chloride and calcium sulfate in an oral bolus given as a supplement to postpartum dairy cows. 产后奶牛口服补充氯化钙和硫酸钙丸的效果。
Veterinary Therapeutics Pub Date : 2009-01-01
J D Sampson, J N Spain, C Jones, L Carstensen
{"title":"Effects of calcium chloride and calcium sulfate in an oral bolus given as a supplement to postpartum dairy cows.","authors":"J D Sampson,&nbsp;J N Spain,&nbsp;C Jones,&nbsp;L Carstensen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An oral calcium bolus (Bovikalc, Boehringer Ingelheim Vetmedica) supplying calcium to dairy cows in the form of calcium chloride and calcium sulfate was evaluated to determine the effect on calcium homeostasis immediately after calving. Cows in the treatment group received one bolus immediately after calving and a second bolus 12 hours later. Control cows received no calcium supplementation. Blood was analyzed for ionized calcium, and urine was collected for urinary pH determination. Postpartum supplementation with the Bovikalc bolus significantly increased serum ionized calcium levels and decreased urine pH values.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 3","pages":"131-9"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28618383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection. 止吐药Cerenia(马洛匹坦)冷藏对注射疼痛的影响。
Veterinary Therapeutics Pub Date : 2009-01-01
Sunil Thomas Narishetty, Betsy Galvan, Eileen Coscarelli, Michelle Aleo, Tim Fleck, William Humphrey, Robert B McCall
{"title":"Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection.","authors":"Sunil Thomas Narishetty,&nbsp;Betsy Galvan,&nbsp;Eileen Coscarelli,&nbsp;Michelle Aleo,&nbsp;Tim Fleck,&nbsp;William Humphrey,&nbsp;Robert B McCall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Injection pain has been associated with veterinary use of the antiemetic maropitant (Cerenia, Pfizer Animal Health). Cerenia is formulated using sulphobutylether-beta-cyclodextrin to bind maropitant and mitigate injection pain. The objective of this study was to determine whether the temperature of Cerenia alters binding between maropitant and sulphobutylether-beta-cyclodextrin and affects injection pain. Binding decreased as temperature increased, and Cerenia-elicited injection pain increased at warmer drug temperatures. These data suggest that the amount of free unbound maropitant increases with temperature and that injection pain increases with temperature in a similar fashion. Clinically, these studies suggest that injection of refrigerated Cerenia may significantly reduce or eliminate pain associated with SC injection of Cerenia.</p>","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 3","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28616963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea. 犬源动物双歧杆菌AHC7益生菌治疗犬急性特发性腹泻的临床疗效
Veterinary Therapeutics Pub Date : 2009-01-01 DOI: 10.5167/UZH-31198
R. L. Kelley, D. Minikhiem, B. Kiely, L. O’Mahony, David O'Sullivan, T. Boileau, J. Park
{"title":"Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea.","authors":"R. L. Kelley, D. Minikhiem, B. Kiely, L. O’Mahony, David O'Sullivan, T. Boileau, J. Park","doi":"10.5167/UZH-31198","DOIUrl":"https://doi.org/10.5167/UZH-31198","url":null,"abstract":"This study evaluated the effect of supplementation with canine-derived probiotic Bifidobacterium animalis strain AHC7 (lams Prostora, Procter & Gamble Pet Care) on the resolution rate of acute idiopathic diarrhea in dogs randomly assigned to receive a placebo (n=18) or the probiotic (n=13). Nutritional management with the probiotic fed at 2 x 10(10) CFU/day significantly reduced the time to resolution (3.9 +/- 2.3 versus 6.6 +/- 2.7 days; P < .01) and reduced the percentage of dogs that were administered metronidazole (38.5% versus 50.0%) compared with placebo. Probiotic B. animalis AHC7 may provide veterinarians another tool for management of acute diarrhea in dogs.","PeriodicalId":51211,"journal":{"name":"Veterinary Therapeutics","volume":"10 3 1","pages":"121-30"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70648317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
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