{"title":"Intraoperative autonomic field block combined with the transversus abdominis plane block: for left-sided colectomies (video forum).","authors":"A Caycedo-Marulanda, A Sánchez, M Ferrara, J Daes","doi":"10.1007/s10151-025-03154-y","DOIUrl":"10.1007/s10151-025-03154-y","url":null,"abstract":"","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"117"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Fuschillo, F Pata, M D'Ambrosio, L Selvaggi, M Pescatori, F Selvaggi, G Pellino
{"title":"Failure rates and complications of four sphincter-sparing techniques for the treatment of fistula-in-ano: a systematic review and network meta-analysis.","authors":"G Fuschillo, F Pata, M D'Ambrosio, L Selvaggi, M Pescatori, F Selvaggi, G Pellino","doi":"10.1007/s10151-025-03152-0","DOIUrl":"10.1007/s10151-025-03152-0","url":null,"abstract":"<p><strong>Background: </strong>Several techniques are available to reduce the risk of sphincter injury when treating anal fistula, such as ligation of the intersphincteric fistula tract (LIFT), video-assisted anal fistula treatment (VAAFT), fistula laser closure (FiLaC) and endoanal flap (EAF). The aim of this meta-analysis is to provide data on the safety, complications and failure of these techniques.</p><p><strong>Methods: </strong>Studies published after 2017, with patients undergoing at least one among LIFT, VAAFT, FiLaC and EAF for perianal fistula and providing data regarding failure, were retrieved from PubMed and EMBASE. Primary outcome was failure; other outcomes included continence disturbance and complications.</p><p><strong>Results: </strong>Forty-nine articles with 3520 patients were included. The failure rates were 28.6% (range 3.8-75) for LIFT, 22.3% (6.2-65.2) for VAAFT, 43.9% (11.1-80) for FiLaC and 25.9% (4.7-100) for EAF, with a mean follow-up of 35.4 (6-80.4), 32.4 (6-48), 31.6(6.3-60) and 42.4 (12-155) months. The available network meta-analysis on failure showed RD of -0.08 (95% CI - 0.58 to 0.42) comparing LIFT vs VAAFT and 0.30 (95% CI 0.03 to 0.58) comparing LIFT vs EAF. No patients undergoing VAAFT or FiLaC reported worsening continence, while for LIFT and EAF, the continence disturbance rate was 1.5% and 7.3%, respectively. No major complications were observed. The most common minor complications were pain (1.4%), bleeding (1.1%) and wound infection (1.2%). Overall, minor complication rates were 4.3% for LIFT, 7.2% for VAAFT, 10.2% for FiLaC and 6.2% for EAF. Crohn's disease was associated with a higher failure rate (39.5% vs 31.4%).</p><p><strong>Conclusions: </strong>FiLaC, VAAFT, LIFT and EAF may represent a valid option in the treatment of anal fistula. VAAFT showed the lowest rate of failure but with no differences from network metanalysis. Wider homogeneous studies with long-term follow-up are necessary to obtain more robust data.</p><p><strong>Prospero number: </strong>CRD42022375600.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"116"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedja Cuk, A W Rosen, M Mashkoor, M B Ellebæk, I Gögenur
{"title":"Surgical stress response and long-term survival in robot-assisted versus laparoscopic surgery for colon cancer: a propensity matched nationwide cohort study.","authors":"Pedja Cuk, A W Rosen, M Mashkoor, M B Ellebæk, I Gögenur","doi":"10.1007/s10151-025-03146-y","DOIUrl":"10.1007/s10151-025-03146-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the potential correlation between the surgical stress response and long-term survival in patients undergoing treatment for colon cancer using either RAS (robot-assisted surgery) or LAS (laparoscopic surgery) and whether this correlation is influenced by the surgical approach. The primary objective was to assess the association between postoperative C-reactive protein (CRP) response and recurrence-free survival in RAS compared with LAS. Secondary endpoints included all-cause mortality and time-to-recurrence.</p><p><strong>Methods: </strong>This Danish nationwide cohort study included patients diagnosed with Union for International Cancer Control (UICC) stage I-III colon cancer who underwent either RAS or LAS between 2010 and 2018. We employed the Cox proportional regression model to analyze the time-to-event outcomes for both primary and secondary endpoints in patients exhibiting either a low postoperative CRP response (< 80 mg/L) or a high CRP response (CRP ≥ 80 mg/L).</p><p><strong>Results: </strong>A total of 3484 patients were included in the study, with 490 (14.1%) undergoing RAS and 2994 (85.9%) undergoing LAS. The median follow-up time was 32.5 months (interquartile range [IQR] = 21.0-48.7) for the RAS group and 35.4 months (IQR = 22.8-50.9) for the LAS group. In the RAS group, a lower CRP response (CRP < 80 mg/L) was not associated with improved recurrence-free survival (HR = 0.78, 95% confidence interval [CI] [0.53-1.13], p = 0.184), all-cause mortality (hazard ratio [HR] = 0.76, 95% CI [0.46-1.26], p = 0.282), or time-to-recurrence (HR = 0.64, 95% CI [0.49-1.06], p = 0.079).</p><p><strong>Conclusions: </strong>The postoperative CRP response was not significantly associated with improved long-term survival outcomes in patients undergoing RAS or LAS for UICC stage I-III colon cancer.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"115"},"PeriodicalIF":2.7,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Sakamoto, K Okabayashi, R Seishima, K Shigeta, H Kiyohara, Y Mikami, T Kanai, Y Kitagawa
{"title":"Radiomics prediction of surgery in ulcerative colitis refractory to medical treatment.","authors":"K Sakamoto, K Okabayashi, R Seishima, K Shigeta, H Kiyohara, Y Mikami, T Kanai, Y Kitagawa","doi":"10.1007/s10151-025-03139-x","DOIUrl":"https://doi.org/10.1007/s10151-025-03139-x","url":null,"abstract":"<p><strong>Background: </strong>The surgeries in drug-resistant ulcerative colitis are determined by complex factors. This study evaluated the predictive performance of radiomics analysis on the basis of whether patients with ulcerative colitis in hospital were in the surgical or medical treatment group by discharge from hospital.</p><p><strong>Methods: </strong>This single-center retrospective cohort study used CT at admission of patients with US admitted from 2015 to 2022. The target of prediction was whether the patient would undergo surgery by the time of discharge. Radiomics features were extracted using the rectal wall at the level of the tailbone tip of the CT as the region of interest. CT data were randomly classified into a training cohort and a validation cohort, and LASSO regression was performed using the training cohort to create a formula for calculating the radiomics score.</p><p><strong>Results: </strong>A total of 147 patients were selected, and data from 184 CT scans were collected. Data from 157 CT scans matched the selection criteria and were included. Five features were used for the radiomics score. Univariate logistic regression analysis of clinical information detected a significant influence of severity (p < 0.001), number of drugs used until surgery (p < 0.001), Lichtiger score (p = 0.024), and hemoglobin (p = 0.010). Using a nomogram combining these items, we found that the discriminatory power in the surgery and medical treatment groups was AUC 0.822 (95% confidence interval (CI) 0.841-0.951) for the training cohort and AUC 0.868 (95% CI 0.729-1.000) for the validation cohort, indicating a good ability to discriminate the outcomes.</p><p><strong>Conclusions: </strong>Radiomics analysis of CT images of patients with US at the time of admission, combined with clinical data, showed high predictive ability regarding a treatment strategy of surgery or medical treatment.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"113"},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Shojaei-Zarghani, K Gorgi, A Bananzadeh, A R Safarpour, S V Hosseini
{"title":"Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis.","authors":"S Shojaei-Zarghani, K Gorgi, A Bananzadeh, A R Safarpour, S V Hosseini","doi":"10.1007/s10151-025-03136-0","DOIUrl":"10.1007/s10151-025-03136-0","url":null,"abstract":"<p><strong>Background: </strong>Low anterior resection syndrome (LARS) is a term that encompasses multidimensional bowel dysfunction that typically occurs following resections of rectum and distal parts of the colon. We aimed to systematically assess the available literature on the effects of bowel dysfunction after colorectal cancer (CRC) surgeries on health-related quality of life (HRQOL) and conduct a meta-analysis.</p><p><strong>Methods: </strong>Studies were included if they assessed patients who had undergone sphincter-preservation surgeries for CRC. Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).</p><p><strong>Results: </strong>Of 1410 reports, 28 studies were included. According to the analyses, patients with major LARS had lower global health status [weighted mean differences (WMD) = - 10.98; 95% confidence interval (CI) - 13.18, - 8.79], physical functioning (WMD = - 5.96; 95% CI - 7.40, - 4.52), role functioning (WMD = - 10.59; 95% CI - 12.54, - 8.63), emotional functioning (WMD = - 11.09; 95% CI - 14.34, 7.84), cognitive functioning (WMD = - 9.27; 95% CI - 12.22, - 6.32), and social functioning (WMD = - 15.73; 95% CI - 18.82, - 12.63) and higher scores of symptoms compared to patients with minor/no LARS.</p><p><strong>Conclusions: </strong>The study findings suggest that patients with major LARS experience worse HRQOL compared to those with minor/no LARS.</p><p><strong>Registration: </strong>PROSPERO, CRD42023479657.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"114"},"PeriodicalIF":2.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Y van Oostendorp, A Eddarazi, C B H Molenaar, D D E Zimmerman, W A Bemelman, I J M Han-Geurts
{"title":"Mid- and long-term functional outcomes of advancement flap for cryptoglandular perianal fistulas.","authors":"J Y van Oostendorp, A Eddarazi, C B H Molenaar, D D E Zimmerman, W A Bemelman, I J M Han-Geurts","doi":"10.1007/s10151-025-03148-w","DOIUrl":"https://doi.org/10.1007/s10151-025-03148-w","url":null,"abstract":"<p><strong>Background: </strong>Surgical treatment for perianal fistulas requires balancing fistula closure with the risk of complications such as incontinence. The advancement flap (AF) is a widely used sphincter-sparing technique, yet it appears to offer only marginally better outcomes compared to alternative techniques, with a notable incontinence rate. This study aimed to evaluate the success rate and long-term functional outcomes of AF at our tertiary referral center.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed prospectively collected data from electronic medical records and questionnaires distributed in December 2023. Patients aged 18 or older with primary or recurrent perianal fistulas treated with AF between 2013 and 2023 were included. Fistulas of non-cryptoglandular origin and rectovaginal fistulas were excluded. The primary outcome was fecal incontinence. Secondary outcomes included disease burden, fistula closure, and risk factors for recurrence.</p><p><strong>Results: </strong>Eighty-one patients were included; 37 (46%) were women, mean age was 45 years, and 93% had a complex fistula. The median follow-up was 27 months (IQR 15.5-64). Before AF, 36% reported some degree of incontinence, increasing to 80% at long-term follow-up after AF. Specifically, 20 out of 26 (77%) preoperative fully continent patients reported incontinence issues at long-term follow-up. Fistula disease impact on daily life was higher for those who failed AF repair. Primary fistula closure was achieved in 35 patients (43%). No risk factors for AF failure could be identified.</p><p><strong>Conclusions: </strong>Advancement flap repair of perianal fistulas is challenging and can lead to fecal incontinence, so thorough preoperative counseling, consistent long-term follow-up, and further research comparing alternative sphincter-sparing techniques are warranted.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"112"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Carvalho, T Leal, B Arroja, P Mesquita, I Malta, T Gago, A R Gonçalves, R Coelho, S B Ponte, P Salgueiro, F Castro-Poças, A C Bravo, C Gouveia, A M Oliveira, M Francisco, R Gonçalves, A C Caetano
{"title":"Efficacy and safety of office-based procedures for hemorrhoidal disease in patients with inflammatory bowel disease.","authors":"T Carvalho, T Leal, B Arroja, P Mesquita, I Malta, T Gago, A R Gonçalves, R Coelho, S B Ponte, P Salgueiro, F Castro-Poças, A C Bravo, C Gouveia, A M Oliveira, M Francisco, R Gonçalves, A C Caetano","doi":"10.1007/s10151-025-03144-0","DOIUrl":"https://doi.org/10.1007/s10151-025-03144-0","url":null,"abstract":"<p><strong>Background: </strong>Hemorrhoidal disease (HD) affects 2-20% of patients with inflammatory bowel disease (IBD) but treatment recommendations are scarce due to fear of higher morbidity in these patients. Currently, there is almost no data regarding nonsurgical treatment for HD in patients with IBD. This study aimed to evaluate the safety and efficacy of office-based procedures for HD in patients with IBD.</p><p><strong>Methods: </strong>A Portuguese multicenter retrospective study of patients with IBD undergoing office-based treatment for HD between July 2013 and December 2021 was performed. Data regarding the patients' IBD (type, disease location, medication, endoscopic remission) and HD (clinical success, recurrence, complications) were analyzed.</p><p><strong>Results: </strong>A total of 129 patients were included, 90 with ulcerative colitis and 37 with Crohn's disease. Only 55% of patients presented endoscopic remission and 18% were under biologics. Additionally, 77 patients underwent rubber band ligation (RBL), 44 underwent polidocanol injection, and 8 had both treatments, for a total of 304 procedures. The treatment of HD was effective in 88% of patients, of which 16% relapsed (mean follow-up time of 55.3 ± 34.5 months). Complications were described in 17 (5.6%) procedures, 2 (0.66%) requiring invasive treatment. There were no cases of suppuration, stenosis, or anal incontinence. Success, relapse, and complications were not associated with IBD features. Clinical success and recurrence were similar between RBL and polidocanol foam sclerotherapy (PFS). RBL had more complications than PFS (15.6% versus 2.6%).</p><p><strong>Conclusions: </strong>This study is the first to focus exclusively on office-based procedures for hemorrhoidal disease in patients with IBD, demonstrating similar efficacy to the general population and a low complication rate.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"111"},"PeriodicalIF":2.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Venara, E Houlet, E Poupard, M André, P E Bouet, J Gillet, J F Hamel
{"title":"Correction: Sphincter repair procedures may be favored in the treatment of obstetrical recto‑vaginal fistula: a systematic review of the literature and meta‑analysis.","authors":"A Venara, E Houlet, E Poupard, M André, P E Bouet, J Gillet, J F Hamel","doi":"10.1007/s10151-025-03168-6","DOIUrl":"10.1007/s10151-025-03168-6","url":null,"abstract":"","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"110"},"PeriodicalIF":2.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Demir, S E Bölük, I Sücüllü, B Güleç, S Bölük
{"title":"Efficacy of crystallized and liquid form phenol application in pilonidal sinus disease: a single-center retrospective study.","authors":"Mustafa Demir, S E Bölük, I Sücüllü, B Güleç, S Bölük","doi":"10.1007/s10151-025-03143-1","DOIUrl":"https://doi.org/10.1007/s10151-025-03143-1","url":null,"abstract":"<p><strong>Aim and objective: </strong>Pilonidal sinus is a frequently observed disease in young adult male patients. Although its treatment is traditionally surgical, the tendency to use minimally invasive interventions has increased over time. This study aims to compare the clinical results of the non-surgical treatment methods for pilonidal sinus: crystallized and liquid phenol applications.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed the data of 102 patients treated with phenol application in the General Surgery Clinic of our hospital between July 2017 and July 2019. Eighty patients were included in the study: 40 treated with crystallized phenol and 40 with liquid phenol. In the 1st month following the application, the recovery rates, complication rates, persistence of complaints, and recurrence at the end of the 1st year were compared between the groups.</p><p><strong>Results: </strong>The mean age was 25.60 ± 7.16 and 25.78 ± 7.83 years in the crystallized (group 1) and liquid phenol group (group 2), respectively. Complications observed up to the 3rd week of follow-up were considered early complications, while those observed after the 3rd week were considered late complications. Early complications were observed in 15% and 37.5% of patients in groups 1 and 2, respectively (p = 0.042). Early complications were significantly higher in the liquid phenol group compared to the crystallized phenol group. At the end of the 1st year, 90% improvement was detected in group 1 and 95% in group 2. However, there was no significant difference between the recovery and recurrence rates between the groups.</p><p><strong>Conclusion: </strong>In pilonidal sinus treatment, successful results are obtained with both crystallized and liquid phenol application. Both methods can be performed safely and easily as an alternative treatment method to surgery.</p>","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"109"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Tokunaga, H Kashihara, T Yoshimoto, D Ishikawa, M Nishi, C Takasu, Y Wada, C Nakasu, M Shimada
{"title":"Transperineal approach alone as minimally invasive surgery for pelvic recurrence of rectal cancer after abdominoperineal resection.","authors":"T Tokunaga, H Kashihara, T Yoshimoto, D Ishikawa, M Nishi, C Takasu, Y Wada, C Nakasu, M Shimada","doi":"10.1007/s10151-025-03147-x","DOIUrl":"https://doi.org/10.1007/s10151-025-03147-x","url":null,"abstract":"","PeriodicalId":51192,"journal":{"name":"Techniques in Coloproctology","volume":"29 1","pages":"108"},"PeriodicalIF":2.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}