Manuela Cerbone, Harshini Katugampola, Helen L Simpson, Mehul T Dattani
{"title":"Approach to the Patient: Management of Pituitary Hormone Replacement Through Transition.","authors":"Manuela Cerbone, Harshini Katugampola, Helen L Simpson, Mehul T Dattani","doi":"10.1210/clinem/dgac129","DOIUrl":"10.1210/clinem/dgac129","url":null,"abstract":"<p><p>Hypopituitarism in childhood is a rare, complex disorder that can present with highly variable phenotypes, which may continue into adult life. Pituitary deficits can evolve over time, with unpredictable patterns resulting in significant morbidity and mortality. Hypopituitarism and hypothalamic dysfunction may be associated with challenging comorbidities such as obesity, learning difficulties, behavioral issues, sleep disturbance, and visual impairment. Transition is the purposeful planned movement of adolescents and young adults with chronic conditions from child-centered to adult-oriented health care systems with a shift from parent- to patient-focused care. To achieve effective transition within a health care setting, the inherent challenges involved in the evolution from a dependent child to an independent adult must be recognized. Transition is a critical time medically for patients with hypopituitarism. Complex issues with respect to puberty, attainment of optimal stature, adherence to treatment, and acceptance of the need for life-sustaining medications need to be addressed. For health care professionals, transition is an opportunity for reassessment of the pituitary deficits and the need for lifelong replacement therapies, often against a background of complex psychological issues. We present 4 illustrative cases of hypopituitarism of differing etiologies with diverse clinical presentations. Diagnostic and management processes from clinical presentation to young adulthood are discussed, with a particular focus on needs and outcomes through transition.</p>","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"33 1","pages":"2077-2091"},"PeriodicalIF":5.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88777278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A model for investigating vehicle-bridge interaction under high moving speed","authors":"Li Hanyun, Yu Zhiwu, W. Guo, Yan Han","doi":"10.12989/SEM.2021.77.5.627","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.5.627","url":null,"abstract":"The speed of rail vehicles become higher and higher over two decades, and China has unveiled a prototype highspeed train in October 2020 that has been able to reach 400 km/h. At such high speeds, wheel-rail force items that had previously been ignored in common computational model should be reevaluated and reconsidered. Aiming at this problem, a new model for investigating the vehicle-bridge interaction at high moving speed is proposed. Comparing with the common model, the new model was more accurate and applicable, because it additionally considers the second-order pseudo-inertia forces effect and its modeling equilibrium position was based on the initial deformed curve of bridge, which could include the influences of temperature, pre-camber, shrinkage and creep deformation, and pier uneven settlement, etc. Taking 5 km/h as the speed interval, the dynamic responses of the classical vehicle-bridge system in the speed range of 5 km/h to 400 km/h are studied. The results show that ignoring the second-order pseudo-inertia force will underestimate the dynamic response of vehicle-bridge system and make the high-speed railway bridge structure design unsafe.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"627-635"},"PeriodicalIF":2.2,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41901933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Damage detection using both energy and displacement damage index on the ASCE benchmark problem","authors":"M. J. Khosraviani, O. Bahar, S. Ghasemi","doi":"10.12989/SEM.2021.77.2.151","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.2.151","url":null,"abstract":"This paper aims to present a novelty damage detection method to identify damage locations by the simultaneous use of both the energy and displacement damage indices. Using this novelty method, the damaged location and even the damaged floor are accurately detected. As a first method, a combination of the instantaneous frequency energy index (EDI) and the structural acceleration responses are used. To evaluate the first method and also present a rapid assessment method, the Displacement Damage Index (DDI), which consists of the error reliability (β) and Normal Probability Density Function (NPDF) indices, are introduced. The innovation of this method is the simultaneous use of displacement-acceleration responses during one process, which is more effective in the rapid evaluation of damage patterns with velocity vectors. In order to evaluate the effectiveness of the proposed method, various damage scenarios of the ASCE benchmark problem, and the effects of measurement noise were studied numerically. Extensive analyses show that the rapid proposed method is capable of accurately detecting the location of sparse damages through the building. Finally, the proposed method was validated by experimental studies of a six‐story steel building structure with single and multiple damage cases.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"151-165"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66120387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Abbas, N. Siddiqui, T. Almusallam, A. Abadel, H. Elsanadedy, Y. Al-Salloum
{"title":"Effect of rebar spacing on the behavior of concrete slabs under projectile impact","authors":"H. Abbas, N. Siddiqui, T. Almusallam, A. Abadel, H. Elsanadedy, Y. Al-Salloum","doi":"10.12989/SEM.2021.77.3.329","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.3.329","url":null,"abstract":"In this paper, the effect of different steel bar configurations on the quasi-static punching and impact response of concrete slabs was studied. A total of forty RC square slab specimens were cast in two groups of concrete strengths of 40 and 63 MPa. In each group of twenty specimens, ten specimens were reinforced at the back face (singly reinforced), and the remaining specimens were reinforced on both faces of the slab (doubly reinforced). Two rebar spacing of 25 and 100 mm, with constant reinforcement ratio and effective depth, were used in both singly and doubly reinforced slab specimens. The specimens were tested against the normal impact of cylindrical projectiles of hemispherical nose shape. Slabs were also quasi-statically tested in punching using the same projectile, which was employed for the impact testing. The experimental response illustrates that 25 mm spaced rebars are effective in (I) decreasing the local damage and overall penetration depth, (II) increasing the absorption of impact energy, and (III) enhancing the ballistic limit of RC slabs. The ballistic limit was predicted using the quasi-static punching test results of slab specimens showing a strong correlation between the dynamic perforation energy and the energy required for quasi-static perforation of slabs.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"329-342"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66120780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun-xiao He, Juan Wang, Qin Yang, Miao Han, Y. Deng
{"title":"Study on mechanical behaviors of loose mortise-tenon joint with neighbouring gap","authors":"Jun-xiao He, Juan Wang, Qin Yang, Miao Han, Y. Deng","doi":"10.12989/SEM.2021.77.4.509","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.4.509","url":null,"abstract":"The neighbouring gaps at the mortise-tenon joint in traditional timber structure, which leads to the complexity of the joint, are considered to impair the mechanical performance of the joint. In this paper, numerical simulation of loose joint was conducted to examine the deformation states, stress distributions, and bearing capacities, which was verified by full-scale test. On the basis of the experimental and numerical results, a simplified mechanics model with gaps has been proposed to present the bending capacity of the loose joint. Besides, the gap effects and parameter studies on the influences of tenon height, friction coefficient, elastic modulus and axial load were also investigated. As a result, the estimated relationship between moment and rotation angle of loose joint showed the agreement with the numerical results, demonstrating validity of the proposed model; The bending bearing capacity and rotational stiffness of loose joint had a certain drop with the increasing of gaps; and the tenon height may be the most important factor affecting the mechanical behaviors of the joint when it is subjected to repeated load; Research results can provide important references on the condition assessments of the existing mortise-tenon joint.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"509-521"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66121412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In-situ dynamic loading test of a hybrid continuous arch bridge","authors":"Hongye Gou, L. Liang, Yu Hong, Y. Bao, Q. Pu","doi":"10.12989/SEM.2021.77.6.809","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.6.809","url":null,"abstract":"In this study, the dynamic behavior of a three-span hybrid continuous arch bridge under vehicle loading is investigated. The natural vibration characteristics of the bridge were analyzed through pulsation test. In the dynamic loading test, the vibrations of the bridge under different truck speeds and different pavement conditions were tested, and time histories of deflection and acceleration of the bridge were measured. Based on the dynamic loading test, the impact coefficient was analyzed. The results indicate that the pavement smoothness had more impacts on the vibration of the bridge than the truck's speed. The vertical damping of the bridge under the excitation of the trucks is larger than the transverse damping. Resonance occurs at the side span of the bridge under a truck at 10 km/h.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"809-817"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66123737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electromagnetic field and initial stress on a porothermoelastic medium","authors":"Elsayed M. Abd‐Elaziz","doi":"10.12989/SEM.2021.78.1.001","DOIUrl":"https://doi.org/10.12989/SEM.2021.78.1.001","url":null,"abstract":"In this study, the porothermoelastic problem with the effect of the magnetic field and initial stress was investigated. We applied normal mode analysis to solve the resulting non-dimensional coupled equations. Numerical results for the displacements, temperature distribution, pore pressure, stresses, induced electric field and induced magnetic field distributions are presented graphically and discussed. The medium deformed because of thermal shock and due to the application of the magnetic field, there result an induced magnetic and an induced electric field in the medium. Numerical analyses are given graphically on the square (2D) and cubic (3D) domains to illustrate the effects of the porosity parameter, magnetic field and initial stress parameter on the physical variables.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"78 1","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66123758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concrete filled double skin square tubular stub columns subjected to compression load","authors":"Kojiro Uenaka","doi":"10.12989/SEM.2021.77.6.745","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.6.745","url":null,"abstract":"Concrete filled double skin tubular members (CFDST) consist of double concentric circular or square steel tubes with concrete filled between the two steel tubes. The CFDST members, having a hollow section inside the internal tube, are generally lighter than ordinary concrete filled steel tubular members (CFT) which have a solid cross-section. Therefore, when the CFDST members are applied to bridge piers, reduction of seismic action can be expected. The present study aims to investigate, experimentally, the behavior of CFDST stub columns with double concentric square steel tubes filled with concrete (SS-CFDST) when working under centric compression. Two test parameters, namely, inner-to-outer width ratio and outer square steel tube's width-to-thickness were selected and outer steel tube's width-to-thickness ratio ranging from 70 to 160 were considered. In the results, shear failure of the concrete fill and local buckling of the double skin tubes having largest inner-toouter width ratio were observed. A method to predict axial loading capacity of SS-CFDST is also proposed. In addition, the load capacity in the axial direction of stub column test on SS-CFDST is compared with that of double circular CFDST. Finally, the biaxial stress behavior of both steel tubes under plane stress is discussed.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"745-751"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66123774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed A. Alhassan, R. Al-Rousan, Moheldeen A. Hejazi
{"title":"Concerning the tensor-based flexural formulation: Applications","authors":"Mohammed A. Alhassan, R. Al-Rousan, Moheldeen A. Hejazi","doi":"10.12989/SEM.2021.77.6.765","DOIUrl":"https://doi.org/10.12989/SEM.2021.77.6.765","url":null,"abstract":"Recently, the plate bending analysis has been interpreted in terms of the tensor's components of curvatures and bending moments by presenting the conceptual perspectives of the Hydrostatic Method of Analysis (HM) and theoretical formulations that combine the continuum mechanics with the graphical statics analysis, the theory of thin orthotropic and isotropic plates, and the elasticity theory. In pursuance of uncovering a genuine formulation of the plate's flexural differential equations, that possess the general-covariance and coordinates-independency. This study had then, tackled various natural and structural problems in both solid and fluid branches of the continuum mechanics in a description of such theoretical and conceptual attainment in uncovering the dimensional independent diffeomorphism covariant partial differential laws.","PeriodicalId":51181,"journal":{"name":"Structural Engineering and Mechanics","volume":"77 1","pages":"765-777"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66123924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}