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Neoadjuvant Capecitabine Plus Temozolomide in Atypical Lung NETs. 新辅助卡培他滨加替莫唑胺治疗非典型肺NET
IF 1.8 4区 医学
Oncology-New York Pub Date : 2024-07-08 DOI: 10.46883/2024.25921024
Georgios Evangelou, Ioannis Vamvakaris, Irene Konstantopoulou, Konstantinos Syrigos
{"title":"Neoadjuvant Capecitabine Plus Temozolomide in Atypical Lung NETs.","authors":"Georgios Evangelou, Ioannis Vamvakaris, Irene Konstantopoulou, Konstantinos Syrigos","doi":"10.46883/2024.25921024","DOIUrl":"10.46883/2024.25921024","url":null,"abstract":"<p><p>Neoadjuvant and adjuvant treatment in lung neuroendocrine tumors (NETs) is a field that has not been explored in-depth, with little information on the impact on disease-free survival. This case study highlights the effectiveness of neoadjuvant treatment with capecitabine plus temozolomide (CAPTEM) in a woman with well-differentiated atypical carcinoid. The patient was asymptomatic at diagnosis and was referred to the outpatient NET clinic at Sotiria Hospital in Athens, following an incidental finding on a chest x-ray. 18F-fluorodeoxyglucose (FDG) PET/CT and 68Ga-Dotatoc PET/CT revealed another mass in the pancreas, with avidity in both imaging studies. The patient underwent treatment for 6 months with CAPTEM with a response in the lung NET and mediastinal lymph nodes. However, the mass in the pancreas slightly increased and was removed with a central pancreatectomy. The patient continued treatment with CAPTEM for 6 more months. There was further response according to RECIST 1.1 criteria (partial response in the mediastinal lymph nodes and a 21% regression in the primary tumor size). Pathology report after lobectomy with lymph node dissection showed a pathologic complete response in the mediastinal lymph nodes. Twenty-four months after surgery, the patient remains disease-free and has a good quality of life. Although large clinical trials are needed, this case study underlines the value of preoperative chemotherapy in atypical carcinoids.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 7","pages":"264-268"},"PeriodicalIF":1.8,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Metastatic Spiradenocarcinoma With CDKN2A Mutation. 一例罕见的 CDKN2A 基因突变转移性螺旋状腺癌病例
IF 1.8 4区 医学
Oncology-New York Pub Date : 2024-06-10 DOI: 10.46883/2024.25921022
Jonathan Q Trinh, Shristi Upadhyay Banskota, Alissa S Marr
{"title":"A Rare Case of Metastatic Spiradenocarcinoma With CDKN2A Mutation.","authors":"Jonathan Q Trinh, Shristi Upadhyay Banskota, Alissa S Marr","doi":"10.46883/2024.25921022","DOIUrl":"10.46883/2024.25921022","url":null,"abstract":"<p><p>Spiradenocarcinomas are rare malignant skin adnexal tumors. We describe a novel case of a patient with an aggressive CDKN2A-mutated spiradenocarcinoma who responded to a CDK4/6 inhibitor. This case highlights the unique nature of spiradenocarcinomas as well as the potential benefit of targeted therapy.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 6","pages":"230-231"},"PeriodicalIF":1.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continued Success of Venetoclax in t(11;14) Multiple Myeloma Despite Negative Trials. 尽管试验结果呈阴性，Venetoclax 在 t(11;14) 多发性骨髓瘤中的应用依然成功。
IF 1.8 4区 医学
Oncology-New York Pub Date : 2024-06-10 DOI: 10.46883/2024.25921023
Zachary M Avigan, Joshua Richter Md
{"title":"Continued Success of Venetoclax in t(11;14) Multiple Myeloma Despite Negative Trials.","authors":"Zachary M Avigan, Joshua Richter Md","doi":"10.46883/2024.25921023","DOIUrl":"10.46883/2024.25921023","url":null,"abstract":"<p><p>The June Hot Topics focuses on the challenges venetoclax regimens have faced in multiple myeloma trials.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 6","pages":"239-241"},"PeriodicalIF":1.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI Use in Prostate Cancer: Potential Improvements in Treatments and Patient Care. 人工智能在前列腺癌中的应用：治疗和患者护理的潜在改进。
IF 1.8 4区 医学
Oncology-New York Pub Date : 2024-05-13 DOI: 10.46883/2024.25921021
James B Yu Md Mhs Fastro, Julian C Hong
{"title":"AI Use in Prostate Cancer: Potential Improvements in Treatments and Patient Care.","authors":"James B Yu Md Mhs Fastro, Julian C Hong","doi":"10.46883/2024.25921021","DOIUrl":"10.46883/2024.25921021","url":null,"abstract":"<p><p>Artificial intelligence use in prostate cancer encompasses 4 main areas including diagnostic imaging, prediction of outcomes, histopathology, and treatment planning.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 5","pages":"208-209"},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Which Treatment for Which Patient: Rectal Cancer Management After PROSPECT Trial. 哪种治疗方法适合哪种患者？PROSPECT 试验后的直肠癌管理。
IF 1.8 4区 医学
Oncology-New York Pub Date : 2024-05-13 DOI: 10.46883/2024.25921019
Seth Felder, Jessica Frakes, Manju George, Allison Rosen, Ibrahim Halil Sahin
{"title":"Which Treatment for Which Patient: Rectal Cancer Management After PROSPECT Trial.","authors":"Seth Felder, Jessica Frakes, Manju George, Allison Rosen, Ibrahim Halil Sahin","doi":"10.46883/2024.25921019","DOIUrl":"10.46883/2024.25921019","url":null,"abstract":"<p><p>Determining treatment options for patients with locally advanced rectal cancer after the PROSPECT trial data readout adds an important level to the decision-making process.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 5","pages":"187-190"},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Well-Differentiated Papillary Mesothelioma and Endometrioid Adenocarcinoma Arising From Endometriosis. 同步分化良好的乳头状间皮瘤和子宫内膜异位症引发的子宫内膜样腺癌
IF 1.8 4区 医学
Oncology-New York Pub Date : 2024-05-13 DOI: 10.46883/2024.25921020
Catherine R Lewis, Jocelyn Uchic-Boccella, Jenna Zimmerman, Eirwen Miller, Sharon Liang, Patrick L Wagner
{"title":"Synchronous Well-Differentiated Papillary Mesothelioma and Endometrioid Adenocarcinoma Arising From Endometriosis.","authors":"Catherine R Lewis, Jocelyn Uchic-Boccella, Jenna Zimmerman, Eirwen Miller, Sharon Liang, Patrick L Wagner","doi":"10.46883/2024.25921020","DOIUrl":"10.46883/2024.25921020","url":null,"abstract":"<p><p>Well-differentiated papillary mesothelioma (WDPM) is a rare mesothelial tumor of uncertain malignant potential. We present a unique case of a woman with synchronous WDPM and well-differentiated endometrioid adenocarcinoma (EA) arising from extraovarian endometriosis. A 56-year-old postmenopausal woman presented with a several-month history of right lower quadrant abdominal pain. She had a history of supracervical hysterectomy and bilateral salpingo-oophorectomy secondary to endometriosis. Imaging reported a mass in the right lower quadrant originating from the distal ileum. At laparotomy, the patient underwent a right colectomy with resection of the terminal ileum and excision of a solitary peritoneal nodule. Pathology was consistent with a diagnosis of well-differentiated EA (arising from extraovarian endometriosis) and WDPM. Further treatment consisted of complete surgical staging/debulking and adjuvant chemotherapy directed toward metastatic well-differentiated EA. Surgeons should be familiar with WDPM as a potential finding in women of reproductive age undergoing abdominal surgery for any indication.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 5","pages":"191-193"},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosing and Treating Blastic Plasmacytoid Dendritic Cell Neoplasm in a Resource-Limited Setting. 在资源有限的环境中诊断和治疗痉挛性浆细胞树突状细胞肿瘤。
4区 医学
Oncology-New York Pub Date : 2024-03-01 DOI: 10.46883/2024.25921014
Fiza Khan, Foorquan Hashmi, Nerses Ghahramanyan, Elen Baloyan, Gevorg Tamamyan, Marina Konopleva, Naveen Pemmaraju, Astghik Voskanyan
{"title":"Diagnosing and Treating Blastic Plasmacytoid Dendritic Cell Neoplasm in a Resource-Limited Setting.","authors":"Fiza Khan, Foorquan Hashmi, Nerses Ghahramanyan, Elen Baloyan, Gevorg Tamamyan, Marina Konopleva, Naveen Pemmaraju, Astghik Voskanyan","doi":"10.46883/2024.25921014","DOIUrl":"10.46883/2024.25921014","url":null,"abstract":"<p><p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy with limited treatment options and poor prognosis. This case report presents the clinical course and management of a 62-year-old man with BPDCN in a resource-limited setting. The patient presented with constitutional symptoms and abnormal complete blood count findings. Initial treatment was performed with an acute lymphoblastic leukemia-based chemotherapy regimen, and the patient achieved complete remission, but the disease recurred 7 months after the initial diagnosis was confirmed in April 2022. The subsequent therapy was not effective, and the patient died during treatment. This case highlights the challenges in managing BPDCN and the need for further research to improve outcomes.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 3","pages":"104-106"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extreme Case of Surgical Port Metastasis in Ovarian Cancer. 卵巢癌手术孔转移的极端病例。
4区 医学
Oncology-New York Pub Date : 2024-03-01 DOI: 10.46883/2024.25921015
Michał Kostrzanowski, Grzegorz Ziółkowski, Filip Dąbrowski
{"title":"Extreme Case of Surgical Port Metastasis in Ovarian Cancer.","authors":"Michał Kostrzanowski, Grzegorz Ziółkowski, Filip Dąbrowski","doi":"10.46883/2024.25921015","DOIUrl":"10.46883/2024.25921015","url":null,"abstract":"<p><p>Ovarian cancer accounts for more deaths than any other malignancy of the female reproductive system. Early diagnosis of this disease is difficult because there are no systematic opportunistic screening methods. At advanced stages, diagnostic laparoscopy is the first step in confirming disease advancement and obtaining samples for genetic and pathologic examination needed to start chemotherapy. Swiftly starting oncological treatment is crucial for increasing the survival rate in these patients. We present the case of a 51-year-old woman with metastatic International Federation of Gynecology and Obstetrics (FIGO) stage IIIC ovarian cancer who had delayed her therapy after initial laparoscopy due to COVID-19 infection and presented with an extreme case of surgical port metastasis.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 3","pages":"110-114"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rising Prices and Lower Medicare Reimbursement Rates Create Outrage Among Clinicians. 价格上涨和医疗保险报销比例降低引起临床医生的愤怒。
4区 医学
Oncology-New York Pub Date : 2024-03-01 DOI: 10.46883/2024.Pubmed Id
Nora Janjan Md Mpsa Mba, Patrick J Silva
{"title":"Rising Prices and Lower Medicare Reimbursement Rates Create Outrage Among Clinicians.","authors":"Nora Janjan Md Mpsa Mba, Patrick J Silva","doi":"10.46883/2024.Pubmed Id","DOIUrl":"10.46883/2024.Pubmed Id","url":null,"abstract":"<p><p>In a recent Hot Topics article, reimbursement rates for Medicare physicians are discussed, and how it will impact their practice.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 3","pages":"115-116"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rising Prices and Lower Medicare Reimbursement Rates Create Outrage Among Clinicians. 价格上涨和医疗保险报销比例降低引起临床医生的愤怒。
4区 医学
Oncology-New York Pub Date : 2024-03-01 DOI: 10.46883/2024.25921016
Nora Janjan Md Mpsa Mba, Patrick J Silva
{"title":"Rising Prices and Lower Medicare Reimbursement Rates Create Outrage Among Clinicians.","authors":"Nora Janjan Md Mpsa Mba, Patrick J Silva","doi":"10.46883/2024.25921016","DOIUrl":"10.46883/2024.25921016","url":null,"abstract":"<p><p>In a recent Hot Topics article, reimbursement rates for Medicare physicians are discussed, and how it will impact their practice.</p>","PeriodicalId":51147,"journal":{"name":"Oncology-New York","volume":"38 3","pages":"115-116"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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