NeurocirugiaPub Date : 2025-05-01DOI: 10.1016/j.neucir.2024.10.002
Carlos A. Ferreira , Carlos E. Quevedo , Gina V. Vilardy , Mario Andrés Arias Depablos
{"title":"Neuroblastoma olfatorio: revisión de literatura y presentación de dos casos clínicos con diferentes infiltraciones tumorales y diferentes abordajes","authors":"Carlos A. Ferreira , Carlos E. Quevedo , Gina V. Vilardy , Mario Andrés Arias Depablos","doi":"10.1016/j.neucir.2024.10.002","DOIUrl":"10.1016/j.neucir.2024.10.002","url":null,"abstract":"<div><div>The olfactory neuroblastoma is a rare malignant neoplasm derived from the olfactory neuroepithelium. It can metastasize to cervical lymph node chains and distant organs through hematogenous or lymphatic routes. Two clinical cases are presented: the first, a 56-year-old man with no pathological history, exhibited symptoms evolving over 2 months, characterized by persistent rhinorrhea with frequent epistaxis, ipsilateral proptosis, left hemicranial pain, anosmia, and dysgeusia. Radiological images showed involvement of paranasal sinuses, left orbital cavity, and intracranial region. The second case involved a 46-year-old male with progressive symptoms over more than 1 year, including nasal obstruction, rhinorrhea, self-limited epistaxis, anosmia, weight loss in the last 3 months, and subjective decrease in visual acuity. A protruding mass in the left nasal fossa was observed without intracranial involvement. Both cases were pathologically and immunohistochemically consistent with olfactory neuroblastoma, Hyams grade 2.</div></div>","PeriodicalId":51145,"journal":{"name":"Neurocirugia","volume":"36 3","pages":"Pages 194-198"},"PeriodicalIF":0.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}