NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-10-08DOI: 10.1016/j.neuchi.2025.101734
Elise Caron , Charlotte Rozenberg , Johann Peltier , Serge Metanbou , Julien Moyet , Olivier Balédent , Cyrille Capel
{"title":"Interobserver reliability of the DESH score in idiopathic chronic hydrocephalus","authors":"Elise Caron , Charlotte Rozenberg , Johann Peltier , Serge Metanbou , Julien Moyet , Olivier Balédent , Cyrille Capel","doi":"10.1016/j.neuchi.2025.101734","DOIUrl":"10.1016/j.neuchi.2025.101734","url":null,"abstract":"<div><h3>Introduction</h3><div>idiopathic chronic hydrocephalus (iCH) is underdiagnosed in older adults. The diagnosis of iCH is important because effective surgical treatment is available. Indeed, iCH is the only curable dementia. The disproportionately enlarged subarachnoid space hydrocephalus (DESH) score was recently developed on the basis of morphologic MRI data, as a guide to the diagnosis of iCH in adults.</div></div><div><h3>Patients and method</h3><div>In a population of 68 patients having undergone placement of a ventriculoperitoneal shunt, the preoperative DESH score was calculated retrospectively by a senior neurosurgeon and a neurosurgery resident. To analyze inter-observer variability, the results obtained for each patient were compared. We calculated sensitivity, specificity, positive and negative predictive values of the DESH score.</div></div><div><h3>Results</h3><div>DESH score of 7 or more present the best diagnostic performance (sensitivity: 83%, specificity: 40%, positive predictive value: 89%, negative predictive value: 29%). The interobserver reliability of the DESH score was excellent, with an intraclass correlation coefficient of 0.936. Similarly, the levels of interobserver agreement for each individual item were fair (for Sylvian fissure dilatation, local focal sulci dilatation, and tight high convexity) to excellent (for the callosal angle).</div></div><div><h3>Conclusion</h3><div>The DESH score is a reliable score obtained by studying brain MRI and radiographic datasets. The score’s excellent reliability means that it can be included in the routine diagnosis of iCH.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101734"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-09-17DOI: 10.1016/j.neuchi.2025.101727
Shuo Gao , Pule Liu , Kai Liu, Qiang Yang
{"title":"Combined endoscopic endonasal transsphenoidal and microscopic transcranial approaches for the primary resection of giant pituitary adenomas","authors":"Shuo Gao , Pule Liu , Kai Liu, Qiang Yang","doi":"10.1016/j.neuchi.2025.101727","DOIUrl":"10.1016/j.neuchi.2025.101727","url":null,"abstract":"<div><h3>Aim</h3><div>Giant pituitary adenomas often present as dumbbell-shaped or multilobulated, presenting significant challenges for surgical treatment. Currently, there is no universally recognized optimal surgical strategy for choosing a dual-scope approach for primary or staged resection. This study aims to present surgical cases and clinical experience with endoscopic endonasal transsphenoidal combined with microscopic transcranial approaches for the primary resection of giant pituitary adenomas.</div></div><div><h3>Material and methods</h3><div>Ten patients with giant pituitary adenomas underwent one-stage surgical resection using endoscopic endonasal transsphenoidal combined with microscopic transcranial approaches. Imaging findings and treatment outcomes were subsequently reviewed.</div></div><div><h3>Results</h3><div>All patients underwent single-stage tumor resection using endoscopic endonasal transsphenoidal combined with microscopic transcranial approaches. Nine patients underwent total resection, while one patient underwent near-total resection. Postoperatively, visual acuity improved in six patients, while four patients experienced no significant change in visual acuity. One patient experienced cerebrospinal fluid leakage postoperatively and underwent a second repair. One patient developed a postoperative infection, and one developed hypopituitarism. No deaths or serious complications occurred.</div></div><div><h3>Conclusion</h3><div>Single-stage resection of giant pituitary adenomas using endoscopic endonasal transsphenoidal combined with microscopic transcranial approaches facilitates complete tumor resection, minimizes the need for residual tumor and staged surgeries, and reduces postoperative bleeding due to tumor remnants. This method improves the total resection rate and reduces postoperative complications and mortality, demonstrating significant effects and clinical application value, making it worthy of promotion.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101727"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Giant Epidermoid Cyst of the Cerebellopontine Angle: Value of Endoscopic Assistance in Microsurgical Resection","authors":"Lotfi Boublata, Mohamed Lamine Boukhanoufa, Nassim Mezlah","doi":"10.1016/j.neuchi.2025.101736","DOIUrl":"10.1016/j.neuchi.2025.101736","url":null,"abstract":"<div><h3>Background</h3><div>Epidermoid cysts of the cerebellopontine angle (CPA) are rare benign congenital lesions derived from ectodermal inclusions during early embryogenesis. Despite their slow growth, they may become giant and cause progressive cranial nerve dysfunction due to their close relationship with critical neurovascular structures.</div></div><div><h3>Case presentation</h3><div>We report the case of a 60-year-old woman who presented with cochleovestibular symptoms, including vertigo, tinnitus, and hearing loss, in association with cerebellar static ataxia. Preoperative examination revealed intact facial and lower cranial nerve function. Magnetic resonance imaging (MRI) revealed a giant CPA epidermoid cyst.</div></div><div><h3>Surgical management</h3><div>The lesion was resected via a retrosigmoid approach in a semi-sitting position under continuous intraoperative facial nerve monitoring. Microsurgical dissection enabled near-total removal of the tumor while preserving the surrounding neurovascular structures. Endoscopic inspection of the surgical cavity revealed residual tumor remnants in blind spots, which were subsequently removed, ensuring complete resection.</div></div><div><h3>Conclusion</h3><div>The combination of microsurgical and endoscopic techniques offers a safe and effective approach to the management of giant CPA epidermoid cysts. Complete resection, including capsule removal, remains the key to minimizing recurrence while preserving neurological function.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101736"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-09-05DOI: 10.1016/j.neuchi.2025.101719
Oumaima Aboubakr , Lelio Guida , Volodia Dangouloff Ros , Emma Losito , Marie Bourgeois , François Doz , Jacques Grill , Gilles Orliaguet , Estelle Vergnaud , Stéphane Auvin , Rima Nabbout , Kevin Beccaria , Nathalie Boddaert , Thomas Blauwblomme
{"title":"Laser Interstitial Thermal Therapy (LITT) in pediatric neurosurgery: Single center retrospective analysis of 41 consecutive procedures","authors":"Oumaima Aboubakr , Lelio Guida , Volodia Dangouloff Ros , Emma Losito , Marie Bourgeois , François Doz , Jacques Grill , Gilles Orliaguet , Estelle Vergnaud , Stéphane Auvin , Rima Nabbout , Kevin Beccaria , Nathalie Boddaert , Thomas Blauwblomme","doi":"10.1016/j.neuchi.2025.101719","DOIUrl":"10.1016/j.neuchi.2025.101719","url":null,"abstract":"<div><h3>Introduction</h3><div>Laser Interstitial Thermal Therapy under MRI control has emerged as a safe and efficient alternative to microsurgery in epilepsy and neurooncology procedures. Yet it has been used only recently in seldom European centers. Here, we report our 4 years’ experience with LITT in children (complications, epileptic and oncologic outcomes).</div></div><div><h3>Methods</h3><div>Single center retrospective study of consecutive LITT procedures during the 2021–2024 period. LITT was restricted to pediatrics in the following indications: (i) circumscribed lesion (ii) benign pathology (iii) problematic location for microsurgical resection. After a robotic stereotactic implantation, ablation was performed under MRI guidance with the VISUALASE system. Post operative outpatient clinic and MRI were systematic at 1, 3, 6 and 12 months. Epileptic outcome was defined after ILAE classification, oncological relapse was defined as a volumetric increase after 1 month of follow up.</div></div><div><h3>Results</h3><div>35 children (mean age 11.4yo, M/F ratio = 0.8) were operated in 41 successive procedures. Main indication was focal epilepsy (<em>n</em> = 28 patients; FCD <em>n</em> = 13, LEAT <em>n</em> = 11, HH <em>n</em> = 4) while 7 children were treated for oncological purposes. Lesions were cortical in the insula (<em>n</em> = 8), mediotemporobasal (<em>n</em> = 8) and paracentral (<em>n</em> = 6) regions or subcortical (hypothalamus and basal ganglia <em>n</em> = 6, mesencephalon <em>n</em> = 4). Perioperative transient adverse events occurred in 25.7% and persistent neurological deficit was noted in 2 children. After a mean follow up of 31.2 months, 67.9% of the patients are seizure free and tumoral recurrence was observed in 3/18 cases.</div></div><div><h3>Conclusion</h3><div>In this pediatric cohort of 35 children with challenging brain lesions, LITT ablation was safe and efficient.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101719"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-09-19DOI: 10.1016/j.neuchi.2025.101724
Paul Maneuvrier-Hervieu , Xavier Humbert
{"title":"Sudden unexpected death in post-traumatic convulsions: An historical case report from the late 18th century","authors":"Paul Maneuvrier-Hervieu , Xavier Humbert","doi":"10.1016/j.neuchi.2025.101724","DOIUrl":"10.1016/j.neuchi.2025.101724","url":null,"abstract":"","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101724"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-09-05DOI: 10.1016/j.neuchi.2025.101713
C. Hervet , C. Le Roux , C. Gaborit , J. Maheut-Lourmiere , C. Fremont , H. Lardy , L. Grammatico-Guillon , T. Odent
{"title":"Spinal cord malformations’s epidemiology in French children: National cross sectional study based on medico-administrative database","authors":"C. Hervet , C. Le Roux , C. Gaborit , J. Maheut-Lourmiere , C. Fremont , H. Lardy , L. Grammatico-Guillon , T. Odent","doi":"10.1016/j.neuchi.2025.101713","DOIUrl":"10.1016/j.neuchi.2025.101713","url":null,"abstract":"<div><h3>Objective</h3><div>Epidemiological data on rare spinal cord malformations in children are lacking in France. Using the national hospital discharge database (PMSI), we studied the care trajectories and estimated the morbidity and mortality burden of these conditions.</div></div><div><h3>Study design</h3><div>We conducted a nationwide historical cohort study from 2010 to 2020, including children diagnosed with rare spinal cord diseases within the scope of the C-MAVEM network. Cases were identified through ICD-10 codes using a semi-automated, multicenter-validated extraction algorithm (positive predictive value >80%). Incidence and in-hospital mortality rates were estimated for the following conditions: Spina Bifida (SB), Arnold Chiari syndrome (ACS), Syringomyelia and Syringobulbia (SM), Diastematomyelia (DM), and Hydromyelia (HM).</div></div><div><h3>Results</h3><div>A total of 10,114 children were identified, corresponding to an estimated prevalence of 67 per 100,000. Incidence rates per 100,000 live births were: 2.6 for SB, 2.2 for ACS, 1.0 for SM, 0.2 for DM, and 0.04 for HM. The mortality was 2.5%, 1.7%, 1.1%, 0.95%, no available for HM, respectively. Most patients were treated in university hospitals with considerable heterogeneity in surgical management depending on etiology and associated malformations.</div></div><div><h3>Conclusion</h3><div>This study provides, for the first time in France, national epidemiological estimates for rare pediatric spinal cord malformations. The use of a validated medico-administrative data extraction approach enables largescale surveillance of these rare conditions, improves understanding of their healthcare burden, and supports planning for specialized care and public health strategies.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101713"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-10-07DOI: 10.1016/j.neuchi.2025.101729
Filipe Virgilio Ribeiro , Rudolfh Batista Arend , Bruno Zilli Peroni , Helvécio Neves Feitosa Filho , Maria Fernanda P. Santana , Leonardo Januario Campos Cardoso , Leandro Vieira Lessa , André Nishizima , Marcelo Porto Sousa , Alex Roman
{"title":"Microsurgical approach versus endovascular treatment of craniocervical junction arteriovenous fistulas: A Systematic Review and Meta-analysis","authors":"Filipe Virgilio Ribeiro , Rudolfh Batista Arend , Bruno Zilli Peroni , Helvécio Neves Feitosa Filho , Maria Fernanda P. Santana , Leonardo Januario Campos Cardoso , Leandro Vieira Lessa , André Nishizima , Marcelo Porto Sousa , Alex Roman","doi":"10.1016/j.neuchi.2025.101729","DOIUrl":"10.1016/j.neuchi.2025.101729","url":null,"abstract":"<div><h3>Introduction</h3><div>Craniocervical junction arteriovenous fistulas (CCJ AVFs) are rare and complex vascular lesions that pose significant diagnostic and therapeutic challenges. Despite advances in neuroimaging, optimal treatment strategies remain controversial. This systematic review and meta-analysis aimed to compare the safety and efficacy of microsurgical versus endovascular approaches for treating CCJ AVFs.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Embase, Web of Science, and Cochrane Library was conducted up to March 2024. Studies were included if they reported outcomes of microsurgical or endovascular treatment for CCJ AVFs, including neurological improvement, complete obliteration, recurrence, and complications. Data were synthesized using a random-effects meta-analysis, and heterogeneity was assessed using the I² statistic.</div></div><div><h3>Results</h3><div>Seven studies with 451 patients were included (microsurgery: n = 348; endovascular: n = 103). Microsurgery showed no statistically significant advantage in neurological improvement compared to endovascular treatment (OR = 2.10, 95% CI: 0.83–5.31, p = 0.5651, I² = 0%). Complete obliteration rates were significantly higher in the microsurgical group (OR = 11.93, 95% CI = 2.12–66.97, p = 0.0049; I² = 70.6%). Recurrence rates did not differ significantly (OR = 0.22, 95% CI: 0.02–2.81, p = 0.2416). Overall complications were similar (OR = 0.63, 95% CI: 0.09–4.62, p = 0.0007, I² = 79.1%), although microsurgery had significantly fewer ischemic complications (OR = 0.23, 95% CI: 0.07–0.70, p = 0.0104). Mortality rates were also comparable (RR = 1.87, 95% CI: 0.28–12.66, p = 0.5213, I² = 25.9%).</div></div><div><h3>Conclusion</h3><div>Microsurgery offers higher obliteration rates and fewer ischemic complications, while overall outcomes support individualized treatment planning.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101729"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-10-21DOI: 10.1016/j.neuchi.2025.101735
William Boisseau , Manon Philibert , Catherine Vignal-Clermont , Koorosh Jeshrani , Amira Al Raaisi , Raphael Blanc , Jean-Philippe Desilles , Simon Escalard , Mikael Mazighi , Michel Piotin , Hocine Redjem , Erwan Robichon , Stanislas Samjda , Rabih Hage , Alexia Tran , Dorian Chauvet , Sorin Aldea , Samiya Abi-Jaoude , Pierre Bourdillon
{"title":"Surgical versus endovascular treatment for idiopathic intracranial hypertension","authors":"William Boisseau , Manon Philibert , Catherine Vignal-Clermont , Koorosh Jeshrani , Amira Al Raaisi , Raphael Blanc , Jean-Philippe Desilles , Simon Escalard , Mikael Mazighi , Michel Piotin , Hocine Redjem , Erwan Robichon , Stanislas Samjda , Rabih Hage , Alexia Tran , Dorian Chauvet , Sorin Aldea , Samiya Abi-Jaoude , Pierre Bourdillon","doi":"10.1016/j.neuchi.2025.101735","DOIUrl":"10.1016/j.neuchi.2025.101735","url":null,"abstract":"<div><h3>Introduction</h3><div>Idiopathic intracranial hypertension (IIH) is severe condition affecting patients’ vision and quality of life. When medical treatment is insufficient, an invasive approach may be proposed, consisting of either performing a ventricular shunt or stenting a stenosed venous sinus. The aim of this study is to compare these two techniques.</div></div><div><h3>Methods</h3><div>All patients who received one of these treatments for IIH associated with papilledema over a 5-year period were analysed. The primary outcome was the resolution of papilledema at 3 months coupled with the absence of complications.</div></div><div><h3>Results</h3><div>Over a 5-year period, 101 patients were analysed, of whom 61 underwent endovascular treatment and 40 underwent surgical treatment. Resolution of papilledema at three months without complications was achieved in 72% of cases in the surgical group and in 89% of cases in the endovascular group (p = 0.04). There was a higher proportion of IIH in the surgical group (60% vs 1.6%, p < 0.001) associated with higher intracranial pressure (38.8 vs 33.1 cmH<sub>2</sub>O) and more severe visual impairment (55% vs 15%). Resolution of papilledema at three months, headache, tinnitus, and visual improvement did not differ significantly between the groups. The average time to improvement was significantly (p < 0.0001) shorter in the surgery-treated group (3.62 vs 8.74 weeks).</div></div><div><h3>Conclusion</h3><div>Endovascular treatment appears to have a better benefit-risk balance compared to surgery, with the caveat that the surgery group had a more severe presentation in this study. This encourages the conduction of a randomized study to have two homogeneous groups.</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101735"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurochirurgiePub Date : 2025-11-01Epub Date: 2025-10-08DOI: 10.1016/j.neuchi.2025.101732
Joseph N. Frazzetta , Seunghyuk Daniel Yang , Oleksandr Strelko , William Y. Shin , John T. Tsiang , Miri Kim , Vikram C. Prabhu
{"title":"Utility of sodium fluorescein in peripheral nerve tumor resection: A single institution experience","authors":"Joseph N. Frazzetta , Seunghyuk Daniel Yang , Oleksandr Strelko , William Y. Shin , John T. Tsiang , Miri Kim , Vikram C. Prabhu","doi":"10.1016/j.neuchi.2025.101732","DOIUrl":"10.1016/j.neuchi.2025.101732","url":null,"abstract":"<div><h3>Introduction</h3><div>The optimal management for symptomatic or enlarging peripheral nerve schwannomas is maximal, safe resection. Sodium Fluorescein (SF) has been utilized to facilitate tumor identification and removal.</div></div><div><h3>Methods</h3><div>This single-institution study evaluated 17 patients with 19 tumors who underwent a microscope assisted peripheral nerve schwannoma resection with intravenous SF administration. White-light and the yellow-560 lens filter were used for microscope visualization. A grading scale was created to assess the utility of SF in differentiating tumor from normal nerve fascicles. In all patients, intraoperative neurophysiological monitoring and nerve stimulation to identify and preserve functional fascicles was utilized.</div></div><div><h3>Results</h3><div>Improved visualization of the tumor and normal fascicles were noted using the operating microscope with white-light. It was possible to distinguish tumor tissue from normal nerve fascicles under both white-light and the yellow-560 lens.Administration of SF imparted a distinct bright-green fluorescence to tumor tissue under the yellow-560 lens. No side effects from SF use were observed. The cost of SF was $32.64 per vial. 1 patient experienced a new motor deficit, and 1 patient developed a new sensory deficit post-operatively that did not resolve at last follow up.</div></div><div><h3>Discussion</h3><div>Microsurgical resection of peripheral nerve schwannomas with the use of SF and the microscope yellow-560 les may be helpful in differentiating tumor from normal healthy nerve fascicles. However, white-light illumination also allowed good visualization of the tumor and normal nerve fascicles. Intraoperative neurophysiological monitoring and nerve stimulation are indispensable to facilitate tumor resection with preservation of normal nerve fascicles</div></div>","PeriodicalId":51141,"journal":{"name":"Neurochirurgie","volume":"71 6","pages":"Article 101732"},"PeriodicalIF":1.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}