Lymphology最新文献_第2页

Breast Edema after Conservative Surgery for Early-Stage Breast Cancer: A Retrospective Single-Center Assessment of Risk Factors. 早期乳腺癌症保守手术后乳房水肿：风险因素的回顾性单中心评估。

IF 2.5 4区医学

Lymphology Pub Date : 2023-08-07 DOI: 10.2458/lymph.5738

C. Cornacchia, S. Dessalvi, G. Santori, F. Canobbio, G. Atzori, F. De Paoli, R. Diaz, S. Franchelli, M. Gipponi, F. Murelli, M. Sparavigna, F. Pitto, A. Fozza, F. Boccardo, D. Friedman, P. Fregatti

{"title":"Breast Edema after Conservative Surgery for Early-Stage Breast Cancer: A Retrospective Single-Center Assessment of Risk Factors.","authors":"C. Cornacchia, S. Dessalvi, G. Santori, F. Canobbio, G. Atzori, F. De Paoli, R. Diaz, S. Franchelli, M. Gipponi, F. Murelli, M. Sparavigna, F. Pitto, A. Fozza, F. Boccardo, D. Friedman, P. Fregatti","doi":"10.2458/lymph.5738","DOIUrl":"https://doi.org/10.2458/lymph.5738","url":null,"abstract":"Breast-conserving surgery (BCS) is the standard of care for early-stage breast cancer. We retrospectively enrolled 530 patients (mean age: 62.96 ± 12.69 years) undergoing BCS between January 1, 2018, and December 31, 2019. During the COVID-19 pandemic, all patients with at least 1 year of follow-up were telephonically asked after surgery to provide clinical signs and symptoms attributable to postoperative breast cancer-related lymphedema of the breast (BCRL-B). Thirty-one (5.8%) patients reported breast edema and were visited to measure the tissue dielectric constant (TDC) and to assess the induration of the skin. There was a difference seen in treatment with lumpectomy + ALND performed more frequently in patients with (29%) than without (12%) BCRL-B. In the subgroup of patients with BCRL-B (n=31), significantly higher values of local total water were calculated in the nine patients who underwent Lump + ALND procedure (1.86 ± 0.48 vs. 1.48 ± 0.38; p = 0.046). Among patients with BCRL-B (n=31), in eight patients (25.8%) tissue induration measured with SkinFibroMeter was >0.100 N, thus suggesting tissue fibrosis. Cumulative survival probability at 1-year after surgery was 0.992. No statistical differences in 1-year survival after surgery were found for type of surgery (p = 0.890) or absence/presence of BCRL-B (p = 0.480). In univariate logistic regression, only lumpectomy + ALND surgery (p = 0.009) and any subsequent axillary lymph node removal surgery (p = 0.003) were associated with BCRL-B. Both of these variables were also found to be statistically significant in the multivariate regression model. Further prospective research is warranted to analyze potentential predictors of BCRL-B and to reduce/ prevent this complication.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 4 1","pages":"167-177"},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49602478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chylous ascites in the neonate: A narrative review. 新生儿乳糜腹水:叙述性回顾。

IF 2.5 4区医学

Lymphology Pub Date : 2022-11-22 DOI: 10.2458/lymph.5404

G. Rocha

引用次数: 0

Iatrogenic systemic lymphedema following multiple myeloma treatment. 多发性骨髓瘤治疗后医源性全身性淋巴水肿。

IF 2.5 4区医学

Lymphology Pub Date : 2022-11-22 DOI: 10.2458/lymph.5403

S. Radu, J. Wilson, A. Bagwell, G. Meyers, A. Nauta

引用次数: 2

Therapeutic thoracic duct drainage: A systematic review of the Eastern European experience and future potential. 治疗性胸导管引流：东欧经验和未来潜力的系统回顾。

IF 2.5 4区医学

Lymphology Pub Date : 2022-11-22 DOI: 10.2458/lymph.5402

P.S. Russell, S. Nachkebia, Victor E. Maldonado-Zimbron, S. Chuklin, G. Gimel'farb, J. Hong, N.D. Martin, M. Itkin, Arj Phillips, J. Windsor

{"title":"Therapeutic thoracic duct drainage: A systematic review of the Eastern European experience and future potential.","authors":"P.S. Russell, S. Nachkebia, Victor E. Maldonado-Zimbron, S. Chuklin, G. Gimel'farb, J. Hong, N.D. Martin, M. Itkin, Arj Phillips, J. Windsor","doi":"10.2458/lymph.5402","DOIUrl":"https://doi.org/10.2458/lymph.5402","url":null,"abstract":"Thoracic duct drainage (TDD) is gaining renewed interest, largely due to accumulation of evidence supporting the gut-lymph model, where toxic mesenteric lymph from the intestine contributes to development of multi-organ failure in acute and critical illness (ACI). Advances in minimally invasive TDD have added to this growing interest. The English TDD literature has been previously reviewed, but the more extensive Eastern European literature has not been available to English readers. Therefore, we undertook a systematic search of Eastern European human TDD studies using Scopus and PubMed databases and Russian language websites. Indications for TDD, clinical outcomes, and complications were reviewed. 113 studies, published between 1965 and 2015, were reviewed. The most common indications for TDD were hepatic failure, acute pancreatitis, and peritonitis. It was often used late and when other treatment options had been exhausted. Human TDD appeared safe and probably effective, especially when combined with lymphosorption. The benefit appeared to correlate with the volume of lymph drained. A randomized controlled trial (and some case-control studies) showed reduced mortality in patients with ACI with TDD. Other benefits included rapid normalization of blood parameters and decreased organ edema. This review provides further support for the gut-lymph model and justification for high quality randomized controlled trials of TDD in ACI. It also highlights other potential indications for TDD, such as bridging patients with liver failure to surgery or transplant.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 3 1","pages":"86-109"},"PeriodicalIF":2.5,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49417881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice. 小鼠中Sos1突变缺乏胚胎纯合子或成年杂合子淋巴表型，纯合子Cx47突变缺乏淋巴胚胎表型。

IF 2.5 4区医学

Lymphology Pub Date : 2022-11-22 DOI: 10.2458/lymph.5405

X. Geng, L. Chen, R. Srinivasan, R. J. Kylat, M. Witte, R. Erickson

引用次数: 1

Addition of local cryotherapy for treatment of post-mastectomy lymphedema. 添加局部冷冻疗法治疗乳房切除术后淋巴水肿。

IF 2.5 4区医学

Lymphology Pub Date : 2022-09-21 DOI: 10.2458/lymph.5269

Z. M. Askary, M. Elshazly

{"title":"Addition of local cryotherapy for treatment of post-mastectomy lymphedema.","authors":"Z. M. Askary, M. Elshazly","doi":"10.2458/lymph.5269","DOIUrl":"https://doi.org/10.2458/lymph.5269","url":null,"abstract":"Worldwide, lymphedema can present as a significant health issue. Left untreated, it can have long-term medical and psychological consequences for patients. Cryotherapy is a new physical therapy modality used for many purposes including reduction of pain, inflammation, and edema. It is thought to decrease interstitial fluid volume through many mechanisms. Therefore, it is reasonable to think that cryotherapy might have a positive effect in treatment of lymphedema. The goal of this study was to investigate how local cryotherapy in combination with standard therapy affects patient outcomes. Forty post-mastectomy female patients aged 40-60 years old with lymphedema were referred to the outpatient clinics of the Faculty of Physical Therapy at South Valley University for medical treatment and follow-up by the vascular surgery department. Patients were randomly divided into two groups of equal size. Traditional physical therapy programs (manual lymphatic drainage, pneumatic compression, bandaging, breathing exercises, circulatory exercises, shoulder mobilizations, and ROM exercises) were combined with pulsed local cryotherapy three times per week for 12 weeks in Group (A). For 12 weeks, Group (B) received only traditional physical therapy three times per week. Patients were evaluated using circumferential measurement with tape at the wrist, below the elbow, and above the elbow level, as well as ultrasonography to assess skin thickness before the start of physical therapy, 6 weeks later, and at the end of the treatment (after 12 weeks). Results indicate that cryotherapy is an effective adjunct modality for the treatment of secondary lymphedema and should be added to physical therapy protocols for lymphedema rehabilitation.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 2 1","pages":"70-76"},"PeriodicalIF":2.5,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46460039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Risk factors for developing upper limb cellulitis after breast cancer treatment. 乳腺癌症治疗后发生上肢蜂窝组织炎的危险因素。

IF 2.5 4区医学

Lymphology Pub Date : 2022-09-21 DOI: 10.2458/lymph.5270

O. Engin, E. Şahin, E. Saribay, B. Dilek, E. Akalın

{"title":"Risk factors for developing upper limb cellulitis after breast cancer treatment.","authors":"O. Engin, E. Şahin, E. Saribay, B. Dilek, E. Akalın","doi":"10.2458/lymph.5270","DOIUrl":"https://doi.org/10.2458/lymph.5270","url":null,"abstract":"Cellulitis is one of the most important troubling complications of breast cancer treatment. Therefore, elucidating the risk factors for cellulitis in patients that have undergone breast cancer treatment is crucial. This is a retrospective medical record study among 523 patients who had received breast cancer treatment and were referred to the Lymphedema Clinic. Data on age, height, weight, BMI (body mass index), education level, arm dominance, history of previous surgery, axillary lymph node dissection, radiotherapy, and chemotherapy were noted. The time between operation and onset of lymphedema, duration of lymphedema, history of cellulitis, and number of cellulitis attacks were recorded. Circumference measurements were taken at four points on the upper limb. Univariate analysis showed that longer duration of lymphedema, larger circumference of the unaffected arm and larger circumference of the arm with lymphedema were associated with higher risk of cellulitis (p=0.008, p=0.007, p< 0.001, respectively). The incidence of cellulitis was higher in patients with lymphedema than patients who had no lymphedema (p< 0.001). Moreover, the frequency of cellulitis was higher in patients with lower education level (p=0.015). It was deter-mined that patients with cellulitis needed more compression garments (p< 0.001) and multi-layered bandage therapy (p< 0.001) than those without. Regression analysis revealed that presence of lymphedema (p=0.036), duration of lymphedema (p=0.048), radiotherapy (p=0.01) and educational level (0.019) are significantly associated with developing upper extremity cellulitis. It is important to consider these risk factors for the prevention and management of cellulitis in patients who undergo treatment for breast cancer. Early detection and treatment of lymphedema also remains essential for these patients.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 2 1","pages":"77-83"},"PeriodicalIF":2.5,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44704503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Plastic bronchitis: A rare complication following a motor vehicle collision. 可塑性支气管炎：机动车碰撞后罕见的并发症。

IF 2.5 4区医学

Lymphology Pub Date : 2022-09-21 DOI: 10.2458/lymph.5268

J. Lee, K. Stanley, M. C. Lowe

{"title":"Plastic bronchitis: A rare complication following a motor vehicle collision.","authors":"J. Lee, K. Stanley, M. C. Lowe","doi":"10.2458/lymph.5268","DOIUrl":"https://doi.org/10.2458/lymph.5268","url":null,"abstract":"Plastic bronchitis, more appropriately termed chyloptysis, is a rare and potentially fatal condition caused by chylous coating of the airways. These cast coating can dislodge and become an obstructive mass in the patient's airway, necessitating rapid intervention. PB is well described to occur following single ventricle physiology heart disease corrective procedures, particularly following Fontan procedures. It is less commonly seen in traumatic settings. We present the youngest known case of a traumatic injury induced plastic bronchitis. A 19-year-old man was involved in a motor vehicle accident with airbag deployment. The airbags struck him in the chest; however, the patient felt well at the time and did not seek medical attention. Several months later the patient began coughing up milky white masses identified as casts. He was initially diagnosed with asthma but did not respond to therapy. He ultimately was found to have evidence of thoracic duct injury. Options for therapy were discussed, including possible thoracic duct ligation. The patient opted to continue a lowfat diet and has remained cast free. This case highlights the importance of considering plastic bronchitis in patients with cast production and a history of trauma to the chest.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 2 1","pages":"65-69"},"PeriodicalIF":2.5,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45387092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Compound heterozygosity for a variably penetrant variant and a variant of unknown significance in FLT4 causes fully penetrant Milroy's lymphedema. 在FLT4中，一种可变渗透性变体和一种意义未知的变体的复合杂合性导致完全渗透性Milroy淋巴水肿。

IF 2.5 4区医学

Lymphology Pub Date : 2022-09-20 DOI: 10.2458/lymph.5264

J. Kim, S. Y. Lim

{"title":"Compound heterozygosity for a variably penetrant variant and a variant of unknown significance in FLT4 causes fully penetrant Milroy's lymphedema.","authors":"J. Kim, S. Y. Lim","doi":"10.2458/lymph.5264","DOIUrl":"https://doi.org/10.2458/lymph.5264","url":null,"abstract":"Milroy disease, known as primary congenital lymphedema, is characterized by chronic tissue swelling due to impaired lymphatic drainage and is inherited in an autosomal dominant manner. This study reports a rare case of Milroy disease affecting siblings from unaffected parents. A one-month-old female infant presented with swelling of the bilateral calf and the dorsum of the feet which had been present since birth. Her 14-month-old brother had a similar presentation since birth with swelling of the bilateral calf and the dorsum of the feet. Milroy disease was diagnosed based on the clinical findings of bilateral lower limb swelling and confirmed by molecular genetic testing. The patient and her family, including her brother, parents, and maternal grandfather, were genetically tested, and two novel missense mutations (NM_182925.4: c.2534T>C; p.Leu845Pro, c.4006G>A; p.Glu1336Lys) were found in the Fms-related tyrosine kinase (FLT4) gene. Mutations segregated by the parents who carried each mutation in the heterozygous state were identified in the patient and her brother. The present case report in which Milroy disease developed in all offspring of parents with a normal phenotype suggests the possibility of a compound heterozygous mutation or non-penetrance during the process of inheritance of Milroy disease.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 2 1","pages":"41-46"},"PeriodicalIF":2.5,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45068032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Short duration of upper extremity lymphedema correlates with a favorable cytokine response after lymph node transfer surgery. 上肢淋巴水肿持续时间短与淋巴结转移手术后良好的细胞因子反应相关。

IF 2.5 4区医学

Lymphology Pub Date : 2022-09-20 DOI: 10.2458/lymph.5266

E. Rannikko, Ida-Maria Leppäpuska, M. Laukka, A. Saarikko, P. Hartiala

{"title":"Short duration of upper extremity lymphedema correlates with a favorable cytokine response after lymph node transfer surgery.","authors":"E. Rannikko, Ida-Maria Leppäpuska, M. Laukka, A. Saarikko, P. Hartiala","doi":"10.2458/lymph.5266","DOIUrl":"https://doi.org/10.2458/lymph.5266","url":null,"abstract":"Vascularized lymph node transfer surgery (VLNT) can provide benefit to lymphedema patients. Cytokines may play a role in the development of lymphedema and in the regeneration of lymphatic vessels after VLNT. Our primary aim was to investigate whether the VLNT patients have a specific cytokine profile. Our secondary aim was to see whether the preoperative lymphedema or severity affects the postoperative cytokine response. Wound exudate was gathered from 18 patients undergoing VLNT on the first and sixth postoperative day (POD). The concentrations of IL-10, TNF-α, TGF-β1 and VEGF-C were analyzed using enzymelinked immune-sorbent assays. A general score was generated to assess the benefit of the surgery. The changes in cytokine concentrations (1st POD-6th POD) were correlated with the pre- and postoperative lymphedema related factors. A shorter duration of lymphedema preoperatively correlated with an increase in the concentration of IL-10 and TNF-β during the first six PODs (IL-10: r=0.495, p=0.051; TNF-α: r=0.737, p=0.006) and a decrease in the concentration of TGF-ß1 (r= -0.613, p=0.020). The increase of the concentration of TNF-α during the first six PODs also correlated with a greater total general score (r=0.775, p=0.005) and hence indicated a better response to the surgery. The patients with a shorter duration of lymphedema preoperatively had a more favorable cytokine response during the first six PODs after VLNT.","PeriodicalId":51122,"journal":{"name":"Lymphology","volume":"55 2 1","pages":"54-64"},"PeriodicalIF":2.5,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45427540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1