Cell Biochemistry and Biophysics最新文献

{"title":"Cytotoxicity and Antiplatelet Activity of Cationic Antimicrobial Peptides of the Medicinal Leech Hirudo Medicinalis.","authors":"Grigoriy D Moroz, Nadezhda A Podoplelova, Mikhail S Iudin, Sabina E Alieva, Anna M Varizhuk, Mikhail A Panteleev, Vassili N Lazarev, Oleg M Panasenko","doi":"10.1007/s12013-025-01860-w","DOIUrl":"https://doi.org/10.1007/s12013-025-01860-w","url":null,"abstract":"","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy Decomposition-Driven Design of Trop2-Targeting Peptide.","authors":"Yu-Chao Meng, He Liu, Bi-Shao Sun, Hong-Yuan Liu, Hong-Wei Li, Qiu-Yu Liao, Mouxin Huang, Qin Ouyang","doi":"10.1007/s12013-025-01866-4","DOIUrl":"https://doi.org/10.1007/s12013-025-01866-4","url":null,"abstract":"","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Cellular Stress: Endoplasmic Reticulum Stress and the Unfolded Protein Response in the Molecular Pathogenesis of Preeclampsia.","authors":"Teeba Ammar Rashid, Shahd Rajab Farhan, Aysar Ashour Khalaf, Gaurav Sanghvi, Subasini Uthirapathy, Renuka Jyothi, Mayank Kundlas, Kamal Kant Joshi, Anna Rudova, Yasser Fakri Mustafa","doi":"10.1007/s12013-025-01833-z","DOIUrl":"https://doi.org/10.1007/s12013-025-01833-z","url":null,"abstract":"<p><p>Preeclampsia (PE) is a leading cause of maternal and fetal morbidity and mortality worldwide, characterized by a complex and not yet fully understood pathophysiology. This paper examines the increasingly important roles of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the pathogenesis of PE. The ER, vital for protein folding, calcium homeostasis, and lipid synthesis, responds to cellular stressors via the UPR pathway. In PE, pathological placental hypoxia compromises mitochondrial and ER function, leading to persistent ER stress marked by upregulation of stress markers like GRP78 and heightened activation of UPR signaling arms-IRE1, ATF6, and PERK. This initiates a harmful feed-forward cycle, increasing endothelial dysfunction, inflammation, and oxidative stress. Current therapeutic strategies targeting these pathways are mainly in preclinical stages, as antioxidant therapies have shown varied clinical outcomes. Despite challenges in understanding disease heterogeneity and ensuring safety during pregnancy, new treatments focusing on precise molecular modulation of ER stress responses show promise. This review synthesizes current knowledge on ER stress in PE and highlights potential therapeutic targets, aiming to enhance maternal and fetal outcomes and transform clinical management of this condition.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antitumor Potential of the Pterocarpanoquinone-Quinone LQB-472 in Prostate Cancer Cells.","authors":"Thayssa G Farias, Rachell R C Thimoteo, Felipe C Demidoff, Alcides J M da Silva, Marcia S Dos Santos, Paulo R R Costa, Chaquip D Netto, Katia C C Sabino, Graça Justo","doi":"10.1007/s12013-025-01858-4","DOIUrl":"https://doi.org/10.1007/s12013-025-01858-4","url":null,"abstract":"","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress in DNA Damage and Neurodegenerative Diseases: Unveiling The Mechanisms and Therapeutic Opportunities.","authors":"Md Anisur Rahman, Mst Tania Khatun, Afsana Khanom Mim, Md Parvez Khandocar, Ahidur Rahman, Md Hasibul Hasan, Afia Ibnath Shimki, Md Sabbir Hossain, Mst Sadia Afroz Shoily, Arafat Faraque, Md Faisal Amin, Rafia Ferdous, Md Shoriful Islam","doi":"10.1007/s12013-025-01845-9","DOIUrl":"https://doi.org/10.1007/s12013-025-01845-9","url":null,"abstract":"<p><p>Oxidative stress is marked by disproportionate levels of reactive oxygen species (ROS) and antioxidant defenses and is a key factor in initiating DNA damage and neurodegenerative diseases. Increased reactive oxygen species (ROS) levels can lead to oxidative DNA lesions, disrupting cellular function and contributing to genomic instability. Oxidative stress is linked to neuronal degeneration, particularly in conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), where DNA damage accelerates the progression of these disorders. Hence, the importance of therapeutic measures to reduce oxidative damage and enhance DNA repair is emphasized. This review reveals the intricate mechanisms by which oxidative stress triggers DNA damage and its subsequent impact on neuronal health. By conducting a comprehensive literature search across various databases, we explore the molecular pathways involved, including mitochondrial dysfunction, inflammation, and altered signaling pathways, which exacerbate neuronal death and dysfunction. Furthermore, we investigate potential therapeutic strategies targeting oxidative stress and DNA repair mechanisms, focusing on antioxidant approaches, gene editing technologies, and pharmacological interventions to mitigate oxidative damage. Understanding the relationship between oxidative stress, DNA damage, and neurodegeneration is essential for developing effective therapies to slow down or stop the worsening of these disabling illnesses.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function and Mechanism of the RNA-binding Protein RBMS3 in Malignant Tumours.","authors":"Ziyun Xin, Huaping Huang, Yingjie Shao","doi":"10.1007/s12013-025-01859-3","DOIUrl":"https://doi.org/10.1007/s12013-025-01859-3","url":null,"abstract":"","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the miRNA-mRNA Interaction Network Regulating Aging Skeletal Muscle in Various Exercise Regimens through Comprehensive Bioinformatics Analysis.","authors":"Zhi Yu, Pin-Shi Ni, Zhuang-Zhi Wang, Zheng-Yang Zhao, Bao-Yi Chen, Zhen-En Zhang, Fang-Hui Li","doi":"10.1007/s12013-025-01848-6","DOIUrl":"https://doi.org/10.1007/s12013-025-01848-6","url":null,"abstract":"<p><p>Understanding the impact of different exercise types on skeletal muscle atrophy in older adults is crucial for designing effective strategies to combat age-related muscle loss. This study explores the molecular mechanisms through which resistance exercise (RES) and endurance exercise (END) mitigate skeletal muscle atrophy. By examining microRNA (miRNA) expression profiles from aging skeletal muscle datasets (GSE165632) in the Gene Expression Omnibus (GEO) database, the research aims to uncover exercise-specific miRNA signatures and their associated regulatory pathways. Using the GEO2R analysis tool, researchers identified differentially expressed miRNAs (DEmiRNAs) between RES and END groups. Predicted target genes of these miRNAs were determined through a combination of miRTarBase, micro-T, and TargetScan databases. Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, were performed via the DAVID database. Transcription factors were predicted using the ChEA3 database, while protein-protein interaction (PPI) networks were constructed with the STRING database to identify hub genes for further functional enrichment studies. The analysis revealed 30 differentially expressed miRNAs in the RES group and 21 in the END group. In the RES group, key pathways such as FoxO signaling, neurotrophic signaling, insulin resistance, and AMPK were regulated by miRNAs like hsa-miR-574-5p, hsa-miR-34a-5p, and hsa-miR-21-5p. These pathways promote protein synthesis and reduce myocyte apoptosis. In the END group, hub genes were linked to FoxO, TGF-β, MAPK, and cGMP-PKG signaling pathways, regulated by miRNAs such as hsa-miR-194-5p, hsa-miR-146a-5p, and hsa-miR-6831-5p, which enhance mitochondrial function and metabolic regulation. Both exercise types shared common regulatory pathways, including MAPK, TGF-β, and PI3K-Akt, which influence genes like SMAD4 and TRAF6 that are essential for myocyte survival and fibrosis suppression. This study sheds light on the unique and overlapping miRNA-driven regulatory mechanisms behind the effects of RES and END on skeletal muscle atrophy in older adults. Resistance exercise primarily boosts protein synthesis and inhibits apoptosis via pathways like AMPK and p53, while endurance exercise enhances mitochondrial function and energy metabolism through cGMP-PKG signaling. Both exercise modalities converge on critical pathways, providing a scientific basis for developing personalized exercise programs to counteract sarcopenia.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics Analysis Implicates Mitochondrial Complex Assembly Protein COX18 in Mitochondrial Signaling and Tumorigenesis across Cancers.","authors":"Devyani Goswami, Sayak Ghosh, Rittick Dutta, Debapriya Ghatak, Debapriya Ranjit, Rudranil De","doi":"10.1007/s12013-025-01857-5","DOIUrl":"https://doi.org/10.1007/s12013-025-01857-5","url":null,"abstract":"","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Mesenchymal Stem Cells in Psoriasis.","authors":"Rebecca Shin Yee Wong, Kien Hui Chua, Ee Wern Tan, Bey Hing Goh","doi":"10.1007/s12013-025-01843-x","DOIUrl":"https://doi.org/10.1007/s12013-025-01843-x","url":null,"abstract":"<p><p>Psoriasis is a chronic immune-mediated disease mainly affecting the skin with different clinical manifestations. As patients with psoriasis may also suffer from psoriatic arthritis and the skin lesions of psoriasis are disfiguring, their quality of life is often impaired. Many environmental and genetic factors have been implicated in psoriasis development. Currently, there is no cure for the disease and long-term drug treatment is usually necessary, especially in moderate to severe cases. Mesenchymal stem cells (MSCs) are popular candidates for cell-based treatment in many immune-mediated diseases due to their ability to secrete a wide array of cytokines and growth factors and their immunomodulatory properties. MSCs from various sources administered via different routes have been shown to ameliorate psoriasis. This review gives an overview of psoriasis and MSCs and examine preclinical and clinical studies concerning the application of MSCs in the treatment of psoriasis, as well as consolidate major findings in this area of research.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRP Channel Inhibition and NF-κB Pathway Suppression in Human Ependymal Tumor cell-line by Achillea Biebersteinii Aqueous Extract.","authors":"Erkan Özbay, Ülkü Çömelekoğlu, Fatma Söğüt, Metin Yıldırım, Serkan Küççüktürk, Tuğce Duran, Mehmet Ali Karaselek, Hasan Hüseyin Doğan, Ümmühan Ünlü","doi":"10.1007/s12013-025-01852-w","DOIUrl":"10.1007/s12013-025-01852-w","url":null,"abstract":"","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}