{"title":"Intraoperative thoracic interfascial plane block with levobupivacaine versus levobupivacaine with dexmedetomidine for postoperative analgesia after modified radical mastectomy: A randomised controlled double-blinded trial","authors":"Nidhi Arun, Raja Avinash, Annu Choudhary","doi":"10.4103/ija.ija_279_24","DOIUrl":"https://doi.org/10.4103/ija.ija_279_24","url":null,"abstract":"\u0000 \u0000 Nearly half of the patients following breast cancer surgery experience postoperative pain. The interfascial plane for the pectoral nerve (PECS) block, along with dexmedetomidine, can alleviate this pain.\u0000 \u0000 \u0000 \u0000 After institutional ethics committee clearance and written informed consent, this randomised, double-blind study was conducted on 60, 18–60 years female patients, who were scheduled for modified radical mastectomy (MRM) under general anaesthesia. Patients were randomised into Group L (20 ml of 0.25% levobupivacaine) and Group DL (20 ml of 0.25% levobupivacaine with 0.5 µg/kg of dexmedetomidine). After resection of the tumour and securing haemostasis, under strict aseptic precaution, 10 ml of the study drug was injected under direct vision between the pectoralis major and pectoralis minor and 10 ml between pectoralis minor and serratus anterior muscles by the operating surgeon (direct PECS block). The primary outcome was to compare the duration of analgesia. Normally distributed variables were compared using Student’s t-test, and non-normally distributed variables were compared using the Mann–Whitney U-test. Qualitative data were analysed using Chi-square/Fisher’s exact test. Statistical significance was kept at P < 0.05.\u0000 \u0000 \u0000 \u0000 The median time of the first analgesic requirement was 8 [inter-quartile range (IQR): 6–8] h in Group L and 18 (IQR: 16–20) h in Group DL (W = 17.000, P < 0.001). The mean total opioid consumption of Group L was 12.53 [standard deviation (SD): 2.29] mg in the first 24 h and 6.93 (SD: 1.89) mg in Group DL.\u0000 \u0000 \u0000 \u0000 Adding 0.5 μg/kg dexmedetomidine to 20 ml of levobupivacaine enhances the duration of analgesia of direct PECS block in patients undergoing MRM.\u0000","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"9 s1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adhip Neupane, Divya Jain, S. Arora, K. Gandhi, Varun Singla, N. Goel, R. Virk, S. Mohindra
{"title":"Evaluation of ultrasound-guided suprazygomatic maxillary nerve block in functional endoscopic sinus surgery for postoperative pain relief: A randomised controlled trial","authors":"Adhip Neupane, Divya Jain, S. Arora, K. Gandhi, Varun Singla, N. Goel, R. Virk, S. Mohindra","doi":"10.4103/ija.ija_81_24","DOIUrl":"https://doi.org/10.4103/ija.ija_81_24","url":null,"abstract":"\u0000 \u0000 Postoperative pain can impede functional recovery and delay hospital discharge after functional endoscopic sinus surgery (FESS). The study aimed to assess the efficacy of ultrasound (USG)-guided suprazygomatic maxillary nerve block (SZMNB) for postoperative pain in FESS.\u0000 \u0000 \u0000 \u0000 Forty-eight adult patients between 18 and 65 years of age with American Society of Anesthesiologists physical status I and II and scheduled to undergo FESS were enroled in this randomised controlled study. Patients were randomly allocated to either receive USG-guided SZMNB with general anaesthesia (n = 24) or general anaesthesia alone (n = 24). The numerical rating scale (NRS) pain score in the immediate postoperative period was recorded as the primary outcome. A total of 24 h postoperative rescue analgesic consumption, surgeon satisfaction score, postoperative haemodynamics, and postoperative complications were noted as secondary outcomes.\u0000 \u0000 \u0000 \u0000 The median (interquartile range) of the NRS pain score in the immediate postoperative period was 0 (0-0.25)[95% confidence interval (CI): 0, 0.08] in the block group compared to 2 (1.75-3) [95% CI: 1.60, 2.40] in the control group, P < 0.001]. Pain scores were significantly reduced at all time intervals till 24 h after surgery (P < 0.001). None of the patients required rescue analgesia in the block group. In contrast, eight patients required diclofenac 75 mg intravenous as rescue analgesia within 1 h of surgery and ten patients within 1–6 h of surgery in the control group. Other secondary outcomes were comparable between groups (P > 0.05).\u0000 \u0000 \u0000 \u0000 The USG-guided SZMNB provides excellent postoperative analgesia for patients undergoing FESS without significant side effects.\u0000","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"13 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Himanti Bansal, Jose Cyriac, Ram Singh, Sohini Ray
{"title":"Efficacy of combined spinal–epidural anaesthesia in mitigating cardiovascular stress during emergency caesarean section in a primigravida with ruptured right sinus of Valsalva aneurysm – A case report","authors":"Himanti Bansal, Jose Cyriac, Ram Singh, Sohini Ray","doi":"10.4103/ija.ija_308_24","DOIUrl":"https://doi.org/10.4103/ija.ija_308_24","url":null,"abstract":"","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond epidurals: Embracing the realities of fascial plane blocks for truncal and chest wall analgesia","authors":"Daniel Werry, V. Uppal","doi":"10.4103/ija.ija_520_24","DOIUrl":"https://doi.org/10.4103/ija.ija_520_24","url":null,"abstract":"","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiwam K. Gupta, Babita Ghai, J. Makkar, Deepanshu Dhiman, D. Chouhan
{"title":"Effectiveness of ultrasound-guided pulsed radiofrequency ablation of suprascapular nerve versus local anaesthetics with steroids in patients with chronic shoulder pain: A randomised controlled trial","authors":"Shiwam K. Gupta, Babita Ghai, J. Makkar, Deepanshu Dhiman, D. Chouhan","doi":"10.4103/ija.ija_939_23","DOIUrl":"https://doi.org/10.4103/ija.ija_939_23","url":null,"abstract":"","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"349 4‐5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roopa Sachidananda, V. Bhat, Mahantesh M. Kurjogi, Gulam Nabi L. Vanti, Madhura Kayara
{"title":"Potential role of mitochondrial uncoupling protein 2 as a biomarker in patients with sepsis and septic shock: A prospective observational study","authors":"Roopa Sachidananda, V. Bhat, Mahantesh M. Kurjogi, Gulam Nabi L. Vanti, Madhura Kayara","doi":"10.4103/ija.ija_1181_23","DOIUrl":"https://doi.org/10.4103/ija.ija_1181_23","url":null,"abstract":"\u0000 \u0000 Early diagnosis of sepsis is crucial. The primary objective of this study was to explore the role of uncoupling protein 2 (UCP2) in diagnosing sepsis and septic shock.\u0000 \u0000 \u0000 \u0000 This prospective observational study was conducted over 19 months. All adult patients aged more than 18 years with a diagnosis of sepsis or septic shock based on quick sequential organ failure assessment (qSOFA) score were enroled. Blood was drawn for procalcitonin (PCT) and UCP2 on days 0, 3, 7 and 28. Blood samples from 50 healthy volunteers were used as controls. An electrochemiluminescence test was done for PCT. A quantitative enzyme-linked immune sorbent assay was used for UCP2. The Chi-square test was used for qualitative variables and the independent t-test for quantitative variables. The receiver operator characteristic curve was used to evaluate the diagnostic efficacy of UCP2.\u0000 \u0000 \u0000 \u0000 A total of 128 subjects were included in the study. Out of these, 78 patients (qSOFA score ≥2) were subcategorised into the infection group, sepsis or septic shock group based on the PCT levels. The UCP2 levels in the infection, sepsis or septic shock group were significantly higher than in the control group (P > 0.001). The UCP2 levels correlated with PCT on admission, day 3 and day 7.\u0000 \u0000 \u0000 \u0000 The UCP2 levels were significantly higher in sepsis and septic shock groups compared to controls and hence could be a potential diagnostic biomarker of sepsis.\u0000","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"40 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruma Thakuria, Ankita Rawat, P. Talawar, Dhatri Jonna
{"title":"Cervical plexus block as an adjunct to general anaesthesia for tracheal resection and anastomosis","authors":"Ruma Thakuria, Ankita Rawat, P. Talawar, Dhatri Jonna","doi":"10.4103/ija.ija_1071_23","DOIUrl":"https://doi.org/10.4103/ija.ija_1071_23","url":null,"abstract":"","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140245760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fifty years of ambulatory anaesthesia: Stepping out and stepping forward!","authors":"S. Mitra, S. Arora, N. Vadivelu","doi":"10.4103/ija.ija_857_23","DOIUrl":"https://doi.org/10.4103/ija.ija_857_23","url":null,"abstract":"","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"2017 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140246045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost analysis of different medical oxygen sources for a healthcare facility in India","authors":"Varun Manhas, Mahipal Rawat, Yogesh S. Kaurav, Sanjay Goyal, Sanjay Dhir, Kalyani Sangineni","doi":"10.4103/ija.ija_335_23","DOIUrl":"https://doi.org/10.4103/ija.ija_335_23","url":null,"abstract":"\u0000 \u0000 Multiple sources of medical oxygen, namely liquid medical oxygen (LMO) tanks, pressure swing adsorption (PSA) plants, concentrators, and gaseous cylinders, are available at different healthcare facilities. These sources of oxygen have varying installation and operational costs. In low-resource settings, it is imperative to utilise these assets optimally. This study investigated the operational costs of multiple oxygen sources available at a healthcare facility.\u0000 \u0000 \u0000 \u0000 A Microsoft (MS) Excel-based model was developed to analyse and compare the oxygen manufacturing costs (in ₹/m3) using PSA plants and procurement costs (in ₹/m3) of LMO and third-party vendor-refilled cylinders.\u0000 \u0000 \u0000 \u0000 The oxygen manufacturing costs for PSA plants of different capacities and running times on electricity and diesel generators (DGs) as a power source were calculated. This study highlights the cost-benefit of using PSA plants over LMO and third-party vendor-refilled cylinders as a source of oxygen. PSA plants are most economical when they are of higher capacity and used to their maximum capacity on electricity as the power source. On the contrary, they are most expensive when used on a DG set as a power source. Furthermore, this study provides evidence of PSA plants being more cost-effective for refilling cylinders using a booster compressor unit when compared to third-party vendor-cylinder refilling.\u0000 \u0000 \u0000 \u0000 Given their cost-effectiveness and low third-party dependence, they should be utilised to their maximum capacity as medical oxygen sources at healthcare facilities.\u0000","PeriodicalId":510762,"journal":{"name":"Indian Journal of Anaesthesia","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140247656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}