Journal of Applied Biomaterials & Biomechanics最新文献_第4页

Macro-Scale Model Study of a Tunable Drug Dispensation Mechanism for Controlled Drug Delivery in Potential Wound-Healing Applications 可调药物分配机制的宏观模型研究，可用于潜在的伤口愈合应用

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-10 DOI: 10.5301/jabfm.5000280

Mariam Mir, Umar Ansari, Murtaza Najabat Ali

{"title":"Macro-Scale Model Study of a Tunable Drug Dispensation Mechanism for Controlled Drug Delivery in Potential Wound-Healing Applications","authors":"Mariam Mir, Umar Ansari, Murtaza Najabat Ali","doi":"10.5301/jabfm.5000280","DOIUrl":"https://doi.org/10.5301/jabfm.5000280","url":null,"abstract":"Background Auxetic materials tend to exhibit stretching in the direction of the applied load as well as in the perpendicular direction. This may be an inherent property of the material, or it might be a particular structural characteristic that confers it with auxetic properties. In this study, the auxetic properties of a rotating squares auxetic design were utilized in tandem with a stretching mechanism to manufacture a device that offers the advantages of adjustable pore size and hence tunable drug delivery characteristics. Methods An auxetic polyurethane film was fabricated through the polymer casting technique. An acrylonitrile-butadiene-styrene (ABS) plastic mold for polymer casting was made through additive manufacturing. Stereolithography was used for fabrication of the mechanism that controlled pore size of the polymeric auxetic film. A laminate arrangement of the film and the mechanism was devised, through which movement of the mechanism controlled stretching of the auxetic film underneath. Results Results were analyzed through image processing. It was observed that a 2-dimensional increase (in length and width) of the auxetic film took place that corresponded to an increase in pore size of the film. Several mathematical correlations were drawn up. Conclusions It may be concluded that the first factor controlling drug release kinetics is the pore size of the film. This study explored a prototype mechanism that has the potential for being used in devices for controlled drug delivery or in smart bandage systems that may enhance wound healing in chronic wound treatment.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"15 1","pages":"63 - 69"},"PeriodicalIF":0.0,"publicationDate":"2016-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Design and Cytocompatibility of Chitosan-Based Thermoresponsive Cell Culture Plates 壳聚糖热反应细胞培养板的设计及细胞相容性研究

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-02 DOI: 10.5301/jabfm.5000276

Xiaoling He, Yuxin Zhao, Z. Jin, Yuhan Su, Huiqin An, Lili Ge, Dongsheng Wei, Li Chen

{"title":"Design and Cytocompatibility of Chitosan-Based Thermoresponsive Cell Culture Plates","authors":"Xiaoling He, Yuxin Zhao, Z. Jin, Yuhan Su, Huiqin An, Lili Ge, Dongsheng Wei, Li Chen","doi":"10.5301/jabfm.5000276","DOIUrl":"https://doi.org/10.5301/jabfm.5000276","url":null,"abstract":"Background The aim of this study was to develop a novel thermoresponsive material suited for tissue engineering and investigate the growth and harmless detachment of cells cultured on the surface of thermoresponsive tissue culture polystyrene (TCPS). Methods Thermoresponsive N-isopropylacrylamide (NIPAAm) and biocompatible chitosan (CS) were grafted onto the surface of TCPS by ultraviolet (UV)–induced graft polymerization. The chemical composition, surface morphology and thermoresponsiveness of the modified TCPS were investigated by X-ray photoelectron spectroscopy (XPS), atom force microscopy (AFM) and contact angle (CA), respectively. Furthermore, the growth and detachment behaviors of mouse fibroblast cells (L929) on the surface of the modified TCPS were studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results The modified TCPS exhibited good hydrophobic/hydrophilic property alterations in response to temperature. The cytocompatibility of the materials was improved due to the introduction of CS. Cells could be spontaneously detached from the surface without any damage, by controlling environmental temperature. The viability of cells obtained by temperature induction was higher than that obtained by enzymatic digestion. Conclusions This study developed a simple and economical method to fabricate thermoresponsive cell culture dishes and provided new thoughts and experimental bases for exploring novel material applied in tissue engineering.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"14 1","pages":"404 - 412"},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Biopolyester-Based Systems Containing Naturally Occurring Compounds with Enhanced Thermo-Oxidative Stability 含有天然存在的具有增强热氧化稳定性的化合物的生物聚酯基系统

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-02 DOI: 10.5301/jabfm.5000322

R. Arrigo, E. Morici, N. T. Dintcheva

{"title":"Biopolyester-Based Systems Containing Naturally Occurring Compounds with Enhanced Thermo-Oxidative Stability","authors":"R. Arrigo, E. Morici, N. T. Dintcheva","doi":"10.5301/jabfm.5000322","DOIUrl":"https://doi.org/10.5301/jabfm.5000322","url":null,"abstract":"Background This work presents a sustainable approach for the stabilization of polylactic acid (PLA) against thermo-oxidative aging. Methods Naturally occurring phenolic and polyphenolic compounds, such as ferulic acid (FerAc), vanillic acid (VanAc), quercetin (Querc) and vitamin E (VitE), were introduced into PLA. Results The preliminary characterization of the systems formulated containing different amounts of natural stabilizers showed that all compounds used acted as plasticizers, leading to a decrease in rheological functions with respect to neat PLA, without significantly modifying the crystallinity of the raw material. The study of the thermo-oxidative behavior of neat PLA and PLA/natural compound systems, performed by spectrometric and thermal analyses, indicated that all stabilizers considered were able to exert a remarkable antioxidant action against thermo-oxidative phenomena. Conclusions All natural compounds considered are thus proposed as ecofriendly stabilizers, to get fully bio-based polymer systems with enhanced thermo-oxidative stability, suitable for biomedical applications.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"14 1","pages":"455 - 462"},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Evaluation of Calcium Dihydroxide- and Silver-Coated Implants in the Rat Tibia 大鼠胫骨二氢氧化钙和镀银植入物的评价

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-02 DOI: 10.5301/jabfm.5000323

N. Harrasser, M. de Wild, Johannes Gorkotte, A. Obermeier, S. Feihl, M. Straub, R. von Eisenhart-Rothe, H. Gollwitzer, Jasmine Rüegg, W. Moser, P. Gruner, R. Burgkart

{"title":"Evaluation of Calcium Dihydroxide- and Silver-Coated Implants in the Rat Tibia","authors":"N. Harrasser, M. de Wild, Johannes Gorkotte, A. Obermeier, S. Feihl, M. Straub, R. von Eisenhart-Rothe, H. Gollwitzer, Jasmine Rüegg, W. Moser, P. Gruner, R. Burgkart","doi":"10.5301/jabfm.5000323","DOIUrl":"https://doi.org/10.5301/jabfm.5000323","url":null,"abstract":"Background Silver ions (Ag+) have strong antibacterial effects, and silver-coated materials are in widespread clinical use. However, the application of silver-coated medical devices is not without concerns: its use with direct bone contact is not established, and systemic toxic side effects of released Ag+ have been described. Therefore, alternative bactericidal coatings with a more localized way of acting – e.g., calcium dihydroxide, Ca(OH)2 (CH) – would be advantageous. Methods A new rat model of the animal's tibial metaphysis was developed. In the left proximal tibiae of 36 male Wistar rats, titanium screws were implanted. The screws were coated with hydroxyapatite (HA; 12 animals: group I), low-dosed HA silver (HA-Ag; 12 animals: group II) and CH (12 animals: group III). After 6 weeks, all rats were sacrificed. The implants were evaluated for morphological changes on their surfaces, by light microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy; for osteointegration, by measurement of resistance to removal; and for bacterial colonization, by quantitative culture analysis. Additionally, the tibial bone was investigated histologically for signs of osteomyelitis and sonicated to detect bacterial loads. Results (i) No microbiological or histological signs of infection could be determined on any of the screws or the surrounding bone. (ii) The bone-implant interface analysis revealed extensive bone formation and direct bone-implant contact on all HA, HA-Ag and HA-CH coated screws. (iii) HA and HA-Ag were partially, and CH was fully, degraded on the screw coating, allowing host bone to osteointegrate.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"14 1","pages":"441 - 448"},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Is Micro-Computed Tomography Useful for Wear Assessment of Ceramic Femoral Heads? A Preliminary Evaluation of Volume Measurements 微计算机断层扫描对陶瓷股骨头的磨损评估有用吗?体积测量的初步评价

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-02 DOI: 10.5301/jabfm.5000324

A. Parrilli, S. Falcioni, M. Fini, S. Affatato

{"title":"Is Micro-Computed Tomography Useful for Wear Assessment of Ceramic Femoral Heads? A Preliminary Evaluation of Volume Measurements","authors":"A. Parrilli, S. Falcioni, M. Fini, S. Affatato","doi":"10.5301/jabfm.5000324","DOIUrl":"https://doi.org/10.5301/jabfm.5000324","url":null,"abstract":"Background Wear associated with hip components represents the main clinical problem in these patients, and it is important to develop new techniques for more accurate measurements of that wear. Currently, the gravimetric method is the gold standard for assessing mass measurements in preclinical evaluations. However, this method does not give other information such as volumetric loss or surface deviation. This work aimed to develop and validate a new technique to quantify ceramic volume loss from in vitro experiments using micro-computed tomography (micro-CT). Methods An alumina (BIOLOX® forte) femoral head (Ø = 28 mm) was used. Mass and volume loss were approached by gravimetric method (using a four decimal place digital microbalance) and by using Skyscan 1176 microtomographic system, respectively. Results Standard error and coefficient of variance of both gravimetric and experimental groups demonstrated the reliability of the micro-CT analysis technique. Conclusions In conclusion, the findings of the present study suggest that this new protocol could be considered an important tool for wear assessment and that we have found a reliable metrological protocol for volumetric analysis of ceramic femoral head prostheses, demonstrating that the micro-CT technique can be an important tool for wear assessment.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"14 1","pages":"483 - 489"},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Poly-Paper: A Sustainable Material for Packaging, Based on Recycled Paper and Recyclable with Paper 复合纸:一种可持续的包装材料，基于再生纸和可回收纸

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-02 DOI: 10.5301/jabfm.5000335

B. Del Curto, N. Barelli, Mauro Profaizer, S. Faré, M. Tanzi, A. Cigada, G. Ognibene, G. Recca, G. Cicala

{"title":"Poly-Paper: A Sustainable Material for Packaging, Based on Recycled Paper and Recyclable with Paper","authors":"B. Del Curto, N. Barelli, Mauro Profaizer, S. Faré, M. Tanzi, A. Cigada, G. Ognibene, G. Recca, G. Cicala","doi":"10.5301/jabfm.5000335","DOIUrl":"https://doi.org/10.5301/jabfm.5000335","url":null,"abstract":"Background Until now, environmental sustainability issues are almost entirely unsolved for packaging materials. With the final aim of finding materials with a single recycling channel, cellulose fiber/poly(vinyl)alcohol composites were investigated. Methods After extrusion and injection molding, samples of composite with different cellulose fiber content (30%, 50% and 70% w/w) were tested. Results Tensile mechanical tests exhibited an improvement in composite stiffness when the reinforcement content was increased together with a decrease in composite elongation. Solubility tests performed at room temperature and 45°C showed different behavior depending on the water-resistant film applied on the composite (50% cellulose fiber content). In particular, the uncoated composite showed complete solubility after 2 hours, whereas at the same time point, no solubility occurred when a non-water-soluble varnish was used. Conclusions The proposed composites, named Poly-paper, appear to warrant further investigation as highly sustainable packaging.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"14 1","pages":"490 - 495"},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70593171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Effect of Cold Drawing on Mechanical Properties of Biodegradable Fibers 冷拔对可生物降解纤维力学性能的影响

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-10-01 DOI: 10.5301/jabfm.5000328

F. L. La Mantia, M. Ceraulo, M. Mistretta, M. Morreale

{"title":"Effect of Cold Drawing on Mechanical Properties of Biodegradable Fibers","authors":"F. L. La Mantia, M. Ceraulo, M. Mistretta, M. Morreale","doi":"10.5301/jabfm.5000328","DOIUrl":"https://doi.org/10.5301/jabfm.5000328","url":null,"abstract":"Purpose Biodegradable polymers are currently gaining importance in several fields, because they allow mitigation of the impact on the environment related to disposal of traditional, nonbiodegradable polymers, as well as reducing the utilization of oil-based sources (when they also come from renewable resources). Fibers made of biodegradable polymers are of particular interest, though, it is not easy to obtain polymer fibers with suitable mechanical properties and to tailor these to the specific application. The main ways to tailor the mechanical properties of a given biodegradable polymer fiber are based on crystallinity and orientation control. However, crystallinity can only marginally be modified during processing, while orientation can be controlled, either during hot drawing or cold stretching. In this paper, a systematic investigation of the influence of cold stretching on the mechanical and thermomechanical properties of fibers prepared from different biodegradable polymer systems was carried out. Methods Rheological and thermal characterization helped in interpreting the orientation mechanisms, also on the basis of the molecular structure of the polymer systems. Results and conclusions It was found that cold drawing strongly improved the elastic modulus, tensile strength and thermomechanical resistance of the fibers, in comparison with hot-spun fibers. The elastic modulus showed higher increment rates in the biodegradable systems upon increasing the draw ratio.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"15 1","pages":"70 - 76"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70593279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Does Acid Etching Morphologically and Chemically Affect Lithium Disilicate Glass Ceramic Surfaces? 酸蚀对二硅酸锂玻璃陶瓷表面的形态和化学影响?

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-09-17 DOI: 10.5301/jabfm.5000303

Y. Maruo, G. Nishigawa, M. Irie, K. Yoshihara, T. Matsumoto, S. Minagi

{"title":"Does Acid Etching Morphologically and Chemically Affect Lithium Disilicate Glass Ceramic Surfaces?","authors":"Y. Maruo, G. Nishigawa, M. Irie, K. Yoshihara, T. Matsumoto, S. Minagi","doi":"10.5301/jabfm.5000303","DOIUrl":"https://doi.org/10.5301/jabfm.5000303","url":null,"abstract":"Background This study evaluated the surface morphology, chemical composition and adhesiveness of lithium disilicate glass ceramic after acid etching with hydrofluoric acid or phosphoric acid. Methods Lithium disilicate glass ceramic specimens polished by 600-grit silicon carbide paper were subjected to one or a combination of these surface treatments: airborne particle abrasion with 50-μm alumina (AA), etching with 5% hydrofluoric acid (HF) or 36% phosphoric acid (Phos), and application of silane coupling agent (Si). Stainless steel rods of 3.6-mm diameter and 2.0-mm height were cemented onto treated ceramic surfaces with a self-adhesive resin cement (Clearfil SA Cement). Shear bond strengths between ceramic and cement were measured after 24-hour storage in 37°C distilled water. Results SEM images of AA revealed the formation of conventional microretentive grooves, but acid etching with HF or Phos produced a porous surface. Bond strengths of AA+HF+Si (28.1 ± 6.0 MPa), AA+Phos+Si (17.5 ± 4.1 MPa) and HF+Si (21.0 ± 3.0 MPa) were significantly greater than those of non-pretreated controls with Si (9.7 ± 3.7 MPa) and without Si (4.1 ± 2.4 MPa) (p<0.05). In addition, HF etching alone (26.2 ± 7.5 MPa) had significantly higher bond strength than AA alone (11.5 ± 4.0 MPa) (p<0.05). AA+HF, AA+Phos and HF showed cohesive failures. Conclusions Etching with HF or Phos yielded higher bond strength between lithium disilicate glass ceramic and self-adhesive resin cement without microcrack formation.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"15 1","pages":"100 - 93"},"PeriodicalIF":0.0,"publicationDate":"2016-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Measuring the Remineralization Potential of Different Agents with Quantitative Light-Induced Fluorescence Digital Biluminator 用定量光致荧光数字发光仪测定不同药剂的再矿化电位

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-09-14 DOI: 10.5301/jabfm.5000317

E. Kucukyilmaz, S. Savaş

{"title":"Measuring the Remineralization Potential of Different Agents with Quantitative Light-Induced Fluorescence Digital Biluminator","authors":"E. Kucukyilmaz, S. Savaş","doi":"10.5301/jabfm.5000317","DOIUrl":"https://doi.org/10.5301/jabfm.5000317","url":null,"abstract":"Background The aim of this study was to investigate the effectiveness of different remineralization agents by quantitative light-induced fluorescence digital Biluminator™ (QLF-D). Methods Artificial caries lesions were created, and the teeth were divided according to the tested materials: (i) distilled water, (ii) acidulated phosphate fluoride (APF), (iii) Curodont Repair (CR), (iv) ammonium hexafluorosilicate (SiF) and (v) ammonium hexafluorosilicate plus cetylpyridinium chloride (SiF + CPC). After treatment procedures, each of the samples was placed in artificial saliva. After demineralization and 1 and 4 weeks of remineralization procedures, fluorescence loss and lesion areas were measured with QLF-D. Data were statistically analyzed (α = 0.05). Results The fluorescence values of the demineralized enamel specimens treated with the various agents differed significantly compared with pretreatment values for both 1 and 4 weeks (p<0.05). At 4 weeks, the highest fluorescence gain was calculated in the CR, APF and SiF groups compared with the control (p<0.05). Conclusions APF, SiF and CR groups yielded greater remineralization ability than SiF + CPC and control groups.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"15 1","pages":"101 - 106"},"PeriodicalIF":0.0,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

From Honeycomb- to Microsphere-Patterned Surfaces of Poly(Lactic Acid) and a Starch-Poly(Lactic Acid) Blend via the Breath Figure Method 通过呼吸图法从蜂窝状到微球状的聚乳酸和淀粉-聚乳酸混合表面

Journal of Applied Biomaterials & Biomechanics Pub Date : 2016-09-14 DOI: 10.5301/jabfm.5000281

A. Duarte, D. Maniglio, Nuno Sousa, J. Mano, R. Reis, C. Migliaresi

{"title":"From Honeycomb- to Microsphere-Patterned Surfaces of Poly(Lactic Acid) and a Starch-Poly(Lactic Acid) Blend via the Breath Figure Method","authors":"A. Duarte, D. Maniglio, Nuno Sousa, J. Mano, R. Reis, C. Migliaresi","doi":"10.5301/jabfm.5000281","DOIUrl":"https://doi.org/10.5301/jabfm.5000281","url":null,"abstract":"Background This study investigated the preparation of ordered patterned surfaces and/or microspheres from a natural-based polymer, using the breath figure and reverse breath figure methods. Methods Poly(D,L-lactic acid) and starch poly(lactic acid) solutions were precipitated in different conditions – namely, polymer concentration, vapor atmosphere temperature and substrate – to evaluate the effect of these conditions on the morphology of the precipitates obtained. Results The possibility of fine-tuning the properties of the final patterns simply by changing the vapor atmosphere was also demonstrated here using a range of compositions of the vapor phase. Porous films or discrete particles are formed when the differences in surface tension determine the ability of polymer solution to surround water droplets or methanol to surround polymer droplets, respectively. In vitro cytotoxicity was assessed applying a simple standard protocol to evaluate the possibility to use these materials in biomedical applications. Moreover, fluorescent microscopy images showed a good interaction of cells with the material, which were able to adhere on the patterned surfaces after 24 hours in culture. Conclusions The development of patterned surfaces using the breath figure method was tested in this work for the preparation of both poly(lactic acid) and a blend containing starch and poly(lactic acid). The potential of these films to be used in the biomedical area was confirmed by a preliminary cytotoxicity test and by morphological observation of cell adhesion.","PeriodicalId":51074,"journal":{"name":"Journal of Applied Biomaterials & Biomechanics","volume":"15 1","pages":"31 - 42"},"PeriodicalIF":0.0,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5301/jabfm.5000281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70592489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10