RETINAL Cases & Brief Reports最新文献

Clinical Characteristics of Four Cases of Presumed Chloroquine Retinopathy 四例假定氯喹视网膜病变病例的临床特征

RETINAL Cases & Brief Reports Pub Date : 2024-07-23 DOI: 10.1097/icb.0000000000001644

Brian P. Hall, Joanne Thomas, Jiong Yan, Nieraj Jain

{"title":"Clinical Characteristics of Four Cases of Presumed Chloroquine Retinopathy","authors":"Brian P. Hall, Joanne Thomas, Jiong Yan, Nieraj Jain","doi":"10.1097/icb.0000000000001644","DOIUrl":"https://doi.org/10.1097/icb.0000000000001644","url":null,"abstract":"\u0000 \u0000 Chloroquine (CQ), primarily used in the management of malaria and autoimmune diseases, has long been known to cause retinal toxicity. However, modern literature with multimodal fundus imaging findings remains limited. This retrospective study explores presumed CQ retinopathy cases at a tertiary United States referral center with an emphasis on multimodal fundus imaging characteristics.\u0000 \u0000 \u0000 \u0000 Retrospective series of cases of presumed CQ toxicity seen at the Emory Eye Center between 2015-2022.\u0000 \u0000 \u0000 \u0000 Four males were identified with presumed CQ retinopathy, with median age of 57 years (range 50-59 years). CQ use occurred in malaria-endemic regions in each case, and the medication was self-administered in three cases. Optical coherence tomography consistently revealed outer band loss and varying degrees of foveal sparing. Fundus autofluorescence imaging demonstrated symmetric bull’s eye pattern of AF abnormality with hyperautofluorescence along the rim of diseased tissue. One case exhibited para-vascular hyperautofluorescence in the setting of repeated intravenous CQ exposure.\u0000 \u0000 \u0000 \u0000 Multimodal retinal imaging revealed distinct yet diverse patterns of degeneration not readily visible on clinical examination. More generally, these findings raise public health concerns regarding self-administration of CQ in malaria-endemic regions.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"65 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141812835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CMV retinitis in non-HIV immunocompromised individuals on tofacitinib for rheumatoid arthritis 服用托法替尼治疗类风湿性关节炎的非艾滋病毒免疫功能低下者中的巨细胞病毒视网膜炎

RETINAL Cases & Brief Reports Pub Date : 2024-07-10 DOI: 10.1097/icb.0000000000001626

Meghan J. Smith, Jennifer I. Lim, Felix Y Chau, Ann-Marie Lobo-Chan

{"title":"CMV retinitis in non-HIV immunocompromised individuals on tofacitinib for rheumatoid arthritis","authors":"Meghan J. Smith, Jennifer I. Lim, Felix Y Chau, Ann-Marie Lobo-Chan","doi":"10.1097/icb.0000000000001626","DOIUrl":"https://doi.org/10.1097/icb.0000000000001626","url":null,"abstract":"\u0000 \u0000 To describe two patients with long-standing rheumatoid arthritis (RA) who developed cytomegalovirus (CMV) retinitis (CMVR) while taking tofacitinib.\u0000 \u0000 \u0000 \u0000 Retrospective case series.\u0000 \u0000 \u0000 \u0000 A 79-year-old woman with RA, treated with oral tofacitinib 11mg once daily, presented with blurred vision and pain in the right eye. Visual acuity (VA) was hand motion, anterior segment showed iritis and the intraocular pressure (IOP) was 35mmHg. Ophthalmoscopy revealed retinal hemorrhages and overlying vitreous hemorrhage. HIV serology was negative, serum CMV IgG was positive and aqueous polymerase chain reaction (PCR) was positive for CMV (802,000 IU/mL). An 82-year-old woman with a history of RA, treated with tofacitinib 11mg once daily, was referred for a white retinal lesion in the left eye. VA was 20/50, anterior segment was quiet and IOP was 23mmHg. Ophthalmoscopy revealed a yellow retinal lesion with ill-defined margins in the macula. She subsequently developed a new area of peripheral retinal whitening in the right eye. HIV serology was negative, serum CMV IgG was positive and aqueous PCR was positive for CMV (5,200,000 IU/mL).\u0000 \u0000 \u0000 \u0000 Diagnosis of CMVR in non-HIV individuals requires awareness of the risk of infectious retinitis in patients taking JAK inhibitors for the treatment of autoimmune disease.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"20 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Tuberculin Stings: A Case of Panophthalmitis Following Tuberculin Skin Test 当结核菌素蜇人时结核菌素皮肤试验后的泛眼炎病例

RETINAL Cases & Brief Reports Pub Date : 2024-07-10 DOI: 10.1097/icb.0000000000001627

A. Majumder, P. Majumder

{"title":"When Tuberculin Stings: A Case of Panophthalmitis Following Tuberculin Skin Test","authors":"A. Majumder, P. Majumder","doi":"10.1097/icb.0000000000001627","DOIUrl":"https://doi.org/10.1097/icb.0000000000001627","url":null,"abstract":"\u0000 \u0000 To report a case of allergic reaction to a tuberculin skin test that incited a panophthalmitis-like reaction with exudative retinal detachment.\u0000 \u0000 \u0000 \u0000 Retrospective Chart Review\u0000 \u0000 \u0000 \u0000 A 38-year-old woman presented with sudden onset ocular pain, redness, and protrusion of both eyes following a tuberculin skin test, part of the investigative process for her recent high-grade fever. On presentation to us, her visual acuity was limited to the perception of light in both eyes. Ophthalmic examination revealed fibrinous anterior chamber reaction, sluggish pupils, diffuse conjunctival chemosis, limited ocular movement in all gazes, and inadequate eyelid closure due to proptosis in both eyes. Fundus examination of both eyes showed grade 3+ vitritis and exudative bullous retinal detachment. All other laboratory investigations were within normal limits. The patient demonstrated a remarkable response to pulse corticosteroid therapy, with significant alleviation of ocular symptoms and partial resolution of inflammation. Further treatment was initiated with oral corticosteroids and mycophenolate mofetil, followed by the addition of cyclosporine, which facilitated complete resolution of the exudative retinal detachment with restoration her BCVA to 6/9.\u0000 \u0000 \u0000 \u0000 This case underscores the importance of ophthalmologists recognizing that acute allergic reactions secondary to tuberculin skin tests can, on rare occasions, present as uveitis, and highlights the need for appropriate management of such conditions.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Hodgkin Lymphoma with Presumed Intraocular Involvement 推测眼内受累的系统性霍奇金淋巴瘤

RETINAL Cases & Brief Reports Pub Date : 2024-07-10 DOI: 10.1097/icb.0000000000001628

Victoria A. Marks, Vijitha S. Vempuluru, Carol L. Shields

{"title":"Systemic Hodgkin Lymphoma with Presumed Intraocular Involvement","authors":"Victoria A. Marks, Vijitha S. Vempuluru, Carol L. Shields","doi":"10.1097/icb.0000000000001628","DOIUrl":"https://doi.org/10.1097/icb.0000000000001628","url":null,"abstract":"\u0000 \u0000 We report a rare case of systemic Hodgkin lymphoma with presumed intraocular involvement that resolved following systemic chemotherapy.\u0000 \u0000 \u0000 \u0000 Observational case report.\u0000 \u0000 \u0000 \u0000 A 32-year-old woman with known stage II Hodgkin lymphoma presented with 3 months of photopsia and decreased vision in the left eye. Fundus examination demonstrated vitreous cells, more than 100 yellow choroidal infiltrates involving the entire fundus, and retinal pigment epithelial defects in the macular region of the left eye. Ultrasonography showed chorioretinal thickening and optical coherence tomography demonstrated vitreous opacities with outer retinal atrophy, irregular retinal pigment epithelial thickening, and hyper-transmission defects. A diagnosis of Hodgkin lymphoma with vitreoretinal involvement was considered. Fine needle aspiration biopsy was considered, but the patient preferred deferral as she was already on cycle 3 of systemic chemotherapy (doxorubicin, bleomycin, vinblastine, dacarbazine). Following the fourth cycle of systemic treatment, the vitreous cells and choroidal lesions resolved.\u0000 \u0000 \u0000 \u0000 This case details a rare presentation of systemic Hodgkin lymphoma with presumed vitreoretinal and choroidal involvement that responded to anti-Hodgkin lymphoma chemotherapy.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"31 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FLUCTUATING EXUDATION IN NON-NEOVASCULAR GEOGRAPHIC ATROPHY 非新血管性地理萎缩中的波动性渗出

RETINAL Cases & Brief Reports Pub Date : 2024-07-10 DOI: 10.1097/icb.0000000000001629

Leonardo Bottazzi, A. Servillo, I. Zucchiatti, R. Sacconi, L. Querques, Francesco Bandello, Giuseppe Querques

{"title":"FLUCTUATING EXUDATION IN NON-NEOVASCULAR GEOGRAPHIC ATROPHY","authors":"Leonardo Bottazzi, A. Servillo, I. Zucchiatti, R. Sacconi, L. Querques, Francesco Bandello, Giuseppe Querques","doi":"10.1097/icb.0000000000001629","DOIUrl":"https://doi.org/10.1097/icb.0000000000001629","url":null,"abstract":"\u0000 \u0000 To report a case series of exudation in non-neovascular geographic atrophy (GA), which fluctuated and spontaneously almost resolved during the follow-up.\u0000 \u0000 \u0000 \u0000 A retrospective study was designed to include consecutive cases with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) associated with intraretinal fluid (IRF) but without macular neovascularization (MNV). Three eyes of 2 patients (one male, one female) were enrolled. Spectral domain optical coherence tomography (SD-OCT) and angiographies (OCT angiography and/or dye angiographies) were performed to confirm diagnosis of IRF and the absence of MNV.\u0000 \u0000 \u0000 \u0000 At baseline best-corrected visual acuity (BCVA) was between 20/50 and 20/36. SD-OCT displayed IRF in the inner and outer retinal layers with an increased central macular thickness. OCT-A and dye angiographies did not show any abnormal neovascular network. Of note, fluorescein angiography showed a leakage in correspondence of the intraretinal cysts, differently from the degenerative pseudocysts. After one month of follow-up, BCVA remained stable, while the IRF spontaneously almost resolved in all cases.\u0000 \u0000 \u0000 \u0000 To our knowledge, this is the first report of a fluctuating exudation in non-neovascular GA. Future studies are required to better define this potential novel clinical phenotype.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"72 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent Central Retinal Vein Occlusion and Rhegmatogenous Retinal Detachment in Two Young Healthy Patients 两名年轻健康患者同时发生视网膜中央静脉闭塞和风湿性视网膜脱离

RETINAL Cases & Brief Reports Pub Date : 2024-07-03 DOI: 10.1097/icb.0000000000001622

Simatul Rashid, Ryan S. Meshkin, Bertan Cakir, S. Hoyek, Elizabeth J. Rossin, D. Eliott, Nimesh A. Patel

{"title":"Concurrent Central Retinal Vein Occlusion and Rhegmatogenous Retinal Detachment in Two Young Healthy Patients","authors":"Simatul Rashid, Ryan S. Meshkin, Bertan Cakir, S. Hoyek, Elizabeth J. Rossin, D. Eliott, Nimesh A. Patel","doi":"10.1097/icb.0000000000001622","DOIUrl":"https://doi.org/10.1097/icb.0000000000001622","url":null,"abstract":"\u0000 \u0000 Central retinal vein occlusion (CRVO) and rhegmatogenous retinal detachment (RRD) are two distinct retinal conditions that typically affect older patient populations with comorbidities or predisposing risk factors. This case report presents unusual co-occurrences of CRVO and RRD in two young, healthy adult patients and proposes potential etiological factors contributing to the complex presentations.\u0000 \u0000 \u0000 \u0000 Retrospective case-series of two young, healthy males with no history of systemic diseases who presented with concurrent CRVO and RRD.\u0000 \u0000 \u0000 \u0000 The first case was a 28-year-old male construction worker, who presented with acute, painless vision loss and extensive intra-retinal hemorrhages in the right eye, tortuous dilated retinal veins, significant macular edema, optic disc edema, and a macula sparing RRD. Treatment included intravitreal injections of bevacizumab followed by RRD repair with scleral buckle, cryotherapy, external drainage, and later a pneumatic retinopexy. His visual acuity had improved from 20/200 to 20/30 in the right eye. The second case was a 19-year-old male patient who also presented with acute painless vision loss in the left eye and was diagnosed with CRVO and concomitant RD. Treatment included intravitreal bevacizumab injections, oral prednisone trial, and surgical repair with scleral buckle, vitrectomy, and silicone oil insertion. Workup for inflammatory, infectious, and hypercoagulable conditions was negative in both cases.\u0000 \u0000 \u0000 \u0000 Concurrent CRVO and RRD can occur in young healthy patients. Prompt surgery is indicated and treatment with anti-VEGF can be initiated in the perioperative period without complications.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"117 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTIMODAL IMAGING OF DIDANOSINE-RELATED RETINOPATHY 与地达诺辛相关的视网膜病变的多模态成像

RETINAL Cases & Brief Reports Pub Date : 2024-07-03 DOI: 10.1097/icb.0000000000001625

J. G. Alexander, G. A. Samico, Lucas Zago Ribeiro, H. M. Vasconcelos Júnior

引用次数: 0

Optic Disc Coloboma May Trigger Multiple Evanescent White Dot Syndrome: Expanding the Clinical Spectrum 视盘色素瘤可能诱发多发性疏散白点综合征：扩大临床范围

RETINAL Cases & Brief Reports Pub Date : 2024-07-03 DOI: 10.1097/icb.0000000000001621

A. AlBloushi, Sarah Mohammed Almuwarraee, Fadwa Al Adel

引用次数: 0

Systemic anti-VEGF biosimilar therapy associated with improved macular anatomy and duration of effect in a patient with nearly recalcitrant neovascular age-related macular degeneration 全身性抗血管内皮生长因子生物类似物疗法改善了一名几乎顽固的新生血管性老年性黄斑变性患者的黄斑解剖结构，并延长了疗效持续时间

RETINAL Cases & Brief Reports Pub Date : 2024-07-03 DOI: 10.1097/icb.0000000000001619

Kipp R Morgan, Paige J Richards, Jonathan S Chang

{"title":"Systemic anti-VEGF biosimilar therapy associated with improved macular anatomy and duration of effect in a patient with nearly recalcitrant neovascular age-related macular degeneration","authors":"Kipp R Morgan, Paige J Richards, Jonathan S Chang","doi":"10.1097/icb.0000000000001619","DOIUrl":"https://doi.org/10.1097/icb.0000000000001619","url":null,"abstract":"\u0000 \u0000 To present a patient with neovascular AMD treated systemically with the biosimilar bevacizumab-awwb (Mvasi) with superior SRF resolution when compared to continuous and repeated intravitreal treatments.\u0000 \u0000 \u0000 \u0000 Retrospective single case report.\u0000 \u0000 \u0000 \u0000 After 3 years of monthly aflibercept treatment for nAMD, the patient had persistent subretinal fluid (SRF). Systemic bevacizumab-awwb (Mvasi) infusions were initiated by her oncologist for ovarian cancer and SRF resolved for the first time. After one additional aflibercept injection, and continued bevacizubam-awwb infusions for her cancer, SRF did not recur. Thirteen weeks later, at final follow-up before the patient passed away, the macula remained dry and no additonal intravitreal treatment was given.\u0000 \u0000 \u0000 \u0000 When systemic anti-VEGF biosimilar therapy was administered, there was improved anatomy and prolonged duration of effect compared to the intravitreal therapy alone. Adverse systemic effects limit the routine use of systemic anti-VEGF therapy for retinal disease. However if a patient requires systemic anti-VEGF or anti-VEGF biosimilar therapy for malignancy, it may also benefit retinal disease leading to benefits in quality of life and fewer office visits.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"171 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recalcitrant Peripapillary Pachychoroid Syndrome Responds to High-Dose Aflibercept Therapy 难治性毛细血管周围蛛网膜综合征对大剂量阿弗利贝赛疗法的反应

RETINAL Cases & Brief Reports Pub Date : 2024-07-03 DOI: 10.1097/icb.0000000000001620

Alessandro Feo, Neda Abraham, Mostafa Mafi, David Sarraf

{"title":"Recalcitrant Peripapillary Pachychoroid Syndrome Responds to High-Dose Aflibercept Therapy","authors":"Alessandro Feo, Neda Abraham, Mostafa Mafi, David Sarraf","doi":"10.1097/icb.0000000000001620","DOIUrl":"https://doi.org/10.1097/icb.0000000000001620","url":null,"abstract":"\u0000 \u0000 To describe a case of recalcitrant bilateral peripapillary pachychoroid syndrome (PPS) treated with high-dose (HD) intravitreal aflibercept injections.\u0000 \u0000 \u0000 \u0000 Medical and imaging records were retrospectively evaluated. Multimodal imaging included ultra-widefield indocyanine green and fluorescein angiography and fundus autofluorescence. Tracked optical coherence tomography (OCT) B scans were reviewed to assess intra- (IRF) and subretinal fluid (SRF), and to measure choroidal thickness (CT). Macular neovascularization was excluded with OCT angiography.\u0000 \u0000 \u0000 \u0000 A 75-year-old man with bilateral PPS and severe peripapillary and macular edema underwent multiple sessions of photodynamic therapy, intravitreal aflibercept injections, and corticosteroid eye drop application with minimal improvement of the fluid. After two monthly intravitreal HD aflibercept injections, the peripapillary and macular fluid was almost completely resolved with commensurate choroidal thickness reduction and significant visual gain in each eye.\u0000 \u0000 \u0000 \u0000 High-dose intravitreal aflibercept therapy may lead to remarkable anatomical and functional improvement in eyes with recalcitrant PPS.\u0000","PeriodicalId":510632,"journal":{"name":"RETINAL Cases & Brief Reports","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETINAL Cases &amp; Brief Reports最新文献

RETINAL Cases & Brief Reports最新文献