Macromol最新文献_第2页

Influence of High-Pressure Processing and Microbial Transglutaminase on the Properties of Pea Protein Isolates 高压加工和微生物转谷氨酰胺酶对豌豆蛋白分离物特性的影响

Macromol Pub Date : 2024-04-08 DOI: 10.3390/macromol4020011

Rui P. Queirós, Nicole Moreira, C. Pinto, Liliana G. Fidalgo, Jorge M. A. Saraiva, J. A. Lopes-da-Silva

{"title":"Influence of High-Pressure Processing and Microbial Transglutaminase on the Properties of Pea Protein Isolates","authors":"Rui P. Queirós, Nicole Moreira, C. Pinto, Liliana G. Fidalgo, Jorge M. A. Saraiva, J. A. Lopes-da-Silva","doi":"10.3390/macromol4020011","DOIUrl":"https://doi.org/10.3390/macromol4020011","url":null,"abstract":"This study investigated the effects of high-pressure processing (HPP; 600 MPa/15 min) and microbial transglutaminase-catalyzed (MTG; 30 U·g of protein−1) crosslinking on the concentration of dissolved proteins (SOL), free sulfhydryl groups (SH), surface hydrophobicity (H0), and viscosity of pea protein isolates (PPI) at different concentrations (1–13%; w/v). The SOL increased by increasing protein concentration (max. 29%). MTG slightly affected SOL. HPP decreased SOL with increasing protein concentration, and the combination MTG + HPP resulted in a lower SOL than HPP alone. The concentration of SH in untreated PPI increased with increasing protein concentration, reaching a maximum of 8.3 μmol·mg prot−1. MTG increased SH at higher protein concentrations. HPP lowered SH, but its concentration increased by increasing protein concentration. HPP + MTG offset the effect of MTG, yielding lower SH. MTG did not affect H0 at 1% concentration but increased it for concentrations from 3–5%, and there was a decrease with 7–9%. HPP increased H0 up to 37% for intermediate protein concentrations but did not affect it at higher concentrations. MTG + HPP decreased H0 at all protein concentrations. The viscosity of the dispersions increased with protein concentration. HPP increased the viscosity of the dispersions for concentrations above 7%, while MTG only caused changes above 9%. Combined MTG + HPP resulted in viscosity increase. The results underscore the opportunity for innovative development of high-protein products with improved properties or textures for industrial application.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":"77 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired Polymers: Bridging Nature’s Ingenuity with Synthetic Innovation 生物启发聚合物：连接自然智慧与合成创新

Macromol Pub Date : 2024-04-02 DOI: 10.3390/macromol4020010

Hamid Omidian, N. Babanejad

引用次数: 0

Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration 模拟 miRNA 和抗 miRNA 激活支架作为促进骨骼、软骨和皮肤再生的治疗策略

Macromol Pub Date : 2024-04-01 DOI: 10.3390/macromol4020009

G. Guelfi, Camilla Capaccia, Polina Anipchenko, Francesco Ciancabilla, Oommen P. Oommen, A. Bufalari, Massimo Zerani, M. Maranesi

{"title":"Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration","authors":"G. Guelfi, Camilla Capaccia, Polina Anipchenko, Francesco Ciancabilla, Oommen P. Oommen, A. Bufalari, Massimo Zerani, M. Maranesi","doi":"10.3390/macromol4020009","DOIUrl":"https://doi.org/10.3390/macromol4020009","url":null,"abstract":"MiRNA-based therapies represent an innovative and promising strategy applicable to various medical fields, such as tissue regeneration and the treatment of numerous diseases, including cancer, cardiovascular problems, and viral infections. MiRNAs, a group of small non-coding RNAs, play a critical role in regulating gene expression at the post-transcriptional level and modulate several signaling pathways that maintain cellular and tissue homeostasis. The clinical trials discussed in the review herald a new therapeutic era for miRNAs, particularly in tissue engineering, using synthetic exogenous mimic miRNAs and antisense miRNAs (anti-miRNAs) to restore tissue health. This review provides an overview of miRNAs’ biogenesis, mechanism of action, regulation, and potential applications, followed by an examination of the challenges associated with the transport and delivery of therapeutic miRNAs. The possibility of using viral and non-viral vectors that protect against degradation and ensure effective miRNA delivery is highlighted, focusing on the advantages of the emerging use of 3D biomaterial scaffolds for the delivery of mimic miRNAs and anti-miRNAs to facilitate tissue repair and regeneration. Finally, the review assesses the current landscape of miRNA-activated scaffold therapies on preclinical and clinical studies in bone, cartilage, and skin tissues, emphasizing their emergence as a promising frontier in personalized medicine.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":"496 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic, Isothermal, and Thermodynamic Analyses of Adsorption of Humic Acid on Quaternized Porous Cellulose Beads 季铵化多孔纤维素珠吸附腐植酸的动力学、等温和热力学分析

Macromol Pub Date : 2024-03-05 DOI: 10.3390/macromol4010006

Kana Uchiyama, Hiromichi Asamoto, Hiroaki Minamisawa, Kazunori Yamada

{"title":"Kinetic, Isothermal, and Thermodynamic Analyses of Adsorption of Humic Acid on Quaternized Porous Cellulose Beads","authors":"Kana Uchiyama, Hiromichi Asamoto, Hiroaki Minamisawa, Kazunori Yamada","doi":"10.3390/macromol4010006","DOIUrl":"https://doi.org/10.3390/macromol4010006","url":null,"abstract":"Porous cellulose beads were quaternized with glycidyltrimethylammonium chloride (GTMAC), and the potential use of the quaternized cellulose beads as an adsorbent was explored for the removal of humic acid (HA) from aqueous media. The introduction of quaternary ammonium groups was verified by FT-IR and XPS analyses, and their content increased to 0.524 mmol/g-Qcell by increasing the GTMAC concentration. The adsorption capacity of the HA increased with decreasing initial pH value and/or increasing content of quaternary ammonium groups, and a maximum adsorption capacity of 575 mg/g-Qcell was obtained for the quaternized cellulose beads with a content of quaternary ammonium groups of 0.380 mmol/g-Qcell. The removal % value increased with increasing dose of quaternized cellulose beads, and HA was highly removed at higher quaternary ammonium groups. The kinetics of the HA adsorption in this study followed a pseudo-second-order equation, and the process exhibited a better fit to the Langmuir isotherm. In addition, the k2 value increased with increasing temperature. These results emphasize that HA adsorption is limited by chemical sorption or chemisorption. The quaternized cellulose beads were repetitively used for the adsorption of HA without appreciable loss in the adsorption capacity. The empirical, equilibrium, and kinetic aspects obtained in this study support that the quaternized cellulose beads can be applied to the removal of HA.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":"125 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospinning: Processes, Structures, and Materials 电纺丝：工艺、结构和材料

Macromol Pub Date : 2024-02-11 DOI: 10.3390/macromol4010004

Mahboubeh Ahmadi Ahmadi Bonakdar, Denis Rodrigue

引用次数: 0

Electrospinning: Processes, Structures, and Materials 电纺丝：工艺、结构和材料

Macromol Pub Date : 2024-02-11 DOI: 10.3390/macromol4010004

Mahboubeh Ahmadi Ahmadi Bonakdar, Denis Rodrigue

引用次数: 0

Structural Characteristics and Improved Thermal Stability of HDPE/Calcium Pimelate Nanocomposites 高密度聚乙烯/菠萝酸钙纳米复合材料的结构特征和热稳定性改进

Macromol Pub Date : 2024-02-05 DOI: 10.3390/macromol4010003

Christina Samiotaki, E. Tarani, Dimitra Karavasili, Alexandra Zamboulis, K. Chrissafis, D. Bikiaris

{"title":"Structural Characteristics and Improved Thermal Stability of HDPE/Calcium Pimelate Nanocomposites","authors":"Christina Samiotaki, E. Tarani, Dimitra Karavasili, Alexandra Zamboulis, K. Chrissafis, D. Bikiaris","doi":"10.3390/macromol4010003","DOIUrl":"https://doi.org/10.3390/macromol4010003","url":null,"abstract":"In the present research work, calcium pimelate (CaPim) was synthesized and investigated as an additive for high-density polyethylene (HDPE). HDPE/CaPim nanocomposites were prepared by melt-mixing, with CaPim content ranging from 0.1% to 1%, affording white homogeneous materials. The chemical structure of the nanocomposites and the incorporation of CaPim was confirmed by infrared spectroscopy. The surficial morphology and the additive distribution were examined by scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction measurements showed that the thermal transitions and crystal structure of HDPE are not affected by the incorporation of CaPim, while the mechanical properties are retained overall. This study focuses on the thermal degradation of HDPE nanocomposites, investigating the degradation mechanism and kinetic parameters through various analytical methods. Isoconversional techniques, including the Friedman method, Vyazovkin analysis, and Ozawa Flynn Wall analysis, were employed to calculate activation energies (Eα). The degradation mechanism and kinetic triplet were determined based on a multivariate non-linear regression method (model-fitting). Finally, the presence of a CaPim additive was shown to increase the Eα of thermal degradation, consistent with the calculated dependence of Eα on the degree of conversion and the improved thermal stability of the HDPE matrix.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":"53 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Characteristics and Improved Thermal Stability of HDPE/Calcium Pimelate Nanocomposites 高密度聚乙烯/菠萝酸钙纳米复合材料的结构特征和热稳定性改进

Macromol Pub Date : 2024-02-05 DOI: 10.3390/macromol4010003

Christina Samiotaki, E. Tarani, Dimitra Karavasili, Alexandra Zamboulis, K. Chrissafis, D. Bikiaris

{"title":"Structural Characteristics and Improved Thermal Stability of HDPE/Calcium Pimelate Nanocomposites","authors":"Christina Samiotaki, E. Tarani, Dimitra Karavasili, Alexandra Zamboulis, K. Chrissafis, D. Bikiaris","doi":"10.3390/macromol4010003","DOIUrl":"https://doi.org/10.3390/macromol4010003","url":null,"abstract":"In the present research work, calcium pimelate (CaPim) was synthesized and investigated as an additive for high-density polyethylene (HDPE). HDPE/CaPim nanocomposites were prepared by melt-mixing, with CaPim content ranging from 0.1% to 1%, affording white homogeneous materials. The chemical structure of the nanocomposites and the incorporation of CaPim was confirmed by infrared spectroscopy. The surficial morphology and the additive distribution were examined by scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction measurements showed that the thermal transitions and crystal structure of HDPE are not affected by the incorporation of CaPim, while the mechanical properties are retained overall. This study focuses on the thermal degradation of HDPE nanocomposites, investigating the degradation mechanism and kinetic parameters through various analytical methods. Isoconversional techniques, including the Friedman method, Vyazovkin analysis, and Ozawa Flynn Wall analysis, were employed to calculate activation energies (Eα). The degradation mechanism and kinetic triplet were determined based on a multivariate non-linear regression method (model-fitting). Finally, the presence of a CaPim additive was shown to increase the Eα of thermal degradation, consistent with the calculated dependence of Eα on the degree of conversion and the improved thermal stability of the HDPE matrix.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":"6 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple One–Pot Synthesis of Hexakis(2-alkoxy-1,5-phenyleneimine) Macrocycles by Precipitation–Driven Cyclization 通过沉淀驱动环化法简单地单锅合成六(2-烷氧基-1,5-苯基亚胺)大环

Macromol Pub Date : 2024-01-03 DOI: 10.3390/macromol4010001

Toshihiko Matsumoto

{"title":"Simple One–Pot Synthesis of Hexakis(2-alkoxy-1,5-phenyleneimine) Macrocycles by Precipitation–Driven Cyclization","authors":"Toshihiko Matsumoto","doi":"10.3390/macromol4010001","DOIUrl":"https://doi.org/10.3390/macromol4010001","url":null,"abstract":"Hexakis(2-alkoxy-1,5-phenyleneimine) macrocycles were synthesized using a simple one-pot procedure through precipitation-driven cyclization. The acetal-protected AB–type monomers, 2-alkoxy-5-aminobenzaldehyde diethyl acetals, underwent polycondensation in water or acid-containing tetrahydrofuran. The precipitation–driven cyclization, based on imine dynamic covalent chemistry and π–stacked columnar aggregation, played a decisive role in the one–pot synthesis. The progress of the reaction was analyzed using MALDI–TOF mass spectrometry. The macrocycles with alkoxy chains were soluble in specific organic solvents, such as chloroform, allowing their structures to be analyzed using NMR. The shape-anisotropic, nearly planar, and shape-persistent macrocycles aggregated into columnar assemblies in polymerization solvents, driven by aromatic π-stacking. The octyloxylated macrocycle OcO–Cm6 exhibited an enantiotropic columnar liquid crystal-like mesophase between 165 °C and 197 °C. In the SEM image of (S)-(–)-3,7-dimethyloctyloxylated macrocycle (–)BCO–Cm6, columnar substances with a diameter of 200–300 nm were observed. The polymerization solution for the 2-(2-methoxyethoxy)ethoxy)ethoxylated macrocycle (TEGO–Cm6) gelled, and showed thixotropic properties by forming a hydrogen bond network.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":"56 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0