Drug Information Journal最新文献_第9页

SYNthesis LIBrary-graphics at the bench. 合成库——工作台上的图形。

Drug Information Journal Pub Date : 1983-01-01 DOI: 10.1177/009286158301700402

D Chodosh, W L Mendelson

{"title":"SYNthesis LIBrary-graphics at the bench.","authors":"D Chodosh, W L Mendelson","doi":"10.1177/009286158301700402","DOIUrl":"https://doi.org/10.1177/009286158301700402","url":null,"abstract":"As part of our continuing research program in the application of computer systems for laboratory scientists, we are developing a chemical reaction retrieval computer program. Program SYNLIB (SYNthesis LIBrary) is a joint research effort between the Chemical Technologies Department, Smith Kline & French Laboratories (SKF), and Professor W. Clark Still, Columbia University. SYNLIB employs very simple graphics instructions that permit the novice user to pose chemical structural questions against a library of chemical reaction citations. The library of citations is gleaned from the published literature and from proprietary research files. Each citation consists of the structural diagram of reactants and products, a literature reference, yield, reaction conditions, steps/reagents, and, when appropriate, disallowed coexisting functional groups. SYNLIB complements the functions of predictive synthesis computer programs (eg, SECS, LHASA), and has been enthusiastically received in our laboratories. The current program strategies will be presented and discussed, along with new research directions that derive from the distribution of chemical graphics technology into the chemical laboratory.","PeriodicalId":51023,"journal":{"name":"Drug Information Journal","volume":"17 4","pages":"231-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/009286158301700402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21147268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

International prescription drug labeling. 国际处方药标签。

Drug Information Journal Pub Date : 1983-01-01 DOI: 10.1177/009286158301700403

P J Roylance, W A Buri

{"title":"International prescription drug labeling.","authors":"P J Roylance, W A Buri","doi":"10.1177/009286158301700403","DOIUrl":"https://doi.org/10.1177/009286158301700403","url":null,"abstract":"Yesterday's therapeutic compounds were meticulously prepared, elegantly presented, and relatively innocuous (Dunlop). Today's powerful and complex drugs are manufactured with sophisticated technology and require clear, concise, and comprehensive information for the physicians throughout the world in order to provide maximum benefit for the patient. Our company, Merck & Co, Inc, has adhered for many years to strict requirements for full and balanced disclosure in all information disseminated to professionals about our products, including circulars, labeling, and advertising. Our practice is to provide complete information to physicians, pharmacists, and regulatory authorities, both on the recommended uses for our products and on their potential adverse effects. The cornerstone of our international disclosure system, the International Physicians Circular (IPC), is provided for each product and comprises part of the initial submission to each national health authority in connection with application for marketing approval. Each IPC sets forth the company's best scientific judgment with respect to both the positive and negative aspects of our drugs, defining actions, indications, and dosage, as well as all contraindications, precautions, and side effects. These circulars are updated in the process of continuous medical review.","PeriodicalId":51023,"journal":{"name":"Drug Information Journal","volume":"17 4","pages":"239-43"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/009286158301700403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21131851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a new approach to geriatric drug education. 老年药物教育新途径的评价。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600401

J F Bonfiglio, L T Sigell, S L Boston, E D Nelson, R E Lee, E A McCray

引用次数: 1

Dissemination of drug information from a non-profit community hospital pharmacy. 非营利性社区医院药房药品信息的传播。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600403

C R Cooper

引用次数: 0

Good reporting practices. 良好的报告实践。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600405

S S Herrick, L A Marek

{"title":"Good reporting practices.","authors":"S S Herrick, L A Marek","doi":"10.1177/009286158201600405","DOIUrl":"https://doi.org/10.1177/009286158201600405","url":null,"abstract":"One aspect of the Good Laboratory Practice (GLP) guidelines issued by the Food and Drug Administration is that they are general in nature and do not specifically state the details of laboratory practice. This generality allows laboratories to conform to existing local practice. However, general guidelines require interpretation and in interpretation lies the potential for disagreement. This article outlines an interpretation of data reporting practice, a very particular laboratory function. Specifically, it outlines some techniques found to be useful in designing and controlling computer generated reports. The vast number of complex, interacting. continuous, time varying, random events which compose the total reality of a study are sampled measured or observed -and recorded at selected points in time, yielding “raw data”. (Since not all parameters can be economically observed or recorded, the selection of the measured values and the sample times are the subject of much professional judgment and folklore). The sample constituting raw data are then collated, sorted, averaged, processed through various algorithms and finally presented in a variety of “reports.” These reports and raw data are interpreted within the context of prior experience, judgment and previous results, yielding “final documents.” In summary: raw data amounts to records of simple, direct measurements of selected processes; reports usually involve mechanical, algorithmic, rehashing or summarizing of the raw data values; and final","PeriodicalId":51023,"journal":{"name":"Drug Information Journal","volume":"16 4","pages":"181-4"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/009286158201600405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21130737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CAS information services for medicinal chemists. CAS药物化学家信息服务。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600406

J J Heyman, E H Karasinskia, P M Giles

引用次数: 5

Evaluation of factors influencing the patterns of use of drug and poison information resources. 影响药物和毒物信息资源使用模式的因素评价。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600412

L T Sigell, S L Boston, J F Bonfiglio, R A Yokel, N M Lorenzi, E D Nelson

引用次数: 0

Reducing drug therapy-induced hospitalization: impact of drug utilization review. 减少药物治疗引起的住院:药物使用的影响。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600409

M L Morse, A A Leroy, T A Gaylord, T Kellenberger

引用次数: 11

Profile of drug information centers in the United States. 美国药物信息中心概况。

Drug Information Journal Pub Date : 1982-10-01 DOI: 10.1177/009286158201600408

J E McDonald

引用次数: 0

Drug information service to community pharmacists: a survey of providers. 社区药师药品信息服务提供者调查。

Drug Information Journal Pub Date : 1982-07-01 DOI: 10.1177/009286158201600304

D H Mose, J L Morrison

引用次数: 0