W. Atsariyasing, Chayanin Foongsathaporn, Quankamon Dejatiwongse Na Ayudhaya, A. Vasupanrajit, Sirinda Chanpen, C. Pornnoppadol
{"title":"Links to Cyberbullying of Risky Online Behavior and Social Media Addiction among Students in Grades 7-9 in Bangkok","authors":"W. Atsariyasing, Chayanin Foongsathaporn, Quankamon Dejatiwongse Na Ayudhaya, A. Vasupanrajit, Sirinda Chanpen, C. Pornnoppadol","doi":"10.31584/jhsmr.20241065","DOIUrl":"https://doi.org/10.31584/jhsmr.20241065","url":null,"abstract":"Objective: This present study examined the connections regarding cyberbullying, risky online behavior and social media addiction, among 7th–9th grade students in Bangkok; Thailand. Material and Methods: A cross-sectional survey was conducted, using a self-report questionnaire consisting of: demographic data, cyberbullying, risky online behavior and the Social Media Addiction Screening Scale (S-MASS), involving 3,667 students.Results: Cyberbullying involvement was significantly associated with almost all risky online behaviors. The three riskiest behaviors, according to the odds ratios, were disclosing personal information (odds ratio (OR)=3.7, 95% confidence interval (CI) [2.7, 5.1]), making appointments to meet with online strangers (OR=3.0, 95% CI [2.1, 4.2]), and having conversations with online strangers (OR=2.6, 95% CI [2.3, 3.0]). Additionally, cyberbullying involvement exhibited a strong association with the high-risk category of social media addiction (OR=4.4, 95% CI [3.3, 5.8]). Furthermore, all subgroups of cyberbullying, including cyber-victims, cyberbullies, bystanders and the combined subgroups, demonstrated associations with almost all risky online behaviors. Moreover, the high risk category of social media addiction, with the combined subgroup, exhibited the highest odds ratio. Conclusion: Cyberbullying involvement was found to be associated with risky online behavior and social media addiction among middle school students in Bangkok.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"47 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accidental Falls Related to Physical and Environmental Risk Factors Among Older Hill Tribe Adults in Northern Thailand","authors":"Chatchada Sutalangka, P. Namkorn, Ekalak Sitthipornvorakul, Sitang Kongkratoke, Anongnad Mee-inta, Wilawan Chaiut","doi":"10.31584/jhsmr.20241037","DOIUrl":"https://doi.org/10.31584/jhsmr.20241037","url":null,"abstract":"Objective: Falls remain a cause of disability in the elderly. The present study was carried out to estimate the prevalence of falls among the hill tribe elderly population in Northern Thailand and identify its associated factors.Material and Methods: A cross-sectional study was conducted in participants from 61 hill tribe villages in Chiang Rai province, Thailand aged more than 60 years. A simple random method was used to select the participants. A questionnaire was developed and validated for data collection. Timed-up and go test (TUGT) was used to assess the dynamic balance and risk of falls in the participants. Logistic regression was used to evaluate the associations between the study variables (p-value<0.05).Results: One hundred eighty-two participants were recruited into the study with a mean age of 69.54 years (S.D.=7.02). 59.9 % were women. It was found that 17.6% of elderly who fell in the previous 6 months and 28.0% of elderly who risks of falls as assessed by the TUGT. The multiple logistic regression model showed that tribe (adjusted odds ratio (aOR)=4.40, 95 confidence interval (CI)%=1.88 to 22.02), dizziness (aOR=3.40, 95 CI%=1.70 to 16.70), history of fall in the last 6 months (aOR=2.42, 95 CI%=1.06 to 8.64), location of falls (aOR=1.37, 95 CI%=1.02 to 18.22), and the 15-item geriatric depression scale (GDS-15) (aOR=12.91, 95 CI%=1.07 to 84.85) were the associated risk factors for having a serious fall for hill tribe elderly.Conclusion: This study provides important determining factors associated with elderly falls, which can assist in developing and implementing an appropriate fall prevention program through environmental adjustments for the elderly.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"28 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139960665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Associated with the Incidence of COVID-19 Infectious Disease in Muang Pattani District, Thailand","authors":"Lukman Dunthara, Arinda Ma-a-lee, S. Sangkhathat","doi":"10.31584/jhsmr.20241035","DOIUrl":"https://doi.org/10.31584/jhsmr.20241035","url":null,"abstract":"Objective: This study aimed to investigate the COVID-19 incidence in Muang Pattani district; from April 2021 and September 2022, Specifically, the main objective was to study the varying distribution by demographic, area and period of COVID-19.Material and Methods: COVID-19 data, with 15,807 reported cases was obtained from the Muang Pattani District Health Office. A descriptive analysis was used to describe the characteristics of the COVID-19 cases. A negative binomial model was used to investigate COVID-19 incidence.Results: The overall incidence of COVID-19 was around 1,188.9 cases per 100,000 of the population. Females had a higher incidence rate of COVID-19 infection than males. People aged from 20 to 39 years old had significantly higher incidence rates than the average, with the highest rate being found in the Barohom sub-district. In 2021, the highest rates were in the month of October, followed by July and August; while March was reported as the highest rate in 2022.Conclusion: The findings of this study can be used by the public health organizations and others involved in COVID-19 for direct prevention and control in those high-incidence areas. This study has also proven that its findings can be applied to cases related to the prevention programs of other infectious diseases in Thailand.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"11 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Associated with the Incidence of COVID-19 Infectious Disease in Muang Pattani District, Thailand","authors":"Lukman Dunthara, Arinda Ma-a-lee, S. Sangkhathat","doi":"10.31584/jhsmr.20241035","DOIUrl":"https://doi.org/10.31584/jhsmr.20241035","url":null,"abstract":"Objective: This study aimed to investigate the COVID-19 incidence in Muang Pattani district; from April 2021 and September 2022, Specifically, the main objective was to study the varying distribution by demographic, area and period of COVID-19.Material and Methods: COVID-19 data, with 15,807 reported cases was obtained from the Muang Pattani District Health Office. A descriptive analysis was used to describe the characteristics of the COVID-19 cases. A negative binomial model was used to investigate COVID-19 incidence.Results: The overall incidence of COVID-19 was around 1,188.9 cases per 100,000 of the population. Females had a higher incidence rate of COVID-19 infection than males. People aged from 20 to 39 years old had significantly higher incidence rates than the average, with the highest rate being found in the Barohom sub-district. In 2021, the highest rates were in the month of October, followed by July and August; while March was reported as the highest rate in 2022.Conclusion: The findings of this study can be used by the public health organizations and others involved in COVID-19 for direct prevention and control in those high-incidence areas. This study has also proven that its findings can be applied to cases related to the prevention programs of other infectious diseases in Thailand.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natsima Viriyaadhammaa, S. Duangmano, Pawaret Panyajai, K. Gyi, Singkome Tima, S. Chiampanichayakul, S. Okonogi, Pornngarm Dejkriengkraikul, Jeffrey Krise, A. Saiai, S. Anuchapreeda
{"title":"Diarylheptanoid 7-(3,4-Dihydroxyphenyl)-5- Hydroxy-1-Phenyl- (1E)-1-Heptene from Curcuma Comosa Roxb. Inhibits Nucleophosmin Localization and Induces Apoptosis in KG-1a Leukemic Stem Cells","authors":"Natsima Viriyaadhammaa, S. Duangmano, Pawaret Panyajai, K. Gyi, Singkome Tima, S. Chiampanichayakul, S. Okonogi, Pornngarm Dejkriengkraikul, Jeffrey Krise, A. Saiai, S. Anuchapreeda","doi":"10.31584/jhsmr.20241034","DOIUrl":"https://doi.org/10.31584/jhsmr.20241034","url":null,"abstract":"Objective: This study aimed to investigate the effect of the diarylheptanoid 7-(3,4-dihydroxyphenyl)-5- hydroxy-1-phenyl-(1E)-1-heptene (DDHPH) from the rhizome of Curcuma comosa Roxb. on nucleophosmin (NPM) protein localization followed by induced cell death in KG-1a leukemic stem cells. Material and Methods: DDHPH was purified by column chromatography and characterized by nuclear magnetic resonance (NMR). Localization of NPM was determined by a confocal microscopy. Induction of cell death was determined by flow cytometry and Western blotting. Results: A previous study showed that NPM directly interacted with p53 and activates p53 function. In this study, DDHPH was found to modify the translocation of NPM and enhance both p53 and cleaved caspase-3 expression. These proteins were found to control cell cycle progression and cell apoptosis induction. Conclusion: This study demonstrated that DDHPH is a novel compound which induces cell death through NPM localization.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139798837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natsima Viriyaadhammaa, S. Duangmano, Pawaret Panyajai, K. Gyi, Singkome Tima, S. Chiampanichayakul, S. Okonogi, Pornngarm Dejkriengkraikul, Jeffrey Krise, A. Saiai, S. Anuchapreeda
{"title":"Diarylheptanoid 7-(3,4-Dihydroxyphenyl)-5- Hydroxy-1-Phenyl- (1E)-1-Heptene from Curcuma Comosa Roxb. Inhibits Nucleophosmin Localization and Induces Apoptosis in KG-1a Leukemic Stem Cells","authors":"Natsima Viriyaadhammaa, S. Duangmano, Pawaret Panyajai, K. Gyi, Singkome Tima, S. Chiampanichayakul, S. Okonogi, Pornngarm Dejkriengkraikul, Jeffrey Krise, A. Saiai, S. Anuchapreeda","doi":"10.31584/jhsmr.20241034","DOIUrl":"https://doi.org/10.31584/jhsmr.20241034","url":null,"abstract":"Objective: This study aimed to investigate the effect of the diarylheptanoid 7-(3,4-dihydroxyphenyl)-5- hydroxy-1-phenyl-(1E)-1-heptene (DDHPH) from the rhizome of Curcuma comosa Roxb. on nucleophosmin (NPM) protein localization followed by induced cell death in KG-1a leukemic stem cells. Material and Methods: DDHPH was purified by column chromatography and characterized by nuclear magnetic resonance (NMR). Localization of NPM was determined by a confocal microscopy. Induction of cell death was determined by flow cytometry and Western blotting. Results: A previous study showed that NPM directly interacted with p53 and activates p53 function. In this study, DDHPH was found to modify the translocation of NPM and enhance both p53 and cleaved caspase-3 expression. These proteins were found to control cell cycle progression and cell apoptosis induction. Conclusion: This study demonstrated that DDHPH is a novel compound which induces cell death through NPM localization.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"132 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139858922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Tuyết, Duong Thi Anh Dao, Nguyen Thi Trung Thu, Nguyen Thi Hong Hanh, Le Thi Thuy Dung, Tran Quang Binh
{"title":"Childhood Obesity as Interactions of Environmental and Genetic Factors: A Community – Based Study on Primary School Children of Hanoi, Vietnam","authors":"L. Tuyết, Duong Thi Anh Dao, Nguyen Thi Trung Thu, Nguyen Thi Hong Hanh, Le Thi Thuy Dung, Tran Quang Binh","doi":"10.31584/jhsmr.20241036","DOIUrl":"https://doi.org/10.31584/jhsmr.20241036","url":null,"abstract":"Objective: Obesity is a complex disease that involves interactions between environmental and genetic factors in its pathogenesis. The aims of this present study were to analyse the overall effects of some nutritional, physical and genetic factors with childhood obesity, and to build predictive models of childhood obesity.Material and Methods: A case-control study was conducted on 559 Hanoi primary school children (278 obese cases and 281 normal controls). Genetic analysis was performed to evaluate genotype on the rs6265 gene BDNF, rs6548238 gene TMEM18, rs6499640 gene FTO, and rs17782313 gene MC4R. Univariate and multivariate regression analysis were conducted to compare the two groups of children, so as to draw conclusions regarding influencing factors and to establish predictive models of obesity for Hanoi primary school children.Results: Factors increasing the risk of obesity found included: urban living areas (odds ratio (OR)=1.5), caesarean section (OR=2.1), high birth weight (OR=1.9-3.1), parental overweight and obesity (OR=2.1-5.1), short night sleeping times (OR=2.6), characteristics of child feeding; including early weaning (OR=2.1), gluttony (OR=19.1), no snacking (OR=2.4), controlled eating (OR=2.4) fat food hobbies (OR=2.7), and CC rs6548238-TMEM18 genotype (OR=1.8). A predictive model of childhood obesity for Hanoi primary school children was built, based on the BMI of parents, gluttonous characteristics, unrestricted eating with ROC=0.871.Conclusion: Childhood obesity develops as a result of interaction between eating habits, lifestyle characteristics of the child and genetic characteristics inherited from over nutritious parents. Encouraging parents to manage both their own weight and their children’s eating habits such as allowing children to consume food without undue restriction and reducing gluttony can serve as effective interventions to diminish the prevalence of childhood obesity within the community.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"1994 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Tuyết, Duong Thi Anh Dao, Nguyen Thi Trung Thu, Nguyen Thi Hong Hanh, Le Thi Thuy Dung, Tran Quang Binh
{"title":"Childhood Obesity as Interactions of Environmental and Genetic Factors: A Community – Based Study on Primary School Children of Hanoi, Vietnam","authors":"L. Tuyết, Duong Thi Anh Dao, Nguyen Thi Trung Thu, Nguyen Thi Hong Hanh, Le Thi Thuy Dung, Tran Quang Binh","doi":"10.31584/jhsmr.20241036","DOIUrl":"https://doi.org/10.31584/jhsmr.20241036","url":null,"abstract":"Objective: Obesity is a complex disease that involves interactions between environmental and genetic factors in its pathogenesis. The aims of this present study were to analyse the overall effects of some nutritional, physical and genetic factors with childhood obesity, and to build predictive models of childhood obesity.Material and Methods: A case-control study was conducted on 559 Hanoi primary school children (278 obese cases and 281 normal controls). Genetic analysis was performed to evaluate genotype on the rs6265 gene BDNF, rs6548238 gene TMEM18, rs6499640 gene FTO, and rs17782313 gene MC4R. Univariate and multivariate regression analysis were conducted to compare the two groups of children, so as to draw conclusions regarding influencing factors and to establish predictive models of obesity for Hanoi primary school children.Results: Factors increasing the risk of obesity found included: urban living areas (odds ratio (OR)=1.5), caesarean section (OR=2.1), high birth weight (OR=1.9-3.1), parental overweight and obesity (OR=2.1-5.1), short night sleeping times (OR=2.6), characteristics of child feeding; including early weaning (OR=2.1), gluttony (OR=19.1), no snacking (OR=2.4), controlled eating (OR=2.4) fat food hobbies (OR=2.7), and CC rs6548238-TMEM18 genotype (OR=1.8). A predictive model of childhood obesity for Hanoi primary school children was built, based on the BMI of parents, gluttonous characteristics, unrestricted eating with ROC=0.871.Conclusion: Childhood obesity develops as a result of interaction between eating habits, lifestyle characteristics of the child and genetic characteristics inherited from over nutritious parents. Encouraging parents to manage both their own weight and their children’s eating habits such as allowing children to consume food without undue restriction and reducing gluttony can serve as effective interventions to diminish the prevalence of childhood obesity within the community.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139867300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Xu, Nuntiya Pahumunto, Supawadee Naorungroj, R. Teanpaisan
{"title":"Association Between Periodontal Pathogens and Severity of Periodontal Diseases Among Adolescents in Kunming City: China","authors":"Jie Xu, Nuntiya Pahumunto, Supawadee Naorungroj, R. Teanpaisan","doi":"10.31584/jhsmr.20231029","DOIUrl":"https://doi.org/10.31584/jhsmr.20231029","url":null,"abstract":"Objective: To investigate the association between periodontal pathogens and periodontal status among adolescents in Kunming City.Material and Methods: A total of 560 adolescents from five high schools within five urban districts in Kunming participated in this study. Clinical periodontal examination was assessed, and the levels of Porphyromonas gingivalis (P. gingivalis), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Prevotella intermedia (P. intermedia), and Fusobacterium nucleatum (F. nucleatum) in saliva samples were examined using a real-time polymerase chain reaction (PCR). The relationship between periodontal pathogens and the severity of periodontal disease was investigated using multivariate logistic regression analysis. Results: The presence of P. gingivalis, A. actinomycetemcomitans, and P. intermedia was positively correlated with the extent of probing depth, clinical attachment level (CAL), and bleeding on probing. P. gingivalis and A. actinomycetemcomitans were detected at approximately 55-58% among adolescents with healthy periodontal status. P. gingivalis and A. actinomycetemcomitans were detected in all adolescents diagnosed with periodontitis (stage I or II), which was an increased number compared to healthy adolescents. It was found that P. gingivalis (odd ratio (OR)=7.03, 95% confidence interval (CI) 3.77-13.11) and A. actinomycetemcomitans (OR=5.37, 95% CI 2.73-10.57) were strongly associated with stage II periodontitis. F. nucleatum had no significant relationship with the occurrence of gingivitis and periodontitis.Conclusion: P. gingivalis, A. actinomycetemcomitans, and P. intermedia are important microbiological risk factors for periodontal diseases in adolescents.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139601277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Ayaz N. Saiyed, Mathew Varghese, Harshal Adinath Patil, Ram Sudhan
{"title":"A Prospective Study of 18F-FDG PET-CT Application in Therapeutic Monitoring of Osteoarticular Tuberculosis","authors":"Mohammed Ayaz N. Saiyed, Mathew Varghese, Harshal Adinath Patil, Ram Sudhan","doi":"10.31584/jhsmr.20231027","DOIUrl":"https://doi.org/10.31584/jhsmr.20231027","url":null,"abstract":"Objective: Confident diagnosis, identification of occult sites, assessing treatment response, and precisely ascertaining the duration and endpoint of treatment in skeletal tuberculosis is often challenging. magnetic resonance imaging (MRI) and computed tomography (CT) are less dependable owing to low sensitivity and the inability to discern current illness and old changes. 18F-FDG PET/CT utilizes variations in glycolysis rates between healthy and diseased tissue to quantitatively estimate the maximal standard uptake value (SUVmax) of 18F-FDG to assess disease activity.Material and Methods: 32 patients who presented to the department with a clinicoradiological suspicion and pathologically proven diagnosis of skeletal tuberculosis were prospectively analyzed. All patients underwent a whole body 18F-FDG PET-CT scan before initiation of anti-tubercular therapy (ATT), and then treatment was started as per the Revised National Tuberculosis Control Program (RNTCP) guidelines. All patients were followed up with repeat PET-CT scans and relevant clinical investigations at 2, 6, and 12 months.Results: A gradual decrease in SUVmax values, as the treatment courses progressed indicated a decrease in disease activity with treatment. There was an overall mean decrease of 6.5 units in the SUVmax values when compared to the pre-treatment levels, which was statistically significant (p-value<0.001). At 2 months of anti-tubercular treatment, the mean SUVmax values decreased by 39%, and at 6 and 12 months of ATT, they were reduced by 60% and 81%, respectively.Conclusion: 18F-FDG PET-CT helps to determine the prevalence of occult multifocal activity elsewhere in the body. The gradual decrease in SUVmax values during the course of ATT is a useful tool to assess disease response and to precisely decide the endpoint of ATT.","PeriodicalId":509706,"journal":{"name":"Journal of Health Science and Medical Research","volume":"36 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139528595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}