{"title":"The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases.","authors":"Ming-Wei Chien, Shin-Huei Fu, Chao-Yuan Hsu, Yu-Wen Liu, Huey-Kang Sytwu","doi":"10.3390/ijms19030780","DOIUrl":"https://doi.org/10.3390/ijms19030780","url":null,"abstract":"<p><p>Glycosylation is a ubiquitous posttranslational modification of proteins that occurs in the endoplasmic reticulum/Golgi. <i>N</i>-glycans and mucin-type <i>O</i>-glycans are achieved via a series of glycohydrolase- and glycosyltransferase-mediated reactions. Glycosylation modulates immune responses by regulating thymocyte development and T helper cell differentiation. Autoimmune diseases result from an abnormal immune response by self-antigens and subsequently lead to the destruction of the target tissues. The modification of <i>N</i>-glycans has been studied in several animal models of T-cell-mediated autoimmune diseases. This review summarizes and highlights the modulatory effects of <i>N</i>-glycosylation in several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and type 1 diabetes mellitus.</p>","PeriodicalId":509625,"journal":{"name":"International Journal of Molecular Sciences","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2018-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/ijms19030780","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35894429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}