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Synthesis and Evaluation of Antifungal Activity of Novel 1,3,4-Oxadiazole Derivatives 新型 1,3,4-恶二唑衍生物的合成与抗真菌活性评估
International Journal of Medical Sciences and Pharma Research Pub Date : 2024-03-15 DOI: 10.22270/ijmspr.v10i1.85
Aswathy Ramesh, R. Jat, R. Arunkumar
{"title":"Synthesis and Evaluation of Antifungal Activity of Novel 1,3,4-Oxadiazole Derivatives","authors":"Aswathy Ramesh, R. Jat, R. Arunkumar","doi":"10.22270/ijmspr.v10i1.85","DOIUrl":"https://doi.org/10.22270/ijmspr.v10i1.85","url":null,"abstract":"Here new eight derivatives of 1,3,4-oxadiazole were synthesised from salicylic acid and phenyl acetic acid by ring condensation mechanism. The synthesized derivatives were characterized and structures were confirmed by various spectral analysis. Antifungal activity studies revealed that Ox1, Ox2 and Ox4 exhibit promising activity.\u0000Keywords: 1,3,4-oxadiazole, antifungal activity, Disc diffusion method, MIC,","PeriodicalId":509624,"journal":{"name":"International Journal of Medical Sciences and Pharma Research","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ghafis (Agrimonia eupatoria): An In-depth Review of its Historical Context, Therapeutic properties, Ethnopharmacological applications, and Scientific research Ghafis（Agrimonia eupatoria）：深入回顾其历史背景、治疗特性、民族药理学应用和科学研究
International Journal of Medical Sciences and Pharma Research Pub Date : 2024-03-15 DOI: 10.22270/ijmspr.v10i1.92
Nida Mehraj, Mahboob Alam
{"title":"Ghafis (Agrimonia eupatoria): An In-depth Review of its Historical Context, Therapeutic properties, Ethnopharmacological applications, and Scientific research","authors":"Nida Mehraj, Mahboob Alam","doi":"10.22270/ijmspr.v10i1.92","DOIUrl":"https://doi.org/10.22270/ijmspr.v10i1.92","url":null,"abstract":"Agrimonia eupatoria, commonly known as Ghafis, holds a significant role in traditional herbal medicine across different regions. This perennial plant, part of the Rosaceae family, has been used in Unani medicine for its various healing properties since ancient times. Ghafis is known for its abilities as a demulcent, stomachic, blood purifier, diuretic, emmenagogue, anti-inflammatory, and astringent agent. Traditionally, it has been employed to treat liver and spleen inflammation, fevers, ulcers, jaundice, wounds, and gastrointestinal disorders. Ethnopharmacological practices have also recognized its antioxidant, antimicrobial, and diuretic effects. Recent scientific studies have further explored its potential in managing diabetes, neuropathic pain, oxidative stress-related disorders, and protecting the liver. This review aims to provide an overview of Ghafis, covering its description, habitat, traditional uses, and recent scientific studies. Ghafis emerges as a valuable herbal remedy with ongoing relevance in herbal medicine and Unani pharmacotherapy.\u0000Keywords: Ghafis, Agrimonia eupatoria, Agrimony, Unani Medicine","PeriodicalId":509624,"journal":{"name":"International Journal of Medical Sciences and Pharma Research","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Evaluation of Novel 1,3,4-Oxadiazole Derivatives 新型 1,3,4-恶二唑衍生物的药理评估
International Journal of Medical Sciences and Pharma Research Pub Date : 2024-03-15 DOI: 10.22270/ijmspr.v10i1.88
Aswathy Ramesh, R. Jat, R. Arunkumar
{"title":"Pharmacological Evaluation of Novel 1,3,4-Oxadiazole Derivatives","authors":"Aswathy Ramesh, R. Jat, R. Arunkumar","doi":"10.22270/ijmspr.v10i1.88","DOIUrl":"https://doi.org/10.22270/ijmspr.v10i1.88","url":null,"abstract":"A series of 2, 5- disubstituted- 1, 3, 4-oxadiazole derivatives (Ox1-Ox10) are synthesized by the ring condensation reaction followed by rearrangement of salicylic acid and phenyl acetic acid with various aromatic acids in presence of phosphorous oxychloride as cyclizing agent. Structure of the new derivatives are confirmed by spectral analysis. Those derivatives having high Pa value in PASS software are subjected to antibacterial, anticancer and antidiabetic studies which yield promising reports. This study helps and stimulate the researcher to exploit the oxadiazole nuclei for the development of more active less harmful drugs.\u0000Keywords: 1,3,4-oxadiazole, antibacterial activity, anticancer activity, antidiabetic activity","PeriodicalId":509624,"journal":{"name":"International Journal of Medical Sciences and Pharma Research","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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