新型 1,3,4-恶二唑衍生物的合成与抗真菌活性评估

International Journal of Medical Sciences and Pharma Research Pub Date : 2024-03-15 DOI:10.22270/ijmspr.v10i1.85

Aswathy Ramesh, R. Jat, R. Arunkumar

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摘要

本文以水杨酸和苯乙酸为原料，通过环缩合机制合成了八种新的 1,3,4-噁二唑衍生物。对合成的衍生物进行了表征，并通过各种光谱分析确认了其结构。抗真菌活性研究表明，Ox1、Ox2 和 Ox4 具有良好的活性：1,3,4-恶二唑抗真菌活性盘扩散法 MIC

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Synthesis and Evaluation of Antifungal Activity of Novel 1,3,4-Oxadiazole Derivatives

Here new eight derivatives of 1,3,4-oxadiazole were synthesised from salicylic acid and phenyl acetic acid by ring condensation mechanism. The synthesized derivatives were characterized and structures were confirmed by various spectral analysis. Antifungal activity studies revealed that Ox1, Ox2 and Ox4 exhibit promising activity. Keywords: 1,3,4-oxadiazole, antifungal activity, Disc diffusion method, MIC,

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International Journal of Medical Sciences and Pharma Research

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