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Acta Gastro-Enterologica Belgica最新文献

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Hepatic chemoembolization: clinical and experimental correlation. 肝化疗栓塞:临床与实验的相关性。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
S Wallace, Z Kan, C Li
{"title":"Hepatic chemoembolization: clinical and experimental correlation.","authors":"S Wallace,&nbsp;Z Kan,&nbsp;C Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chemoembolization has become the preferred treatment for patients with inoperable, hypervascular hepatic malignancies in the Far East, but controversial elsewhere. In vivo microscopy in addition to other experimental procedures are used in this presentation to better understand the mechanisms involved in chemoembolization. In chemoembolization Lipiodol acts as a contrast material, a vehicle for chemotherapy and an embolic agent. Although not optimal, Lipiodol injected into the hepatic artery, traverses the peribiliary plexus to the portal veins resulting in a dual embolization. Chemoembolization creates ischemia, slows arterial flow and increases the contact time between the infusate and the neoplasms, increasing the tumor cell kill. However, the vascular occlusion also produces infarction and fibrosis compounding the already existing cirrhosis frequently associated with hepatocellular carcinoma. Lipiodol/ethanol (3:1) injected into the segmental or lobar hepatic artery supplying the neoplasm also gains access to the associated portal venous branches causing focal ablation. This preoperative approach is easier to perform than direct portal vein occlusion, with less parenchymal damage and comparable hypertrophy of the remnant liver frequently necessary for adequate hepatic function following resection. Polymer-drug conjugates, e.g. PG-TXL, have considerable potential for intra-arterial delivery especially with the dramatic increase in concentration of the drug in the tumor and its efficacy. Using in vivo microscopy especially with green fluorescent protein (GFP) gene as an efficient and non-toxic tumor cell marker, the events leading to hepatic metastases can be documented which will serve to better evaluate these varied techniques of chemoembolization.</p>","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"169-73"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of chronic hepatitis B: lamivudine. 慢性乙型肝炎的治疗：拉米夫定。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
N Leung
{"title":"Treatment of chronic hepatitis B: lamivudine.","authors":"N Leung","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"189-90"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic factors determining the outcome of treatment in chronic hepatitis C. 决定慢性丙型肝炎治疗结果的预后因素。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
S J Hadziyannis
{"title":"Prognostic factors determining the outcome of treatment in chronic hepatitis C.","authors":"S J Hadziyannis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After a brief introduction in terminology and a distinction between predictors and determinants or response to therapy in chronic hepatitis C, a review of the wide literature on this topic is presented. None of the pretreatment variables or combination of them can be used as an absolute predictor of response in individual patients. Prognostic factors can help in clinical practice for informing and counseling patients of the likelihood of response. Information on pretreatment HCV RNA levels and HCV genotype can improve the cost benefit of therapy. Predictors of response should be properly evaluated in terms of positive predictive value, negative predictive value and accuracy. The strongest hitherto predictor of sustained response to any therapeutic regimen in chronic hepatitis is the clearance of HCV RNA during treatment. Recent data suggest that sequencing of several regions of the HCV genome may provide important prognostic information on the outcome of therapy. In complex and difficult to treat subsets of patients with chronic HCV infection, available data on predictors and determinants of the outcome of treatment are limited.</p>","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"207-9"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview on a novel adjuvanted prophylactic hepatitis B vaccine. 新型佐剂预防性乙型肝炎疫苗概述。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
S Thoelen
{"title":"An overview on a novel adjuvanted prophylactic hepatitis B vaccine.","authors":"S Thoelen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"185-6"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of chronic active hepatitis C in chronically infected chimpanzees after therapeutic vaccination with the HCV E1 protein. 治疗性接种HCV E1蛋白后慢性感染黑猩猩慢性活动性丙型肝炎的改善
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
G Maertens, S Priem, A Ducatteeuw, E Verschoorl, B Verstrepen, T Roskams, V Desmet, S Fuller, K Van Hoek, P Vandeponseele, F Bosman, M A Buyse, L J van Doorn, J Heeney, A Kos, E Depla
{"title":"Improvement of chronic active hepatitis C in chronically infected chimpanzees after therapeutic vaccination with the HCV E1 protein.","authors":"G Maertens,&nbsp;S Priem,&nbsp;A Ducatteeuw,&nbsp;E Verschoorl,&nbsp;B Verstrepen,&nbsp;T Roskams,&nbsp;V Desmet,&nbsp;S Fuller,&nbsp;K Van Hoek,&nbsp;P Vandeponseele,&nbsp;F Bosman,&nbsp;M A Buyse,&nbsp;L J van Doorn,&nbsp;J Heeney,&nbsp;A Kos,&nbsp;E Depla","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"203"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21854812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphangioma of the colon: a case report and review of the Japanese literature. 结肠淋巴管瘤:1例报告及日本文献复习。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
T Hatada, H Ikeda, A Tanigawa, Y Fujiwara, Y Hanada, T Yamamura
{"title":"Lymphangioma of the colon: a case report and review of the Japanese literature.","authors":"T Hatada,&nbsp;H Ikeda,&nbsp;A Tanigawa,&nbsp;Y Fujiwara,&nbsp;Y Hanada,&nbsp;T Yamamura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intraabdominal lymphangiomas are rare, although these lesions can occur in the mesentery, omentum, retroperitoneum, or gastrointestinal tract wall. Here we report a case of lymphangioma of the transverse colon and review the other cases reported in the Japanese literature. Our patient presented with lower abdominal pain and barium enema revealed a filling defect in the transverse colon. Colonoscopy disclosed a submucosal tumor, which changed shape with alteration the patient's position and showed the cushion sign. This lesion was covered with normal-looking mucosa. A correct diagnosis was made from these findings. Knowledge of these endoscopic features may help physicians to provide appropriate diagnosis and treatment of colonic lymphangioma.</p>","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"239-41"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21765301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S gene variation of HBV. HBV 的 S 基因变异。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
W F Carman
{"title":"S gene variation of HBV.","authors":"W F Carman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"182-4"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment for chronic hepatitis B: interferon what we have learned after so many years? 慢性乙型肝炎的治疗：干扰素这么多年后我们学到了什么？
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
F Nevens
{"title":"Treatment for chronic hepatitis B: interferon what we have learned after so many years?","authors":"F Nevens","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"187-8"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis C: virology, clinical aspects and the relation to cryoglobulinemia. 丙型肝炎：病毒学、临床方面以及与冷球蛋白血症的关系。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
J M Pawlotsky
{"title":"Hepatitis C: virology, clinical aspects and the relation to cryoglobulinemia.","authors":"J M Pawlotsky","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"200-1"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of hepatocellular carcinoma and its viral risk factors. 肝细胞癌的流行病学及其病毒风险因素。
IF 1.5 4区 医学
Acta Gastro-Enterologica Belgica Pub Date : 2000-04-01
M C Kew
{"title":"Epidemiology of hepatocellular carcinoma and its viral risk factors.","authors":"M C Kew","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"227-9"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21765296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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