Acta Gastro-Enterologica Belgica最新文献_第3页

Statins and Clarithromycin : a dangerous combination. Case report and review of the literature. 他汀类药物和克拉霉素:危险的组合。病例报告及文献复习。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2019-01-01

A Werion, M Komuta, O S Descamps, J Henrion

引用次数: 0

Cholestatic pruritus : an update. 胆汁淤积性瘙痒:最新进展。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2019-01-01

C De Vloo, F Nevens

{"title":"Cholestatic pruritus : an update.","authors":"C De Vloo, F Nevens","doi":"","DOIUrl":"","url":null,"abstract":"Pruritus is a common, troublesome symptom in patients with cholestatic liver diseases, especially frequent in intrahepatic cholestasis of pregnancy (ICP) and in primary biliary cholangitis (PBC). Cholestatic associated pruritus can have profound effects on the quality of life. The underlying mechanism is still poorly understood. Severe potential pruritogens have been discussed, such as bile salts, opioids, steroid and lysophosphatidic acid (LPA), but none of these are considered as key mediators. Because of this unraveling pathophysiology the treatment of hepatogenic pruritus often represents a clinical challenge. The EASL guidelines have suggested a step-wise approach, starting with elimination of pruritogens by bile acid sequestrants (cholestyramine), in second line managing the metabolism of pruritogens (rifampicin) and in third-line and fourth- line by modifying the itch perception with μ-opioid antagonist or selective serotonin reuptake inhibitors (SSRI). In treatment-refractory pruritus interruption of the enterohepatic cycle by molecular absorbent recirculating system (MARS), nasobiliairy drainage or experimental therapy such as Ultraviolet B light therapy can be considered. Liver transplantation may be reserved for intractable pruritus. Clinical trials with novel agents are ongoing, potentially providing efficacious options in the future.","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"82 1","pages":"75-82"},"PeriodicalIF":1.5,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37071265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TT virus infection in acute and chronic liver diseases and in patients regularly receiving blood products in Belgium. 比利时急性和慢性肝病患者以及定期接受血液制品患者的TT病毒感染。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2004-04-01

Soegianto Ali, Jos F van Pelt, Chris Verslype, Frederik Nevens, Johan Fevery, Sing H Yap

{"title":"TT virus infection in acute and chronic liver diseases and in patients regularly receiving blood products in Belgium.","authors":"Soegianto Ali, Jos F van Pelt, Chris Verslype, Frederik Nevens, Johan Fevery, Sing H Yap","doi":"","DOIUrl":"","url":null,"abstract":"Background: TT viruses are single-stranded DNA viruses, suggested to be involved in non A-E hepatitis. We studied the prevalence of TTV infection in acute or chronic hepatitis in Belgium in comparison with that in blood donors and in patients regularly receiving blood products.Methods: TTV-DNA was detected by PCR using the primer set of Takahashi et al (1998) or a nested-PCR specific for genotype-2, because it had been reported that this subtype might be more pathogenic (Tagger et al. 1999).Results: TTV-DNA was present in 49% of 128 patients with chronic hepatitis C, in 54% of 54 with chronic hepatitis B and in 54% of 24 with acute liver failure. This prevalence is similar to the 47% in 127 patients with clotting disorders, or the 64% in 103 undergoing chronic haemodialysis, but lower than the 29.7% found in 340 healthy blood donors. Significant differences in clinical or biochemical characteristics between TTV- positive or TTV-negative patients could not be substantiated. The genotype-2 subgroup comprised 3.9%, but they also did not differ from non genotype-2 patients.Conclusions: The prevalence of TTV infection was higher in patients than in healthy blood donors. Its clinical significance remains questionable since clinical and biochemical characteristics were not different between TTV positive and TTV negative patients. The higher prevalence of TTV in patients might be related to parenteral transmission, but the relatively high prevalence in healthy blood donors points to an additional presumably faeco-oral infection. The presence of TTV in animals suggests that infection might also originate from food. Long term follow-up will have to define whether co-infection with TTV eventually alters the natural history of chronic hepatitis.","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"67 2","pages":"161-5"},"PeriodicalIF":1.5,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40880466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of hepatocellular carcinoma at the dawn of the third millennium: liver transplantation and its alternatives. 第三个千年之初肝细胞癌的治疗:肝移植及其替代品。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2004-04-01

P Majno, G Mentha, E Giostra, S Terraz, L Rubbia-Brandt, Th Berney, L Buhler, Ch Toso, O Huber, L Spahr, I Morard, A Hadengue, Ch Becker, F Terrier, Ph Morel

引用次数: 0

The paediatric liver transplantation program at the Université catholique de Louvain. 鲁汶天主教大学的儿科肝移植项目。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2004-04-01

R Reding, C Bourdeaux, J Gras, V Evrard, J P Buts, M Carlier, O Ciccarelli, P Clapuyt, S Clement de Clety, M De Kock, D Hermans, M Janssen, D Moulin, J Rahier, C Saint-Martin, C Sempoux, L Van Obbergh, F Veyckemans, J Lerut, J de Ville de Goyet, E Sokal, J B Otte

{"title":"The paediatric liver transplantation program at the Université catholique de Louvain.","authors":"R Reding, C Bourdeaux, J Gras, V Evrard, J P Buts, M Carlier, O Ciccarelli, P Clapuyt, S Clement de Clety, M De Kock, D Hermans, M Janssen, D Moulin, J Rahier, C Saint-Martin, C Sempoux, L Van Obbergh, F Veyckemans, J Lerut, J de Ville de Goyet, E Sokal, J B Otte","doi":"","DOIUrl":"","url":null,"abstract":"The Paediatric Liver Transplant Program at Saint-Luc University Clinics constitutes a substantial single centre experience, including 667 transplantations performed between March 1984 and April 2003, and the history of this program reflects the tremendous progress in this field since twenty years. Liver transplantation in children constitutes a considerable undertaking and its results depend on multiple, intermingled risk factors. An analysis of the respective impact of several surgical and immunological parameters on patient/graft outcome and allograft rejection after paediatric liver transplantation showed a significant learning curve effect as well as the respective impact of pre-transplant diagnosis on survival and of primary immunosuppression on the rejection incidence. The introduction of living related liver transplantation in 1993 not only permitted to provide access to liver replacement in as many as 74% more candidate recipients, but also resulted in better graft survival and reduced retransplantation rate. The results of a recent pilot study suggest that steroid avoidance is not harmful, and could even be beneficial for paediatric liver recipients, particularly regarding growth, and that combining tacrolimus with basiliximab (anti-CD25 chimeric monoclonal antibody) for steroid substitution appears to constitute a safe alternative in this context. The long-term issues represent the main future challenges in the field, including the possibility of a full rehabilitation through immunosuppression withdrawal and tolerance induction, the development of adolescence transplant medicine, and the risk of early atherogenesis in the adulthood.","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"67 2","pages":"176-8"},"PeriodicalIF":1.5,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40880468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic eosinophilic oesophagitis: atypical presentation of a rare disease. 特发性嗜酸性粒细胞性食管炎:罕见疾病的不典型表现。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2004-04-01

S Evrard, H Louis, M Kahaleh, M Zalcman, N Nagy, I El Nakadi, J Devière

引用次数: 0

The psychological challenge of paediatric organ transplantation: gift and incorporation. 儿童器官移植的心理挑战:赠予与结合。

IF 1.5 4区医学

Acta Gastro-Enterologica Belgica Pub Date : 2004-04-01

K-L Schwering

引用次数: 0

Viral hepatitis B, C and D. 病毒性乙型、丙型和丁型肝炎。