TT virus infection in acute and chronic liver diseases and in patients regularly receiving blood products in Belgium.

IF 1.5 4区医学 Q2 Medicine

Acta Gastro-Enterologica Belgica Pub Date : 2004-04-01

Soegianto Ali, Jos F van Pelt, Chris Verslype, Frederik Nevens, Johan Fevery, Sing H Yap

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引用次数: 0

Abstract

Background: TT viruses are single-stranded DNA viruses, suggested to be involved in non A-E hepatitis. We studied the prevalence of TTV infection in acute or chronic hepatitis in Belgium in comparison with that in blood donors and in patients regularly receiving blood products.

Methods: TTV-DNA was detected by PCR using the primer set of Takahashi et al (1998) or a nested-PCR specific for genotype-2, because it had been reported that this subtype might be more pathogenic (Tagger et al. 1999).

Results: TTV-DNA was present in 49% of 128 patients with chronic hepatitis C, in 54% of 54 with chronic hepatitis B and in 54% of 24 with acute liver failure. This prevalence is similar to the 47% in 127 patients with clotting disorders, or the 64% in 103 undergoing chronic haemodialysis, but lower than the 29.7% found in 340 healthy blood donors. Significant differences in clinical or biochemical characteristics between TTV- positive or TTV-negative patients could not be substantiated. The genotype-2 subgroup comprised 3.9%, but they also did not differ from non genotype-2 patients.

Conclusions: The prevalence of TTV infection was higher in patients than in healthy blood donors. Its clinical significance remains questionable since clinical and biochemical characteristics were not different between TTV positive and TTV negative patients. The higher prevalence of TTV in patients might be related to parenteral transmission, but the relatively high prevalence in healthy blood donors points to an additional presumably faeco-oral infection. The presence of TTV in animals suggests that infection might also originate from food. Long term follow-up will have to define whether co-infection with TTV eventually alters the natural history of chronic hepatitis.

本刊更多论文

比利时急性和慢性肝病患者以及定期接受血液制品患者的TT病毒感染。

背景:TT病毒为单链DNA病毒，提示与非戊型肝炎有关。我们研究了比利时急性或慢性肝炎中TTV感染的流行情况，并与献血者和定期接受血液制品的患者进行了比较。方法:采用Takahashi等人(1998)的引物组或针对基因型2的巢式PCR检测TTV-DNA，因为有报道称该亚型可能更具致病性(Tagger等人，1999)。结果:128例慢性丙型肝炎患者中有49%、54例慢性乙型肝炎患者中有54%、24例急性肝衰竭患者中有54%存在TTV-DNA。这一患病率与127名凝血障碍患者的47%或103名慢性血液透析患者的64%相似，但低于340名健康献血者的29.7%。TTV阳性和TTV阴性患者的临床或生化特征没有显著差异。基因2型亚组占3.9%，但与非基因2型患者也没有差异。结论:患者的TTV感染率高于健康献血者。由于TTV阳性和TTV阴性患者的临床和生化特征没有差异，其临床意义尚存疑问。患者中较高的TTV流行率可能与肠外传播有关，但健康献血者中相对较高的流行率表明可能存在另外的粪口感染。在动物身上发现TTV表明，感染也可能来自食物。长期随访将确定是否与TTV合并感染最终改变慢性肝炎的自然史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Gastro-Enterologica Belgica 医学-胃肠肝病学

CiteScore

2.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.