Endoscopy International Open最新文献_第2页

Prognostic significance of Deprivation on Esophago-Gastro-Duodenoscopy (EGD) outcome 贫困对食道-胃-十二指肠镜检查（EGD）结果的预后意义

Endoscopy International Open Pub Date : 2024-04-02 DOI: 10.1055/a-2297-9905

C. Eley, Neil Hawkes, Emma Barlow, Richard Egan, Wyn Lewis

{"title":"Prognostic significance of Deprivation on Esophago-Gastro-Duodenoscopy (EGD) outcome","authors":"C. Eley, Neil Hawkes, Emma Barlow, Richard Egan, Wyn Lewis","doi":"10.1055/a-2297-9905","DOIUrl":"https://doi.org/10.1055/a-2297-9905","url":null,"abstract":"Introduction: Socio-Economic Deprivation has long been associated with many gastrointestinal diseases yet its influence on esophago-gastro-duodenoscopy (EGD) diagnosis has not been evaluated. The aim of this study was to investigate the influence of deprivation on outcomes of EGD irrespective of referral reason.\u0000Method: Two-thousand consecutive patients presenting to four Health Boards in Wales from June 2019 were studied retrospectively with deprivation scores calculated using the Wales Indices of Multiple Deprivation (WIMD). Patients were sub-classified into quintiles for analysis (Q1 most, Q5 least Deprived).\u0000Results: Inhabitants of the most deprived areas were more likely to be diagnosed with Peptic Ulcer (Q1 7.9%, Q5 4.7%; OR 0.498, p=0.018), Severe Esophagitis (LA4, Q1 2.7% v Q5 0%, OR 0.089, p=0.002), Helicobacter Pylori infection (Q1 5.4%, Q5 1.7%; OR 0.284, p=0.002), but less likely to be diagnosed with Barrett’s Eesophagus (Q1 6.3% v Q5 12.3%, OR 2.146, p=0.004) than those from least deprived areas. New cancer diagnoses numbered 53 and were proportionately higher after Urgent Suspected Cancer (USC, n=35, 4.6%) than routine referral (n=3, 0.6%, p<0.001). Deprivation was associated with more advanced staged cancer (stage III Q1 16.7% v Q5 5.6%, OR 0.997, p=0.006: stage IV Q1 16.7% v Q2 38.9% v Q5 22.2%, OR 0.998, p=0.049).\u0000Conclusion: Deprivation was associated with two-fold more peptic ulcer disease, three-fold more Helicobacter Pylori infection, and 12-fold more severe esophagitis, and more advanced cancer stage. \u0000","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"40 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes following duodenectomy in patients with familial adenomatous polyposis 家族性腺瘤性息肉病患者十二指肠切除术后的疗效

Endoscopy International Open Pub Date : 2024-04-02 DOI: 10.1055/a-2298-0038

A. Aelvoet, Isabel Martin, James Cockburn, Cherryl Cabalit, V. Cuthill, Duncan Spalding, Olivier Busch, B. Bastiaansen, Sue Clark, Evelien Dekker, A. Latchford

{"title":"Outcomes following duodenectomy in patients with familial adenomatous polyposis","authors":"A. Aelvoet, Isabel Martin, James Cockburn, Cherryl Cabalit, V. Cuthill, Duncan Spalding, Olivier Busch, B. Bastiaansen, Sue Clark, Evelien Dekker, A. Latchford","doi":"10.1055/a-2298-0038","DOIUrl":"https://doi.org/10.1055/a-2298-0038","url":null,"abstract":"Background\u0000Some patients with FAP and extensive duodenal polyposis or cancer require total duodenectomy. Regular postoperative endoscopic surveillance of the remaining jejunum and stomach is recommended, but little is known about the outcomes after this surgery. \u0000Methods\u0000Patients with FAP who underwent either pancreatoduodenectomy (PD) or pancreas-preserving total duodenectomy (PPTD) were identified from two expert centers. Postoperative endoscopic surveillance outcomes were collected, as well as survival outcomes.\u0000Results\u0000Overall, 119 patients (50% female) underwent duodenectomy (86 PD and 33 PPTD); 100 for benign duodenal polyposis and 19 for duodenal or ampullary cancer. Details of postoperative endoscopic surveillance were available for 88 patients (74%). During a median follow-up of 106 months, 36 patients (41%) were diagnosed with jejunal adenomas after duodenectomy, with a significant higher proportion in patients who underwent PPTD compared to patients who underwent PD (log-rank, p < 0.01). Two patients developed jejunal cancer (2%). Twenty-six patients (30%) were diagnosed with a total of 66 gastric adenomas, of which 61% were located in the fundus/body and 39% in the antrum. Five patients (6%) developed gastric cancer after a median of 15 years (range 6-23 years), all but one within carpeting fundic gland polyposis. Patients who underwent surgery for cancer had a worse survival than patients with benign disease and all but one patient with postoperative gastric/jejunal cancer died.\u0000Conclusions\u0000After duodenectomy in FAP, a considerable risk of developing adenomas and cancer in the stomach and jejunum exists with poor cancer prognosis, highlighting the need for close postoperative endoscopic surveillance.\u0000","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"254 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed tomography-based prediction of pancreatitis following biliary metal stent placement with the convolutional neural network 基于计算机断层扫描的卷积神经网络预测胆道金属支架置入术后的胰腺炎

Endoscopy International Open Pub Date : 2024-04-02 DOI: 10.1055/a-2298-0147

T. Hamada, K. Yasaka, Y. Nakai, Rintaro Fukuda, R. Hakuta, K. Ishigaki, S. Kanai, Kensaku Noguchi, Hiroki Oyama, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, N. Takahara, Hiroyuki Isayama, Osamu Abe, Mitsuhiro Fujishiro

{"title":"Computed tomography-based prediction of pancreatitis following biliary metal stent placement with the convolutional neural network","authors":"T. Hamada, K. Yasaka, Y. Nakai, Rintaro Fukuda, R. Hakuta, K. Ishigaki, S. Kanai, Kensaku Noguchi, Hiroki Oyama, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, N. Takahara, Hiroyuki Isayama, Osamu Abe, Mitsuhiro Fujishiro","doi":"10.1055/a-2298-0147","DOIUrl":"https://doi.org/10.1055/a-2298-0147","url":null,"abstract":"Introduction: Pancreatitis is a potentially lethal adverse event of endoscopic transpapillary placement of a self-expandable metal stent (SEMS) for malignant biliary obstruction (MBO). Deep learning-based image recognition has not been investigated in predicting pancreatitis in this setting.\u0000Methods: We included 70 patients who received endoscopic placement of a SEMS for nonresectable distal MBO. We constructed a convolutional neural network (CNN) model for pancreatitis prediction using a series of preprocedural computed tomography images covering the whole pancreas (≥ 120,960 augmented images in total). We examined the additional effects of the CNN-based probabilities on the following machine learning models based on clinical parameters: logistic regression, support vector machine with a linear or RBF kernel, random forest classifier, and gradient boosting classifier. Model performance was assessed based on the area under the curve (AUC) in the receiver operating characteristic analysis, positive predictive value (PPV), accuracy, and specificity.\u0000Results: The CNN model was associated with moderate levels of performance metrics: AUC, 0.67; PPV, 0.45; accuracy, 0.66; and specificity, 0.63. When added to the machine learning models, the CNN-based probabilities increased the performance metrics. The logistic regression model with the CNN-based probabilities had an AUC of 0.74, PPV of 0.85, accuracy of 0.83, and specificity of 0.96, compared to 0.72, 0.78, 0.77, and 0.96, respectively, without the probabilities.\u0000Conclusions: The CNN-based model may increase the predictability for pancreatitis following endoscopic placement of a biliary SEMS. Our findings support the potential of deep learning technology in improving prognostic models in pancreatobiliary therapeutic endoscopy.","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Potential for expanded application of endoscopic hand suturing: A pilot study of 15 cases 更正：扩大内窥镜手部缝合术应用范围的潜力：15 个病例的试点研究

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2302-6845

K. Higuchi, O. Goto, E. Koizumi, S. Nakagome, T. Habu, Y. Ishikawa, K. Kirita, H. Noda, T. Onda, J. Omori, N. Akimoto, K. Iwakiri

引用次数: 0

Water pressure method for endoscopic submucosal dissection of a rectal tumor on the gravitational side close to the dentate line 在靠近齿状线的重力侧采用水压法进行直肠肿瘤内窥镜黏膜下剥离术

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2272-1012

Tao Dong, Hanying Wang, Lin Jing, Xuan Zhou, Yaohui Wang, Jun Xiao

引用次数: 0

Primary anastomosis closure after endoscopic ultrasound-directed transgastric intervention 内镜超声引导下经胃介入术后的原发性吻合口闭合术

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2272-0927

Yong-Chao Cui, J. A. Almario, M. Bejjani, M. Khashab, S. Irani

{"title":"Primary anastomosis closure after endoscopic ultrasound-directed transgastric intervention","authors":"Yong-Chao Cui, J. A. Almario, M. Bejjani, M. Khashab, S. Irani","doi":"10.1055/a-2272-0927","DOIUrl":"https://doi.org/10.1055/a-2272-0927","url":null,"abstract":"Background and study aims Endoscopic ultrasound-directed transgastric intervention (EDGI) is a technique that creates an anastomosis between the gastric pouch or jejunum to the excluded stomach in Roux-en-Y gastric bypass (RYGB) anatomy to allow access to the pancreaticobiliary system. Thus far, management of anastomosis closure at the time of lumen-apposing metal stent (LAMS) removal has varied widely. This study aimed to assess the efficacy of primary closure at the time of LAMS removal using a through-the-scope (TTS) tack-based suture system. Patients and methods This was a two-center retrospective study of RYGB patients who underwent single-stage EDGI using a 20-mm LAMS and subsequent primary anastomosis closure with the X-tack system at the time of stent removal. Patient demographics, procedure details, clinical outcomes, and imaging findings are reported. Results Nineteen patients (median age 63 years, 84% female) underwent single-stage EDGI with a median follow-up of 31.5 months. Adverse events occurred in two patients (11%) who had abdominal pain requiring hospitalization. The median LAMS dwell time was 32 days (range 16–86). All patients (100%) who underwent follow-up studies after LAMS removal had confirmed anastomosis closure (n = 18). Most patients had documented weight loss at the time of LAMS removal and at last follow-up (68%, n = 13). Conclusions Single-stage EDGI is an effective approach to managing RYGB patients with pancreaticobiliary pathology. Thus far, endoscopic TTS tack-based suturing appears to have a high success rate in anastomosis closure after LAMS removal and should be considered as a primary method for preventing chronic fistulae.","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"2 2","pages":"E526 - E531"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140787617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of interstitial cells of Cajal and fibrosis during gastric per-oral endoscopic myotomy and its association with clinical outcomes 胃经口内镜肌切开术期间卡贾尔间质细胞和纤维化的定量及其与临床结果的关系

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2290-0502

Dennis Yang, M. Hasan, BahaAldeen Bani Fawwaz, Aimen Farooq, Yiyang Zhang, Hafiz M Khan, Tony S Brar, Sanmeet Singh, Artur Viana, Gurdeep Singh, Kambiz S. Kadkhodayan, Mustafa A Arain, Natalie Cosgrove, Deepanshu Jain, I. Inayat, Charanjeet Singh

{"title":"Quantification of interstitial cells of Cajal and fibrosis during gastric per-oral endoscopic myotomy and its association with clinical outcomes","authors":"Dennis Yang, M. Hasan, BahaAldeen Bani Fawwaz, Aimen Farooq, Yiyang Zhang, Hafiz M Khan, Tony S Brar, Sanmeet Singh, Artur Viana, Gurdeep Singh, Kambiz S. Kadkhodayan, Mustafa A Arain, Natalie Cosgrove, Deepanshu Jain, I. Inayat, Charanjeet Singh","doi":"10.1055/a-2290-0502","DOIUrl":"https://doi.org/10.1055/a-2290-0502","url":null,"abstract":"Background and study aims Alterations to interstitial cells of Cajal (ICC) and collagen fibrosis have been implicated in the pathogenesis of gastroparesis. We aimed to evaluate the feasibility and safety of pyloric muscle sampling during gastric peroral endoscopic myotomy (G-POEM) and the association between pyloric ICC density and degree of fibrosis with clinical outcomes. Patients and methods This was a single-center prospective study of gastroparetic patients who underwent G-POEM and intraprocedural pyloric muscle biopsies between January 2022 and April 2023. ICC count was estimated using CD117 stain and trichome for collagen fibrosis. Clinical response to G-POEM was defined as an improvement of ≥ 1 point on the Gastroparesis Cardinal Symptom Index. Results Fifty-six patients (median age 60 years, 71.4% women) underwent G-POEM (100% technical success; 71.4% clinical response). ICC depletion (< 10/high-power field) and fibrosis were encountered in 70.4% and 75% of the cases, respectively. There was no difference in mean ICC count between G-POEM responders vs. non-responders (7±3.6 vs. 7.7±3.3; P = 0.9). There was no association between ICC density or degree of fibrosis with the etiology of gastroparesis, duration of symptoms, gastric emptying rate, or pyloric impedance planimetry. Patients who did not respond to G-POEM had a significantly higher degree of moderate/severe fibrosis when compared with those who responded (81.3% vs. 25%; P = 0.0002). Conclusions Pyloric muscle biopsies during G-POEM was feasible and safe. ICC depletion and pyloric muscle fibrosis are common in gastroparetic patients. The degree of fibrosis may be related to pyloric dysfunction and clinical response to G-POEM. Additional studies are needed to confirm these results.","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"47 30","pages":"E585 - E592"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel “NOTES” technique for treating incarcerated stones in the gallbladder neck 治疗胆囊颈部嵌顿结石的新型 "NOTES "技术

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2285-2286

Congying Chen, Xiao Han, Jingnan Chen, Zhenni Yin, Rong Wan

引用次数: 0

Long-term course of untreated asymptomatic esophageal eosinophilia and minimally symptomatic eosinophilic esophagitis 未经治疗的无症状食管嗜酸性粒细胞增多症和症状轻微的嗜酸性粒细胞食管炎的长期过程

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2280-8277

Y. Abe, Ryosuke Kikuchi, Y. Sasaki, Naoko Mizumoto, M. Yagi, Y. Onozato, Takahiro Watabe, Hiroki Goto, Takahiro Miura, Ryou Sato, Minami Ito, Hiroko Tsuchiya, Yoshiyuki Ueno

{"title":"Long-term course of untreated asymptomatic esophageal eosinophilia and minimally symptomatic eosinophilic esophagitis","authors":"Y. Abe, Ryosuke Kikuchi, Y. Sasaki, Naoko Mizumoto, M. Yagi, Y. Onozato, Takahiro Watabe, Hiroki Goto, Takahiro Miura, Ryou Sato, Minami Ito, Hiroko Tsuchiya, Yoshiyuki Ueno","doi":"10.1055/a-2280-8277","DOIUrl":"https://doi.org/10.1055/a-2280-8277","url":null,"abstract":"Background and study aims The long-term course of untreated asymptomatic esophageal eosinophilia (aEE) and minimally symptomatic eosinophilic esophagitis (mEoE) are not well understood. This study aimed to clarify this course. Patients and methods A total of 36 patients with EE who were endoscopically followed up for more than 5 years, and who underwent more than one endoscopy evaluation after the first diagnosis, were investigated. These patients were divided into two groups according to the presence or absence of the continuous treatment: no treatment group (NT group, n=22) and proton pump inhibitor/potassium competitive acid blocker group (Tx group, n=14). Symptoms and endoscopic and histological findings were retrospectively reviewed according to endoscopic phenotypes. Endoscopic assessment was performed using the EoE endoscopic reference score (EREFS). Results The median follow-up period was 84.5 months in the Tx group and 92 months in the NT group. During the follow-up period, about half of the patients in the Tx-diffuse group persisted EREFS >3, while the remaining half had EREFS ≤2. The total EREFS in the NT-diffuse group remained almost unchanged (median: 2–4) without apparent exacerbation. In contrast, EREFS in the NT-localized group exhibited an unchanged or gradually decreasing trend, with statistical significance from the first diagnosis to 72 to 83 months after. Conclusions Untreated aEE and mEoE are not likely to worsen even without treatment at least for a median follow-up of 7 years. Instead, the localized type may spontaneously improve, implying a different pathogenesis in the presence of the diffuse type. Further studies should clarify the long-term prognosis.","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"87 ","pages":"E545 - E553"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between endoscopist adenoma detection rate and serrated polyp detection: Retrospective analysis of over 200,000 screening colonoscopies 内镜医师腺瘤检出率与锯齿状息肉检出率之间的关系：对超过 20 万例筛查结肠镜手术的回顾性分析

Endoscopy International Open Pub Date : 2024-04-01 DOI: 10.1055/a-2271-1929

D. Penz, D. Pammer, E. Waldmann, A. Asaturi, Aleksrandra Szymanska, Michael Trauner, M. Ferlitsch

{"title":"Association between endoscopist adenoma detection rate and serrated polyp detection: Retrospective analysis of over 200,000 screening colonoscopies","authors":"D. Penz, D. Pammer, E. Waldmann, A. Asaturi, Aleksrandra Szymanska, Michael Trauner, M. Ferlitsch","doi":"10.1055/a-2271-1929","DOIUrl":"https://doi.org/10.1055/a-2271-1929","url":null,"abstract":"Background and study aims Serrated lesions have been identified as precursor lesions for 20% to 35% of colorectal cancers (CRCs) and may contribute to a significant proportion of interval-cancer. Sessile-serrated-lesions (SSLs), in particular, tend to be flat and located in the proximal colon, making their detection challenging and requiring expertise. It remains unclear whether the detection rate for serrated polyps should be considered as a quality indicator in addition to the adenoma detection rate (ADR). This study sought to assess whether the ADR has an effect on the detection rate for serrated polyps. atients and methods In this retrospective analysis, prospectively collected data from 212,668 screening colonoscopies performed between 2012 and September 2018 were included. Spearman correlation and Whitney-Mann U-test were used to assess the association of ADR and the detection rate of SSLs with (SDR) and without hyperplastic polyps (SPADRs), the sessile serrated detection rate (SSLDR) as well as the clinically relevant serrated detection rate (CRSDR), including all SSLs and traditional serrated adenoma, hyperplastic polyps (HPs) >10 mm anywhere in the colon or HPs > 5 mm proximal to the sigmoid. Results The overall mean ADR was 21.78% (standard deviation [SD] 9.27), SDR 21.08% (SD 11.44), SPADR 2.19% (SD 2.49), and CRSDR was 3.81% (3.40). Significant correlations were found between the ADR and the SDR, SPADR, SSLDR, and CRSDR (rho=0.73 vs. rho=0.51 vs. rho=0.51 vs. rho=0.63; all P <0.001). Endoscopists with a mean ADR ≥25% had significantly higher SDR, SPADR, and CRSDR than endoscopists with a mean ADR <25% (all P <0.001; Mann-Whitney U-Test). Conclusions This study shows that endoscopists with higher ADR detect significantly more serrated lesions than those with a lower ADR.","PeriodicalId":508938,"journal":{"name":"Endoscopy International Open","volume":"209 ","pages":"E488 - E497"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0