Current Drug Research Reviews最新文献

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Radiosensitizing Effects of Metformin on Ionizing Irradiation: An Overview of Animal and Clinical Studies 二甲双胍对电离辐射的辐射敏感效应：动物和临床研究综述

Current Drug Research Reviews Pub Date : 2024-07-09 DOI: 10.2174/0125899775300432240625045414

Seyedeh Kimia Javadi Haghighi, R. Fardid, A. Safari

{"title":"Radiosensitizing Effects of Metformin on Ionizing Irradiation: An Overview of Animal and Clinical Studies","authors":"Seyedeh Kimia Javadi Haghighi, R. Fardid, A. Safari","doi":"10.2174/0125899775300432240625045414","DOIUrl":"https://doi.org/10.2174/0125899775300432240625045414","url":null,"abstract":"\u0000\u0000Radiation therapy is the most common modality to treat various types of\u0000cancers. The use of radiosensitizers as an adjuvant therapy to increase the sensitivity of tumors\u0000against radiation and to improve the efficiency of radiotherapy has risen over the past years. Metformin,\u0000the first-line drug in type two diabetes has attracted the researcher’s attention because of\u0000its anti-cancer and anti-proliferative properties and many studies have been conducted to investigate\u0000the radiosensitization effects of metformin in different types of malignancies.\u0000\u0000\u0000\u0000This review aims to gather the existing evidence of radiosensitizing effects of metformin\u0000in animal and clinical studies.\u0000\u0000\u0000\u0000Various databases like PubMed, Scopus, and Google Scholar were searched over a period\u0000of 35 years for this review.\u0000\u0000\u0000\u0000The results include 54 studies on the radiosensitization effect of metformin in in-vivo and\u0000clinical conditions including breast, colorectal, prostate, lung, liver, and other cancers.\u0000\u0000\u0000\u0000This review shows that metformin in animal and clinical studies appears to be a potential\u0000radiosensitizer for many types of cancers. However, further investigations are needed to determine\u0000whether metformin can be used as a radiosensitizer in adjuvant radiotherapy.\u0000","PeriodicalId":508923,"journal":{"name":"Current Drug Research Reviews","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide Drugs: Current Status and Treatment for the Treatment of Various Diseases. 多肽药物：肽类药物：治疗各种疾病的现状和治疗方法》（Peptide Drugs: Current Status and Treatment for the Treatment of Various Diseases）。

Current Drug Research Reviews Pub Date : 2024-04-17 DOI: 10.2174/0125899775295960240406073630

Chandani Chandarana, Isha Juwarwala, Shravi Shetty, Anushree Bose

{"title":"Peptide Drugs: Current Status and Treatment for the Treatment of Various Diseases.","authors":"Chandani Chandarana, Isha Juwarwala, Shravi Shetty, Anushree Bose","doi":"10.2174/0125899775295960240406073630","DOIUrl":"https://doi.org/10.2174/0125899775295960240406073630","url":null,"abstract":"Peptides represent a class of natural molecules with diverse physiological functions, including hormone regulation, neurotransmission, and immune modulation. In recent years, peptide-based therapeutics have gained significant attention in pharmaceutical research and development due to their high specificity, efficacy, and relatively low toxicity. This review provides an overview of the current landscape of peptide drug development, highlighting the challenges faced in their formulation and delivery and the innovative strategies employed to overcome these hurdles. The review explores the wide range of applications of peptide drugs in treating various diseases, including HIV, multiple sclerosis, osteoporosis, chronic pain, diabetes, and cancer. Examples of FDA-approved peptide drugs and ongoing clinical trials are presented, showcasing the continuous advancements in peptide-based therapeutics across different therapeutic areas. This review underscores the promising potential of peptide drugs as targeted and effective treatments for a multitude of medical conditions, offering improved therapeutic outcomes and enhanced patient care.","PeriodicalId":508923,"journal":{"name":"Current Drug Research Reviews","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review 接触大麻对青少年健康和发展的影响：叙述性综述

Current Drug Research Reviews Pub Date : 2024-01-15 DOI: 10.2174/0125899775273727231224185028

Ruixuan Li, Feng Tao

{"title":"Effects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review","authors":"Ruixuan Li, Feng Tao","doi":"10.2174/0125899775273727231224185028","DOIUrl":"https://doi.org/10.2174/0125899775273727231224185028","url":null,"abstract":"\u0000\u0000Adolescence is an immature but adventurous time period of exploration. Due to rapid\u0000developments of the brain with unbalanced release of neurotransmitters, adolescents are prone\u0000to impulsivity that may carry out potentially dangerous behaviors. According to the Centers for\u0000Disease Control and Prevention, more than one-third of high school students have reported the\u0000use of cannabis or marijuana in 2019, and the trend has not declined since. Previous studies\u0000have shown that cannabis not only affects cognitive and social behaviors, but also produces\u0000psychological responses to stress. In this review, we have summarized recent studies on cannabis-\u0000produced effects during the unique period of adolescent development, and we have also\u0000briefly discussed the legalization of cannabis. Though there are slight differences between cannabis\u0000and marijuana, the major active component of them is tetrahydrocannabinol. We have\u0000used the term “cannabis” in this review. Cannabis use in adolescents causes structural and functional\u0000changes in the brain, increasing the probability of depression, which is also associated\u0000with other illicit substance use, and impairs education achievement. Given that cannabis use can\u0000cause detrimental harm to adolescents, it is suggested that adolescents should generally avoid\u0000using cannabis in a recreational manner. More preclinical and clinical studies are needed to\u0000provide detailed information for evidence-based decisions.\u0000","PeriodicalId":508923,"journal":{"name":"Current Drug Research Reviews","volume":"36 5-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0