多肽药物:肽类药物:治疗各种疾病的现状和治疗方法》(Peptide Drugs: Current Status and Treatment for the Treatment of Various Diseases)。

Chandani Chandarana, Isha Juwarwala, Shravi Shetty, Anushree Bose
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引用次数: 0

摘要

肽是一类天然分子,具有多种生理功能,包括激素调节、神经传递和免疫调节。近年来,多肽类药物因其特异性强、疗效好、毒性相对较低等特点,在医药研发领域备受关注。本综述概述了多肽药物开发的现状,重点介绍了多肽药物制剂和给药过程中面临的挑战,以及克服这些障碍所采用的创新策略。综述探讨了多肽药物在治疗各种疾病方面的广泛应用,包括艾滋病、多发性硬化症、骨质疏松症、慢性疼痛、糖尿病和癌症。文中列举了美国食品及药物管理局批准的多肽药物和正在进行的临床试验,展示了不同治疗领域多肽疗法的不断进步。这篇综述强调了肽类药物作为多种疾病的靶向有效治疗方法的巨大潜力,可改善治疗效果和加强患者护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peptide Drugs: Current Status and Treatment for the Treatment of Various Diseases.
Peptides represent a class of natural molecules with diverse physiological functions, including hormone regulation, neurotransmission, and immune modulation. In recent years, peptide-based therapeutics have gained significant attention in pharmaceutical research and development due to their high specificity, efficacy, and relatively low toxicity. This review provides an overview of the current landscape of peptide drug development, highlighting the challenges faced in their formulation and delivery and the innovative strategies employed to overcome these hurdles. The review explores the wide range of applications of peptide drugs in treating various diseases, including HIV, multiple sclerosis, osteoporosis, chronic pain, diabetes, and cancer. Examples of FDA-approved peptide drugs and ongoing clinical trials are presented, showcasing the continuous advancements in peptide-based therapeutics across different therapeutic areas. This review underscores the promising potential of peptide drugs as targeted and effective treatments for a multitude of medical conditions, offering improved therapeutic outcomes and enhanced patient care.
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