Advances in Cancer Research最新文献_第3页

Toxic chemotherapeutic nutrition of cancer cells by alkaline glucosodiene molecules via targeting metabolic of cancerous tumors: a promising theory for cancer treatment 碱性葡萄糖二烯分子通过靶向肿瘤代谢对癌细胞进行毒性化疗营养:一种有前景的癌症治疗理论

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.53388/2023623010

M. Akl, A. M. Abou El Naga

引用次数: 4

Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway 苦参碱通过SREBP信号通路调控脂质代谢抗肿瘤作用机制的研究

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.53388/2023623012

Fang-Hua Wu, Fei Huang, Yan Chen, Kui Chen, Chao Gong, Shen-Zhou Huang, Jiang-Yue Yu, Ruohuan Zhao, Peishuo Zhu, Li-Qun Wang

{"title":"Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway","authors":"Fang-Hua Wu, Fei Huang, Yan Chen, Kui Chen, Chao Gong, Shen-Zhou Huang, Jiang-Yue Yu, Ruohuan Zhao, Peishuo Zhu, Li-Qun Wang","doi":"10.53388/2023623012","DOIUrl":"https://doi.org/10.53388/2023623012","url":null,"abstract":"Author contributions Fang-Hua Wu and Fei Huang wrote the original draft; Yan Chen, Kui Chen, Chao Gong, Shen-Zhou Huang, Jiang-Yue Yu, Ruo-Qin Zhao, Pei-Wen Zhu was responsible for reviewing, editing, and supervision; Li-Qun Wang was responsible for project administration, supervision and methodology. Competing interests The authors declare no conflicts of interest. Acknowledgments This work was supported by grants from the Natural Science Foundation of Fujian province (No. 2020J011181). Peer review information Cancer Advances thanks Huang Wei Ling, Huan-Tian Cui and other anonymous reviewers for their contribution to the peer review of this paper. Abbreviations SREBP: sterol regulatory element binding protein; HE: hematoxylin and eosin; qPCR: quantitative polymerase chain reaction; Srebf1: transcription factor 1; Acly: ATP citrate lyase; Acc: acetyl-Coenzyme A carboxylase alpha. Citation Wu FH, Huang F, Chen Y, et al. Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway. Cancer Adv. 2023;6:12. doi: 10.53388/2023623012.","PeriodicalId":50875,"journal":{"name":"Advances in Cancer Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82546554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An updated review of pineapple and its bioactive compounds in breast cancer 菠萝及其生物活性化合物在乳腺癌中的最新研究进展

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.53388/2023623005

Virender Kumar, Davinder Kumar, V. Garg, H. Dureja

引用次数: 0

Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery. 靶向致癌转录驱动肿瘤的超延伸复合体:结构、机制和小分子抑制剂的发现进展。

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.1016/bs.acr.2022.12.007

Xinyu Wu, Yanqiu Xie, Kehao Zhao, Jing Lu

引用次数: 0

Clinico-pathological characteristics and prognosis of young women with breast cancer in southwest China 中国西南地区年轻女性乳腺癌的临床病理特征及预后分析

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.53388/2023623008

Juan Xu, Ling-Fan Li, H. Xiao, Juncheng Li, Shenghu He, X. Ai, Peng Sun

引用次数: 0

PFKP: More than phosphofructokinase. PFKP：不仅仅是磷酸果糖激酶。

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 Epub Date: 2023-03-30 DOI: 10.1016/bs.acr.2023.03.001

Haizhen Wang, Tiffany Penaloza, Amanda J Manea, Xueliang Gao

引用次数: 0

Targeting epigenetic regulation for cancer therapy using small molecule inhibitors. 利用小分子抑制剂靶向表观遗传调控癌症治疗。

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.1016/bs.acr.2023.01.001

Amit Kumar, Luni Emdad, Paul B Fisher, Swadesh K Das

{"title":"Targeting epigenetic regulation for cancer therapy using small molecule inhibitors.","authors":"Amit Kumar, Luni Emdad, Paul B Fisher, Swadesh K Das","doi":"10.1016/bs.acr.2023.01.001","DOIUrl":"https://doi.org/10.1016/bs.acr.2023.01.001","url":null,"abstract":"<p><p>Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone posttranslational modification, chromatin composition or organization and regulatory element activities that alter normal programs of gene expression. It is becoming increasingly clear that disturbances in the epigenome are hallmarks of cancer, which are targetable and represent attractive starting points for drug creation. Remarkable progress has been made in the past decades in discovering and developing epigenetic-based small molecule inhibitors. Recently, epigenetic-targeted agents in hematologic malignancies and solid tumors have been identified and these agents are either in current clinical trials or approved for treatment. However, epigenetic drug applications face many challenges, including low selectivity, poor bioavailability, instability and acquired drug resistance. New multidisciplinary approaches are being designed to overcome these limitations, e.g., applications of machine learning, drug repurposing, high throughput virtual screening technologies, to identify selective compounds with improved stability and better bioavailability. We provide an overview of the key proteins that mediate epigenetic regulation that encompass histone and DNA modifications and discuss effector proteins that affect the organization of chromatin structure and function as well as presently available inhibitors as potential drugs. Current anticancer small-molecule inhibitors targeting epigenetic modified enzymes that have been approved by therapeutic regulatory authorities across the world are highlighted. Many of these are in different stages of clinical evaluation. We also assess emerging strategies for combinatorial approaches of epigenetic drugs with immunotherapy, standard chemotherapy or other classes of agents and advances in the design of novel epigenetic therapies.</p>","PeriodicalId":50875,"journal":{"name":"Advances in Cancer Research","volume":"158 ","pages":"73-161"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9282553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The pleiotropic role of galectin-3 in melanoma progression: Unraveling the enigma. galectin-3 在黑色素瘤进展过程中的多向作用：解开谜团

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 Epub Date: 2022-08-08 DOI: 10.1016/bs.acr.2022.06.001

Norhan B B Mohammed, Aristotelis Antonopoulos, Anne Dell, Stuart M Haslam, Charles J Dimitroff

引用次数: 0

Therapeutic approaches and challenges for modulating the microbiota to prevent adenoma colon cancer 调节微生物群预防腺瘤结肠癌的治疗方法和挑战

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.53388/2023623016

A. Patil, Neha Singh, Nita Pawar

{"title":"Therapeutic approaches and challenges for modulating the microbiota to prevent adenoma colon cancer","authors":"A. Patil, Neha Singh, Nita Pawar","doi":"10.53388/2023623016","DOIUrl":"https://doi.org/10.53388/2023623016","url":null,"abstract":"New research suggests that gut microbiota helps adenoma colon cancer spread worldwide. This study seeks therapeutic microbiota changes to prevent adenoma colon cancer and discusses their drawbacks. Prebiotics feed good bacteria and promote the formation of short-chain fatty acids, which have anti-inflammatory and anti-cancer properties. To promote healthy gut bacteria and reduce adenoma risk, fiber-rich diets and particular dietary interventions are being researched. FMT (fecal microbiota transplantation) may help restore gut flora and prevent adenoma colon cancer, according to the study. FMT transfers healthy donor feces to patients to restore microbial diversity. Different gut flora, persons, and therapies make it tricky to draw conclusions. Personalizing therapeutic approaches to each person’s microbiota, host features, and genetic factors can improve treatment. Changing microorganisms may prevent adenoma colon cancer. Probiotics, prebiotics, dietary modifications, FMT, and bacteria metabolites may assist. More research is needed to determine the best ways to aid, solve difficulties, and personalize methods. We can prevent adenoma colon cancer and improve public health by learning more about gut flora and optimizing treatment methods.","PeriodicalId":50875,"journal":{"name":"Advances in Cancer Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85685086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of primary ovarian carcinoid and the review of the literature 原发性类卵巢癌1例及文献复习

2区医学

Advances in Cancer Research Pub Date : 2023-01-01 DOI: 10.53388/2023623003

Zhi-Ying Xia, Pei-Fang Chen, Lu-Shan Chen, Xiu-Shan Feng

引用次数: 0