Advances in Organometallic Chemistry最新文献

40 Years of GEQO-RSEQ GEQO-RSEQ 40年

2区化学

Advances in Organometallic Chemistry Pub Date : 2022-01-01 DOI: 10.1016/s0065-3055(22)x0002-6

引用次数: 0

Copyright 版权

2区化学

Advances in Organometallic Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-3055(21)00025-3

引用次数: 0

3rd Symposium in Carbene and Nitrene Chemistry 第三届碳和硝基化学研讨会

2区化学

Advances in Organometallic Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-3055(21)x0003-2

引用次数: 0

Copyright 版权

2区化学

Advances in Organometallic Chemistry Pub Date : 2020-01-01 DOI: 10.1016/s0065-3055(20)30006-x

引用次数: 0

Copyright 版权

2区化学

Advances in Organometallic Chemistry Pub Date : 2020-01-01 DOI: 10.1016/s0065-3055(20)30022-8

引用次数: 0

Contributors 贡献者

2区化学

Advances in Organometallic Chemistry Pub Date : 2020-01-01 DOI: 10.1016/s0065-3055(20)30024-1

引用次数: 0

Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression. 环状 RNA Cdr1as 通过抑制 miR-1270 上调 SCAI 以抑制卵巢癌的顺铂抗性

IF 8.8 2区化学

Advances in Organometallic Chemistry Pub Date : 2019-12-06 Epub Date: 2019-07-29 DOI: 10.1016/j.omtn.2019.07.012

Zhao Zhao, Mei Ji, Qianqing Wang, Nannan He, Yue Li

{"title":"Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression.","authors":"Zhao Zhao, Mei Ji, Qianqing Wang, Nannan He, Yue Li","doi":"10.1016/j.omtn.2019.07.012","DOIUrl":"10.1016/j.omtn.2019.07.012","url":null,"abstract":"<p><p>The aim of this study is to explore the roles of circular RNA (circRNA) Cdr1as on cisplatin resistance in ovarian cancer and explore the underlying mechanisms. We investigated the expression of circRNAs in five paired cisplatin-sensitive and cisplatin-resistant tissues of ovarian cancer by microarray analysis. The quantitative real-time PCR analysis was to investigate the expression pattern of Cdr1as in cisplatin-resistant ovarian cancer patient tissues and cell lines. Then, the effects of Cdr1as on cisplatin resistance, cell proliferation, and apoptosis were assessed in ovarian cancer cells. In this study, Cdr1as was observed to be downregulated in cisplatin-resistant patient tissues and cell lines. Overexpression of Cdr1as inhibited cell proliferation and promoted the cisplatin-induced cell apoptosis in ovarian cancer cells. Then we demonstrated that repressed Cdr1as promoted the miR-1270 expression, and miR-1270 could bind to the predicted binding site of Cdr1as. Furthermore, we found that miR-1270 displayed its role via modulating the Suppressor of Cancer Cell Invasion (SCAI) expression. Importantly, we demonstrated that Cdr1as was downregulated in serum exosomes from cisplatin-resistant patients. In summary, our study demonstrated that Cdr1as sensitizes ovarian cancer to cisplatin by regulating the miR-1270/SCAI signaling pathway.</p>","PeriodicalId":50855,"journal":{"name":"Advances in Organometallic Chemistry","volume":"14 1","pages":"24-33"},"PeriodicalIF":8.8,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77849462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in transition metal-mediated transformations of white phosphorus 过渡金属介导的白磷转化研究进展

2区化学

Advances in Organometallic Chemistry Pub Date : 2019-07-11 DOI: 10.1016/BS.ADOMC.2019.06.001

Franco Scalambra, M. Peruzzini, A. Romerosa

引用次数: 8

Boranes in Organic Chemistry 有机化学中的硼烷

2区化学

Advances in Organometallic Chemistry Pub Date : 2019-06-30 DOI: 10.7591/9781501741432

H. Brown

{"title":"Boranes in Organic Chemistry","authors":"H. Brown","doi":"10.7591/9781501741432","DOIUrl":"https://doi.org/10.7591/9781501741432","url":null,"abstract":"Publisher Summary This chapter discusses boranes in organic chemistry, diborane as a reducing agent, volatile compounds of uranium, the alkali metal hydride approach to diborane, and alkali metal borohydrides. The search for solvents led to the discovery of sodium borohydride's being an excellent reducing agent for aldehydes and ketones. The search for catalysts to enhance the reducing power of sodium borohydride led to an anomalous result in the reduction of ethyl oleate. Investigation of this anomalous result led to the discovery of hydroboration. Hydroboration made the organoboranes readily available for the first time. This led to a systematic exploration of the chemistry of the organoboranes and established the fact that they constitute the most versatile organometallic available currently. The chapter describes molecular addition compounds and steric strains, steric assistance in solvolysis, the nonclassical ion problem, selective reductions, hydroboration, and versatile organoboranes. On the theoretical side, study of the dissociation of addition compounds of amines with trimethylborane, boron trifluoride, and borane provides a new quantitative approach to steric strains. These studies quickly removed doubts as to the importance of steric effects in chemical behavior and led to the study of related carbon compounds and the establishment of steric effects as an important factor in their behavior. One phase of these studies involved steric assistance to ionization in highly branched tertiary halides and related derivatives.","PeriodicalId":50855,"journal":{"name":"Advances in Organometallic Chemistry","volume":"11 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47029494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Copyright 版权

2区化学

Advances in Organometallic Chemistry Pub Date : 2019-01-01 DOI: 10.1016/s0065-3055(19)30029-2

引用次数: 0