Ajar-African Journal of Aids Research最新文献_第5页

HIV-sensitive social protection: an assessment of east and southern Africa's social protection policies and programmes. 对艾滋病毒敏感的社会保护:对东部和南部非洲社会保护政策和方案的评估。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-07-01 DOI: 10.2989/16085906.2023.2203131

Zitha Mokomane, Nonhlanhla Xaba, Kai Roehm, Mutinta Hambayi, Manaan Mumma, Giovanni Giordana, Simphiwe Mabhele, Christian Mouala

{"title":"HIV-sensitive social protection: an assessment of east and southern Africa's social protection policies and programmes.","authors":"Zitha Mokomane, Nonhlanhla Xaba, Kai Roehm, Mutinta Hambayi, Manaan Mumma, Giovanni Giordana, Simphiwe Mabhele, Christian Mouala","doi":"10.2989/16085906.2023.2203131","DOIUrl":"https://doi.org/10.2989/16085906.2023.2203131","url":null,"abstract":"Despite notable political and financial commitment to fight the HIV epidemic, east and southern Africa (ESA) remains the world regions most affected. Given increasing calls for the implementation of HIV-sensitive social protection programmes to address the multiple individual, community and societal factors that heighten the risk of HIV infection, this article explores the extent to which social protection mechanisms in the region are HIV sensitive. The article is based on a two-phase project where the first phase entailed a desktop review of national social protection policies and programmes. In the second phase, multisectoral stakeholder consultations conducted were 15 fast-track countries in the region. The key findings suggest that social protection policies and social assistance programmes in ESA do not specifically target HIV issues or people living with, at risk of, or affected by HIV. Rather, and in line with the countries' constitutional provisions, the programmes tend to be inclusive of the vulnerabilities of various populations including people living with HIV. To this end, the programmes can be seen as generally sufficient to encompass HIV-related issues and the needs of people infected and affected by the epidemic. However, a recurring argument from many stakeholders is that, to the extent that people living with HIV are often reluctant to either disclose their status and/or access social protection services, it is critical for social protection policies and programmes to be explicitly HIV sensitive. The article thus concludes by making recommendations in this regard as well as by making a class for multisectoral partners to work collaboratively to ensure that social protection policies and programmes are transformative.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 2","pages":"113-122"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9934659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Provider perspectives on antiretroviral therapy adherence among psychiatric inpatients in Botswana. 提供者对博茨瓦纳精神病住院患者抗逆转录病毒治疗依从性的看法。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-07-01 DOI: 10.2989/16085906.2023.2213211

Maria Albin Qambayot, Sarita Naidoo

{"title":"Provider perspectives on antiretroviral therapy adherence among psychiatric inpatients in Botswana.","authors":"Maria Albin Qambayot, Sarita Naidoo","doi":"10.2989/16085906.2023.2213211","DOIUrl":"https://doi.org/10.2989/16085906.2023.2213211","url":null,"abstract":"Background: Optimal adherence to antiretroviral therapy (ART) is crucial for the effective management of HIV. Mental disorders often co-occur with HIV infection which often compromises ART adherence. Little is known about ART adherence in psychiatric settings in sub-Saharan Africa.Aims: This study aimed at exploring the health care providers' perspectives on ART adherence among psychiatric inpatients. The study further assessed the facilitators and strategies enhancing ART adherence in hospitalised psychiatric patients.Methods: In-depth interviews were conducted with 25 health care providers at the Sbrana Psychiatric Hospital in Botswana. Interviews were focused on barriers and facilitators to psychiatric inpatients' adherence to ART, and strategies and recommendations to support adherence. Data were manually analysed using a thematic analysis approach.Results: Key barriers were lack of insight, HIV-related stigma, lack of HIV-related knowledge, antiretroviral side effects and delays in re-initiating ART. Facilitators of ART adherence included motivation to be discharged from the hospital, fear of being sick, peer support, longer duration of hospitalisation, good provider-patient relationships, good diet, privacy and confidentiality and a single-tablet regimen. Health care providers described the various strategies currently used to support adherence, including directly observed therapy and family support, and recommended potential approaches to enhance psychiatric inpatient adherence to ART, including the use of injectable antiretrovirals and the introduction of halfway house centres.Conclusions: Findings from this study revealed unique insights into the numerous factors that influence ART adherence among psychiatric inpatients, and underscore the need to implement tailored strategies to support ART adherence in this population with complex health needs.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 2","pages":"123-130"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9940774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial support services to enhance well-being of orphaned and vulnerable learners in Eswatini early childhood centres and primary schools. 社会心理支持服务，以提高斯瓦蒂尼幼儿中心和小学的孤儿和弱势学习者的福祉。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-07-01 DOI: 10.2989/16085906.2023.2203128

Patronella Bimha, Maureen Nokuthula Sibiya

{"title":"Psychosocial support services to enhance well-being of orphaned and vulnerable learners in Eswatini early childhood centres and primary schools.","authors":"Patronella Bimha, Maureen Nokuthula Sibiya","doi":"10.2989/16085906.2023.2203128","DOIUrl":"https://doi.org/10.2989/16085906.2023.2203128","url":null,"abstract":"In Eswatini (formerly Swaziland), the increasing number of orphans and vulnerable children due to HIV/AIDS has spurred demand for psychosocial support services. When the Ministry of Education and Training assumed responsibility for delivering psychosocial support, educators were burdened with the additional role of looking after orphans and vulnerable learners. This exploratory, sequential, mixed-methods study was employed to analyse factors that enhance the provision of psychosocial support services and the perceptions of educators towards psychosocial support delivery. The qualitative study phase entailed 16 in-depth interviews with multi-sectoral psychosocial support specialists and seven focus group discussions with orphans and vulnerable learners. In the quantitative study phase, 296 educators were surveyed. Thematic analysis was used for the qualitative data, and the quantitative data was analysed using Statistical Package for the Social Sciences version 25 software. The findings reveal problems associated with psychosocial support service delivery at strategy, policy and operational levels. The results indicate that orphans and vulnerable children are offered material support (e.g. food and sanitary pads) and spiritual support, but were rarely referred for social and psychological needs. There were no proper counselling facilities and not all teachers received relevant training in children's psychosocial needs. Training of educators in specific psychosocial support areas was considered significant to enhance service delivery and the psychosocial well-being of the learners. Overall, accountability was difficult to establish because the administration of psychosocial support is split among the Ministry of Education and Training, the Deputy Prime Minister's office and Tinkhundla administration. There is unequal distribution of qualified early childhood development teachers to cater for early childhood educational needs.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 2","pages":"102-112"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9940775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Factors associated with buying sex and the knowledge that condoms prevent HIV among long-distance truck drivers at Kazungula weighbridge terminal, Chobe District, Botswana. 在博茨瓦纳乔贝区Kazungula地磅桥终点站，长途卡车司机中与购买性行为有关的因素和避孕套预防艾滋病的知识。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2176331

Wada Gaolaolwe, Mathildah Mokgatle

{"title":"Factors associated with buying sex and the knowledge that condoms prevent HIV among long-distance truck drivers at Kazungula weighbridge terminal, Chobe District, Botswana.","authors":"Wada Gaolaolwe, Mathildah Mokgatle","doi":"10.2989/16085906.2023.2176331","DOIUrl":"https://doi.org/10.2989/16085906.2023.2176331","url":null,"abstract":"Background: Long-distance truck drivers (LDTDs) have a higher rate of HIV infection compared to the general population. This is due to their living and working conditions which predispose them to riskier sexual behaviours. Inadequate knowledge of HIV and AIDS, coupled with risky sexual behaviours such as unprotected sex with commercial sex workers (CSWs), predisposes LDTDs to contract and propagate HIV. This study aims to determine the factors associated with buying sex and the knowledge that condoms prevent HIV transmission among long-distance truck drivers at Kazungula weighbridge terminal in the Chobe District of Botswana.Methods: A cross-sectional descriptive survey was employed and 399 LDTDs participated. A questionnaire was used to collect sociodemographic data and information on knowledge of HIV and AIDS and the sexual behaviours of the LDTDs.Results: The results reveal that more than half of the LDTDs (56.9%; n = 227) had paid for sex with CSWs at some point in their travels, and 27.1% (n = 108) reported having had unprotected sex with CSWs. The LDTDs who preferred to have sex with CSWs without a condom had about five times the odds of buying sex with CSWs than those who preferred to use a condom (AOR 4.9; 95% CI 2.85-8.46). Disliking condom use was a factor contributing to less knowledge of condom use preventing HIV among the LDTDs (AOR 0.4; CI 0.17-0.97).Conclusion: It can be concluded from the results of this study that the LDTDs engage in considerable risky sexual behaviours, and associated factors were found to be multidimensional. This population remains of concern in HIV acquisition and transmission. Therefore, there is a need for a robust public health response to deal with the problem of both new infection and re-infection with HIV in this population.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 1","pages":"35-45"},"PeriodicalIF":1.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9360737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of multi-month antiretroviral dispensing on HIV clinic attendance at 68 Nigerian Army Reference Hospital, Yaba, Nigeria. 多个月抗逆转录病毒药物分配对尼日利亚亚巴68家尼日利亚陆军参考医院艾滋病毒门诊就诊人数的影响。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2188232

Nkechinyere Harrison, Ismail Lawal, Kehinde Aribisala, Kenneth Oruka, Yakubu Adamu, Patricia Agaba, Elizabeth Lee, Laura Chittenden, Nathan Okeji

{"title":"Effect of multi-month antiretroviral dispensing on HIV clinic attendance at 68 Nigerian Army Reference Hospital, Yaba, Nigeria.","authors":"Nkechinyere Harrison, Ismail Lawal, Kehinde Aribisala, Kenneth Oruka, Yakubu Adamu, Patricia Agaba, Elizabeth Lee, Laura Chittenden, Nathan Okeji","doi":"10.2989/16085906.2023.2188232","DOIUrl":"https://doi.org/10.2989/16085906.2023.2188232","url":null,"abstract":"Background: Multi-month dispensing (MMD) of antiretroviral therapy has demonstrated benefits for HIV patients and health service delivery systems, including reduced frequency of hospital visits and improved retention. We evaluated the effect of 6-monthly dispensing (MMD6) on patient clinic attendance at a single military facility in the one-year pre- and post-policy change. Methods: This was a descriptive, retrospective, cross-sectional study, exploring the relationship between MMD6 and clinic attendance numbers. We reviewed aggregate clinic attendance records for clients on ART and documented monthly trends in clinic attendance numbers, number of clients current on ART, and amount of ART dispensed. Results: In the pre-MMD6 group, 4 150 patients were included, and 4 190 in the post-MMD6 group. Clinic attendance was 30 407 visits (16 111 pre-MMD6 and 14 296 post-MMD6). An overall mean increase of 326.58 ± 861.81 (95% CI = −874.15 ± 220.98) drugs were dispensed per month; t(11) = −1.31, p = 0.22; mean monthly clinic attendance declined from 1342.8 ± 220.10 visits pre-MMD6 to 1191.33 ± 309.10 post-MMD6 with t(11) = 1.601, p = 0.14, but was not statistically significant. Conclusion: Six-monthly dispensing can be an important tool to reduce HIV clinic volumes and improve antiretroviral access. It is particularly important for care continuity in military facilities where service members may be deployed or transferred to other bases along with their dependents.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 1","pages":"63-68"},"PeriodicalIF":1.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9521596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV infections averted at PEPFAR-APIN clinics in Nigeria: a ten-year retrospective evaluation of the clinical outcomes of post-exposure prophylaxis services. 在尼日利亚的PEPFAR-APIN诊所避免了艾滋病毒感染:接触后预防服务临床结果的十年回顾性评估。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2178317

Abdulmuminu Isah, Nneka Uchenna Igboeli, Obinna Felix Dim, Azubuike Amos Ekwuofu

{"title":"HIV infections averted at PEPFAR-APIN clinics in Nigeria: a ten-year retrospective evaluation of the clinical outcomes of post-exposure prophylaxis services.","authors":"Abdulmuminu Isah, Nneka Uchenna Igboeli, Obinna Felix Dim, Azubuike Amos Ekwuofu","doi":"10.2989/16085906.2023.2178317","DOIUrl":"https://doi.org/10.2989/16085906.2023.2178317","url":null,"abstract":"Introduction: Nigeria contributes a high fraction to the global burden of HIV infections. Post-exposure prophylaxis (PEP) is a proven strategy to prevent transmission of the virus. The aim of this study was to determine the clinical outcomes of PEP in Nigeria at four clinics funded by United States President's Emergency Plan for AIDS Relief and AIDS Prevention Initiative in Nigeria (PEPFAR-APIN): Ahmadu Bello University Teaching Hospital (ABUTH), Jos University Teaching Hospital (JUTH), University of Maiduguri Teaching Hospital (UMTH) and University College Hospital (UCH).Methods: This study adopted a multisite retrospective design using the site's databases (2006-2016). Retrieved data was exported into SPSS version 25 for statistical analysis. Outcomes were measured as a proportion of HIV infections averted after PEP. Frequencies and percentages were used to describe the findings, while binary logistic regression was used to determine the sociodemographic predictors of clinical outcomes.Results: The average age of the 575 PEP patients whose data were retrieved was 30.45 (SD ±9.50 years), with 344 (59.8%) being females. Out of 545 patients,157 (28.8%) indicated their job status as students. Out of 273 patients, 198 (72.5%) reported their exposure type was non-occupational. The HIV status of 129 (22.4%) patients was negative after completing PEP. Prescribed regimen (β = -0.048, 95% CI -0.095 to -0.001, p = 0.045) and type of exposure (β = 0.351, 95% CI 0.042-0.660, p = 0.027) were predictors of post-PEP HIV status in JUTH and ABUTH respectively.Conclusion: There was a high rate of lost-to-follow-up among the PEP patients, but the incidence of seroconversion was low in those who were tested after PEP. The right choice of regimen and presenting with non-occupational exposure affected the outcome of the service.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 1","pages":"46-53"},"PeriodicalIF":1.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9360738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2202504

引用次数: 0

Symptoms of depression, anxiety, and thoughts of suicide/self-injury in adolescents and young adults living with HIV in Botswana. 博茨瓦纳感染艾滋病毒的青少年和青年的抑郁、焦虑症状和自杀/自残想法。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2186252

Merrian Brooks, Barbara Burmen, Anthony Olashore, Alemayehu Mekonnen Gezmu, Keneilwe Molebatsi, Ontibile Tshume, Onkemetse Phoi, Knashawn Morales, Mogomotsi Matshaba, Tami Benton, Elizabeth D Lowenthal

{"title":"Symptoms of depression, anxiety, and thoughts of suicide/self-injury in adolescents and young adults living with HIV in Botswana.","authors":"Merrian Brooks, Barbara Burmen, Anthony Olashore, Alemayehu Mekonnen Gezmu, Keneilwe Molebatsi, Ontibile Tshume, Onkemetse Phoi, Knashawn Morales, Mogomotsi Matshaba, Tami Benton, Elizabeth D Lowenthal","doi":"10.2989/16085906.2023.2186252","DOIUrl":"10.2989/16085906.2023.2186252","url":null,"abstract":"Globally, mental health problems have been reported to be more common in youth living with HIV (YLWH) than in the general population, but routine mental health screening is rarely done in high-volume HIV clinics. In 2019, YLWH in a large HIV clinic in Botswana were screened using the Generalized Anxiety Scale-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) in a pilot standard-of-care screening programme. Two-way ANOVA was used to describe the effects of age group (12-<16, 16-<20 and 20-25 years old) and sex on GAD-7 and PHQ-9 scores. Chi-square statistics were used to compare characteristics of YLWH with and without potential suicidality/self-harm symptoms based on question 9 in the PHQ-9. Among 1 469 YLWH, 33.1%, 44.3% and 15.0% had anxiety, depression and potential suicidality/self-harm symptoms respectively. YLWH of 20-25 years old and 16-<20 years old had higher GAD-7 scores compared to 12-<16-year-olds (p = 0.014 and p = <0.001 respectively). Female YLWH of 20-25 years old had higher PHQ-9 scores compared to 12-<16-year-olds (p = 0.002). There were no other sex-age dynamics that were statistically significant. Female YLWH endorsed more thoughts of suicidality/self-harm than males (17% versus 13%, p = 0.03 respectively). Given the proportion of YLWH with mental health symptoms, Botswana should enhance investments in mental health services for YLWH, especially for young female adults who bear a disproportionate burden.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 1","pages":"54-62"},"PeriodicalIF":1.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9373335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles and responsibilities of expert clients in adolescent HIV service delivery in Eswatini: a conventional content analysis. 专家客户在斯瓦蒂尼青少年艾滋病毒服务中的作用和责任:传统内容分析。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2169178

Charisse V Ahmed, Guy Weissinger, Anne M Teitelman, Ndumiso Sabelo Dlamini, Nontsikelelo Patience Dlamini, Thuthukile Cebsile Dlamini, Angel Nkambule, Siphesihle Nkambule, Bridgette M Rice, Marianne Calnan

{"title":"Roles and responsibilities of expert clients in adolescent HIV service delivery in Eswatini: a conventional content analysis.","authors":"Charisse V Ahmed, Guy Weissinger, Anne M Teitelman, Ndumiso Sabelo Dlamini, Nontsikelelo Patience Dlamini, Thuthukile Cebsile Dlamini, Angel Nkambule, Siphesihle Nkambule, Bridgette M Rice, Marianne Calnan","doi":"10.2989/16085906.2023.2169178","DOIUrl":"https://doi.org/10.2989/16085906.2023.2169178","url":null,"abstract":"We aimed to elucidate the specific roles and responsibilities of expert clients in service delivery among adolescents living with HIV in Eswatini, and to provide recommendations for enhancing adolescent service provision among expert clients and similar lay health workers throughout low- and middle-income countries. An exploratory qualitative descriptive methodology using conventional content analysis was used to meet our study aims. We recruited 20 expert clients and 12 key informants (programme managers, programme coordinators and nurses) to participate in semi-structured interviews, and we arranged four focus group discussions among adolescents living with HIV with seven to ten participants per focus group. Adherence counselling in clinical and community settings was considered paramount to the roles and responsibilities of expert clients with regard to adolescent-specific HIV service delivery. The following recommendations were made to enhance expert client service delivery practices among adolescents: (1) training in adolescent developmental, sexual and reproductive needs; (2) training to enhance clinical knowledge and skills; (3) additional work equipment and compensation; and d) more parent and guardian engagement in their work. While expert clients meet the needs of adolescents living with HIV in several capacities, they require additional resources, skills and training to improve their work, especially in the realm of sexual and reproductive health. Future research is needed to evaluate the impact of expert client service delivery on adolescent health outcomes.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 1","pages":"27-34"},"PeriodicalIF":1.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9424858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Key stakeholders' perspectives on providing oral pre-exposure prophylaxis as HIV-prevention standard of care in clinical trials in South Africa. 南非临床试验中提供口服暴露前预防作为艾滋病毒预防标准护理的主要利益相关者的观点。

IF 1.2 4区医学

Ajar-African Journal of Aids Research Pub Date : 2023-04-01 DOI: 10.2989/16085906.2023.2169177

Ivana Beesham, Cecilia Milford, Dvora L Joseph Davey, Jenni Smit, Leila E Mansoor, Mags Beksinska

{"title":"Key stakeholders' perspectives on providing oral pre-exposure prophylaxis as HIV-prevention standard of care in clinical trials in South Africa.","authors":"Ivana Beesham, Cecilia Milford, Dvora L Joseph Davey, Jenni Smit, Leila E Mansoor, Mags Beksinska","doi":"10.2989/16085906.2023.2169177","DOIUrl":"https://doi.org/10.2989/16085906.2023.2169177","url":null,"abstract":"Introduction: HIV-prevention and endpoint-driven clinical trials enrol individuals at substantial risk of HIV. Recently, these trials have provided oral pre-exposure prophylaxis (PrEP) as HIV-prevention standard of care; however, data on PrEP uptake and use during the trial and post-trial access are lacking.Methods: We conducted once-off, telephonic, in-depth interviews from August 2020 to March 2021, with 15 key stakeholders (including site directors/leaders, principal investigators and clinicians), purposively recruited from research sites across South Africa that are known to conduct HIV-prevention and endpoint-driven clinical trials. The interview guide probed for facilitators and barriers to PrEP uptake and use during the trial, and post-trial PrEP access. Interviews were audio recorded and transcribed. Coding was facilitated using NVivo and emergent themes were identified.Results: Most stakeholders reported incorporating PrEP as part of the HIV-prevention package in HIV-prevention and endpoint-driven clinical trials. Stakeholders identified multiple barriers to PrEP uptake and use, including difficulties with daily pill taking, side effects, stigma, a lack of demand creation and limited knowledge and education about PrEP in communities. Facilitators of PrEP uptake and use included demand-creation campaigns and trial staff providing quality counselling and education. Post-trial PrEP access was frequently challenging as facilities were located a considerable distance from research sites, had long queues and inconvenient operating hours.Conclusions: Strategies to address barriers to PrEP uptake and use during trials and post-trial access, such as PrEP demand creation, education and counselling, addressing stigma, support for daily pill-taking and increased post-trial access, are urgently needed.","PeriodicalId":50833,"journal":{"name":"Ajar-African Journal of Aids Research","volume":"22 1","pages":"18-26"},"PeriodicalIF":1.2,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9360739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0