Italian Journal of Medicine最新文献_第2页

Is Rome ready to react to chemical, biological, radiological, nuclear, and explosive attacks? A tabletop simulation 罗马准备好应对化学、生物、放射、核和爆炸袭击了吗？桌面模拟

Italian Journal of Medicine Pub Date : 2024-05-14 DOI: 10.4081/itjm.2024.1731

F. Rosiello, Antonio Vinci, Matteo Vitali, Manuel Monti, Lidia Ricci, E. D'oca, F. Damato, Virgilio Costanzo, Giovanni Ferrari, Matteo Ruggeri, Serafino Ricci

{"title":"Is Rome ready to react to chemical, biological, radiological, nuclear, and explosive attacks? A tabletop simulation","authors":"F. Rosiello, Antonio Vinci, Matteo Vitali, Manuel Monti, Lidia Ricci, E. D'oca, F. Damato, Virgilio Costanzo, Giovanni Ferrari, Matteo Ruggeri, Serafino Ricci","doi":"10.4081/itjm.2024.1731","DOIUrl":"https://doi.org/10.4081/itjm.2024.1731","url":null,"abstract":"Rome is vulnerable to chemical, biological, radiological, nuclear, and explosive (CBRNe) attacks. The study evaluates Rome’s advanced emergency departments’ state of emergency plans for massive influx of injures (PEIMAF) plans for CBRNe attacks. We propose a chemical attack on Saint Peter’s Square during the Pope’s General Assembly and its effects. The National Stockpile Antidotes’ activation and territorial distribution timing work well for chemical attacks. We also estimated activation timing. Our data show that despite a good organization, travel times can be improved. We also believe that all major Roman hospitals must develop the PEIMAF, which should be followed by an organized training plan involving theoretical teaching and indoor and outdoor simulation to train hospital staff and evaluate PEIMAF weaknesses and vulnerabilities. The effectiveness and efficiency of first aid depend on timing, and each PEIMAF analyzed, while coherent and adequate for internal purposes, fails to integrate with the other hospitals. Integration can speed up National Stockpile Antidotes delivery and save lives. For the best CBRNe response, detailed intervention protocols must be created, updated daily, and exercised.","PeriodicalId":508241,"journal":{"name":"Italian Journal of Medicine","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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XXIX Congresso Nazionale della Società Scientifica FADOI | 11-13 maggio 2024 第二十九届 FADOI 科学学会全国大会 | 2024 年 5 月 11-13 日

Italian Journal of Medicine Pub Date : 2024-05-10 DOI: 10.4081/itjm.2024.s1

F. Dentali

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Could internal jugular vein ultrasound be useful in the assessment of patients with heart failure? A systematic review 颈内静脉超声能否用于评估心力衰竭患者？系统回顾

Italian Journal of Medicine Pub Date : 2024-05-09 DOI: 10.4081/itjm.2024.1726

Nicola Parenti, C. Palazzi, Matilde Parenti, Sergio D'Addato

{"title":"Could internal jugular vein ultrasound be useful in the assessment of patients with heart failure? A systematic review","authors":"Nicola Parenti, C. Palazzi, Matilde Parenti, Sergio D'Addato","doi":"10.4081/itjm.2024.1726","DOIUrl":"https://doi.org/10.4081/itjm.2024.1726","url":null,"abstract":"Many recent studies have validated the internal jugular vein ultrasound (IJV-US) ultrasound for estimating volemic status in critical patients. If research confirms its accuracy in detecting intravascular volume, congestion, and prognosis, this method could help manage heart failure (HF) because it is simple, fast, and applicable in several settings. This review examines the IJV-US’s reliability, diagnostic accuracy, and ability to predict poor outcomes for HF, as well as its correlation with surrogate congestion tests like natriuretic peptides and elevated central venous pressure (CVP). Our systematic review followed the PRISMA statement for systematic reviews and meta-analyses. Eleven studies examined the reliability and validity of IJV-US measures in predicting congestion, volume status, and prognosis in adult spontaneously breathing HF patients. We searched PubMed, Cochrane Library, and EMBASE. IJV-US measurements using Valsalva and sniffing seem more accurate for predicting congestion, volume status, high CVP, and poor prognosis. The IJV ratio in chronic HF and out-hospital patients and the absence of IJV area [cross-sectional area (CSA)] changes in acute HF (AHF) and in-hospital patients are the most validated measurements. No evidence suggests the method is reliable between and within raters. AHF patients’ IJV ratio and CSA absence appear to correlate with CVP and atrial natriuretic peptides. In conclusion, the IJV-US may be useful for managing HF patients, but more research is needed to confirm its reliability and prognostic accuracy. Develop a standard US protocol lastly.","PeriodicalId":508241,"journal":{"name":"Italian Journal of Medicine","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Actinomyces turicensis: a peculiar case of empyema after COVID-19 in a patient with ulcerative colitis 土耳其放线菌：溃疡性结肠炎患者 COVID-19 后出现气肿的特殊病例

Italian Journal of Medicine Pub Date : 2024-05-09 DOI: 10.4081/itjm.2024.1708

Federico Marzi, Antonio D'Errico, Mario Alessandri, Veronica De Crescenzo, M. Manini

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Leptomeningeal carcinomatosis, an emerging disease in internal medicine departments with a generally poor prognosis: two case reports 多发性脑膜癌，内科中一种新出现的疾病，预后普遍较差：两份病例报告

Italian Journal of Medicine Pub Date : 2024-05-07 DOI: 10.4081/itjm.2024.1727

F. Pietrantonio, Margherita Lordi, Fabio Vinci, Elena Alessi, Matteo Pascucci, M. Delli Castelli, Antonio Vinci, Enrica Cipriano, F. Rosiello, A. Ciamei

{"title":"Leptomeningeal carcinomatosis, an emerging disease in internal medicine departments with a generally poor prognosis: two case reports","authors":"F. Pietrantonio, Margherita Lordi, Fabio Vinci, Elena Alessi, Matteo Pascucci, M. Delli Castelli, Antonio Vinci, Enrica Cipriano, F. Rosiello, A. Ciamei","doi":"10.4081/itjm.2024.1727","DOIUrl":"https://doi.org/10.4081/itjm.2024.1727","url":null,"abstract":"As a result of improved diagnostic methods and higher cancer patient survival rates, leptomeningeal carcinomatosis is being found in internal medicine departments more frequently. Melanoma, lung cancer, and breast adenocarcinoma are the three cancers that are most commonly associated. When the main tumor diffuses through the bloodstream, cerebrospinal fluid, or direct diffusion and causes multiple focal neurological symptoms, it is known as leptomeningeal involvement; the prognosis is usually not good. Despite multimodal treatment, leptomeningeal carcinomatosis is an advanced form of cancer that frequently results in rapid death. Treatment is typically palliative and consists primarily of intrathecal or systemic radiation and/or chemotherapy. New experimental therapies and immunotherapy are promising means of lowering morbidity and mortality. Clinical cases of leptomeningeal carcinomatosis are reported; both cases were identified at the Ospedale dei Castelli’s Department of Internal Medicine and resulted from primary breast pathology.","PeriodicalId":508241,"journal":{"name":"Italian Journal of Medicine","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anticancer effects of punicalagin and 5-fluorouracil on laryngeal squamous cell carcinoma: an in vitro study 潘尼卡星和 5-氟尿嘧啶对喉鳞状细胞癌的抗癌作用：体外研究

Italian Journal of Medicine Pub Date : 2024-02-22 DOI: 10.4081/itjm.2024.1699

Amany M. Taha, Eman Abd-Elshafy, Asmaa M. Khalifa, N. Dar-Odeh, Shadia Elsayed, Daniah S. Alharkan, Aishah Alhodhodi, Ahmed Saaduddin Sapri, Yassmeen SalahEldin Ragheb, G. Balbola

{"title":"Anticancer effects of punicalagin and 5-fluorouracil on laryngeal squamous cell carcinoma: an in vitro study","authors":"Amany M. Taha, Eman Abd-Elshafy, Asmaa M. Khalifa, N. Dar-Odeh, Shadia Elsayed, Daniah S. Alharkan, Aishah Alhodhodi, Ahmed Saaduddin Sapri, Yassmeen SalahEldin Ragheb, G. Balbola","doi":"10.4081/itjm.2024.1699","DOIUrl":"https://doi.org/10.4081/itjm.2024.1699","url":null,"abstract":"The purpose of this study was to assess the apoptotic effects of punicalagin alone and in combination with 5-fluorouracil (5-FU) on laryngeal squamous cell carcinoma (Hep-2) cell line. Hep-2 cells were cultured and divided into four groups: Group 1 received no therapy and served as control, Group 2 received 5-FU only, Group 3 received punicalagin only, and Group 4 received a combination of 5-FU and punicalagin. After 48 hours of incubation, cellular changes were examined under an inverted microscope. The methyl thiazolyl tetrazolium assay, caspase-3 gene level, and vascular endothelial growth factor (VEGF) level were assessed. The control group showed the highest mean value of cancer cell proliferation rate (1.595±0.58), followed by the punicalagin group (1.263±0.447), then the 5-FU group (0.827±0.256), while the combination group showed the lowest proliferation rate (0.253±0.111). The combination group showed the highest mean value of caspase-3 concentration (3.177±0.736), followed by the 5-FU group (1.830±0.646), and punicalagin group (0.741±0.302), while the control group showed the lowest mean value (0.359±0.117). Regarding VEGF levels, the control group had a statistically significant higher mean value, followed by the punicalagin and 5-FU groups, and finally, the combination group which showed the lowest value. Punicalagin exerts an anticancer effect through anti-proliferative action and induction of apoptosis on Hep-2 cell line. Combining punicalagin with 5-FU potentiates its anti-proliferative, apoptotic, and anti-angiogenic actions. It, further, helps in mitigating the putative side effects of 5-FU by reducing the dose required for its therapeutic effects.","PeriodicalId":508241,"journal":{"name":"Italian Journal of Medicine","volume":"6 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Il referral del paziente internistico in cardiologia riabilitativa - Position paper FADOI, ITACARE-P 康复心脏病学中的内科病人转诊--FADOI、ITACARE-P 立场文件

Italian Journal of Medicine Pub Date : 2024-02-19 DOI: 10.4081/itjm.q.2024.1

Francesco Dentali, Francesco Fattirolli, P. Gnerre, Franco Mastroianni, Gian Francesco Mureddu, Marco Ambrosetti

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Medicinal potential of antimicrobial peptides from two plants against Bacillus cereus and Staphylococcus aureus 两种植物的抗菌肽对蜡样芽孢杆菌和金黄色葡萄球菌的药用潜力

Italian Journal of Medicine Pub Date : 2024-02-01 DOI: 10.4081/itjm.2024.1670

Raheela Jabeen, Eqaza Javed, Ume Habiba, Muhammad Akram Choohan, Muhammad Asim, F. Alatawi, Hamza Ishfaq, Jaweria Nisar

{"title":"Medicinal potential of antimicrobial peptides from two plants against Bacillus cereus and Staphylococcus aureus","authors":"Raheela Jabeen, Eqaza Javed, Ume Habiba, Muhammad Akram Choohan, Muhammad Asim, F. Alatawi, Hamza Ishfaq, Jaweria Nisar","doi":"10.4081/itjm.2024.1670","DOIUrl":"https://doi.org/10.4081/itjm.2024.1670","url":null,"abstract":"Bacillus cereus and Staphylococcus aureus are the most important bacteria that cause nosocomial infection and are resistant to antibiotics. Crude proteins from Cassia fistula and Ricinus communis were isolated to study their medicinal potential against Bacillus cereus, and Staphylococcus aureus. Extraction of the crude proteins from plants was done by phosphate buffer saline (PBS) and Tris NaCl buffer by using the roots and seeds of both plants. Antimicrobial activity was checked against bacterial strains by using agar disc diffusion and agar well diffusion methods. Zones of inhibitions were measured. On well diffusion method, PBS buffer protein extract of C. fistula roots showed a maximum zone of inhibition of 25 mm against B. cereus. Tris NaCl buffer extracts of C. fistula roots and seeds showed zones of inhibition of 12mm and 5mm respectively against S. aureus while Ricinus communis roots showed a zone of 12mm against B. cereus. Because the protein of the plants showed good antimicrobial activity, we can use these plants against various diseases caused by Bacillus cereus and Staphylococcus aureus.","PeriodicalId":508241,"journal":{"name":"Italian Journal of Medicine","volume":"59 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139686720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0