Functional Foods in Health and Disease最新文献

{"title":"Clinical effect of phytosterol-enriched saw palmetto extract on urinary function in healthy middle-aged and older males: a double-blind, placebo-controlled randomized comparative study","authors":"Tatsuya Hisajima, H. Waki, Takuya Suzuki, Takashi Izumi","doi":"10.31989/ffhd.v14i2.1312","DOIUrl":"https://doi.org/10.31989/ffhd.v14i2.1312","url":null,"abstract":"Background: Saw palmetto extract (SPE) is one of the most widely used supplements for benign prostatic hyperplasia (BPH) due to its pharmacological effects. β-sitosterol-enriched saw palmetto oil (VISPO™) contains more than 3% β-sitosterol and 85% total fatty acids and has been shown to improve symptoms in patients with BPH. Lower urinary tract symptoms (LUTS) require primary preventive measures in countries with accelerated population aging, including Japan. VISPO™ is expected to be effective against the early symptoms of LUTS. However, the effect of VISPO™ on urinary function in healthy individuals has not been elucidated.\u0000Objective: This clinical study evaluated the efficacy and tolerability of VISPO™ in the management of urinary complaints among healthy middle-aged and older men who did not require treatment.\u0000Methods: We conducted a randomized, double-blind, placebo-controlled trial that included 54 male participants who were assigned to consume VISPO™ or placebo (olive oil) capsules for 12 weeks. Biometric data, uroflowmetry results, and salivary hormone levels were assessed at weeks 1 and 12. Urinary function and quality of life were assessed at weeks 1, 4, 8, and 12 using the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Core Lower Urinary Tract Symptom Score (CLSS), and WHOQOL-26.\u0000Results: Two-way analysis of variance revealed that IPSS and OABSS were significantly lower in the VISPO™ group that in the placebo group. However, there were no significant differences in urine volume, urinary flow rate, or salivary hormone levels. In addition, no participants reported adverse effects (diarrhea, abdominal pain, etc.). \u0000Conclusion: The results of the present study, which is the first randomized controlled trial of VISPO™ conducted among healthy participants, demonstrate the effectiveness of VISPO™ in the management of lower urinary tract complaints that do not require treatment. \u0000Trial Registration: University Hospital Medical Information Network Clinical Trials Registry (UMIN000046386).\u0000\u0000Keywords: saw palmetto, VISPO™, β-sitosterol, fatty acids, healthy subjects, primary preventive, IPSS, OABSS, lower urinary tract symptoms (LUTS)","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effect of phytosterol-enriched saw palmetto extract on urinary function in healthy middle-aged and older males: a double-blind, placebo-controlled randomized comparative study","authors":"Tatsuya Hisajima, H. Waki, Takuya Suzuki, Takashi Izumi","doi":"10.31989/ffhd.v14i2.1312","DOIUrl":"https://doi.org/10.31989/ffhd.v14i2.1312","url":null,"abstract":"Background: Saw palmetto extract (SPE) is one of the most widely used supplements for benign prostatic hyperplasia (BPH) due to its pharmacological effects. β-sitosterol-enriched saw palmetto oil (VISPO™) contains more than 3% β-sitosterol and 85% total fatty acids and has been shown to improve symptoms in patients with BPH. Lower urinary tract symptoms (LUTS) require primary preventive measures in countries with accelerated population aging, including Japan. VISPO™ is expected to be effective against the early symptoms of LUTS. However, the effect of VISPO™ on urinary function in healthy individuals has not been elucidated.\u0000Objective: This clinical study evaluated the efficacy and tolerability of VISPO™ in the management of urinary complaints among healthy middle-aged and older men who did not require treatment.\u0000Methods: We conducted a randomized, double-blind, placebo-controlled trial that included 54 male participants who were assigned to consume VISPO™ or placebo (olive oil) capsules for 12 weeks. Biometric data, uroflowmetry results, and salivary hormone levels were assessed at weeks 1 and 12. Urinary function and quality of life were assessed at weeks 1, 4, 8, and 12 using the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Core Lower Urinary Tract Symptom Score (CLSS), and WHOQOL-26.\u0000Results: Two-way analysis of variance revealed that IPSS and OABSS were significantly lower in the VISPO™ group that in the placebo group. However, there were no significant differences in urine volume, urinary flow rate, or salivary hormone levels. In addition, no participants reported adverse effects (diarrhea, abdominal pain, etc.). \u0000Conclusion: The results of the present study, which is the first randomized controlled trial of VISPO™ conducted among healthy participants, demonstrate the effectiveness of VISPO™ in the management of lower urinary tract complaints that do not require treatment. \u0000Trial Registration: University Hospital Medical Information Network Clinical Trials Registry (UMIN000046386).\u0000\u0000Keywords: saw palmetto, VISPO™, β-sitosterol, fatty acids, healthy subjects, primary preventive, IPSS, OABSS, lower urinary tract symptoms (LUTS)","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"111 2-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an iron-fortified gummy on iron-deficiency anemia in young women","authors":"Yan Xiao, Bingjie Yang, Jiayi Ni, Ran Hu","doi":"10.31989/ffhd.v14i2.1239","DOIUrl":"https://doi.org/10.31989/ffhd.v14i2.1239","url":null,"abstract":"Objective: We conducted this single-center, double-blinded, randomized and placebo-controlled study to explore the efficacy of an iron-fortified gummy on relieving iron-deficiency anemia in young Chinese women. Participants’ blood hemoglobin level was set as the primary outcome. The secondary objectives were to assess the effects of the iron-fortified gummy on participants’ blood iron levels, skin barrier functions, skin temperature regulating ability, menstruation and leucorrhea status, sleep quality, and overall quality of life.Methods: Seventy female participants aged 18-35 years with moderate iron-deficiency anemia (blood hemoglobin 90-120 g/L) were recruited and randomly assigned to an intervention group or a placebo group. We supplemented the diets of the participants with an iron-fortified gummy or a placebo for eight weeks. Their blood hemoglobin level, iron biomarkers, skin biophysical characteristics, hand temperature, self-reported menstruation and leucorrhea status, life quality and sleep quality were recorded at baseline, mid-way through the study and the end of the study. We compared the differences of the above outcomes between the intervention group and the control group. Results: After eight weeks of daily iron-fortified gummy intake, 80% of the participants showed improvement in blood hemoglobin concentration, with a mean increase of 14.5 g/L (95% confidence interval: 9.4, 19.5 g/L) compared to the control. Their serum iron and ferritin levels had significantly increased. They also had improved facial skin hydration and complexions, reduced transepidermal water loss, and accelerated temperature recovery in their hands. Intake of the iron-fortified gummy effectively reduced the incidence of menstrual headaches and insomnia. Participants reported prolonged sleep time, improved energy level, mobility, mental concentration, ability to engage in daily activities and work, as well as better perception of quality of life and health satisfaction.Conclusion:Daily consumption of the iron-fortified gummy over eight weeks could help build up blood iron levels to generate hemoglobin, relieve iron-deficiency anemia and related symptoms in young Chinese women. Intake of iron through gummy on a daily basis is an effective method to gradually increase the participants’ iron levels, leading to sustainable long-term benefits.Study registration: Chinese Clinical Trial Registry (ChiCTR2200061345).","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"60 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an iron-fortified gummy on iron-deficiency anemia in young women","authors":"Yan Xiao, Bingjie Yang, Jiayi Ni, Ran Hu","doi":"10.31989/ffhd.v14i2.1239","DOIUrl":"https://doi.org/10.31989/ffhd.v14i2.1239","url":null,"abstract":"Objective: We conducted this single-center, double-blinded, randomized and placebo-controlled study to explore the efficacy of an iron-fortified gummy on relieving iron-deficiency anemia in young Chinese women. Participants’ blood hemoglobin level was set as the primary outcome. The secondary objectives were to assess the effects of the iron-fortified gummy on participants’ blood iron levels, skin barrier functions, skin temperature regulating ability, menstruation and leucorrhea status, sleep quality, and overall quality of life.Methods: Seventy female participants aged 18-35 years with moderate iron-deficiency anemia (blood hemoglobin 90-120 g/L) were recruited and randomly assigned to an intervention group or a placebo group. We supplemented the diets of the participants with an iron-fortified gummy or a placebo for eight weeks. Their blood hemoglobin level, iron biomarkers, skin biophysical characteristics, hand temperature, self-reported menstruation and leucorrhea status, life quality and sleep quality were recorded at baseline, mid-way through the study and the end of the study. We compared the differences of the above outcomes between the intervention group and the control group. Results: After eight weeks of daily iron-fortified gummy intake, 80% of the participants showed improvement in blood hemoglobin concentration, with a mean increase of 14.5 g/L (95% confidence interval: 9.4, 19.5 g/L) compared to the control. Their serum iron and ferritin levels had significantly increased. They also had improved facial skin hydration and complexions, reduced transepidermal water loss, and accelerated temperature recovery in their hands. Intake of the iron-fortified gummy effectively reduced the incidence of menstrual headaches and insomnia. Participants reported prolonged sleep time, improved energy level, mobility, mental concentration, ability to engage in daily activities and work, as well as better perception of quality of life and health satisfaction.Conclusion:Daily consumption of the iron-fortified gummy over eight weeks could help build up blood iron levels to generate hemoglobin, relieve iron-deficiency anemia and related symptoms in young Chinese women. Intake of iron through gummy on a daily basis is an effective method to gradually increase the participants’ iron levels, leading to sustainable long-term benefits.Study registration: Chinese Clinical Trial Registry (ChiCTR2200061345).","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"1218 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of functional components in Sakekasu (Sake lees)","authors":"Yuto Nishidono, S. Misaka, Yuko Maejima, Kenju Shimomura, Ken Tanaka","doi":"10.31989/ffhd.v14i1.1272","DOIUrl":"https://doi.org/10.31989/ffhd.v14i1.1272","url":null,"abstract":"Background:Sake lees (Sakekasu), a byproduct of sake production, has been recently attracting attention as a functional food. Sakekasu is rich in nutrients and contains glycerophosphocholine (GPC) and S-adenosylmethionine (SAM), which are well-known functional compounds. The content of these compounds in Sakekasu depends on a variety of factors, including fermentation conditions, especially the method and length of ripening. These differences are reflected prominently in the color of Sakekasu, which becomes darker due to the long ripening period and high drying temperature. Objective: This study aimed to clarify the contents of functional components in Sakekasu with different color tones (i.e., ripening period).Methods:Three types of Sakekasu with different color tones (white, ocher, and brawn) were collected from several breweries. The contents of multiple functional components in their extracts were determined by liquid chromatography coupled to high resolution ion-trap/time-of-flight mass spectrometry.Results: Sakekasu with white color had more abundant GPC, SAM, and fatty acids than those with darker color. However, ethyl glucoside and glyceryl glucosides did not differ significantly by color tone. Furthermore, the Maillard reaction products of sugar and dipeptide were mainly found in dark-colored Sakekasu, and their structures were annotated by tandem mass spectrometry.Conclusions:This study has clarified many functional compounds in Sakekasu in relation to color tone (i.e., ripening period) and highlighted the potential of Sakekasu with white color tone as a functional food.Keywords: Sakekasu, functional components, glycerophosphocholine, S-adenosylmethionine, tandem mass spectrometer  ","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139618369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sorghum intake on postprandial blood glucose levels: A randomized, double-blind, crossover study","authors":"Hitomi Miyazaki, Masumi Nagae, Hiroshi Uchida, Kuniyoshi Shimizu","doi":"10.31989/ffhd.v14i1.1266","DOIUrl":"https://doi.org/10.31989/ffhd.v14i1.1266","url":null,"abstract":"Background: Sorghum is consumed in Africa, North and South America, India, and other parts of the world, but it is one of several millets in Japan, and its physiological function for Japanese is not well known. In this study, we examined the effect of sorghum on postprandial blood glucose levels in healthy Japanese.Objective: This study aims to investigate the effect of sorghum intake on postprandial blood glucose in healthy adults. Methods: A double-blind crossover study was done on 17 healthy adult men and women recruited from the general population. After an early morning fasting blood glucose test, a placebo or sorghum porridge was administered and blood glucose levels were measured at 30, 60, and 120 minutes after the first washout period. Result: At 60 and 120 minutes after intake, the blood glucose level of people who were administered sorghum porridge was significantly lower than that of those who were administered the placebo. The area under the blood glucose curve was also significantly lower for the test product than for the placebo. Conclusion: Sorghum consumption can suppress the increase in postprandial blood glucose, suggesting that sorghum is useful in preventing the development of diabetes mellitus.Trial registration: UMIN-CTR: UMIN000046235Keywords: Sorghum, blood glucose, postprandial blood glucose","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":" June","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139618341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helichrysum arenarium as a source of flavonoids: Evaluation of antimicrobial activity and flavonoid content of extracts of Helichrysum flowers in vitro","authors":"Asya Badalyan, Syuzanna Abrahamyan, Arevik Abovyan, Armen Badalyan, G. Semerjyan, Narine Hovhannisyan","doi":"10.31989/ffhd.v14i1.1257","DOIUrl":"https://doi.org/10.31989/ffhd.v14i1.1257","url":null,"abstract":"Background: Helichrysum (family Asteraceae, kind of H. armenium, subfamily of Asteroideae) is known in Armenian traditional medicine for its diuretic, antioxidant, choleretic and anti-inflammatory properties. Studies have shown that Helichrysum flowers have a high content of flavonoids. In this study, we investigated the impact of various extraction process parameters on the yield of flavonoids obtained from Helichrysum flowers in Armenia. Subsequently, a comprehensive antimicrobial assay was conducted on the ethanol and aqueous extracts derived from the dried flower heads of Helichrysum. Objective: The objective of this study is to explore the influence of extraction process parameters on the yield of flavonoids from H. arenarium flowers and to determine their antibacterial activity.Methods: Antibacterial activity was determined using the agar-well diffusion method against four bacterial species (E. coli, Salmonella enterica, Staphylococcus aureus and S. typhimirium). The assessment of the total flavonoid content in the ethanol extract of Helichrysum was conducted using the AlCl3 method, following the procedure outlined by Andreeva and Kalinkina. Results: The ethanolic and aqueous extracts demonstrated antibacterial activity against Staphylococcus aureus ATCC 6538 and Bacillus Subtilis 168. However, no significant activity was observed against Escherichia coli ATCC 8739 and Salmonella Typhimurium ATCC 14028. The research findings affirm that the extract derived from everlasting flowers exhibits antimicrobial properties, particularly targeting Gram-positive bacteria. Conclusion: The results of our tests indicate that the extract of Helichrysum belonging to Armenian flora, is rich in flavonoids and has significant antimicrobial activity and may find application in the food industry, as well as in organic agriculture.Keywords: Helichrysum, plant extracts, flavonoids, antimicrobial activity, spectrophotometry","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"39 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tartaric acid new derivatives as prospective and safe alternative to antimicrobials for food products packing","authors":"A. Mikaelyan, B. Babayan, Armen L. Grigoryan, A. Grigoryan, Nona Asatryan, M. Melkumyan","doi":"10.31989/ffhd.v14i1.1195","DOIUrl":"https://doi.org/10.31989/ffhd.v14i1.1195","url":null,"abstract":"Introduction: Multi-drug resistance of pathogens and food spoilage bacteria is one of the most prevalent problems in contemporary science because the microbial adaptation potential is permanently being stimulated by the excessive antibiotic usage by mankind. In this research, seven new derivatives of tartaric acid (TA) were studied. Their high activity against the multi-drug resistant bacteria and the biodegradation potential by soil microflora was demonstrated.Objective: Based on multiple literature data about aldaric acids antimicrobial properties, for combating pan-drug and especially multi-drug resistant pathogenic microbes,  natural L-tartaric acid was target-derivatized by cyclohexyl-, phenyl-, benzyl- and ethanolamine- functional groups into complex amino salts and cyclic imides, which have demonstrated the significant bactericidal and bacteriostatic activity against the spoilage agent bacteria, as well as phytopathogenic and human opportunistic pathogens.Results: In vitro analyses of TA ethanolamine- benzyl-, cyclohexyl- and phenyl- imides and complex amino salts have shown that the mentioned substances are highly active agents for combating multi-drug resistant Gram-positive and Gram-negative pathogens and food spoilage microbes, such as: Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Klebsiella pneumonia, Salmonella enteritidis, Staphylococcus aureus, etc. These compounds are biodegradable by P. chlororaphis group non-pathogenic bacteria and their resistance is ensured by genes of nucleoid as well as are not transmitted by plasmids. In silico analyses have demonstrated their alternative mechanism of action. Conclusions: The results suggest that TA new derivatives can be potentially recommended as safe alternative antimicrobials for food packaging.Keywords: tartaric acid imides, tartaric acid complex aminosalts, spoilage microorganisms, antimicrobial activity, multi-drug resistance. ","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139444783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of vitamin- and mineral-content stability of tomato fruits as a potential raw material to produce functional food","authors":"Zharkova Irina, Pochitskaya Irina, Efremov Dmitriy, Plotnikova Inessa, Chusova Alla, Pronkina Alena, Harutyunyan Natalya","doi":"10.31989/ffhd.v14i1.1259","DOIUrl":"https://doi.org/10.31989/ffhd.v14i1.1259","url":null,"abstract":"Background: Tomatoes are a valuable source of biologically active substances (vitamin C, lycopene, lutein, macro- and microelements) and can be used to produce functional foods.Objective: Nine varieties of tomato fruits, featuring a spectrum of colors such as red, yellow, and dark hues (brown, burgundy), were examined. These tomatoes were cultivated in open ground in both the Russian Federation and the Republic of Belarus. Methods: The mineral composition of tomato fruit samples was determined using an atomic emission spectrometer with inductively coupled plasma, mass fractions of vitamin C and carotenoids were determined by high-performance liquid chromatography.Results: The highest vitamin C content was observed in the fruits of tomato varieties Viagra and Chocolate, cultivated in the villages of Khokhol and Nikonovo in the Voronezh Region, Russia, and in the variety Budenovka, grown in Nikonovo. Additionally, the highest lycopene content was identified in the fruits of The Black Prince, cultivated in the agro-town Samokhvalovichi, Belarus; Volgogradskiy skorospelyi, grown in Nikonovo; Bull's Heart, cultivated in Khokhol in the Voronezh Region, Russia; and Black Heart of Bull, cultivated in Khokhol and Nikonovo respectively. Notably, tomatoes of the varieties The Black Prince (agro-town Samokhvalovichi, Belarus), Chocolate, Black Heart of Bull, and Bull's Heart (Khokhol, Russia) exhibited a significant amount of lutein. Furthermore, tomatoes of the variety Budenovka, grown in Khokhol, Russia, displayed high mineral saturation. Varieties Bull's Heart and Black Heart of Bull, grown in the same region, were found to be rich in macro- and trace elements (K, Ca, Mg, P, Mn, Fe). The optimal calcium-to-phosphorus ratio (1:1.5) was observed in varieties Bull's Forehead, Black Heart of Bull, and Budenovka, while the optimal calcium-to-magnesium ratio (1:0.7) was present in the fruits of tomato varieties Volgogradskiy skorospelyi, Bull's Forehead, Budenovka, Black Heart of Bull, Bull's Heart, and Orange, grown in various regions of the Russian Federation. Conclusion: The inclusion of biologically active substances, notably lycopene, lutein, Vitamin C, and essential minerals (Potassium, Calcium, Magnesium, Phosphorus), positions tomatoes as valuable sources for developing functional foods and those designed to prevent cardiovascular diseases. The composition of tomatoes varies significantly based on the fruit's color and the cultivation location. This variability underscores the importance of considering these factors to achieve the desired level of functional ingredients in the final product.Keywords: tomato fruits, biologically active substances, vitamin C, lycopene, lutein, macro- and microelements.","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"45 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perilla seed oil as an adjunctive treatment with statins improves lipid profiles in elderly patients: a post hoc data analysis","authors":"Rapeebhorn Chanapuk, Sombat Mungtaweepongsa, Kusuma Sriyakul, Parunkul Tungsukruthai, Junya Pattaraarchachai, Chuntida Kamalashiran","doi":"10.31989/ffhd.v13i12.1258","DOIUrl":"https://doi.org/10.31989/ffhd.v13i12.1258","url":null,"abstract":"Background: Dyslipidemia is characterized by abnormal lipid concentrations in the bloodstream, heightening the risk of atherosclerosis. While statins are primarily prescribed to treat dyslipidemia, not all patients benefit from them for various reasons, such as intolerance, myopathy, and hepatotoxicity. Perilla frutescens (L.) Britton, traditionally grown in East Asia, has been used for various therapeutic purposes. The seed oil of this plant is prosperous in omega-3 polyunsaturated fatty acids. Previous research found the efficacy of perilla (P. frutescens) seed oil in reducing cholesterol in patients with dementia. Our study aimed to determine if the lipid-lowering effects of P. frutescens seed oil occur on their own or alongside statin treatments by conducting a retrospective analysis of existing data to assess its efficacy in improving lipid profiles among the elderly.Objective: This study aimed to understand if P. frutescens seed oil inherently possesses lipid-lowering properties or if these effects are amplified when combined with statins.Methods: A retrospective post hoc analysis was performed on 182 geriatric patients previously involved in a dementia study. These patients were categorized into four groups: those administered both P. frutescens seed oil and a statin (G1), only P. frutescens seed oil (G2), only a statin (G3), and neither (G4). The outcomes evaluated post-intervention included lipid profiles, liver and renal functions, complete blood count, and neutrophils to lymphocytes and platelets (N/LP) ratio.Results: Patients in G1 exhibited the most pronounced reductions in total cholesterol and LDL-C levels, suggesting a potential synergistic effect when P. frutescens seed oil is combined with statins. Liver enzyme levels remained stable across all groups, suggesting the hepatic safety of P. frutescens seed oil even when co-administered with statins.Conclusion: P. frutescens seed oil, particularly when used alongside statins, exhibits the potential to improve lipid profiles and may also offer liver protection. However, extended studies are necessary to understand its therapeutic significance in cardiovascular disease management fully.Keywords: Perilla frutescens,omega-3,statins, lipid profile, elderly, hepatoprotection, functional food, bioactive compound","PeriodicalId":507841,"journal":{"name":"Functional Foods in Health and Disease","volume":"346 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}