National Science Review最新文献_第2页

Earth's core-mantle boundary shaped by crystalizing a hydrous terrestrial magma ocean 地核-地幔边界是由含水陆地岩浆海洋结晶形成的

National Science Review Pub Date : 2024-05-13 DOI: 10.1093/nsr/nwae169

Qingyang Hu, Jie Deng, Yukuai Zhuang, Zhenzhong Yang, Rong Huang

引用次数: 0

Non-innocent partners: bias distribution between photoanodes and cathodes in photoelectrochemical overall water-splitting cells 非无辜伙伴：光电化学整体分水电池中光电阳极和阴极之间的偏压分布

National Science Review Pub Date : 2024-05-01 DOI: 10.1093/nsr/nwae155

Wei Li, Dunwei Wang

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Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma 免疫-肿瘤相互作用决定食管鳞状细胞癌的空间定向演化

National Science Review Pub Date : 2024-04-23 DOI: 10.1093/nsr/nwae150

Yong Zhou, Shanlan Mo, Heyang Cui, Ruifang Sun, Weimin Zhang, Xiaofei Zhuang, Enwei Xu, Hongyi Li, Yikun Cheng, Yongsheng Meng, Meilin Liu, Ting Yan, Huijuan Liu, Ling Zhang, Bin Yang, Yanfeng Xi, Shubin Wang, Xiaolong Cheng, ShuaiCheng Li, Zhihua Liu, Qimin Zhan, Zheng Hu, Yongping Cui

{"title":"Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma","authors":"Yong Zhou, Shanlan Mo, Heyang Cui, Ruifang Sun, Weimin Zhang, Xiaofei Zhuang, Enwei Xu, Hongyi Li, Yikun Cheng, Yongsheng Meng, Meilin Liu, Ting Yan, Huijuan Liu, Ling Zhang, Bin Yang, Yanfeng Xi, Shubin Wang, Xiaolong Cheng, ShuaiCheng Li, Zhihua Liu, Qimin Zhan, Zheng Hu, Yongping Cui","doi":"10.1093/nsr/nwae150","DOIUrl":"https://doi.org/10.1093/nsr/nwae150","url":null,"abstract":"\u0000 Esophageal squamous cell carcinoma (ESCC) is a poor-prognostic cancer type with extensive intra- and inter-patient heterogeneity in both genomic variations and tumor microenvironment (TME). However, the patterns and drivers of spatial genomic and microenvironmental heterogeneity of ESCC remain largely unknown. Here, we generated a spatial multi-omic atlas by whole-exome, transcriptome, and methylome sequencing of 507 tumor samples from 103 patients. We identified a novel tumor suppressor PREX2, accounting for 22% ESCCs with frequent somatic mutations or hyper-methylation, which promoted migration and invasion of ESCC cells in vitro. Analysis of the tumor microenvironment and quantification of subclonal expansion indicated that ESCCs undergo spatially directed evolution, where subclones mostly originated from the tumor center but had a biased clonal expansion to the upper direction of the esophagus. Interestingly, we found upper regions of ESCCs often underwent stronger immunoediting with increased selective fitness, suggesting more stringent immune selection. In addition, distinct TMEs were associated with variable genomic and clinical outcomes. Of which, hot TME was associated with high immune evasion and subclonal heterogeneity. We also found that immunoediting, instead of CD8+ T cell abundance, acts as an independent prognostic factor of ESCCs. Importantly, we found significant heterogeneity in previously considered potential therapeutic targets, as well as BRCAness characteristics in a subset of patients, emphasizing the importance of focusing on heterogeneity in ESCC targeted therapy. Collectively, these findings provide novel insights into the mechanisms of the spatial evolution of ESCC and inform precision therapeutic strategies.","PeriodicalId":507754,"journal":{"name":"National Science Review","volume":"42 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140668206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human brain computing and brain-inspired intelligence 人脑计算和脑启发智能

National Science Review Pub Date : 2024-04-22 DOI: 10.1093/nsr/nwae144

Jianfeng Feng, V. Jirsa, Wenlian Lu

引用次数: 0

Wireless powering solution for implantable electronics based on ultra-low frequency magnetic energy focusing 基于超低频磁能聚焦的植入式电子设备无线供电解决方案

National Science Review Pub Date : 2024-04-09 DOI: 10.1093/nsr/nwae140

Haoyuan Wang, Xinge Yu

引用次数: 0

Toward multicomponent mesoporous single-crystalline metal oxides 开发多组分介孔单晶金属氧化物

National Science Review Pub Date : 2024-04-05 DOI: 10.1093/nsr/nwae104

Minkyeong Ban, Jinwoo Lee

引用次数: 0

Endovascular embolization by a magnetic microfiberbot 利用磁性微纤维栓塞器进行血管内栓塞

National Science Review Pub Date : 2024-04-04 DOI: 10.1093/nsr/nwae117

Shuning Zhang, Wenlong Yang, Junbo Ge

引用次数: 0

Volatiles in the mantle transition zone and their effects on big mantle wedge systems 地幔过渡带的挥发物及其对大地幔楔系统的影响

National Science Review Pub Date : 2024-04-04 DOI: 10.1093/nsr/nwae136

Yu Wang, Yi‐Gang Xu

引用次数: 0

Towards high-field applications: high-performance, low-cost iron-based superconductors 迈向高场应用：高性能、低成本铁基超导体

National Science Review Pub Date : 2024-03-30 DOI: 10.1093/nsr/nwae122

C. Dong, Qingjin Xu, Yanwei Ma

引用次数: 0

Pulsed operation of perovskite LEDs: A study on the role of mobile ions 过氧化物发光二极管的脉冲操作：关于移动离子作用的研究

National Science Review Pub Date : 2024-03-29 DOI: 10.1093/nsr/nwae128

Miguel A Torre Cachafeiro, N. K. Kumawat, Feng Gao, Wolfgang Tress

{"title":"Pulsed operation of perovskite LEDs: A study on the role of mobile ions","authors":"Miguel A Torre Cachafeiro, N. K. Kumawat, Feng Gao, Wolfgang Tress","doi":"10.1093/nsr/nwae128","DOIUrl":"https://doi.org/10.1093/nsr/nwae128","url":null,"abstract":"\u0000 Metal halide perovskite light emitting diodes (PeLEDs) are a promising technology for energy-efficient and cost-effective lighting and displays, thanks to their tunable color emission, high brightness, color purity, and low-temperature fabrication. However, the mixed ionic-electronic conductivity of perovskite materials presents unique challenges, as ionic defects can redistribute under operation, affecting the energy landscape and charge recombination mechanisms. Our drift-diffusion simulations establish a connection between the transient electroluminescence (TrEL) signals of PeLEDs under pulsed operation and the influence of mobile ions. We find that the TrEL plateau value’s dependence on duty cycle and the end-of-pulse overshoot can be explained by the time-varying distribution of ionic defects. The inclusion of mobile ions is crucial to understand the TrEL response. Moreover, the simulations highlight injection barriers at the perovskite/charge-transport layer interfaces, such as is the case for the hole transport layer (HTL) in our example, as a significant source of non-radiative charge recombination. These findings contribute to the understanding of transient ionic processes in perovskite-based devices.","PeriodicalId":507754,"journal":{"name":"National Science Review","volume":"14 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140368687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0